Malignant fibrus histiocytoma (MFH) is a deep seated plemorphic sarcoma of older adults, which occurs most frequently in the deep fascia and skeletal muscle of the extremities and trunk. A rare tumor initially described in 1964 by OBriend and Stout, who considered it to have a histiocytic origin, it has been increasingly recognized as a discrete entity. There are only few descriptions of the intrathoracic occurrence of the MFI-l. Here, we report two cases of MFH originated from the mediastium which is a very unusual site. Radiation appeared to be a useful adjuvant treatment to surgical therapy in one case. Clinical features of the other reported cases of the intrathoracic MFH were also reviewed.