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J Korean Cancer Assoc > Volume 26(6); 1994 > Article
Journal of the Korean Cancer Association 1994;26(6): 912-926.
유방암종에서 다약물 내성 유전자 단백질 P-Glycoprotein 발현에 대한 연구
강성식, 조세헌, 김상순, 정진숙, 홍숙희
Expression of Multidrug Resistance P-Glycoprotein in Breast Carcinoma
Sung Sik Kang, Se Heon Cho, Sang Soon Kim, Jin Sook Jung, Sook Hee Hong
In 38 women with breast carcinoma who had locally advanced cancer without distant metastasis, the expression of P-glycoprotein was evaluated, using JSB-1 monoclonal antibody by ABC-immunoperoxidase method, P-glycoprotein was detected in 35 of 38 tumor samples(91.4%). Result were expressed in a semiguantitative manner, taking into account the number of posi- tive tumor cells(N index) and the specific staining index(I index). The frequencies of higher expression(N+I+2 or I+3) were detected in 0% of grade I, 33% of grade II and 90.9% of grade III in infiltrating duct carcinoma. Recurred cases were 4 out of 38(10.5%), of which 3 cases showed high histologic grade and more advanced stage with strong P-glycoprotein expression (N+I+3). Strong P-glycoprotein-positive staining in a majority of tumor cells(N-/I+3) was significantly correlated with histoiogic group with poor prognosis hi#gh histologic grade and recurrence. Thus, the pretreatment evaluation of P-glycoprotein expression may be of prognostic value in patients with locally advanced breast cancer. The possiblity that Mdrl enhances the invasiveness of cancer was suggested.
Key words: P-Glycoprotein, Breast Ca.
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