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Increased Radiosensitivity of Solid Tumors Harboring ATM and BRCA1/2 Mutations |
Kyung Hwan Kim, Han Sang Kim, Seung-seob Kim, Hyo Sup Shim, Andrew Jihoon Yang, Jason Joon Bock Lee, Hong In Yoon, Joong Bae Ahn, Jee Suk Chang |
Cancer Research and Treatment. 2022;54(1):54-64. Published online 2021 June 4 DOI: https://doi.org/10.4143/crt.2020.1247 |
Increased Radiosensitivity of Solid Tumors Harboring ATM and BRCA1/2 Mutations Hemizygous fibroblast cell strains established from patients with BRCA1 or BRCA2 mutations demonstrate an increased rate of spontaneous mutations and increased radiosensitivity Re: Catherine H. Marshall, Alexandra O. Sokolova, Andrea L. McNatty, et al. Differential Response to Olaparib Treatment Among Men with Metastatic Castration-resistant Prostate Cancer Harboring BRCA1 or BRCA2 Versus ATM Mutations. Eur Urol 2019;76:452–8 Increased Chromosomal Radiosensitivity in Women Carrying BRCA1/BRCA2 Mutations Assessed With the G2 Assay Clinical radiosensitivity in breast cancer patients carrying pathogenic ATM gene mutations: no observation of increased radiation-induced acute or late effects Radiosensitivity to high energy iron ions is influenced by heterozygosity for Atm, Rad9 and Brca1 Hepatoid tumors of the pancreas harboring CTNNB1 somatic mutations: a new entity among solid pseudopapillary neoplasms. ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues? BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications |
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