1Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
2Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
3Center for RNA Research, Institute for Basic Science, Korea School of Biological Sciences, Seoul National University, Seoul, Korea
4Department of Biochemistry, Chonnam National University Medical School, Gwangju, Korea
5Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu, Korea
6Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea
7Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
8Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Korea
9Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
Copyright © 2017 by the Korean Cancer Association
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Group | Total No. of mice | No. of mice finally evaluated | Dead No. of mice (%) |
---|---|---|---|
WT mouse | 59 | 53 | 6 (10.16) |
TG mouse | 76 | 65 | 11 (14.47) |
Histological type | WT | Percentage | TG | Percentage | p-value |
---|---|---|---|---|---|
Normal | 23 | 43.40 | 9 | 13.85 | < 0.001* |
Hyperplasia | 2 | 3.77 | 12 | 18.46 | 0.020* |
Adenoma | 11 | 20.75 | 17 | 26.15 | 0.522 |
Carcinoma | 17 | 32.08 | 27 | 41.54 | 0.341 |
Total | 53 | 65 | 0.001* |
Variable | Male |
Female |
||
---|---|---|---|---|
WT mouse (n=6) | TG mouse (n=6) | WT mouse (n=3) | TG mouse (n=3) | |
Body weight | 32.950 | 39.600 | 28.280 | 29.100 |
Spleen | 0.057 | 0.056 | 0.059 | 0.061 |
Liver | 0.089 | 0.089 | 0.059 | 0.061 |
Kidney, left | 0.130 | 0.133 | 0.098 | 0.108 |
Kidney, right | 0.139 | 0.133 | 0.105 | 0.111 |
Thymus | 0.036 | 0.034 | 0.002 | 0.002 |
Heart | 0.283 | 0.116 | 0.104 | 0.104 |
Lung | 0.134 | 0.126 | 0.132 | 0.089 |
Brain | 0.423 | 0.415 | 0.427 | 0.427 |
WBC (103/mm3) | 2.36 | 1.30 | - | - |
RBC (106/mm3) | 7.36 | 7.82 | - | - |
HGB (g/dL) | 11.20 | 11.50 | - | - |
HCT (L%) | 30.00 | 32.60 | - | - |
PLT (103/mm3) | 678 | 665 | - | - |
MCV | 40.80 | 41.70 | - | - |
MCH (pg) | 15.30 | 14.80 | - | - |
MCHC (g/dL) | 37.40 | 35.50 | - | - |
Neutrophil (%) | 6.75 | 5.70 | - | - |
Eosinophil (%) | 0.10 | 0.00 | - | - |
Basophil (%) | 0.20 | 0.20 | - | - |
Lymphocyte (%) | 88.20 | 90.30 | - | - |
Monocyte (%) | 3.90 | 2.90 | - | - |
Group | Total No. of mice | No. of mice finally evaluated | Dead No. of mice (%) |
---|---|---|---|
WT mouse | 59 | 53 | 6 (10.16) |
TG mouse | 76 | 65 | 11 (14.47) |
Histological type | WT | Percentage | TG | Percentage | p-value |
---|---|---|---|---|---|
Normal | 23 | 43.40 | 9 | 13.85 | < 0.001 |
Hyperplasia | 2 | 3.77 | 12 | 18.46 | 0.020 |
Adenoma | 11 | 20.75 | 17 | 26.15 | 0.522 |
Carcinoma | 17 | 32.08 | 27 | 41.54 | 0.341 |
Total | 53 | 65 | 0.001 |
WT, wild-type mouse; TG, miR-222/221 transgenic mouse; WBC, white blood cell; RBC, red blood cell; HGB, hemoglobin; HCT, hematocrit; PLT, platelet count; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration.
MNU,
WT, wild-type mouse; TG, miR-222/221 transgenic mouse. Statistically significant.