Cancer Research and Treatment

The role of matrix metalloproteinase-2 in the metastatic cascade: a review

Tumor-associated macrophages in colorectal cancer metastasis: molecular insights and translational perspectives

Siyu Hou, Yuanchun Zhao, Jiajia Chen, Yuxin Lin, Xin Qi

Journal of Translational Medicine.2024;[Epub] CrossRef

The role of stromal cells in epithelial–mesenchymal plasticity and its therapeutic potential

Juanjing Wang, Junmei Peng, Yonglin Chen, M. I. Nasser, Hui Qin

Isolation and purification of polysaccharides from Bupleurum marginatum Wall.ex DC and their anti-liver fibrosis activities

Li Xiao, Hafsa Sunniya, Jingyi Li, Mohib Ullah Kakar, Rongji Dai, Bo Li

Retinoic acid-loaded PLGA nanocarriers targeting cell cholesterol potentialize the antitumour effect of PD-L1 antibody by preventing epithelial-mesenchymal transition mediated by M2-TAM in colorectal cancer

Raimundo Fernandes de Araújo Júnior, George A Lira, Timo Schomann, Rômulo S Cavalcante, Natalia Feitosa Vilar, Regina Célia Monteiro de Paula, Raelle Ferreira Gomes, Chih Kit Chung, Carla Jorquera-Cordero, Olena Vepris, Alan B Chan, Luis J. Cruz

Translational Oncology.2023; 31: 101647. CrossRef

The ceRNA network regulates epithelial-mesenchymal transition in colorectal cancer

Do Elevated YKL-40 Levels Drive the Immunosuppressive Tumor Microenvironment in Colorectal Cancer? Assessment of the Association of the Expression of YKL-40, MMP-8, IL17A, and PD-L1 with Coexisting Type 2 Diabetes, Obesity, and Active Smoking

Błażej Ochman, Sylwia Mielcarska, Agnieszka Kula, Miriam Dawidowicz, Julia Robotycka, Jerzy Piecuch, Monika Szrot, Sylwia Dzięgielewska-Gęsiak, Małgorzata Muc-Wierzgoń, Dariusz Waniczek, Elżbieta Świętochowska

Current Issues in Molecular Biology.2023; 45(4): 2781. CrossRef

TGFβ and the Tumor Microenvironment in Colorectal Cancer

Exosomes in metastasis of colorectal cancers: Friends or foes?

Zheng Wu, Ze-Xuan Fang, Yan-Yu Hou, Bing-Xuan Wu, Yu Deng, Hua-Tao Wu, Jing Liu

World Journal of Gastrointestinal Oncology.2023; 15(5): 731. CrossRef

Dynamic polarization of tumor-associated macrophages and their interaction with intratumoral T cells in an inflamed tumor microenvironment: from mechanistic insights to therapeutic opportunities

MicroRNA functional metal-organic framework nanocomposite for efficient inhibition of drug-resistant breast cancer cells

Yuxin Shen, Yao Zhang, Xiyue Gao, Mengdi Shang, Yanfei Cai, Zhaoqi Yang

Impact of Opioids on Cellular Metabolism: Implications for Metabolic Pathways Involved in Cancer

Suppressing epithelial‐mesenchymal‐transition blue light therapy for reducing macrophage‐mediated cancerous pulmonary fibrosis: An in‐vitro study

Metastasis organotropism in colorectal cancer: advancing toward innovative therapies

Kai He, Zhihan Wang, Maochao Luo, Bowen Li, Ning Ding, Lei Li, Bo He, Han Wang, Jiangjun Cao, Canhua Huang, Jun Yang, Hai-Ning Chen

Journal of Translational Medicine.2023;[Epub] CrossRef

Thermal/ultrasound-triggered release of liposomes loaded with Ganoderma applanatum polysaccharide from microbubbles for enhanced tumour ablation

Jiani Yuan, Lei Ding, Lu Han, Lina Pang, Peidi Zhang, Xiao Yang, Haijing Liu, Minjuan Zheng, Yunfei Zhang, Wen Luo

Journal of Controlled Release.2023; 363: 84. CrossRef

MicroRNAs and their vital role in apoptosis in hepatocellular carcinoma: miRNA-based diagnostic and treatment methods

Masoumeh Hajizadeh, Farnaz Hajizadeh, Sevil Ghaffarei, Mohammad Amin Doustvandi, Khadijeh Hajizadeh, Seyyed Mohammad Yaghoubi, Fateme Mohammadnejad, Nadia Allahyarzadeh Khiabani, Pegah Mousavi, Behzad Baradaran

Tumour-associated macrophages: versatile players in the tumour microenvironment

Zoey Zeyuan Ji, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Kam-Tong Leung, Xiaohua Jiang, Ka-Fai To, Yi Wu, Patrick Ming-Kuen Tang

Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef

Exploiting innate immunity for cancer immunotherapy

Ming Yi, Tianye Li, Mengke Niu, Qi Mei, Bin Zhao, Qian Chu, Zhijun Dai, Kongming Wu

Functional and Therapeutic Significance of Tumor-Associated Macrophages in Colorectal Cancer

Yitong Li, Zhenmei Chen, Jiahao Han, Xiaochen Ma, Xin Zheng, Jinhong Chen

Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies

Lili Qiao, Yanfei Chen, Ning Liang, Jian Xie, Guodong Deng, Fangjie Chen, Xiaojuan Wang, Fengjun Liu, Yupeng Li, Jiandong Zhang

SNAIL driven by a feed forward loop motif promotes TGFβ induced epithelial to mesenchymal transition

Biomedical Physics & Engineering Express.2022; 8(4): 045012. CrossRef

Comparative analysis of tumor control gene and microRNA expression profiles in tumor and adjacent tissues in patients with colorectal cancer

M. I. Sluzhev, M. I. Zaraisky, V. V. Semiglazov, T. Yu. Semiglazova, E. V. Tkachenko, S. V. Kondratev, N. A. Brish, Yu. V. Alekseeva, Iu. V. Petrik, A. N. Sidorova

Siberian journal of oncology.2022; 21(2): 55. CrossRef

D-tryptophan triggered epithelial-mesenchymal transition by activating TGF-β signaling pathway

Food Science and Human Wellness.2022; 11(5): 1215. CrossRef

AST·MLR index and operation injury condition are novel prognostic predictor for the prediction of survival in patients with colorectal cancer liver metastases undergoing surgical resection

Qichen Chen, Mingxia Li, Jinghua Chen, Zhen Huang, Xiao Chen, Hong Zhao, Jianqiang Cai

Molecular Characterizations of Gynecologic Carcinosarcomas: A Focus on the Immune Microenvironment

Sanaa Nakad Borrego, Ernst Lengyel, Katherine C. Kurnit

miR‑382 inhibits breast cancer progression and metastasis by affecting the M2 polarization of tumor‑associated macrophages by targeting PGC‑1α

Hua Zhou, Mingyu Gan, Xin Jin, Meng Dai, Yuanyuan Wang, Youyang Lei, Zijing Lin, Jia Ming

International Journal of Oncology.2022;[Epub] CrossRef

TGF-β Signaling in Metastatic Colorectal Cancer (mCRC): From Underlying Mechanism to Potential Applications in Clinical Development

International Journal of Molecular Sciences.2022; 23(22): 14436. CrossRef

Naringenin in the Prevention of Colon Cancer: An Updated Review

Relationship between Epithelial-to-Mesenchymal Transition and Tumor-Associated Macrophages in Colorectal Liver Metastases

Aurora Gazzillo, Michela Anna Polidoro, Cristiana Soldani, Barbara Franceschini, Ana Lleo, Matteo Donadon

International Journal of Molecular Sciences.2022; 23(24): 16197. CrossRef

CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ

Ruo Chen, Ke Wang, Zhuan Feng, Ming-Yang Zhang, Jiao Wu, Jie-Jie Geng, Zhi-Nan Chen

Cellular & Molecular Immunology.2021; 18(1): 171. CrossRef

TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer

Karen Slattery, Elena Woods, Vanessa Zaiatz-Bittencourt, Sam Marks, Sonya Chew, Michael Conroy, Caitriona Goggin, Colm MacEochagain, John Kennedy, Sophie Lucas, David K Finlay, Clair M Gardiner

Journal for ImmunoTherapy of Cancer.2021; 9(2): e002044. CrossRef

Long non-coding RNA ZFAS1 is a major regulator of epithelial-mesenchymal transition through miR-200/ZEB1/E-cadherin, vimentin signaling in colon adenocarcinoma

Stephen J. O’Brien, Casey Fiechter, James Burton, Jacob Hallion, Mason Paas, Ankur Patel, Ajay Patel, Andre Rochet, Katharina Scheurlen, Sarah Gardner, Maurice Eichenberger, Harshini Sarojini, Sudhir Srivastava, Shesh Rai, Theodore Kalbfleisch, Hiram C. P

Creatine promotes cancer metastasis through activation of Smad2/3

Liwen Zhang, Zijing Zhu, Huiwen Yan, Wen Wang, Zhenzhen Wu, Fei Zhang, Qixiang Zhang, Guizhi Shi, Junfeng Du, Huiyun Cai, Xuanxuan Zhang, David Hsu, Pu Gao, Hai-long Piao, Gang Chen, Pengcheng Bu

