Cancer Research and Treatment

Molecular Mechanisms of Gastrointestinal Stromal Tumors and Their Impact on Systemic Therapy Decision

Mojca Unk, Barbara Jezeršek Novaković, Srdjan Novaković

Precision Oncology in Gastrointestinal Stromal Tumors

Hiba Mechahougui, Montemurro Michael, Alex Friedlaender

New treatment strategies for advanced-stage gastrointestinal stromal tumours

Lillian R. Klug, Homma M. Khosroyani, Jason D. Kent, Michael C. Heinrich

Nature Reviews Clinical Oncology.2022; 19(5): 328. CrossRef

Clinicopathologic Characteristics and Prognosis of PDGFRA-Mutant Gastrointestinal Stromal Tumors: A Large-Scale, Multi-Institutional, Observational Study in China

Peng Zhang, Ming Wang, Jian Li, Xiaodong Gao, Bo Zhang, Han Liang, Ye Zhou, Guoqing Liao, Fan Feng, Yanbing Zhou, Jiren Yu, Jun Zhang, Yongjian Zhou, Yingjiang Ye, Jiansi Chen, Qun Zhao, Kuntang Shen, Hui Cao, Kaixiong Tao

ACR Appropriateness Criteria® Staging of Colorectal Cancer: 2021 Update

Elena K. Korngold, Courtney Moreno, David H. Kim, Kathryn J. Fowler, Brooks D. Cash, Kevin J. Chang, Kenneth L. Gage, Aakash H. Gajjar, Evelyn M. Garcia, Avinash R. Kambadakone, Peter S. Liu, Meghan Macomber, Daniele Marin, Jason A. Pietryga, Cynthia S. S

Journal of the American College of Radiology.2022; 19(5): S208. CrossRef

Gastrointestinal stromal tumors caused by novel germline variants in SDHB and KIT: a report of two cases and literature review

Sean Rasmussen, Ashley Stueck, Bruce Colwell, Daniel Gaston, Michael Carter

Clinical Journal of Gastroenterology.2022; 15(5): 869. CrossRef

An overview of agents and treatments for PDGFRA-mutated gastrointestinal stromal tumors

A literature review and database of how the primary KIT/PDGFRA variant of a gastrointestinal stromal tumour predicts for sensitivity to imatinib

Newton A.C.S. Wong, Christel Garcia-Petit, Adam Dangoor, Nicola Andrew

Correlation of treatment outcome in sanger/RT‑qPCR KIT/PDGFRA wild‑type metastatic gastrointestinal stromal tumors with next‑generation sequencing results: A single‑center report

Mojca Unk, Alenka Bombač, Barbara Jezeršek Novaković, Vida Stegel, Vita Šetrajčič, Olga Blatnik, Gašper Klančar, Srdjan Novaković

Optimal Avapritinib Treatment Strategies for Patients with Metastatic or Unresectable Gastrointestinal Stromal Tumors

Cissimol P. Joseph, Sarah N. Abaricia, Michelle A. Angelis, Kathleen Polson, Robin L. Jones, Yoon-Koo Kang, Richard F. Riedel, Patrick Schöffski, César Serrano, Jonathan Trent, Eric D. Tetzlaff, Tuan Dong Si, Teresa Zhou, Ashley Doyle, Sebastian Bauer, Ma

Avapritinib in unresectable or metastatic PDGFRA D842V-mutant gastrointestinal stromal tumours: Long-term efficacy and safety data from the NAVIGATOR phase I trial

Robin L. Jones, César Serrano, Margaret von Mehren, Suzanne George, Michael C. Heinrich, Yoon-Koo Kang, Patrick Schöffski, Philippe A. Cassier, Olivier Mir, Sant P. Chawla, Ferry A.L.M. Eskens, Piotr Rutkowski, William D. Tap, Teresa Zhou, Maria Roche, Se

European Journal of Cancer.2021; 145: 132. CrossRef

Prognostic and predictive values of the KIT11-mutated grading system in patients with gastrointestinal stromal tumors: a retrospective study

Ling-Jun Song, Hui-Juan Ge, Xiao-Qin Shi, Wei-Wei Shen

The Identity of PDGFRA D842V-Mutant Gastrointestinal Stromal Tumors (GIST)

Alessandro Rizzo, Maria Abbondanza Pantaleo, Annalisa Astolfi, Valentina Indio, Margherita Nannini

