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Integrin αvβ3 Induces HSP90 Inhibitor Resistance via FAK Activation in KRAS-Mutant Non-Small Cell Lung Cancer

Shinkyo Yoon, Hannah Yang, Hyun-Min Ryu, Eunjin Lee, Yujin Jo, Seyoung Seo, Deokhoon Kim, Chang Hoon Lee, Wanlim Kim, Kyung Hae Jung, Sook Ryun Park, Eun Kyung Choi, Sang-We Kim, Kang-Seo Park, Dae Ho Lee

Cancer Research and Treatment. 2022;54(3):767-781. Published online 2021 September 30 DOI: https://doi.org/10.4143/crt.2021.651

Integrin αvβ3 Induces HSP90 Inhibitor Resistance via FAK Activation in KRAS-Mutant Non-Small Cell Lung Cancer

Cancer Research and Treatment. 2022;54(3):767-781

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The HSP90 inhibitor, NVP-AUY922, sensitizes KRAS-mutant non-small cell lung cancer with intrinsic resistance to MEK inhibitor, trametinib

Kang-Seo Park, Bora Oh, Mi-Hee Lee, Ky-Youb Nam, Hae Ran Jin, Hannah Yang, Junyoung Choi, Sang-We Kim, Dae Ho Lee

Cancer Letters. 2016;372(1):75-81

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Publisher’s Note ‘Phase 2 Study of the Focal Adhesion Kinase Inhibitor Defactinib (VS-6063) in Previously Treated Advanced KRAS Mutant Non-small Cell Lung Cancer’

Lung Cancer. 2020;139:169

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FAK-targeting PROTAC demonstrates enhanced antitumor activity against KRAS mutant non-small cell lung cancer

Jinyuan Liu, Lei Xue, Xiang Xu, Jinhua Luo, Shijiang Zhang

Experimental Cell Research. 2021;408(2):112868

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The HSP90 inhibitor, NVP-AUY922, attenuates intrinsic PI3K inhibitor resistance in KRAS-mutant non-small cell lung cancer

Kang-Seo Park, Hannah Yang, Junyoung Choi, Seyoung Seo, Deokhoon Kim, Chang Hoon Lee, Hanwool Jeon, Sang-We Kim, Dae Ho Lee

Cancer Letters. 2017;406:47-53

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M2 macrophage-derived exosome facilitates metastasis in non-small-cell lung cancer via delivering integrin αvβ3

Lamei Huang, Jianye Zhang, Xueping Wang, Chaoyue Su, Shaocong Wu, Chuan Yang, Min Luo, Fang Wang, Liwu Fu

. 2022;

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Frequency of point mutational activation of the Kras oncogene in non-small cell lung cancer in Hong Kong

Lung Cancer. 1991;7:21

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Reversal of EGFR inhibitors’ resistance by co-delivering EGFR and integrin αvβ3 inhibitors with nanoparticles in non-small cell lung cancer

Fei He, Yanzhong Wang, Wanru Cai, Minjing Li, Lei Dong

Bioscience Reports. 2019;39(8):

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HMGB1 induces human non-small cell lung cancer cell motility by activating integrin αvβ3/FAK through TLR4/NF-κB signaling pathway

Jianhua Zhu, Jing Luo, Yongchao Li, Min Jia, Yueqin Wang, Yan Huang, Shuhong Ke

Biochemical and Biophysical Research Communications. 2016;480(4):522-527

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Key roles of EMT for adaptive resistance to MEK inhibitor in KRAS mutant lung cancer

Hidenori Kitai, Hiromichi Ebi

Small GTPases. 2016;8(3):172-176

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