Lactate Dehydrogenase-A (LDH-A) Preserves Cancer Stemness and Recruitment of Tumor-Associated Macrophages to Promote Breast Cancer Progression

Shengnan Wang, Lingyu Ma, Ziyuan Wang, Huiwen He, Huilin Chen, Zhaojun Duan, Yuyang Li, Qin Si, Tsung-Hsien Chuang, Chong Chen, Yunping Luo

Partial EMT in head and neck cancer biology: a spectrum instead of a switch

Ananya Pal, Thomas F. Barrett, Rachel Paolini, Anuraag Parikh, Sidharth V. Puram

Macrophages, as a Promising Strategy to Targeted Treatment for Colorectal Cancer Metastasis in Tumor Immune Microenvironment

Tumor‐associated macrophage‐derived CCL5 promotes chemotherapy resistance and metastasis in prostatic cancer

Jian Ma, Fuerhaiti Shayiti, Jing Ma, Meng Wei, Tingting Hua, Rong Zhang, Junyan Su, Peng Chen

Cell Biology International.2021; 45(10): 2054. CrossRef

Tumor Microenvironment: Involved Factors and Signaling Pathways in Epithelial-Mesenchymal Transition

International Journal of Cancer Management.2021;[Epub] CrossRef

The Multifaceted Role of TGF-β in Gastrointestinal Tumors

Fabio Sabbadini, Monica Bertolini, Serena De Matteis, Domenico Mangiameli, Serena Contarelli, Silvia Pietrobono, Davide Melisi

TMEM100 Modulates TGF-β Signaling Pathway to Inhibit Colorectal Cancer Progression

Huixia Li, Chuan Cheng, Weibo You, Jiujian Zheng, Jie Xu, Peng Gao, Jianping Wang, Tatsuya Toyokawa

Gastroenterology Research and Practice.2021; 2021: 1. CrossRef

Green Synthesized Honokiol Transfersomes Relieve the Immunosuppressive and Stem-Like Cell Characteristics of the Aggressive B16F10 Melanoma

Yasmeen Ezzeldeen, Shady Swidan, Aliaa ElMeshad, Aya Sebak

International Journal of Nanomedicine.2021; Volume 16: 5693. CrossRef

Copper content in ascitic fluid is associated with angiogenesis and progression in ovarian cancer

Toshimichi Onuma, Tetsuya Mizutani, Yuko Fujita, Shizuka Yamada, Yoshio Yoshida

Journal of Trace Elements in Medicine and Biology.2021; 68: 126865. CrossRef

KLK8 promotes the proliferation and metastasis of colorectal cancer via the activation of EMT associated with PAR1

Qing Hua, Zhirong Sun, Yi Liu, Xuefang Shen, Weiwei Zhao, Xiaoyan Zhu, Pingbo Xu

Tumor-Released Products Promote Bone Marrow-Derived Macrophage Survival and Proliferation

Juliana Maria Motta, Vivian Mary Rumjanek, Alberto Mantovani, Massimo Locati

Potential role of tumor-infiltrating T-, B-lymphocytes, tumor-associated macrophages and IgA-secreting plasma cells in long-term survival in the rectal adenocarcinoma patients

Dmitry A. Zinovkin, Suheyla Y. Kose, Eldar A. Nadyrov, Sergey L. Achinovich, Dmitry M. Los', Tatyana E. Gavrilenko, Dmitry I. Gavrilenko, Jale Yuzugulen, Md Zahidul Islam Pranjol

Targeting Tumor-Associated Macrophages in Cancer Immunotherapy

Amy J. Petty, Dwight H. Owen, Yiping Yang, Xiaopei Huang

Tumour microenvironment: a non-negligible driver for epithelial−mesenchymal transition in colorectal cancer

Lei Han, Shuyi Wang, Chen Wei, Yan Fang, Sihao Huang, Tailang Yin, Bin Xiong, Chaogang Yang

Expert Reviews in Molecular Medicine.2021;[Epub] CrossRef

Anti-Cancer Activity Profiling of Chemotherapeutic Agents in 3D Co-Cultures of Pancreatic Tumor Spheroids with Cancer-Associated Fibroblasts and Macrophages

So-Dam Jang, Jeeyeun Song, Hyun-Ah Kim, Chang-Nim Im, Iftikhar Ali Khawar, Jong Kook Park, Hyo-Jeong Kuh

M2-Type Macrophages Induce Tregs Generation by Activating the TGF-β/Smad Signalling Pathway to Promote Colorectal Cancer Development

Xueqian Ma, Yu Gao, Yanlei Chen, Jinhao Liu, Chunyu Yang, Cuifen Bao, Yanping Wang, Yang Feng, Xiaoyu Song, Shifeng Qiao

