Cancer Research and Treatment

A comprehensive review on therapeutic potentials of photobiomodulation for neurodegenerative disorders

Pooja Ramakrishnan, Aradhana Joshi, Mohamed Fazil, Pankaj Yadav

Novel benzochromenes: design, synthesis, cytotoxicity, molecular docking and mechanistic investigations

Fatma G Abdulrahman, Hamada S Abulkhair, Riham A Zidan, Asmaa I Alwakeel, Ahmed A Al-Karmalawy, Ebtehal M Husseiny

Future Medicinal Chemistry.2024; 16(2): 105. CrossRef

Targeting HIF-1 for prostate cancer: a synthesis of preclinical evidence

Expert Opinion on Therapeutic Targets.2023; 27(8): 715. CrossRef

Transcriptome Analysis on Hepatopancreas Reveals the Metabolic Dysregulation Caused by Vibrio parahaemolyticus Infection in Litopenaeus vannamei

Determination of HIF-1α degradation pathways via modulation of the propionyl mark

Kwanyoung Jeong, Jinmi Choi, Ahrum Choi, Joohee Shim, Young Ah Kim, Changseok Oh, Hong-Duk Youn, Eun-Jung Cho

Baf155 regulates skeletal muscle metabolism via HIF-1a signaling

Jong-Seol Kang, Dongha Kim, Joonwoo Rhee, Ji-Yun Seo, Inkuk Park, Ji-Hoon Kim, Daewon Lee, WonUk Lee, Ye Lynne Kim, Kyusang Yoo, Sunghwan Bae, Jongkyeong Chung, Rho Hyun Seong, Young-Yun Kong, Simon M. Hughes

Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease

Christopher Bailey, Yuanyi Wei, Jinsong Yan, Dan Huang, Peng Zhang, Chong Qi, Christopher Lazarski, JuanJuan Su, Fei Tang, Chun-shu Wong, Pan Zheng, Yan Liu, Yang Liu, Yin Wang

Cell Reports Medicine.2023; 4(11): 101236. CrossRef

Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies

Jade Fantin, Jérôme Toutain, Elodie A. Pérès, Benoit Bernay, Sarina Maya Mehani, Charly Helaine, Mickael Bourgeois, Carole Brunaud, Laurent Chazalviel, Julien Pontin, Aurélien Corroyer-Dulmont, Samuel Valable, Michel Cherel, Myriam Bernaudin

Novel thioether linked 4-hydroxycoumarin derivatives: Synthesis, characterization, in vitro pharmacological investigation and molecular docking studies

B. Manjunatha, Yadav D. Bodke, H.M. Kumaraswamy, P. Meghana, O. Nagaraja, G.C. Anjan kumar

Journal of Molecular Structure.2022; 1249: 131642. CrossRef

A Concise Synthesis of Pleurotin Enabled by a Nontraditional C–H Epimerization

Journal of the American Chemical Society.2022; 144(31): 14042. CrossRef

Regulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells

Hsing-Hua Chao, Jun-Liang Luo, Ming-Hsuan Hsu, Li-Han Chen, Tzu-Pin Lu, Mong-Hsun Tsai, Eric Y. Chuang, Li-Ling Chuang, Liang-Chuan Lai

A dynamic fluorescence probed glycolysis suppression process in HeLa cells treated with trichostatin A

Fengqiu Zhang, Changsheng Shao, Yahui Wu, Wei Zhao, Xumiao Jing, Cao Fang, Qing Huang

Polystyrene-Based Slippery Surfaces Enable the Generation and Easy Retrieval of Tumor Spheroids

Priyanka Pulugu, Neha Arya, Prasoon Kumar, Akshay Srivastava

ACS Applied Bio Materials.2022; 5(12): 5582. CrossRef

Prognostic Significance of VEGF and HIF-1 α in Hepatocellular Carcinoma Patients Receiving Sorafenib Versus Metformin Sorafenib Combination

Shereen El Shorbagy, Fouad abuTaleb, Hany A. Labib, Huda Ebian, Ola A. Harb, Mona Saeed Mohammed, Hanaa A. Rashied, Khaled A. Elbana, Rasha Haggag

Journal of Gastrointestinal Cancer.2021; 52(1): 269. CrossRef

Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages

Wei-Yao Chin, Chi-Ying He, Tsun Wai Chow, Qi-You Yu, Liang-Chuan Lai, Shi-Chuen Miaw

Stabilization of Hypoxia-Inducible Factor Promotes Antimicrobial Activity of Human Macrophages Against Mycobacterium tuberculosis

