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J Korean Cancer Assoc > Volume 26(4); 1994 > Article
Journal of the Korean Cancer Association 1994;26(4): 529-534.
수술전 화학요법을 시행한 식도암종의 병리학적 변화와 P-glycoprotein 발현양상
하창원, 조경자, 심영목, 조재일, 장자준
Pathologic Observatiosn and P-glycoprotein Expression in Esophageal Carcinomas Treated with Preoperative chemotherapy
Chang Won Ha, Kyung Ja Cho, Young Mog Shim, Jae Ill Zo, Ja June Jang
Neoadjuvant chemotherpay of esophageal cancers is recently considered to be beneficial to downstaging of tumors. This study was aimed ta describe morphologic alterations and expression of P-glycoprotein in esophageal cancers after chemotherapy and discuse their clinical sig- nificances. Eleven cases of esophageal cancers which were surgicelly resected l-5 cycles of chemotherapy with C-DDP/VP-16/5-FU(PEF)or C-DDP/5-FU(FP) were reviewed. On microscopic examination, all of ll cases(100%) revealed no major pathologic alterations. Only five cases(45%) showed non-specific partial pathologic responses, histologically observing foreign body reaction, calcification, necrosis, desmoplasia, vascular dilatation, and nuclear anaplasia. The changes were also observed in metastatic tumors in regional lymph nodes. The presence of non-specific pathologic responses and downstaging of tumors did not correlate each other. Immunohistochemically, all of the cases were negative for P-glycoprotein. Our data suggest that PEF or FP neoadjuvant chemotherpay for esophageal cancers is ineffecitive.
Key words: Esophageai cancer, chemotherapy, Pathologic response
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