Cancer Research and Treatment

Hyperglycemia predicts adverse prognosis in advanced pancreatic cancer patients

Xinzhe Zhu, Huaxiang Xu, Zhiwen Xiao, He Liu, Quanxing Ni, Xianjun Yu, Guopei Luo

Influence of diabetes mellitus and effectiveness of metformin on hepatocellular carcinoma

Masafumi Ono, Koji Fujita, Kiyoyuki Kobayashi, Tsutomu Masaki

Diabetes duration and weight loss are associated with onset age and remote metastasis of pancreatic cancer in patients with diabetes mellitus

Minglei Ma, Wei Li, Lingling Xu, Fan Ping, Huabing Zhang, Yuxiu Li

Diabetes Mellitus and Pancreatic Ductal Adenocarcinoma—Prevalence, Clinicopathological Variables, and Clinical Outcomes

Anna Badowska-Kozakiewicz, Marta Fudalej, Daria Kwaśniewska, Marek Durlik, Anna Nasierowska-Guttmejer, Agata Mormul, Emilia Włoszek, Aleksandra Czerw, Tomasz Banaś, Andrzej Deptała

Prognostic value of metformin in cancers: An updated meta-analysis based on 80 cohort studies

Jing Yang, Hang Yang, Ling Cao, Yuzhen Yin, Ying Shen, Wei Zhu

Impact of Diabetes and Insulin Use on Prognosis in Patients With Resected Pancreatic Cancer: An Ancillary Analysis of NRG Oncology RTOG 9704

Danielle S. Bitterman, Kathryn A. Winter, Theodore S. Hong, Charles S. Fuchs, William F. Regine, Ross A. Abrams, Howard Safran, John P. Hoffman, Al B. Benson, Timothy Kasunic, Mary Mulcahy, James F. Strauss, Thomas DiPetrillo, Philip J. Stella, Yuhchyau C

International Journal of Radiation Oncology*Biology*Physics.2021; 109(1): 201. CrossRef

Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer

Ayşegül SAKİN, Suleyman SAHİN, Abdullah SAKİN, Muhammed ATCİ, Çağlayan GEREDELİ, Şener CİHAN

Journal of Surgery and Medicine.2021; 5(1): 17. CrossRef

Pancreatic Tumorigenesis: Oncogenic KRAS and the Vulnerability of the Pancreas to Obesity

Yongde Luo, Xiaokun Li, Jianjia Ma, James L. Abbruzzese, Weiqin Lu

Repurposing metformin for the treatment of gastrointestinal cancer

Ademar Dantas Cunha Júnior, Arinilda Campos Bragagnoli, Felipe Osório Costa, José Barreto Campello Carvalheira

World Journal of Gastroenterology.2021; 27(17): 1883. CrossRef

Metformin Use and the Outcome of Metastatic Renal Cell Carcinoma Treated with Sunitinib or Pazopanib

Ondřej Fiala, Pavel Ostašov, Aneta Rozsypalová, Milan Hora, Ondrej Sorejs, Jan Šustr, Barbora Bendová, Ivan Trávníček, Jan Filipovský, Jindřich Fínek, Tomáš Büchler

Cancer Management and Research.2021; Volume 13: 4077. CrossRef

Magic of a Common Sugar Pill in Cancer: Can Metformin Raise Survival in Pancreatic Cancer Patients?

Mallika Gyawali, Nanditha Venkatesan, Opemipo D Ogeyingbo, Renu Bhandari, Rinky A Botleroo, Roaa Kareem, Rowan Ahmed, Abeer O Elshaikh

Identification of Key Genes Involved in Diabetic Peripheral Neuropathy Progression and Associated with Pancreatic Cancer

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 463. CrossRef

Oncological benefit of metformin in patients with pancreatic ductal adenocarcinoma and comorbid diabetes mellitus

Fumihiro Terasaki, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhisa Ohgi, Katsuhiko Uesaka

Langenbeck's Archives of Surgery.2020; 405(3): 313. CrossRef

The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives

Bao Quoc Lam, Sushant K. Shrivastava, Anju Shrivastava, Sharmila Shankar, Rakesh K. Srivastava

Journal of Cellular and Molecular Medicine.2020; 24(14): 7706. CrossRef

Association between Metformin Use and Clinical Outcomes Following Pancreaticoduodenectomy in Patients with Type 2 Diabetes and Pancreatic Ductal Adenocarcinoma

Daegwang Yoo, Nayoung Kim, Dae Wook Hwang, Ki Byung Song, Jae Hoon Lee, Woohyung Lee, Jaewoo Kwon, Yejong Park, Sarang Hong, Jong Woo Lee, Kyungyeon Hwang, Dakyum Shin, Eunyoung Tak, Song Cheol Kim

