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HOME > J Korean Cancer Assoc > Volume 20(1); 1988 > Article
Original Article
5-FU Infusion and Cisplatin in Patients with Disseminated or Recurrent Head and Neck Cancer
Jae Hoon Lee, Sung Soo Yoon, Keun Chil Park, Seung Taek Kim, Yung Jue Bang, Noe Kyeong Kim, Kwang Hyun Kim, Yang Gi Min, Charn Il Park
Journal of the Korean Cancer Association 1988;20(1): 67-73.
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56 patients with dissminated or recurrent head and neck cancer were treated with 5-FU infusion and cisplatin between July, 1983 and June, 1986. The results were as follows; 1) Among 54 evaluable patients, response rate was 48.1% (complete responses 7.4% partial responses 40.7%).Response rates of disseminated and recurrent group were 88.9% and 40%, respectively (p<0. 05). 2) Median time to disease progression was 4.4 months for overall patients, and 7.5 months and 2. 9 month for responders and nonresponders; there was statistically significant difference (P<0.05). 3) Median survival was 15.3 month for overall patients and 24.5 month and 9.2 month for responders and nonresponders; there was statistically significant difference (P<0.05). 4) Nausea and vomitting were observed in all patients but easily controlled, and stomatitis, alopecia, diarrhea were obrerved infrequently, 1eukopenia and thrombocytopenia were observed in 25, 9% and 1, 9%, In conclusion, combination chemotherapy with 5 FV infusion and cisplatin in patients with disseninated or recurrent head and neck cancer seemed to be relatively effective and well tolerable.

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    5-FU Infusion and Cisplatin in Patients with Disseminated or Recurrent Head and Neck Cancer
    J Korean Cancer Assoc. 1988;20(1):67-73.
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