| 두경부 편평상피암 조직에서 c-myc 종양의 증폭 |
| 문한림, 한치화, 김훈교, 김춘추, 이경식, 김동집, 김민식, 조승호, 서병도 |
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| c-myc Oncogens Amplification in Squamous Cell Cancer ( SCC ) of Head and Neck |
| Han Lim Moon, Chi Wha Han, Hoon Kyo Kim, Choon Choo Kim, Kyung Shik Lee, Dong Jip Kim, Min Sik Kim, Seung Ho Cho, Byung Do Suh |
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| ABSTRACT |
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Proto-oncogenes are highly conservative genes in human cell, which code growth factors, growth factor receptors. enzymes and nuclear protein and are necessary for cell growth and function. Alteration in these genes such as amplification, rearrangement, or mutation appeared to be associated with malignant transfarmation of cells. We examined 14 DNA samples from human squamous cell carcinoma of head and neck with slot blot analysi.. Two out of fourteen samples showed c-myc gene amplification. Nodal involvements (N2a. and N3b) vrere observed in both patients. They were maderately differentiated SCC of larynx. Further studies about c-myc gene rearrangenment and mutaiton should be confirmeg in these samples and examine whether c-myc amplification is correlated with the biologic characteristics of SCC of head and neck. |
| Key words:
Proto-oncogenes, Squamous cell cancer of head and neck, C-myc gene, Amplification |
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