Cancer Research and Treatment

The tertiary lymphoid structure-related signature identified PTGDS in regulating PD-L1 and promoting the proliferation and migration of glioblastoma

Wantao Wu, He Li, Zeyu Wang, Ziyu Dai, Xisong Liang, Peng Luo, Kun Liu, Hao Zhang, Nan Zhang, Shuyu Li, Chi Zhang

Tertiary lymphoid structures, a historical reappraisal

Immune cells within tertiary lymphoid structures are associated with progression‐free survival in patients with locoregional recurrent breast cancer

Jinyuan Gu, Jiaming Wang, Yue Sun, Xinrui Mao, Chao Qian, Xinyu Tang, Ji Wang, Hui Xie, Lijun Ling, Yi Zhao, Xiaoan Liu, Kai Zhang, Hong Pan, Shui Wang, Cong Wang, Wenbin Zhou

Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer

Benedetta Donati, Francesca Reggiani, Federica Torricelli, Giacomo Santandrea, Teresa Rossi, Alessandra Bisagni, Elisa Gasparini, Antonino Neri, Laura Cortesi, Guglielmo Ferrari, Giancarlo Bisagni, Moira Ragazzi, Alessia Ciarrocchi

Cancer Immunology Research.2024; 12(1): 120. CrossRef

The Emerging Role of Tertiary Lymphoid Structures in Breast Cancer: A Narrative Review

Dana Narvaez, Jorge Nadal, Adrian Nervo, María Victoria Costanzo, Claudio Paletta, Fernando E. Petracci, Sergio Rivero, Alexis Ostinelli, Berenice Freile, Diego Enrico, Maria Teresa Pombo, Mora Amat, Edgar Danilo Aguirre, Matias Chacon, Federico Waisberg

Digital image analysis and machine learning-assisted prediction of neoadjuvant chemotherapy response in triple-negative breast cancer

Timothy B. Fisher, Geetanjali Saini, T. S. Rekha, Jayashree Krishnamurthy, Shristi Bhattarai, Grace Callagy, Mark Webber, Emiel A. M. Janssen, Jun Kong, Ritu Aneja

Translational and oncologic significance of tertiary lymphoid structures in pancreatic adenocarcinoma

Zachary Gao, Joseph Azar, Huili Zhu, Sophia Williams-Perez, Sung Wook Kang, Celia Marginean, Mark P. Rubinstein, Shalini Makawita, Hyun-Sung Lee, E. Ramsay Camp

Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer

Qianyu Wang, Wentao Zhong, Xiaofei Shen, Zechen Hao, Meng Wan, Xiaopeng Yang, Ran An, Hongyan Zhu, Huiyun Cai, Tao Li, Yuan Lv, Xing Dong, Gang Chen, Aijun Liu, Junfeng Du

Advances in the study of tertiary lymphoid structures in the immunotherapy of breast cancer

The prognostic impact of tumor-infiltrating B lymphocytes in patients with solid malignancies: A systematic review and meta-analysis

Hao Liu, Zhuoqun Li, Xuan Han, Zhujun Li, Yan Zhao, Fenghua Liu, Ziyu Zhu, Yi Lv, Zhijun Liu, Nana Zhang

Critical Reviews in Oncology/Hematology.2023; 181: 103893. CrossRef

Tertiary lymphoid structures in breast ductal carcinoma in situ correlate with adverse pathological parameters

Lixia Zeng, Valerie Cui Yun Koh, Xiao‐Yang Chen, Puay Hoon Tan

Can CXCL13 be a prognostic marker in clear cell renal cell carcinoma?

Indian Journal of Pathology and Microbiology.2023; 66(1): 54. CrossRef

Clinical Significance of Tumour-Infiltrating B Lymphocytes (TIL-Bs) in Breast Cancer: A Systematic Literature Review

B cell‐dependent subtypes and treatment‐based immune correlates to survival in stage 3 and 4 lung adenocarcinomas

Susan Raju Paul, Ivan Valiev, Skylar E. Korek, Vladimir Zyrin, Diana Shamsutdinova, Olga Gancharova, Alexander Zaitsev, Ekaterina Nuzhdina, Diane L. Davies, Ibiayi Dagogo‐Jack, Felix Frenkel, Jessica H. Brown, Joshua M. Hess, Sarah Viet, Jason L. Petersen

High endothelial venules in cancer: Regulation, function, and therapeutic implication

Mengyuan Li, Angela Quintana, Elena Alberts, Miu Shing Hung, Victoire Boulat, Mercè Martí Ripoll, Anita Grigoriadis

Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast Cancer

Gyöngyi Munkácsy, Libero Santarpia, Balázs Győrffy

International Journal of Molecular Sciences.2023; 24(8): 6945. CrossRef

Antibodies against endogenous retroviruses promote lung cancer immunotherapy

Kevin W. Ng, Jesse Boumelha, Katey S. S. Enfield, Jorge Almagro, Hongui Cha, Oriol Pich, Takahiro Karasaki, David A. Moore, Roberto Salgado, Monica Sivakumar, George Young, Miriam Molina-Arcas, Sophie de Carné Trécesson, Panayiotis Anastasiou, Annika Fend

Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2‐negative breast cancer

François Bertucci, Alexandre De Nonneville, Pascal Finetti, Emilie Mamessier

P16 expression and presence of lymphoid stroma are correlated with good prognosis in mucoepidermoid carcinoma of the head and neck

Yeseul Kim, Joon Seon Song, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Kyung-Ja Cho

Pathology - Research and Practice.2023; 251: 154874. CrossRef

The Possible Role of Anti- and Protumor-Infiltrating Lymphocytes in Pathologic Complete Response in Early Breast Cancer Patients Treated with Neoadjuvant Systemic Therapy

Klara Geršak, Blaž Matija Geršak, Barbara Gazić, Andreja Klevišar Ivančič, Primož Drev, Nina Ružić Gorenjec, Cvetka Grašič Kuhar

Detection and quantitative analysis of tumor-associated tertiary lymphoid structures

Man Yang, Yurou Che, Kezhen Li, Zengyi Fang, Simin Li, Mei Wang, Yiyao Zhang, Zhu Xu, Liping Luo, Chuan Wu, Xin Lai, Weidong Wang

Journal of Zhejiang University-SCIENCE B.2023; 24(9): 779. CrossRef

Identification of an exosome-related signature associated with prognosis and immune infiltration in breast cancer

Qiaonan Guo, Kelun Pan, Pengjun Qiu, Zundong Liu, Jianpeng Chen, Jianqing Lin

Association of systemic inflammatory markers and tertiary lymphoid structure with pathological complete response in gastric cancer patients receiving preoperative treatment: a retrospective cohort study

Yingying Wu, Junjie Zhao, Zhaoming Wang, Dan Liu, Chenyu Tian, Botian Ye, Yihong Sun, Haojie Li, Xuefei Wang

International Journal of Surgery.2023; 109(12): 4151. CrossRef

The Characteristics of Tumor Microenvironment in Triple Negative Breast Cancer

Cancer Management and Research.2022; Volume 14: 1. CrossRef

Peripheral node addressin, a ligand for L-selectin is found in tumor cells and in high endothelial venules in endometrial cancer

Georgia Karpathiou, Viviana Sramek, Sami Dagher, Mousa Mobarki, Maroa Dridi, Tiphanie Picot, Celine Chauleur, Michel Peoc’h

Pathology - Research and Practice.2022; 233: 153888. CrossRef

The Presence of Tertiary Lymphoid Structures Provides New Insight Into the Clinicopathological Features and Prognosis of Patients With Breast Cancer

Bin Wang, Jie Liu, Yin Han, Yaotiao Deng, Jinze Li, Yu Jiang

Role of tertiary lymphoid organs in the regulation of immune responses in the periphery

Amit I. Bery, Hailey M. Shepherd, Wenjun Li, Alexander S. Krupnick, Andrew E. Gelman, Daniel Kreisel

Cellular and Molecular Life Sciences.2022;[Epub] CrossRef

Tertiary Lymphoid Structures as Mediators of Immunotherapy Response

Immunotherapy in triple-negative breast cancer: Insights into tumor immune landscape and therapeutic opportunities

Rita Ribeiro, Maria João Carvalho, João Goncalves, João Nuno Moreira

Frontiers in Molecular Biosciences.2022;[Epub] CrossRef

Predictive and prognostic values of tumor infiltrating lymphocytes in breast cancers treated with neoadjuvant chemotherapy: A meta-analysis

Shiqi Li, Ying Zhang, Peigen Zhang, Shuijing Xue, Yu Chen, Lihua Sun, Rui Yang

Multiplexed In Situ Spatial Protein Profiling in the Pursuit of Precision Immuno-Oncology for Patients with Breast Cancer

Davide Massa, Anna Tosi, Antonio Rosato, Valentina Guarneri, Maria Vittoria Dieci

The Association of Estrogen Receptor Activity, Interferon Signaling, and MHC Class I Expression in Breast Cancer

