Cancer Research and Treatment

Tumor-Promoting ATAD2 and Its Preclinical Challenges

Haicheng Liu, Qianghai Wen, Sheng Yan, Weikun Zeng, Yuhua Zou, Quanliang Liu, Guoxi Zhang, Junrong Zou, Xiaofeng Zou

Metabolism-Related Gene Pairs to Predict the Clinical Outcome and Molecular Characteristics of Early Hepatocellular Carcinoma

Junling Wu, Zeman Lin, Daihan Ji, Zhenli Li, Huarong Zhang, Shuting Lu, Shenglin Wang, Xiaolong Liu, Lu Ao

ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration

Can Wang, Yue Yin, Zhenxing Sun, Yiru Wang, Fei Li, Yan Wang, Zexue Zhang, Xiuwei Chen, Luca Falzone

Elevated serum alpha-fetoprotein levels are associated with poor prognosis of hepatocellular carcinoma after surgical resection: A systematic review and meta-analysis

Hong-Lin Chen, Yu-Hua Chen, Lin Du, Yi-Ping Song, Bin Zhu

Arab Journal of Gastroenterology.2021; 22(1): 12. CrossRef

Emerging oncogene ATAD2: Signaling cascades and therapeutic initiatives

ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling

Lian-Jing Cao, Yi-Jun Zhang, Si-Qi Dong, Xi-Zhao Li, Xia-Ting Tong, Dong Chen, Zi-Yi Wu, Xiao-Hui Zheng, Wen-Qiong Xue, Wei-Hua Jia, Jiang-Bo Zhang

Journal of Experimental & Clinical Cancer Research.2021;[Epub] CrossRef

Evaluation of ATAD2 as a Potential Target in Hepatocellular Carcinoma

Umut Ekin, Haluk Yuzugullu, Cigdem Ozen, Peyda Korhan, Ezgi Bagirsakci, Funda Yilmaz, Ozge Gursoy Yuzugullu, Hamdiye Uzuner, Hani Alotaibi, Petek Ballar Kirmizibayrak, Nese Atabey, Gökhan Karakülah, Mehmet Ozturk

Journal of Gastrointestinal Cancer.2021; 52(4): 1356. CrossRef

Downregulation of AAA-domain-containing protein 2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway

American Journal of Physiology-Cell Physiology.2020; 319(1): C93. CrossRef

Integrated Bioinformatics Analysis of the Clinical Value and Biological Function of ATAD2 in Hepatocellular Carcinoma

Xiangyu Meng, Lu Wang, Bo Zhu, Jun Zhang, Shuai Guo, Qiang Li, Tao Zhang, Zhichao Zheng, Gang Wu, Yan Zhao

BioMed Research International.2020; 2020: 1. CrossRef

Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers

Aymeric Dolbois, Laurent Batiste, Lars Wiedmer, Jing Dong, Manuela Brütsch, Danzhi Huang, Nicholas M. Deerain, Dimitrios Spiliotopoulos, Iván Cheng-Sánchez, Eleen Laul, Cristina Nevado, Paweł Śledź, Amedeo Caflisch

ACS Medicinal Chemistry Letters.2020; 11(8): 1573. CrossRef

Fibrolamellar hepatocellular carcinoma: Case report

Ivan I. Shtefanov, Darkhan N. Akhmedin, Assiya M. Kukanova, Ainagul A. Zhakipova, Abai K. Makishev

Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain

Jonathan T. Lloyd, Kyle McLaughlin, Mulu Y. Lubula, Jamie C. Gay, Andrea Dest, Cong Gao, Margaret Phillips, Marco Tonelli, Gabriel Cornilescu, Matthew R. Marunde, Chiara M. Evans, Samuel P. Boyson, Samuel Carlson, Michael-Christopher Keogh, John L. Markle

Journal of Medicinal Chemistry.2020; 63(21): 12799. CrossRef

Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain

Jamie C. Gay, Brian E. Eckenroth, Chiara M. Evans, Cassiano Langini, Samuel Carlson, Jonathan T. Lloyd, Amedeo Caflisch, Karen C. Glass

Proteins: Structure, Function, and Bioinformatics.2019; 87(2): 157. CrossRef

Overexpression of microRNA‐186 inhibits angiogenesis in retinoblastoma via the Hedgehog signaling pathway by targeting ATAD2

