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HOME > J Korean Cancer Assoc > Volume 22(3); 1990 > Article
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Inhibitory Effect of Chinese Cabbage Extract on Diethylnitrosamine - Induced Hepatic Foci in Sprague - Dawley Rats
Yun Sil Lee, Won Suk Jang, Mi Jung Eui, Sun Ju Lee, Ja June Jang
Journal of the Korean Cancer Association 1990;22(3): 355-360.
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The modifying effect of Chinese cabbage extract on the development of preneoplastic hepatic enzyme altered foci was examined in an in vivo mid-term assay system. Diethylnitrosamine (DEN) of 15 mg/kg body weight was injected to newborn Sprague-Dawley rat subcutaneously within 24 hours, and after 3 weeks, Chinese cabbage (95% ethanol extract) was given at a dose of 2 mg/ml in drinking water. All rats were sacrificed at week 12. The modifying effect was evaluated comparing the number of foci and area/cm of induced glutathione S-transferase placental form positive (GST-P ) foci in the liver with those of the corresponding control group given DEN alone. Chinese cabbage extract showed statistically significant decrease in the number and area of GST-P+ foci. The result suggests that Chinese cabbage could have inhibitory effect on rat hepatocar- cinogenesie.

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    Inhibitory Effect of Chinese Cabbage Extract on Diethylnitrosamine - Induced Hepatic Foci in Sprague - Dawley Rats
    J Korean Cancer Assoc. 1990;22(3):355-360.
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