Sebastian F. Zenk, Sebastian Hauck, Daniel Mayer, Mark Grieshober, Steffen Stenger

BICD Cargo Adaptor 1 (BICD1) Downregulation Correlates with a Decreased Level of PD-L1 and Predicts a Favorable Prognosis in Patients with IDH1-Mutant Lower-Grade Gliomas

Shang-Pen Huang, Chien-Hsiu Li, Wei-Min Chang, Yuan-Feng Lin

The cytotoxic effect of Baeckea frustescens extracts in eliminating hypoxic breast cancer cells

S. H. Shahruzaman, F. Z. Yusof, S. Maniam, S. Fakurazi, S. Maniam

BMC Complementary Medicine and Therapies.2021;[Epub] CrossRef

A highly annotated database of genes associated with platinum resistance in cancer

Dongqing Huang, Sara R. Savage, Anna P. Calinawan, Chenwei Lin, Bing Zhang, Pei Wang, Timothy K. Starr, Michael J. Birrer, Amanda G. Paulovich

Lung Adenocarcinoma Transcriptomic Analysis Predicts Adenylate Kinase Signatures Contributing to Tumor Progression and Negative Patient Prognosis

Jonathan A. Chacon-Barahona, Ivan A. Salladay-Perez, Nathan James Lanning

Clinicopathological significance and angiogenic role of the constitutive phosphorylation of the FOXO1 transcription factor in colorectal cancer

Pathology - Research and Practice.2020; 216(11): 153150. CrossRef

Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors

Yue Zhao, Fei Feng, Qing-Hong Guo, Yu-Ping Wang, Rui Zhao

World Journal of Gastroenterology.2020; 26(34): 5074. CrossRef

Still Living Better through Chemistry: An Update on Caloric Restriction and Caloric Restriction Mimetics as Tools to Promote Health and Lifespan

Carla Almendáriz-Palacios, Darrell D. Mousseau, Christopher H. Eskiw, Zoe E. Gillespie

International Journal of Molecular Sciences.2020; 21(23): 9220. CrossRef

Long Noncoding RNA Expression Profiling Reveals Upregulation of Uroplakin 1A and Uroplakin 1A Antisense RNA 1 under Hypoxic Conditions in Lung Cancer Cells

Yuree Byun, Young-Chul Choi, Yongsu Jeong, Jaeseung Yoon, Kwanghee Baek

Convergent evolution on the hypoxia-inducible factor (HIF) pathway genes EGLN1 and EPAS1 in high-altitude ducks

Inhibitory effects of plasmid small interfering RNA targeting signal transducer and activator of transcription‑3 in C6 glioma cells

Jiajun Chen, Yue Zhou, Xiangyu Zhou, Jia Li, Feng Liu, Qingwei Zhou

Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease: A Review

Dongqing Guo, Colin E. Murdoch, Tianhua Liu, Jia Qu, Shihong Jiao, Yong Wang, Wei Wang, Xing Chen

ARD1/NAA10 in hepatocellular carcinoma: pathways and clinical implications

Danbi Lee, Myoung-Kuk Jang, Ji Hae Seo, Soo Hyung Ryu, Jeong A. Kim, Young-Hwa Chung

Experimental & Molecular Medicine.2018; 50(7): 1. CrossRef

Low dose radiation primed iNOS + M1macrophages modulate angiogenic programming of tumor derived endothelium

Vinod Nadella, Sandhya Singh, Aklank Jain, Manju Jain, Karen M. Vasquez, Ashok Sharma, Pranay Tanwar, Goura Kishore Rath, Hridayesh Prakash

Molecular Carcinogenesis.2018; 57(11): 1664. CrossRef

HIF-1 as a Marker of Age-Related Diseases Associated with Tissue Hypoxia

E. S. Popravka, N. S. Linkova, S. V. Trofimova, V. Kh. Khavinson

Biology Bulletin Reviews.2018; 8(6): 497. CrossRef

HRAS as a potential therapeutic target of salirasib RAS inhibitor in bladder cancer

Satoshi Sugita, Hideki Enokida, Hirofumi Yoshino, Kazutaka Miyamoto, Masaya Yonemori, Takashi Sakaguchi, Yoichi Osako, Masayuki Nakagawa

International Journal of Oncology.2018;[Epub] CrossRef

HIF-1α contributes to tube malformation of human lymphatic endothelial cells by upregulating VEGFR-3

Tao Han, Jun Yan, Haini Chen, Yi Ji, Jianbing Chen, Jie Cui, Weimin Shen, Jijun Zou