Journal of Cellular Physiology.2019; 234(10): 19059. CrossRef

A Humanized Yeast Phenomic Model of Deoxycytidine Kinase to Predict Genetic Buffering of Nucleoside Analog Cytotoxicity

Santos, Icyuz, Pound, William, Guo, McKinney, Niederweis, Rodgers, IV

Prognostic value of ATPase family, AAA+ domain containing 2 expression in human cancers

Hua-Jing Han, Qian-Yi Huang, Li-Jun Huang, Fan Chang, Qi-Zhi Diao

The clinical significance of lipopolysaccharide binding protein in hepatocellular carcinoma

Quan‑Yu Cai, Jing‑Hua Jiang, Ri‑Ming Jin, Guang‑Zhi Jin, Ning‑Yang Jia

ATAD2 is associated with malignant characteristics of pancreatic cancer cells

Nairong Liu, Kohei Funasaka, Tomohiko Obayashi, Ryoji Miyahara, Yoshiki Hirooka, Hidemi Goto, Takeshi Senga

Bromodomain-containing proteins in prostate cancer

Molecular and Cellular Endocrinology.2018; 462: 31. CrossRef

Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach

Duncan C. Miller, Mathew P. Martin, Santosh Adhikari, Alfie Brennan, Jane A. Endicott, Bernard T. Golding, Ian R. Hardcastle, Amy Heptinstall, Stephen Hobson, Claire Jennings, Lauren Molyneux, Yvonne Ng, Stephen R. Wedge, Martin E. M. Noble, Celine Cano

Organic & Biomolecular Chemistry.2018; 16(11): 1843. CrossRef

A Panel of Genes Identified as Targets for 8q24.13-24.3 Gain Contributing to Unfavorable Overall Survival in Patients with Hepatocellular Carcinoma

Kun Zhao, Yu Zhao, Jia-yi Zhu, Hui Dong, Wen-ming Cong, Yi Yu, Hui Wang, Zhong-Zheng Zhu, Qing Xu

Current Medical Science.2018; 38(4): 590. CrossRef

Decreased Expression of ZWINT is Associated With Poor Prognosis in Patients With HCC After Surgery

Xiao-Yu Yang, Bin Wu, Sen-Lin Ma, Lei Yin, Meng-Chao Wu, Ai-Jun Li

Technology in Cancer Research & Treatment.2018; 17: 153303381879419. CrossRef

MicroRNA-372 functions as a tumor suppressor in cell invasion, migration and epithelial-mesenchymal transition by targeting ATAD2 in renal cell carcinoma

Shiqi Ji, Xiaolin Su, Haijian Zhang, Zhixing Han, Yuqian Zhao, Qingjun Liu

The role of miR-372 in ovarian carcinoma cell proliferation

Xue Guan, Zhi-Hong Zong, Shuo Chen, Xiu-Bo Sang, Dan-dan Wu, Li-li Wang, Yao Liu, Yang Zhao

ATAD2 overexpression is associated with progression and prognosis in colorectal cancer

Mingming Hou, Rui Huang, Yanni Song, Di Feng, Yang Jiang, Ming Liu

Japanese Journal of Clinical Oncology.2016; 46(3): 222. CrossRef

Clinical and Prognostic Significance of ANCCA in Squamous Cell Lung Carcinoma Patients

Dingmiao Wang, Yang Pan, Ting Hao, Yong Chen, Shiming Qiu, Ling Chen, Jinping Zhao

Archives of Medical Research.2016; 47(2): 89. CrossRef

ATAD2 is overexpressed in gastric cancer and serves as an independent poor prognostic biomarker

M.- J. Zhang, C.- Z. Zhang, W.- J. Du, X.- Z. Yang, Z.- P. Chen

Clinical and Translational Oncology.2016; 18(8): 776. CrossRef

Low expression of DCXR protein indicates a poor prognosis for hepatocellular carcinoma patients

Xiaofeng Hang, Zhiqin Wu, Kaijian Chu, Guanzhen Yu, Haoran Peng, Haiguang Xin, Xiaohui Miao, Junxue Wang, Wensheng Xu

ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication

Seong Joo Koo, Amaury E. Fernández-Montalván, Volker Badock, Christopher J. Ott, Simon J. Holton, Oliver von Ahsen, Joern Toedling, Sarah Vittori, James E. Bradner, Mátyás Gorjánácz

Suppression of ATAD2 inhibits hepatocellular carcinoma progression through activation of p53- and p38-mediated apoptotic signaling