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Integrin αvβ3 Induces HSP90 Inhibitor Resistance via FAK Activation in KRAS-Mutant Non-Small Cell Lung Cancer
Shinkyo Yoon, Hannah Yang, Hyun-Min Ryu, Eunjin Lee, Yujin Jo, Seyoung Seo, Deokhoon Kim, Chang Hoon Lee, Wanlim Kim, Kyung Hae Jung, Sook Ryun Park, Eun Kyung Choi, Sang-We Kim, Kang-Seo Park, Dae Ho Lee
Cancer Research and Treatment. 2022;54(3):767-781.   Published online 2021 September 30    DOI: https://doi.org/10.4143/crt.2021.651

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Integrin αvβ3 Induces HSP90 Inhibitor Resistance via FAK Activation in KRAS-Mutant Non-Small Cell Lung Cancer
Cancer Research and Treatment. 2022;54(3):767-781   Crossref logo
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The HSP90 inhibitor, NVP-AUY922, sensitizes KRAS-mutant non-small cell lung cancer with intrinsic resistance to MEK inhibitor, trametinib
Cancer Letters. 2016;372(1):75-81   Crossref logo
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Publisher’s Note ‘Phase 2 Study of the Focal Adhesion Kinase Inhibitor Defactinib (VS-6063) in Previously Treated Advanced KRAS Mutant Non-small Cell Lung Cancer’
Lung Cancer. 2020;139:169   Crossref logo
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FAK-targeting PROTAC demonstrates enhanced antitumor activity against KRAS mutant non-small cell lung cancer
Experimental Cell Research. 2021;408(2):112868   Crossref logo
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The HSP90 inhibitor, NVP-AUY922, attenuates intrinsic PI3K inhibitor resistance in KRAS-mutant non-small cell lung cancer
Cancer Letters. 2017;406:47-53   Crossref logo
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M2 macrophage-derived exosome facilitates metastasis in non-small-cell lung cancer via delivering integrin αvβ3
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Frequency of point mutational activation of the Kras oncogene in non-small cell lung cancer in Hong Kong
Lung Cancer. 1991;7:21   Crossref logo
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Reversal of EGFR inhibitors’ resistance by co-delivering EGFR and integrin αvβ3 inhibitors with nanoparticles in non-small cell lung cancer
Bioscience Reports. 2019;39(8):   Crossref logo
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HMGB1 induces human non-small cell lung cancer cell motility by activating integrin αvβ3/FAK through TLR4/NF-κB signaling pathway
Biochemical and Biophysical Research Communications. 2016;480(4):522-527   Crossref logo
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Key roles of EMT for adaptive resistance to MEK inhibitor in KRAS mutant lung cancer
Small GTPases. 2016;8(3):172-176   Crossref logo
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