Journal of Clinical Medicine.2020; 9(6): 1953. CrossRef

The Role of Dysfunctional Adipose Tissue in Pancreatic Cancer: A Molecular Perspective

Davide Brocco, Rosalba Florio, Laura De Lellis, Serena Veschi, Antonino Grassadonia, Nicola Tinari, Alessandro Cama

Cohort Study of Antihyperglycemic Medication and Pancreatic Cancer Patients Survival

Audrius Dulskas, Ausvydas Patasius, Donata Linkeviciute-Ulinskiene, Lina Zabuliene, Giedre Smailyte

International Journal of Environmental Research and Public Health.2020; 17(17): 6016. CrossRef

Relationships are between metformin use and survival in pancreatic cancer patients concurrent with diabetes

Yu-Qi Shi, Xiao-Chong Zhou, Peng Du, Min-Yue Yin, Lan Xu, Wen-Jie Chen, Chun-Fang Xu

Metformin Use and Pancreatic Cancer Survival among Non-Hispanic White and African American U.S. Veterans with Diabetes Mellitus

Adetunji T. Toriola, Suhong Luo, Theodore S. Thomas, Bettina F. Drake, Su-Hsin Chang, Kristen M. Sanfilippo, Kenneth R. Carson

Cancer Epidemiology, Biomarkers & Prevention.2020; 29(1): 169. CrossRef

Metformin and pancreatic cancer survival: Real effect or immortal time bias?

International Journal of Cancer.2019; 145(7): 1822. CrossRef

The effect of diabetes mellitus on pharmacokinetics, pharmacodynamics and adverse drug reactions of anticancer drugs

Habibeh Mashayekhi‐Sardoo, Amir Hooshang Mohammadpour, Homa Nomani, Amirhossein Sahebkar

Journal of Cellular Physiology.2019; 234(11): 19339. CrossRef

The impact of diabetes mellitus on clinical outcomes following chemotherapy for the patients with pancreatic cancer: a meta-analysis

Jichun Ma, Jing Wang, Long Ge, Bo Long, Junqiang Zhang

Mu Xu, Xiaoman Jung, O. Joe Hines, Guido Eibl, Yijun Chen

Impact of Concurrent Medication Use on Pancreatic Cancer Survival—SEER-Medicare Analysis

Muhammad S. Beg, Arjun Gupta, David Sher, Sadia Ali, Saad Khan, Ang Gao, Tyler Stewart, Chul Ahn, Jarett Berry, Eric M. Mortensen

American Journal of Clinical Oncology.2018; 41(8): 766. CrossRef

Metformin as an Adjunctive Therapy for Pancreatic Cancer: A Review of the Literature on Its Potential Therapeutic Use

Digestive Diseases and Sciences.2018; 63(11): 2840. CrossRef

Exploring the bi-directional relationship between pancreatic cancer and diabetes mellitus: a retrospective study

Journal of Diabetes & Metabolic Disorders.2018; 17(2): 247. CrossRef

No association between metformin use and survival in patients with pancreatic cancer

Martine A. Frouws, Babs G. Sibinga Mulder, Esther Bastiaannet, Marjolein M.J. Zanders, Myrthe P.P. van Herk-Sukel, Eleonora M. de Leede, Bert A. Bonsing, J. Sven. D. Mieog, Cornelis J.H. Van de Velde, Gerrit-Jan Liefers

Chloride intracellular channel 1 regulates the antineoplastic effects of metformin in gallbladder cancer cells

Yongchen Liu, Zheng Wang, Maolan Li, Yuanyuan Ye, Yi Xu, Yichi Zhang, Ruiyan Yuan, Yunpeng Jin, Yajuan Hao, Lin Jiang, Yunping Hu, Shili Chen, Fatao Liu, Yijian Zhang, Wenguang Wu, Yingbin Liu

The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis

Xiaogang Li, Tong Li, Zhiqiang Liu, Shanmiao Gou, Chunyou Wang

The Effect of Metformin on Mortality Among Diabetic Cancer Patients: A Systematic Review and Meta-analysis

Xun Cao, Yaopan Wu, Jing Wang, Kuiyuan Liu, Xin Wang

Association of elevated risk of pancreatic cancer in diabetic patients: A systematic review and meta-analysis

Jiaxin Tan, Yu You, Fei Guo, Jianhua Xu, Haisu Dai, Ping Bie

Gastroenterology & Hepatology: Open Access.2017;[Epub] CrossRef

Association between metformin use and mortality in patients with type 2 diabetes mellitus and localized resectable pancreatic cancer: a nationwide population-based study in korea

Won Il Jang, Mi-Sook Kim, Shin Hee Kang, Ae Jung Jo, Yun Jung Kim, Ha Jin Tchoe, Chan Mi Park, Hyo Jeong Kim, Jin A Choi, Hyung Jin Choi, Eun-Kyung Paik, Young Seok Seo, Hyung Jun Yoo, Jin-Kyu Kang, Chul Ju Han, Yeon Ju Kim, Sang Beom Kim, Min Jung Ko

