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J Korean Cancer Assoc > Volume 16(1); 1984 > Article
Journal of the Korean Cancer Association 1984;16(1): 12-20.
위암환자의 자연살해세포 파괴능에 미치는 인터폐론의 효과
허선회, 김한수, 박충기, 방익수, 장린, 민영일, 임규성
The Effect of Interforon on NK Cell Activity in Patients with Stomach Cacner in Vitro
Suon Hawe Huo, Han Su Kim, Chung Gi Park, Ik Soo Bang, Rin Chang, Young Il Min, Gyu Sung Lim
ABSTRACT
Natural Killer cell activity against "Cr-K 562 cells as farget cells had been studied on 27 patients with stomach cancer and 18 normal subjects in vitro. Also we studied the natural killer cell activity with treatment of a-interferon in patients with atomach cancer. The results were as follows; 1) There was no sex difference in NK cell activity in normal dornor and patients with stomach cancer and NK cell activity in patients with stomach cancer was significantly lower than that in normal dornor. 2) In vitro. NK cell activities after infusion of a-interferon 100 IU/ml and 500 IU/ml were considerably greater than basal level in normal donor and patients with stomach cancer but there waa no difference bet-ween NK cell activity after infusion of 100 IU/ml a-IFN and that of 500 IU/ml a-IFN in both groups. There were no difference between NK cell activities after infusion of 100 IU/ml a-IFN and 500 IU/ml a-IFN in normal donor and those in patients with stomach cancer. 3) Natural killer cell activity in patients with stomach cancer who was treated with a-interforon(3x10 IU/ml IM/day) for SO days was 66. 5%. While it was greater than pretreatment NK cell activity, it was almost same level as shown in normal controL So our data suggested that NK cell activity in patients with stomach cancer was decreased by impaired functien of interferon or decreased concentration of endogenous interferon than impairment of NK cell activity itself, and that decreased NK cell activity in patient with stomach could be normalized by receiving exogenous interferon therapy.
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