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J Korean Cancer Assoc > Volume 22(1); 1990 > Article
Journal of the Korean Cancer Association 1990;22(1): 61-66.
인형 암세포주에 대한 Doxorubicin 의 In Vitro Chemosencitivity 에 관한 연구
박정규, 임동균, 국윤호, 차창룡, 백철기
In Vitro Chemosencitivity of Doxorubicin on Human Cancer Cell Lines
Chung Gyu Park, Dong Kyun Lim, Yoon Hoh Kook, Chang Yong Cha, Chul Gi Paik
The anticancer effect of doxorubicin was evaluated on human cancer cell lines (K562, KATOIII, PC-14, HeLa, SNU-C5, NCI-H417 and Nalm-6) after exposure to doxorubicin at 5, 50, 500 ng/ml for 1 hour at 37`C using in vitro agar-methylcellulose clonogenic assay. The drug concentration which produced 50g inhibition of colony formation (ID) of each cell line were as follows: K562, 258.2 (ng/ml); KATO IIL, 473 (ng/ml); PC-14, 268.5 (ng/ml); HeLa, 355.7 (ng/ ml), SNU-C5, 241.5 (ng/ml); NCI-H417, 13 (ng/ml); Nalm-6, 20 (ng/ml). From this assay NCI-H417 and Nalm-6 were considered to be sensitive to doxorubicin on the basis of the fact that the ID,. for these cell lines was within a clinically achievable range.
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