Clinical efficacy comparison of avapritinib with other tyrosine kinase inhibitors in gastrointestinal stromal tumors with PDGFRA D842V mutation: a retrospective analysis of clinical trial and real-world data

Margaret von Mehren, Michael C. Heinrich, Hongliang Shi, Sergio Iannazzo, Raymond Mankoski, Saša Dimitrijević, Gerard Hoehn, Silvia Chiroli, Suzanne George

Magdalena Wiśniewska, Michał Wiśniewski, Marzena A. Lewandowska

Stellungnahme der AIO, DGHO und DGVS zur Nutzenbewertung von Avapritinib bei gastrointestinalen Stromatumoren (GIST)

Zeitschrift für Gastroenterologie.2021; 59(04): 366. CrossRef

Nationwide evaluation of mutation-tailored treatment of gastrointestinal stromal tumors in daily clinical practice

Elisabeth M. P. Steeghs, Hans Gelderblom, Vincent K. Y. Ho, Quirinus J. M. Voorham, Stefan M. Willems, Katrien Grünberg, Marjolijn J. L. Ligtenberg

New FDA oncology small molecule drugs approvals in 2020: Mechanism of action and clinical applications

Thais Cristina Mendonça Nogueira, Marcus Vinicius Nora de Souza

Bioorganic & Medicinal Chemistry.2021; 46: 116340. CrossRef

Gene Expression Profiling of PDGFRA Mutant GIST Reveals Immune Signatures as a Specific Fingerprint of D842V Exon 18 Mutation

Valentina Indio, Gloria Ravegnini, Annalisa Astolfi, Milena Urbini, Maristella Saponara, Antonio De Leo, Elisa Gruppioni, Giuseppe Tarantino, Sabrina Angelini, Andrea Pession, Maria Abbondanza Pantaleo, Margherita Nannini

Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR): a multicentre, open-label, phase 1 trial

Michael C Heinrich, Robin L Jones, Margaret von Mehren, Patrick Schöffski, César Serrano, Yoon-Koo Kang, Philippe A Cassier, Olivier Mir, Ferry Eskens, William D Tap, Piotr Rutkowski, Sant P Chawla, Jonathan Trent, Meera Tugnait, Erica K Evans, Tamieka La

Adult Jejuno-Jejunal Intussusceptions due to Gastrointestinal Stromal Tumor

Indian Journal of Medical and Paediatric Oncology.2020; 41(04): 602. CrossRef

Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib

Margherita Nannini, Giuseppe Tarantino, Valentina Indio, Gloria Ravegnini, Annalisa Astolfi, Milena Urbini, Antonio De Leo, Donatella Santini, Claudio Ceccarelli, Elisa Gruppioni, Annalisa Altimari, Paolo Castellucci, Stefano Fanti, Valerio Di Scioscio, M

Clinical relevance of molecular diagnostics in gastrointestinal (GI) cancer: European Society of Digestive Oncology (ESDO) expert discussion and recommendations from the 17th European Society for Medical Oncology (ESMO)/World Congress on Gastrointestinal

Alexander Baraniskin, Jean-Luc Van Laethem, Lucjan Wyrwicz, Ulrich Guller, Harpreet S. Wasan, Tamara Matysiak-Budnik, Thomas Gruenberger, Michel Ducreux, Fatima Carneiro, Eric Van Cutsem, Thomas Seufferlein, Wolff Schmiegel

European Journal of Cancer.2017; 86: 305. CrossRef

A precision therapy against cancers driven by KIT/PDGFRA mutations

Erica K. Evans, Alexandra K. Gardino, Joseph L. Kim, Brian L. Hodous, Adam Shutes, Alison Davis, Xing Julia Zhu, Oleg Schmidt-Kittler, Doug Wilson, Kevin Wilson, Lucian DiPietro, Yulian Zhang, Natasja Brooijmans, Timothy P. LaBranche, Agnieszka Wozniak, Y

Science Translational Medicine.2017;[Epub] CrossRef

Tyrosine kinase inhibitor sensitive PDGFRΑ mutations in GIST: Two cases and review of the literature

Pieter A. Boonstra, Jourik A. Gietema, Albert J.H. Suurmeijer, Matthew R. Groves, Fernando de Assis Batista, Ed Schuuring, Anna K.L. Reyners

Molecular subtypes of gastrointestinal stromal tumor requiring specific treatments

Michael Pogorzelski, Johanna Falkenhorst, Sebastian Bauer

Current Opinion in Oncology.2016; 28(4): 331. CrossRef