In Hye Song, Young-Ae Kim, Sun-Hee Heo, Won Seon Bang, Hye Seon Park, Yeon ho Choi, Heejae Lee, Jeong-Han Seo, Youngjin Cho, Sung Wook Jung, Hee Jeong Kim, Sei Hyun Ahn, Hee Jin Lee, Gyungyub Gong

Cancer Research and Treatment.2022; 54(4): 1111. CrossRef

High endothelial venules associated with better prognosis in esophageal squamous cell carcinoma

Hongmu Li, Lu Tang, Xue Han, Leqi Zhong, Wuyou Gao, Youfang Chen, Jinhua Huang, Zhesheng Wen

Annals of Diagnostic Pathology.2022; 61: 152051. CrossRef

Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes

Journal of Zhejiang University-SCIENCE B.2022; 23(10): 812. CrossRef

Tertiary Lymphoid Structures: A Potential Biomarker for Anti-Cancer Therapy

Ji’an Zou, Yingzhe Zhang, Yue Zeng, Yurong Peng, Junqi Liu, Chaoyue Xiao, Fang Wu

Impact of mature tertiary lymphoid structures on prognosis and therapeutic response of Epstein-Barr virus-associated gastric cancer patients

Yi-Xin Yin, Yi-Hong Ling, Xiao-Li Wei, Cai-Yun He, Bing-Zhi Wang, Chun-Fang Hu, Wen-Ping Lin, Run-Cong Nie, Jie-Wei Chen, Jin-Long Lin, Jie Zhou, Juan-Juan Xie, Jing-Ping Yun, Dan Xie, Li-Yan Xue, Mu-Yan Cai

The Role of Immune Cells in Breast Tissue and Immunotherapy for the Treatment of Breast Cancer

Clinical Breast Cancer.2021; 21(1): e63. CrossRef

Immune microenvironment in different molecular subtypes of ductal breast carcinoma

Mona Sadeghalvad, Hamid-Reza Mohammadi-Motlagh, Nima Rezaei

Breast Cancer Research and Treatment.2021; 185(2): 261. CrossRef

Cancer-Associated Fibroblasts and T Cells: From Mechanisms to Outcomes

Alfie T. Baker, Mohammed H. Abuwarwar, Lylarath Poly, Simon Wilkins, Anne L. Fletcher

The Journal of Immunology.2021; 206(2): 310. CrossRef

Repenser la place des lymphocytes B et des structures lymphoïdes tertiaires dans l’immunothérapie des cancers

Claire Germain, Hélène Kaplon, Marie-Caroline Dieu-Nosjean

High endothelial venules are present in pharyngeal and laryngeal carcinomas and they are associated with better prognosis

Georgia Karpathiou, Jean Marc Dumollard, Marie Gavid, Francois Casteillo, Marine Vieville, Jean Michel Prades, Marios Froudarakis, Michel Peoc’h

Pathology - Research and Practice.2021; 220: 153392. CrossRef

Prognostic value of tumor-infiltrating B lymphocytes and plasma cells in triple-negative breast cancer

Hajime Kuroda, Tsengelmaa Jamiyan, Rin Yamaguchi, Akinari Kakumoto, Akihito Abe, Oi Harada, Bayarmaa Enkhbat, Atsuko Masunaga

Tumor-infiltrating B cells and T cells correlate with postoperative prognosis in triple-negative carcinoma of the breast

Hajime Kuroda, Tsengelmaa Jamiyan, Rin Yamaguchi, Akinari Kakumoto, Akihito Abe, Oi Harada, Atsuko Masunaga

Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies

High endothelial venules (HEVs) in immunity, inflammation and cancer

Immunohistochemical analysis of L1 cell adhesion molecule and high endothelial venules in breast cancer brain metastasis

Georgia Karpathiou, Florian Camy, Jean Marc Dumollard, Michel Peoc’h

Pathology - Research and Practice.2021; 223: 153484. CrossRef

The Immunology of Hormone Receptor Positive Breast Cancer

Jonathan Goldberg, Ricardo G. Pastorello, Tuulia Vallius, Janae Davis, Yvonne Xiaoyong Cui, Judith Agudo, Adrienne G. Waks, Tanya Keenan, Sandra S. McAllister, Sara M. Tolaney, Elizabeth A. Mittendorf, Jennifer L. Guerriero

Immune Crosstalk Between Lymph Nodes and Breast Carcinomas, With a Focus on B Cells

Elena Alberts, Isobelle Wall, Dinis Pedro Calado, Anita Grigoriadis

Frontiers in Molecular Biosciences.2021;[Epub] CrossRef

Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation

Charlotte Domblides, Juliette Rochefort, Clémence Riffard, Marylou Panouillot, Géraldine Lescaille, Jean-Luc Teillaud, Véronique Mateo, Marie-Caroline Dieu-Nosjean

