| 5-Fluorouracil 과 Mitomycin-C 복합화학요법에 의한 위암의 근치적 위절제술후 보조적 화학요법 |
| 박영석, 서창인, 강원기, 김흥태, 방영주, 김노경, 박재갑, 이건욱, 최국진, 김수태 |
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| The Postoperative Adjuvant Chemotherapy with Combined 5-Fluorouracil and Mitomycin-C following curative resection for gastric Cancer |
| Young Suk Park, Chang In Suh, Won Ki Kang, Heung Tae Kim, Yung Jue Bang, Noe Kyeong Kim, Jae Gahb Park, Kuhn Uk Lee, Kuk Jin Choe, Soo Tae Kim |
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| ABSTRACT |
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The postoperative adjuvant chemotherapy with 12 cycles of 5-FU and mitomycin-C has been administered in 162 patients with stage II or lll gastric adenocarcinoma after curative gastric resection. 1) After a median follow-up time of 81 months, 94/163 treated patients recurred (58%). The sites of recurrent cancer were as follows: loco-regional, 419, peritoneal, 24%, distant metastases, 26%, multiple sites, 9%. 2) The 5-year disease free survival rates were 36.8% 3) The 5-year overall survival rates were 45.0% and the median survival was 50.2 months. 4) The number of lymph nodes involvement and the T stage affected disease free and overall survival. 5) The FM regimen was well tolerated, and produced moderate bone marrow suppression, anorexia, nausea, vomiting and diarrhea. |
| Key words:
Stomach cancer, Adjuvant chemotherapy, 5-FU and Mitomycin-C |
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