| 고형암의 항암제 치료후 발생하는 호중구감소증에 대한 Granulocyte Colony Stimulation Factor ( G - CSF ) 의 효과 |
| 신상원, 남용진, 최철원, 송관규, 김준석, 김순덕, 김열홍 |
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| The Effects of Granulocyte Colony Stimulating Factor on Neutropenia Induced by the Chemotherapy in the Solid Tumor Patient |
| Sang Won Shin, Young Jin Nam, Chul Won Choi, Gwan Gyu Song, Jun Suk Kim, Soon Duck Kim, Yeul Hong Kim |
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| ABSTRACT |
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We evaluated the effect of aranulocyte colony stimulating factor (G-CSF) to prevent chemo- therapy induced neutropenia and fever development during neutropenic period. The twenty patients with solid tumor were treated with various cytotoxic chemotherapeutic agents at least two cycles. The patients were given G-CSF 75pg/day after 2nd cycle chemotherapy for least 14 consecutive days and clinical, laboratory results were compared to the first cycle's results. Treatment with G-CSF resulted in increase of mean neutrophil count(320+-230/mm(3) vs 1030 +-1020/mm(2)), reduced the duration of neutropenic days(4.25 dyas vs 1.30 days, absolute neutrophil count less than 500/mm) snd reduced the incidence of neutropenic fever(75% vs 25% ). The side effect af G-CSF was not so significant. These results demonsrated that the use of G-CSF as an adjunct to chemotherapy with various solid cancer patients was well tolerated and led to reduction in the incidence of neutropenic fever; in the terms of incidence, duratian, and severity of neutropenia. |
| Key words:
Granulocyte colony stimulating factor, Neutropenia, Chemotherapy |
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