Between 1980 and l992, 3l76 patients with adenocarcinoma of stomach underwent surgical treatment at the department of Surgery, Kosin Medical Collage. The purpose of this study was to evaluate clinical characteristics according to the WHO and Laurens classification and the implication of both classifications as a prognostic factor in stage III gastric cancer. The clinical characteristic according to the histopathologic factor in stage III gastric cancer. The clinical characteristic according to the histopathologic classification were evaluated in 788 patients with stage III gastric cancer who underwent gastrectomy. The relation of pathologic features according to WHO and Laurens classification and prognoss was studied. The 788 patients were classified as papillary type(11/788 1.40%), tubular well differenciated(l36/788 17.26%), tubular moderate differenciated(202/788 25.6%), poor differenciated(320/788 40.6%) mucinous(62/788 7.8 %), signet ring cell(50/788 6.35%), and others(7/788 0.8%) according to WHO, and as intestinal (399/788 50.6%), diffuse(293/788 37.1%), mixed(96/788 12.8%) according to Lauren. Carcinoma of tubular well differenciated and moderate differenciated were mostly intestinal type and carcinoma of poorly differenciated type were mostly diffuse type. The poorly differenciated and diffuse type were distributed considerably young age group and Borrmann type III and IV were significantly frequentr in tubular poor and diffuse type. But there no significant differ- ences were in tumor locations. The 5-years survival rate of stage IIIa patients were 63.3% in tubular well differenciated, 52.2% in tubular moderate differenciated, 39.8% in poorly differenciated, 44.l% in mucinous, 67.6% in signet ring cell, and 56.5% in intestinal, 40.7% in dif- fuse, 43.96% in mixed. The 5-years survival rate of stage IIIb patients were 40.7% in tubular well differenciate, 36.5% in tubular moderate differencite, 21.9% in poor differenciate, 34.3% in mixed. The combination of WHO histologic type and Lauren claesification may provide a good prognostic prediction in stage III gastric cancer.
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