Abstract

A murine ascites tumor was treated with intraperitoneal chlorophyll derivatives (CpD), which were developed as a new photosensitizer in Korea, and light of an appropriate wavelength (670nm). Photodynamic therapy (PDT) was given 3 times at 24h, 48h, and 72h after injection of CpD intraperitoneally. When the PDT was started at 1 week after inoculation of S-180 tumor cells, 80% of the complete remission(clinical) ratewas obtained. When the PDT was started at the 14th day or at the 21st day, the complete remission (clinical) rate was 30% or 0% respectively. This suggested that the lesser the tumor burden was, the higher the complete remission rate was. Our results illustrate the effective use of CpD in photodynamic therapy for the treatment of ascites tumors and reveal the possibility for photodynamic therapy in human ascites tumors.

• Keywords: Photodynamic therapy, photosensitizer, chlorophyll derivatives (CpD), ascites tumor