Metformin is associated with survival benefit in pancreatic cancer patients with diabetes: a systematic review and meta-analysis

Ping-Ting Zhou, Bo Li, Fu-Rao Liu, Mei-Chao Zhang, Qian Wang, Yan-Yan Li, Ci Xu, Yuan-Hua Liu, Yuan Yao, Dong Li

Effects of metformin on survival outcomes of pancreatic cancer: a meta-analysis

Yi-Wei Dong, Yan-Qiang Shi, Li-Wen He, Xi-Yu Cui, Pei-Zhu Su

Prognostic significance of anti-diabetic medications in pancreatic cancer: A meta-analysis

Dong-Chu Zhou, Hui Gong, Chong-Qing Tan, Jian-Quan Luo

Effects of metformin on survival outcomes of pancreatic cancer patients with diabetes: A meta-analysis

Wenxiu Xin, Luo Fang, Qilu Fang, Xiaowei Zheng, Ping Huang

Molecular and Clinical Oncology.2017;[Epub] CrossRef

Obesity and Cancer: An Angiogenic and Inflammatory Link

Dai Fukumura, Joao Incio, Ram C. Shankaraiah, Rakesh K. Jain

Metformin in pancreatic cancer treatment: from clinical trials through basic research to biomarker quantification

Journal of Cancer Research and Clinical Oncology.2016; 142(10): 2159. CrossRef

Metformin Use Is Associated with Improved Survival in Patients Undergoing Resection for Pancreatic Cancer

Marcelo Cerullo, Faiz Gani, Sophia Y. Chen, Joe Canner, Timothy M. Pawlik

Journal of Gastrointestinal Surgery.2016; 20(9): 1572. CrossRef

Effect of Diabetes on Survival after Resection of Pancreatic Adenocarcinoma. A Prospective, Observational Study

Gianpaolo Balzano, Erica Dugnani, Alessandra Gandolfi, Marina Scavini, Valentina Pasquale, Francesca Aleotti, Daniela Liberati, Gaetano Di Terlizzi, Giovanna Petrella, Michele Reni, Claudio Doglioni, Emanuele Bosi, Massimo Falconi, Lorenzo Piemonti, Surin

Type 2 diabetes mellitus is associated with increased risk of pancreatic cancer: A veteran administration registry study

SAGE Open Medicine.2016; 4: 205031211668225. CrossRef

Inhibitory effect of metformin combined with gemcitabine on pancreatic cancer cells in vitro and in vivo

Molecular Medicine Reports.2016; 14(4): 2921. CrossRef

Diabetes mellitus and metformin in hepatocellular carcinoma

Koji Fujita, Hisakazu Iwama, Hisaaki Miyoshi, Joji Tani, Kyoko Oura, Tomoko Tadokoro, Teppei Sakamoto, Takako Nomura, Asahiro Morishita, Hirohito Yoneyama, Tsutomu Masaki

World Journal of Gastroenterology.2016; 22(27): 6100. CrossRef

High prevalence of diabetes mellitus and impaired glucose tolerance in liver cancer patients: A hospital based study of 4610 patients with benign tumors or specific cancers

(Ir)relevance of Metformin Treatment in Patients with Metastatic Pancreatic Cancer: An Open-Label, Randomized Phase II Trial

Michele Reni, Erica Dugnani, Stefano Cereda, Carmen Belli, Gianpaolo Balzano, Roberto Nicoletti, Daniela Liberati, Valentina Pasquale, Marina Scavini, Paola Maggiora, Valeria Sordi, Vito Lampasona, Domenica Ceraulo, Gaetano Di Terlizzi, Claudio Doglioni,

Clinical Cancer Research.2016; 22(5): 1076. CrossRef

Can metformin improve ‘the tomorrow’ of patients treated for oesophageal cancer?

L. Van De Voorde, L. Janssen, R. Larue, R. Houben, J. Buijsen, M. Sosef, B. Vanneste, M.-C. Schraepen, M. Berbée, P. Lambin

European Journal of Surgical Oncology (EJSO).2015; 41(10): 1333. CrossRef

Can metformin change the prognosis of pancreatic cancer? Retrospective study for pancreatic cancer patients with pre-existing diabetes mellitus type 2

Sang Hoon Lee, Sang Hyun Yoon, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Jae Bock Chung, Seungmin Bang

Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling

Xinqun Chai, Hongpeng Chu, Xuan Yang, Yuanpu Meng, Pengfei Shi, Shanmiao Gou

Obesity and cancer, a case for insulin signaling

Cell Death & Disease.2015; 6(12): e2037. CrossRef