| 자궁 경부종양에서 Keratin 표편형에 대한 면역조직화학적 연구 |
| 기근홍, 임성철 |
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| Immunohistochemical Expression of Keratin Subtypes in Tumors of Uterine Cervix |
| Keun Hong Kee, Sung Chul Lim |
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| ABSTRACT |
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Keratin is a major class of intermediate filaments in epithelial cells, and comprises a group of at least 20 different multigene-derived proteins. It is expressed in different epithelia with specific combinations. The materials for this study consisted of chronic cervicitis, reserve cell hyperplasias, squamous metaplasias, cervical intraepithelial neoplasias, squamous cell carcinomas, and adenocarcinomas. All cases were performed by immunohistochemical stains for panel of monoclonal cytokerain(CK) antibodies. Also, some cases were examined by immunoelectron microscopy. The basal cells of exocervix were positively stained for CK 5/6, 8, 14, 18 and 19. The intermediate and superficial cells of exocervix were positive for CK 1, 5/6, 7, 8, 13 and 18. The endocervical columnar cells were positive for CK 7, 8, 18 and 19. The reserve cells were positively stained for CK 5/6, 8, 14, 18 and 19. The metaplastic cells were positively stained for CK 1, 5/6, 7, 8, 10 and 18. The dysplastic cells were positively stained for CK 5/6, 10, 13, l4, 18 and 19. The keratinizing squamous cell carcinomas were positively stained for CK 5/6, 8, 14 and 19. The nonkeratinizing squamous cell carcinomas were positively stained for CK 1, 5/6, 10, 13, 14 and 19. The adenocarcinomas were positively stained for CK 5/6, 7, 8, 10, 14, 18 and 19. In conclusion, individual normal epithelial cells and numerous tumor cells of the uterine cervix have two or more different subtypes of keratin. Keratinizing squamous cell carcinomas show similar staining pattern to those of reserve cells or basal cells. The cytokeratin subtypes of dysplastic cells are similar to those of nonkeratinizing squamous cell carcinomas. |
| Key words:
Keratin subtype, Uterine cervix |
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