The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures

Roger Li, Anders Berglund, Logan Zemp, Jasreman Dhillon, Ryan Putney, Youngchul Kim, Rohit K. Jain, G. Daniel Grass, José Conejo-Garcia, James J. Mulé

Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells

Alyssa Vito, Omar Salem, Nader El-Sayes, Ian P. MacFawn, Ana L. Portillo, Katy Milne, Danielle Harrington, Ali A. Ashkar, Yonghong Wan, Samuel T. Workenhe, Brad H. Nelson, Tullia C. Bruno, Karen L. Mossman

Cancer Immunotherapies: From Efficacy to Resistance Mechanisms – Not Only Checkpoint Matters

High Endothelial Venules: A Vascular Perspective on Tertiary Lymphoid Structures in Cancer

Tumor-Infiltrating B Lymphocyte Profiling Identifies IgG-Biased, Clonally Expanded Prognostic Phenotypes in Triple-Negative Breast Cancer

Robert J. Harris, Anthony Cheung, Joseph C.F. Ng, Roman Laddach, Alicia M. Chenoweth, Silvia Crescioli, Matthew Fittall, Diana Dominguez-Rodriguez, James Roberts, Dina Levi, Fangfang Liu, Elena Alberts, Jelmar Quist, Aida Santaolalla, Sarah E. Pinder, Che

Tertiary lymphoid structure and B‑cell‑related pathways: A potential target in tumor immunotherapy (Review)

Heterogeneity of Circulating Tumor Cell–Associated Genomic Gains in Breast Cancer and Its Association with the Host Immune Response

Nisha Kanwar, Zaldy Balde, Ranju Nair, Melanie Dawe, Shiyi Chen, Manjula Maganti, Eshetu G. Atenafu, Sabrina Manolescu, Carrie Wei, Amanda Mao, Fred Fu, Dan Wang, Alison Cheung, Yulia Yerofeyeva, Rachel Peters, Kela Liu, Christine Desmedt, Christos Sotiri

Oral cancer-associated tertiary lymphoid structures: gene expression profile and prognostic value

K Li, Q Guo, X Zhang, X Dong, W Liu, A Zhang, Y Li, J Yan, G Jia, Z Zheng, W Tang, L Pan, M An, B Zhang, S Liu, B Fu

Clinical and Experimental Immunology.2020; 199(2): 172. CrossRef

B cells and tertiary lymphoid structures promote immunotherapy response

Beth A. Helmink, Sangeetha M. Reddy, Jianjun Gao, Shaojun Zhang, Rafet Basar, Rohit Thakur, Keren Yizhak, Moshe Sade-Feldman, Jorge Blando, Guangchun Han, Vancheswaran Gopalakrishnan, Yuanxin Xi, Hao Zhao, Rodabe N. Amaria, Hussein A. Tawbi, Alex P. Cogdi

Neolymphogenesis and Immunogistogochemical Study of Lymph Nodes in Breast Cancer

Sh. Kh. Gantsev, R. A. Rustamkhanov, Sh. R. Kzyrgalin, D. S. Tursumetov

Creative surgery and oncology.2020; 9(4): 266. CrossRef

Duality of B Cell-CXCL13 Axis in Tumor Immunology

Predictive and prognostic role of tumour-infiltrating lymphocytes in breast cancer patients with different molecular subtypes: a meta-analysis

Insights into Tumor-Associated Tertiary Lymphoid Structures: Novel Targets for Antitumor Immunity and Cancer Immunotherapy

Cancer Immunology Research.2020; 8(11): 1338. CrossRef

Pan-cancer analysis of genomic properties and clinical outcome associated with tumor tertiary lymphoid structure

Ziying Lin, Lixia Huang, ShaoLi Li, Jincui Gu, Xiaoxian Cui, Yanbin Zhou

Presence of tertiary lymphoid structures determines the level of tumor-infiltrating lymphocytes in primary breast cancer and metastasis

Miseon Lee, Sun-Hee Heo, In Hye Song, Hajar Rajayi, Hye Seon Park, In Ah Park, Young-Ae Kim, Heejae Lee, Gyungyub Gong, Hee Jin Lee

Strong CD8+ lymphocyte infiltration in combination with expression of HLA class I is associated with better tumor control in breast cancer patients treated with neoadjuvant chemotherapy

A. F. de Groot, E. J. Blok, A. Charehbili, C. C. Engels, V. T. H. B. M. Smit, N. G. Dekker-Ensink, H. Putter, E. Meershoek-Klein Kranenbarg, C. J. H. van de Velde, G. J. Liefers, J. W. R. Nortier, P. J. K. Kuppen, S. H. van der Burg, J. R. Kroep

