Cancer Research and Treatment

Research progress of LSD1-based dual-target agents for cancer therapy

Bioorganic & Medicinal Chemistry.2024; 101: 117651. CrossRef

Inhibition of DCUN1D1 attenuates periodontitis by suppressing NF-κB signaling

Li Zou, Zhijian Su, Chao Pan, Honghui Xie, Shuangjing Li, Jian Qin

Discovery of WS-384, a first-in-class dual LSD1 and DCN1-UBC12 protein-protein interaction inhibitor for the treatment of non-small cell lung cancer

Anqi Li, Ting Ma, Shuai Wang, Yueyang Guo, Qianqian Song, Hongmin Liu, Bin Yu, Siqi Feng

Biomedicine & Pharmacotherapy.2024; 173: 116240. CrossRef

DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway

Akhona Vava, Juliano D. Paccez, Yihong Wang, Xuesong Gu, Manoj K. Bhasin, Michael Myers, Nelson C. Soares, Towia A. Libermann, Luiz F. Zerbini

Advances in the Biology and Molecular Study of Brain Metastasis from Non-Small Cell Lung Cancer

Advances in Clinical Medicine.2022; 12(06): 5561. CrossRef

Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction

Wenjuan Zhou, Chenhao Xu, Guanjun Dong, Hui Qiao, Jing Yang, Hongmin Liu, Lina Ding, Kai Sun, Wen Zhao

European Journal of Medicinal Chemistry.2021; 217: 113326. CrossRef

Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer

Ilenia Chatziandreou, Adriana Psaraki, Konstantinos Paschidis, Andreas C. Lazaris, Angelica A. Saetta

Pathology - Research and Practice.2021; 221: 153412. CrossRef

DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up-regulates PD-L1 in non-small-cell lung cancer

Jing Li, Tao Yu, Mingxia Yan, Xiao Zhang, Li Liao, Miaoxin Zhu, Hechun Lin, Hongyu Pan, Ming Yao

Experimental Cell Research.2019; 374(2): 304. CrossRef

Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5-a]pyrimidine-Based Inhibitors Targeting the DCN1–UBC12 Protein–Protein Interaction

Shuai Wang, Lijie Zhao, Xiao-Jing Shi, Lina Ding, Linlin Yang, Zhi-Zheng Wang, Dandan Shen, Kai Tang, Xiao-Jing Li, MAA Mamun, Huiju Li, Bin Yu, Yi-Chao Zheng, Shaomeng Wang, Hong-Min Liu

Journal of Medicinal Chemistry.2019; 62(5): 2772. CrossRef

Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU‐177 cells after interfered by RNA

Jing Liu, Yu Shuang, Chao Li, Xuan Zhou, Yongwang Huang, Lun Zhang

Clinical and Experimental Pharmacology and Physiology.2018; 45(5): 461. CrossRef

Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

Jared T. Hammill, Deepak Bhasin, Daniel C. Scott, Jaeki Min, Yizhe Chen, Yan Lu, Lei Yang, Ho Shin Kim, Michele C. Connelly, Courtney Hammill, Gloria Holbrook, Cynthia Jeffries, Bhuvanesh Singh, Brenda A. Schulman, R. Kiplin Guy

Journal of Medicinal Chemistry.2018; 61(7): 2694. CrossRef

MicroRNA‑302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1

Yongjie Jiang, Ruijie Hou, Shaoping Li, Shaoru Li, Ge Dang

Experimental and Therapeutic Medicine.2018;[Epub] CrossRef

MicroRNA-520b Functions as a Tumor Suppressor in Colorectal Cancer by Inhibiting Defective in Cullin Neddylation 1 Domain Containing 1 (DCUN1D1)

Jing Xiao, Guang Li, Jingyu Zhou, Shalong Wang, Dongcai Liu, Guoshun Shu, Jianping Zhou, Feng Ren

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics.2018; 26(4): 593. CrossRef

MicroRNA-195 inhibits growth and invasion of laryngeal carcinoma cells by directly targeting DCUN1D1

Yu Shuang, Chao Li, Xuan Zhou, Yongwang Huang, Lun Zhang

Oncology Reports.2017; 38(4): 2155. CrossRef

Osteosarcoma tissues and cell lines from patients with differing serum alkaline phosphatase concentrations display minimal differences in gene expression patterns

L. C. de Sá Rodrigues, K. E. Holmes, V. Thompson, C. M. Piskun, S. E. Lana, M. A. Newton, T. J. Stein

Veterinary and Comparative Oncology.2016;[Epub] CrossRef

Ubiquitin-specific protease 4 controls metastatic potential through β-catenin stabilization in brain metastatic lung adenocarcinoma

Su Jin Hwang, Hye Won Lee, Hye Ree Kim, Hong Lee, Chang Hoon Shin, Sun-Il Yun, Dong Heon Lee, Duk-Hwan Kim, Kyeong Kyu Kim, Kyeung Min Joo, Hyeon Ho Kim

Blood-brain Barrier Remodeling during Brain Metastasis Formation

Molecular Medicine.2016; 22(1): 32. CrossRef

MicroRNA-218 inhibits EMT, migration and invasion by targeting SFMBT1 and DCUN1D1 in cervical cancer

Zhaojing Jiang, Qiancheng Song, Rong Zeng, Jing Li, Jingyu Li, Xiaochun Lin, Xing Chen, Jiren Zhang, Yanfang Zheng

Value of Oncogenes for the Prediction of Brain Metastases at Initial Diagnosis: A Review of Published Data

The International Journal of Biological Markers.2014; 29(4): 291. CrossRef

The molecular biology of lung cancer brain metastasis: an overview of current comprehensions and future perspectives

Masaki Hanibuchi, Sun-Jin Kim, Isaiah J. Fidler, Yasuhiko Nishioka

The Journal of Medical Investigation.2014; 61(3.4): 241. CrossRef

Predictive biochemical-markers for the development of brain metastases from lung cancer: Clinical evidence and future directions

Cancer Epidemiology.2013; 37(5): 703. CrossRef

Coamplification and Cooperation: Toward Identifying Biologically Relevant Oncogenes

Clinical Cancer Research.2013; 19(20): 5549. CrossRef