OncoTargets and Therapy.2021; Volume 14: 5391. CrossRef

Communication between EMT and PD-L1 signaling: New insights into tumor immune evasion

Signaling of Macrophages that Contours the Tumor Microenvironment for Promoting Cancer Development

The roles of tumor-associated macrophages in tumor angiogenesis and metastasis

Luo-Qin Fu, Wen-Lin Du, Mao-Hua Cai, Jia-Yu Yao, Yuan-Yuan Zhao, Xiao-Zhou Mou

Pro-tumorigenic functions of macrophages at the primary, invasive and metastatic tumor site

Elaheh Nasrollahzadeh, Sepideh Razi, Mahsa Keshavarz-Fathi, Massimiliano Mazzone, Nima Rezaei

Cancer Immunology, Immunotherapy.2020; 69(9): 1673. CrossRef

Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer

Jung Yoon Choi, Sunho Choi, Minhyeok Lee, Young Soo Park, Jae Sook Sung, Won Jin Chang, Ju Won Kim, Yoon Ji Choi, Jin Kim, Dong-Sik Kim, Sung-Ho Lee, Junhee Seok, Kyong Hwa Park, Seon Hahn Kim, Yeul Hong Kim

Cancer Research and Treatment.2020; 52(3): 764. CrossRef

Caspase Recruitment Domain Containing Protein 9 Suppresses Non-Small Cell Lung Cancer Proliferation and Invasion via Inhibiting MAPK/p38 Pathway

Linyue Pan, Yuting Tan, Bin Wang, Wenjia Qiu, Yulei Yin, Haiyan Ge, Huili Zhu

Cancer Research and Treatment.2020; 52(3): 867. CrossRef

RUNX1 regulates TGF-β induced migration and EMT in colorectal cancer

Chenghao Lu, Zheyu Yang, Dingye Yu, Jianwei Lin, Wei Cai

Pathology - Research and Practice.2020; 216(11): 153142. CrossRef

Targeting Tumor-Associated Macrophages in Anti-Cancer Therapies: Convincing the Traitors to Do the Right Thing

Cristina Belgiovine, Elisabeth Digifico, Clément Anfray, Aldo Ummarino, Fernando Torres Andón

Journal of Clinical Medicine.2020; 9(10): 3226. CrossRef

Mapping a Circular RNA–microRNA–mRNA-Signaling Regulatory Axis that Modulates Stemness Properties of Cancer Stem Cell Populations in Colorectal Cancer Spheroid Cells

Vimalan Rengganaten, Chiu-Jung Huang, Ping-Hsing Tsai, Mong-Lien Wang, Yi-Ping Yang, Yuan-Tzu Lan, Wen-Liang Fang, Shelly Soo, Hooi Tin Ong, Soon Keng Cheong, Kong Bung Choo, Shih-Hwa Chiou

International Journal of Molecular Sciences.2020; 21(21): 7864. CrossRef

A Window of Opportunity: Targeting Cancer Endothelium to Enhance Immunotherapy

Modeling of the immune response in the pathogenesis of solid tumors and its prognostic significance

Łukasz Zadka, Damian J. Grybowski, Piotr Dzięgiel

Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights

Ammad Ahmad Farooqi, Marc de la Roche, Mustafa B.A. Djamgoz, Zahid H. Siddik

Transcriptome Sequencing Investigated the Tumor-Related Factors Changes After T. gondii Infection

Gang Lu, Jian Zhou, Ying hui Zhao, Qiao ling Li, Yun yun Gao, Lin Wang

Advances in Molecular Mechanisms and Immunotherapy Involving the Immune Cell-Promoted Epithelial-to-Mesenchymal Transition in Lung Cancer

Serena De Matteis, Matteo Canale, Alberto Verlicchi, Giuseppe Bronte, Angelo Delmonte, Lucio Crinò, Giovanni Martinelli, Paola Ulivi

Tumor-associated macrophages: an accomplice in solid tumor progression

Yibing Chen, Yucen Song, Wei Du, Longlong Gong, Haocai Chang, Zhengzhi Zou

Journal of Biomedical Science.2019;[Epub] CrossRef

Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor Microenvironment

International Journal of Molecular Sciences.2019; 20(23): 5822. CrossRef

Gastric cancer-derived mesenchymal stromal cells trigger M2 macrophage polarization that promotes metastasis and EMT in gastric cancer

Wei Li, Xu Zhang, Fenglei Wu, Ying Zhou, Zengtao Bao, Haining Li, Ping Zheng, Shaolin Zhao

Pimozide suppresses colorectal cancer via inhibition of Wnt/β-catenin signaling pathway

Yonggang Ren, Jia Tao, Zhen Jiang, Dongmei Guo, Jiancai Tang