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J Korean Cancer Assoc > Volume 21(2); 1989 > Article
Journal of the Korean Cancer Association 1989;21(2): 406-413.
5-Fluorouracil 과 Mitomycin-C 복합화학요법에 의한 위암의 근치적 위절제술후 보조적 화학요법
박영석, 서창인, 강원기, 김흥태, 방영주, 김노경, 박재갑, 이건욱, 최국진, 김수태
The Postoperative Adjuvant Chemotherapy with Combined 5-Fluorouracil and Mitomycin-C following curative resection for gastric Cancer
Young Suk Park, Chang In Suh, Won Ki Kang, Heung Tae Kim, Yung Jue Bang, Noe Kyeong Kim, Jae Gahb Park, Kuhn Uk Lee, Kuk Jin Choe, Soo Tae Kim
The postoperative adjuvant chemotherapy with 12 cycles of 5-FU and mitomycin-C has been administered in 162 patients with stage II or lll gastric adenocarcinoma after curative gastric resection. 1) After a median follow-up time of 81 months, 94/163 treated patients recurred (58%). The sites of recurrent cancer were as follows: loco-regional, 419, peritoneal, 24%, distant metastases, 26%, multiple sites, 9%. 2) The 5-year disease free survival rates were 36.8% 3) The 5-year overall survival rates were 45.0% and the median survival was 50.2 months. 4) The number of lymph nodes involvement and the T stage affected disease free and overall survival. 5) The FM regimen was well tolerated, and produced moderate bone marrow suppression, anorexia, nausea, vomiting and diarrhea.
Key words: Stomach cancer, Adjuvant chemotherapy, 5-FU and Mitomycin-C
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