International Journal of Oncology.2018;[Epub] CrossRef

Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin�43 SUMOylation

Dianying Zhang, Kai Yu, Zhong Yang, Yanxia Li, Xiaofang Ma, Xiyun Bian, Fengting Liu, Lili Li, Xiaozhi Liu, Wenhan Wu

International Journal of Oncology.2018;[Epub] CrossRef

BP-1T, an antiangiogenic benzophenone-thiazole pharmacophore, counteracts HIF-1 signalling through p53/MDM2-mediated HIF-1α proteasomal degradation

Prabhu Thirusangu, V. Vigneshwaran, T. Prashanth, B. R. Vijay Avin, Vikas H. Malojirao, H. Rakesh, Shaukath Ara Khanum, Riaz Mahmood, B. T. Prabhakar

Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories

Anthony R. Martin, Cyril Ronco, Luc Demange, Rachid Benhida

A tumoural angiogenic gateway blocker, Benzophenone-1B represses the HIF-1α nuclear translocation and its target gene activation against neoplastic progression

Prabhu Thirusangu, V. Vigneshwaran, V. Lakshmi Ranganatha, B.R. Vijay Avin, Shaukath Ara Khanum, Riaz Mahmood, K. Jayashree, B.T. Prabhakar

Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling

Ming Yue Li, Chunliu Mi, Ke Si Wang, Zhe Wang, Hong Xiang Zuo, Lian Xun Piao, Guang Hua Xu, Xuezheng Li, Juan Ma, Xuejun Jin

Chemico-Biological Interactions.2017; 274: 58. CrossRef

Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines

Xinkun Guo, Zhaoqin Zhu, Wanju Zhang, Xiaoxiao Meng, Yong Zhu, Peng Han, Xiaohui Zhou, Yunwen Hu, Ruilan Wang

Emerging Microbes & Infections.2017; 6(1): 1. CrossRef

Hypoxia-inducible factor-1α in Antarctic notothenioids contains a polyglutamine and glutamic acid insert that varies in length with phylogeny

125I seed irradiation induces apoptosis and inhibits angiogenesis by decreasing HIF-1α and VEGF expression in lung carcinoma xenografts

Gui-Ling Xiang, Xin-Hong Zhu, Cun-Zhi Lin, Li-Jun Wang, Yong Sun, Yi-Wei Cao, Fang-Fang Wang

Forkhead Transcription Factor FOXO1 Inhibits Angiogenesis in Gastric Cancer in Relation to SIRT1

Sue Youn Kim, Young San Ko, Jinju Park, Yiseul Choi, Jong-Wan Park, Younghoon Kim, Jung-Soo Pyo, Young Bok Yoo, Jae-Seon Lee, Byung Lan Lee

Cancer Research and Treatment.2016; 48(1): 345. CrossRef

Aryl Hydrocarbon Receptor Activates NDRG1 Transcription under Hypoxia in Breast Cancer Cells

En-Yu Li, Wei-Yung Huang, Ya-Chu Chang, Mong-Hsun Tsai, Eric Y. Chuang, Qian-Yu Kuok, Shih-Ting Bai, Lo-Yun Chao, Yuh-Pyng Sher, Liang-Chuan Lai

Transcriptional regulation of human and murine short-chain dehydrogenase/reductases (SDRs) – an in silico approach

Drug Metabolism Reviews.2016; 48(2): 183. CrossRef

Arsenic trioxide plus PX-478 achieves effective treatment in pancreatic ductal adenocarcinoma

Mingxiao Lang, Xiuchao Wang, Hongwei Wang, Jie Dong, Chungen Lan, Jihui Hao, Chongbiao Huang, Xin Li, Ming Yu, Yanhui Yang, Shengyu Yang, He Ren

Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)

Cheryl de Vallière, Jesus Cosin-Roger, Simona Simmen, Kirstin Atrott, Hassan Melhem, Jonas Zeitz, Mehdi Madanchi, Irina Tcymbarevich, Michael Fried, Gerd A. Kullak-Ublick, Stephan R. Vavricka, Benjamin Misselwitz, Klaus Seuwen, Carsten A. Wagner, Jyrki J.