Breast Cancer Research and Treatment.2019; 175(3): 605. CrossRef

The effect of C-X-C motif chemokine ligand 13 in cutaneous squamous cell carcinoma treated with aminolevulinic acid-photodynamic therapy

Lude Zhu, Guolong Zhang, Peiru Wang, Linglin Zhang, Jie Ji, Xiaojing Liu, Zhongxia Zhou, Jingjun Zhao, Xiuli Wang

Photodiagnosis and Photodynamic Therapy.2019; 26: 389. CrossRef

Tertiary lymphoid structures in the era of cancer immunotherapy

Catherine Sautès-Fridman, Florent Petitprez, Julien Calderaro, Wolf Herman Fridman

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

Johannes Griss, Wolfgang Bauer, Christine Wagner, Martin Simon, Minyi Chen, Katharina Grabmeier-Pfistershammer, Margarita Maurer-Granofszky, Florian Roka, Thomas Penz, Christoph Bock, Gao Zhang, Meenhard Herlyn, Katharina Glatz, Heinz Läubli, Kirsten D. M

Poor Response to Neoadjuvant Chemotherapy Correlates with Mast Cell Infiltration in Inflammatory Breast Cancer

Sangeetha M. Reddy, Alexandre Reuben, Souptik Barua, Hong Jiang, Shaojun Zhang, Linghua Wang, Vancheswaran Gopalakrishnan, Courtney W. Hudgens, Michael T. Tetzlaff, James M. Reuben, Takahiro Tsujikawa, Lisa M. Coussens, Khalida Wani, Yan He, Lily Villarea

Cancer Immunology Research.2019; 7(6): 1025. CrossRef

New Insights into Tumor-Infiltrating B Lymphocytes in Breast Cancer: Clinical Impacts and Regulatory Mechanisms

Hot Spot and Whole-Tumor Enumeration of CD8+ Tumor-Infiltrating Lymphocytes Utilizing Digital Image Analysis Is Prognostic in Triple-Negative Breast Cancer

Patrick J. McIntire, Lina Irshaid, Yifang Liu, Zhengming Chen, Faith Menken, Eugene Nowak, Sandra J. Shin, Paula S. Ginter

Clinical Breast Cancer.2018; 18(6): 451. CrossRef

Correlation with lymphocyte infiltration, but lack of prognostic significance of MECA-79-positive high endothelial venules in primary malignant melanoma

Tímea Sebestyén, Anita Mohos, Gabriella Liszkay, Beáta Somlai, István Gaudi, Andrea Ladányi

Lymphocyte-Activation Gene-3 Expression and Prognostic Value in Neoadjuvant-Treated Triple-Negative Breast Cancer

Yunxuan Wang, Tieying Dong, Qijia Xuan, Hong Zhao, Ling Qin, Qingyuan Zhang

Journal of Breast Cancer.2018; 21(2): 124. CrossRef

Functions of the CXC ligand family in the pancreatic tumor microenvironment

Antigen Specificity and Clinical Significance of IgG and IgA Autoantibodies Produced in situ by Tumor-Infiltrating B Cells in Breast Cancer

Soizic Garaud, Pawel Zayakin, Laurence Buisseret, Undine Rulle, Karina Silina, Alexandre de Wind, Gert Van den Eyden, Denis Larsimont, Karen Willard-Gallo, Aija Linē

Prognostic Significance of Tumor-Infiltrating B Cells and Plasma Cells in Human Cancer

Clinical Cancer Research.2018; 24(24): 6125. CrossRef

The Multifaceted Roles of B Cells in Solid Tumors: Emerging Treatment Opportunities

Nicole J. Flynn, Rajasekharan Somasundaram, Kimberly M. Arnold, Jennifer Sims-Mourtada

CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer

Chunyan Gu-Trantien, Edoardo Migliori, Laurence Buisseret, Alexandre de Wind, Sylvain Brohée, Soizic Garaud, Grégory Noël, Luan Dang C.V., Jean-Nicolas Lodewyckx, Céline Naveaux, Hugues Duvillier, Stanislas Goriely, Denis Larsimont, Karen Willard-Gallo

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

Emily Jayne Colbeck, Ann Ager, Awen Gallimore, Gareth Wyn Jones

Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers

Xia Liu, Julia Y.S. Tsang, Thazin Hlaing, Jintao Hu, Yun-Bi Ni, Siu Ki Chan, Sai Yin Cheung, Gary M. Tse