KCA
Articles
- Page Path
- HOME > J Korean Cancer Assoc > Volume 30(3); 1998 > Article
-
Original Article
- The Expression of Phospholipase C-gamma1 and Its Cellular Characteristics
- Dong Young Noh, Han Sung Kang, Young Chul Kim, In Ae Park, Yeo Kyu Yong, Seung Keun Oh, Kuk Jin Choe
-
Journal of the Korean Cancer Association 1998;30(3): 457-463.
1Department of Surgery, Seoul National University College of Medicine.
2Department of Pathology, Seoul National University College of Medicine.
2Department of Pathology, Seoul National University College of Medicine.
- 2,522 Views
- 14 Download
- 0 Crossref
- 0 Scopus
Abstract
BACKGROUND
The activation of phospholipase C(PLC) is one of the early cellular events in various growth process, including malignant transformation. PLC-gamma1 is activated through direct interaction with growth factor receptor tyrosine kinase. MATERIAL AND METHODS: Using immunoblot assay, we evaluated overexpression of PLC-gamma1 expression in twenty human breast cancer tissues. It was also determined whether there was any connection between other prognostic factors(numbers of metastatic axillary nodes, nuclear and histological grade, c-erbB2, p53 and E-cadherin) and the overexpression of PLC-gamma1 protein.
RESULTS
Seventeen of 20 breast cancer tissues showed overexpression of PLC-gamma1, which was corresponded to that seen on the immunohistochemistry( kappa= 0.8275, p = 0.003).
Of 3 tumor markers, immunohistochemically determined, positive expression of E-cadherin only was associated with PLC-gamma1 protein overexpression in a range of statistical significance (p=0.045, kappa=0.607).
CONCLUSION
PLC-gamma1 overexpression might be pathogenic trigger involved in breast cancer and the relationship between expression of E-cadherin and PLC-gamma1 would require further elucidation.
Cite