Cellular and Molecular Gastroenterology and Hepatology.2016; 2(6): 796. CrossRef

Bile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell models

J. P. Phelan, F. J. Reen, N. Dunphy, R. O’Connor, F. O’Gara

Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and Lifespan

Zoe E. Gillespie, Joshua Pickering, Christopher H. Eskiw

Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α Pathway

Xiaoyan Huang, Zhiying He, Xinwei Jiang, Mengjun Hou, Zhihong Tang, Xiaozhou Zhen, Yuming Liang, Jing Ma, George Simos

Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor-1α expression during tumor progression

Woom-Yee Bae, Jae-Sun Choi, Ja-Eun Kim, Joo-Won Jeong

Biochemical Pharmacology.2015; 98(1): 41. CrossRef

Clinicopathological Significance of MicroRNA-20b Expression in Hepatocellular Carcinoma and Regulation of HIF-1αand VEGF Effect on Cell Biological Behaviour

Tong-min Xue, Li-de Tao, Miao Zhang, Jie Zhang, Xia Liu, Guo-feng Chen, Yi-jia Zhu, Pei-Jian Zhang

HIF-1α Contributes to Proliferation and Invasiveness of Neuroblastoma Cells via SHH Signaling

Sheng Chen, Min Zhang, Lili Xing, Yue Wang, Yongtao Xiao, Yeming Wu, Sharmila Shankar

Autoacetylation regulates differentially the roles of ARD1 variants in tumorigenesis

JI HAE SEO, JI-HYEON PARK, EUN JI LEE, TAM THUY LU VO, HOON CHOI, JAE KYUNG JANG, HEE-JUN WEE, BUM JU AHN, JONG-HO CHA, MIN WOOK SHIN, KYU-WON KIM

International Journal of Oncology.2015; 46(1): 99. CrossRef

Transcriptome sequencing revealed differences in the response of renal cancer cells to hypoxia and CoCl2 treatment

Nadezhda Zhigalova, Artem Artemov, Alexander M. Mazur, Egor B. Prokhortchouk

The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma

Dongjun Luo, Zhongxia Wang, Junyi Wu, Chunping Jiang, Junhua Wu

BioMed Research International.2014; 2014: 1. CrossRef

Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer

Kelie M Reece, Emily D Richardson, Kristina M Cook, Tessa J Campbell, Stephen T Pisle, Alesia J Holly, David J Venzon, David J Liewehr, Cindy H Chau, Douglas K Price, William D Figg

Exploring the Modulation of Hypoxia-Inducible Factor (HIF)-1α by Volatile Anesthetics as a Possible Mechanism Underlying Volatile Anesthetic-Induced CNS Injury

Emma K. Giles, Andrew J. Lawrence, Jhodie R. Duncan

Neurochemical Research.2014; 39(9): 1640. CrossRef

Activation-induced necroptosis contributes to B-cell lymphopenia in active systemic lupus erythematosus

H Fan, F Liu, G Dong, D Ren, Y Xu, J Dou, T Wang, L Sun, Y Hou

[18F]Fluorodeoxyglucose accumulation as a biological marker of hypoxic status but not glucose transport ability in gastric cancer

Ryusuke Takebayashi, Kunihiko Izuishi, Yuka Yamamoto, Reiko Kameyama, Hirohito Mori, Tsutomu Masaki, Yasuyuki Suzuki

Journal of Experimental & Clinical Cancer Research.2013;[Epub] CrossRef

The influence of pH and hypoxia on tumor metastasis

Expert Review of Anticancer Therapy.2013; 13(10): 1229. CrossRef

Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors

European Journal of Medicinal Chemistry.2012; 49: 24. CrossRef

Molecular Mechanism Underlying the Detection of Colorectal Cancer by 18F-2-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography

Kunihiko Izuishi, Yuka Yamamoto, Takanori Sano, Ryusuke Takebayashi, Yoshihiro Nishiyama, Hirohito Mori, Tsutomu Masaki, Asahiro Morishita, Yasuyuki Suzuki

Journal of Gastrointestinal Surgery.2012; 16(2): 394. CrossRef

A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumour growth and angiogenesis

S Y Nam, Y S Ko, J Jung, J Yoon, Y H Kim, Y J Choi, J W Park, M S Chang, W H Kim, B L Lee

British Journal of Cancer.2011; 104(1): 166. CrossRef

Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules

Sue Youn Kim, Jiyeon Yoon, Young San Ko, Mee Soo Chang, Jong-Wan Park, Hee Eun Lee, Min A Kim, Ji Hun Kim, Woo Ho Kim, Byung Lan Lee

Terpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing

Hye Jin Jung, Joong Sup Shim, Jiyong Lee, Young Mi Song, Ki Chung Park, Seung Hoon Choi, Nam Doo Kim, Jeong Hyeok Yoon, Paul T. Mungai, Paul T. Schumacker, Ho Jeong Kwon

Journal of Biological Chemistry.2010; 285(15): 11584. CrossRef

The Clinicopathological Significance of Tissue Levels of Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor in Gastric Cancer

Seong-Eun Kim, Ki-Nam Shim, Sung-Ae Jung, Kwon Yoo, Joo Ho Lee