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J Korean Cancer Assoc > Volume 26(2); 1994 > Article
Journal of the Korean Cancer Association 1994;26(2): 296-304.
상피성 난소암에서 p53 종양억제 유전자의 변이
김진우, 권동진, 나덕진, 이준모, 김대훈, 남궁성은, 김승조
Mutations of the p53 Tumor Suppressor Gene in Human Epithelial Overian Cancer
Jin Woo Kim, Dong Jin Kwon, Duk Jin Rha, Joon Mo Lee, Dae Hoon Kim, Sung Eun Namkoong, Seung Jo Kim
The p53 gene on chromosome 17p is considered to be a tumor suppressor gene, and frequent mutations in highly conserved regions of the p53 gene have been found in a wide variety of human cancers. Mutations in this portion of the gene are known to lead to the loss of the oncosuppressive potential of p53. To detect in a more sensitive manner p53 gene mutations in 28 human epithelial ovarian cancers we utilized the polymerase chain reaction-single strand conformation polymorphism(PCR- SSCP) technique. Using PCR primers for the regions of the p53 gene, including exons 4-9, p53 mutations were detected in 35.7%(10 of 28) of the ovarian cancers, Of the 10 mutations observed, 1 was found in exon 4, 7 were found in the region encompassing exons 5 and 6, 1 was found in exon 7 and 1 was found in the region encompassing exons 8 and 9. Mutations were clustered in exons 5 and 6 in highly conserved regions of the p53 gene. There results suggest that the mutations of the p53 gene play an important role in the development of human epthelial ovarian cancers.
Key words: Ovarian carcinoma, Tumor suppressor gene
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