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HOME > J Korean Cancer Assoc > Volume 29(3); 1997 > Article
Original Article
Significant Correlation of Hepatocyte Growth Factor Level with Progression of Gastric Adenocarcinoma
Sang Uk Han, Jae Ho Lee, Wook Hwan Kim, Hee Jung Wang, Yong Kwan Cho, Myung Wook Kim
Journal of the Korean Cancer Association 1997;29(3): 367-374.
1Department of Surgery, Ajou University School of Medicine, Korea.
2Department of Biochemistry, Ajou University School of Medicine, Korea.
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PURPOSE
Hepatocyte growth factor (HGF) is a modulator of epithelial cell proliferation and motility. In this study, we measured the level of HGF in sera and tumor extracts of gastric adenocarcinoma using an enzyme-linked immunoassay and evaluated its association with tumor progression.
MATERIALS AND METHODS
The level of HGF in the sera of seventy-five patients with gastric adenocarcinoma and in the tumor extracts of forty-two tumors were examined in this study. The level of HGF was determined by an Immunis HGF EIA kit (Institute of Immunology).
RESULTS
The mean level of HGF in the sera of patients was 0.26+/-0.19 ng/ml, which was significantly higher than in those of healthy controls (0.14+/-0.07 ng/ml, p<0.05); the levels of HGF in the sera of patients increased according to the progression of the stage of cancer (p<0.05). The mean level of HGF in tumor extracts was 8.22+/-9.27 microgram/g protein, which was significantly higher than in those of healthy controls (1.95+/-1.45 microgram/g protein, p<0.05); the levels of HGF in the tumor extracts were correlated significantly with the progression of the tumor stage (p<0.05). The mean level of HGF in the tumors of diffuse type was 11.28+/-11.74 microgram/g protein, which was significantly higher than in those of intestinal type (5.16+/-4.31 microgram/g protein, p<0.05).
CONCLUSION
HGF may play an important role in the progression and differentiation of gastric adenocarcinoma.

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    Significant Correlation of Hepatocyte Growth Factor Level with Progression of Gastric Adenocarcinoma
    J Korean Cancer Assoc. 1997;29(3):367-374.
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