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J Korean Cancer Assoc > Volume 27(1); 1995 > Article
Journal of the Korean Cancer Association 1995;27(1): 111-121.
원발성 편평상피암과 유도된 세포주의 세포 - 분자유전학적 비교
강중신, 손수상, 김대광, 장성익
Cyto - Melecular Conparison between Primary Squamous Cell Line from Bladder
Joong Shin Kang, Soo Sang Sohn, Dage Kwang Kim, Sung Ik Chang
ABSTRACT
To evaluate which cyto-molecular genetic evolutionary patterns take place during the in vitro establishment of permanent squamous cell carcinoma cell line of urinary bladder, cytomolecular genetic follow up was performed on primary culture for two weeks and on cancer cell line after contineued culture for three years in vitro. Near-diploid cells present on primary culture and near-hypertriploid or hypotetraploid cells, in contrast, present on cancer cell line. Chromosomal gains or losses are random from primary cancer to cell line. There are two kinds af structural cytogenetic abnormalities through progress in culture time. One is maintaining abnormal clone from original cancer to derived cancer cell line. Others are cytogenetic alteration during progessing culture time; Increasing and decreasing abnormal clones are coexisted in both grouy. Activation of oncogenes are different from primary cancer to cancer cell line. In conclusion, there are genetic alterations through progressing from primary cancer to cancer cell line. Due to these alterations, cancer ce11 1ines don't substituted for primary cancer and can not be availabe for using materials to choose production on monoclonal antibody and theraputic test.
Key words: Cyto-molecular, Carcinoma, Cancer cell, Cancer cell line, hypertriploid, Diploid, Abnormalities, Monoclonal antibody
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