Cancer Research and Treatment

Compound K: A systematic review of its anticancer properties and probable mechanisms

Dao Ngoc Hien Tam, Nguyen Hai Nam, Nguyen The Ky Cuong, Dang The Hung, Dang Thi Soa, Ahmad Altom, Linh Tran, Heba Elhadad, Nguyen Tien Huy

Fundamental & Clinical Pharmacology.2023; 37(4): 684. CrossRef

Antioxidant Activity of Panax ginseng to Regulate ROS in Various Chronic Diseases

Md Niaj Morshed, Jong Chan Ahn, Ramya Mathiyalagan, Esrat Jahan Rupa, Reshmi Akter, Md. Rezaul Karim, Dae Hyo Jung, Dong Uk Yang, Deok Chun Yang, Seok Kyu Jung

Applied Sciences.2023; 13(5): 2893. CrossRef

Anticancer therapeutic effect of ginsenosides through mediating reactive oxygen species

Xiaonan Li, Donghui Cao, Siming Sun, Yuehui Wang

Frontiers in Pharmacology.2023;[Epub] CrossRef

Metabolites-Based Network Pharmacology to Preliminarily Verify In Vitro Anti-Inflammatory Effect of Ardisiacrispin B

Wen Zhou, Guixiang Yang, Yushuang Wen, Qian Xiao, Le Sun, Yongjun Li, Zipeng Gong, Yonglin Wang

International Journal of Molecular Sciences.2023; 24(23): 17059. CrossRef

The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition

El-Shaimaa A. Arafa, Mohamed S. Refaey, Omnia A.M. Abd El-Ghafar, Emad H.M. Hassanein, Ahmed M. Sayed

Ginseng: A dietary supplement as immune-modulator in various diseases

Muhammad Riaz, Najm Ur Rahman, Muhammad Zia-Ul-Haq, Hawa Z.E. Jaffar, Rosana Manea

Trends in Food Science & Technology.2019; 83: 12. CrossRef

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines

Weixiao An, Honglin Lai, Yangyang Zhang, Minghua Liu, Xiukun Lin, Shousong Cao

Frontiers in Pharmacology.2019;[Epub] CrossRef

Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

Wu Song, Lin Wei, Yanwei Du, Yimei Wang, Shuang Jiang

International Immunopharmacology.2018; 63: 227. CrossRef

Functional role of ginseng-derived compounds in cancer

Akash Ahuja, Ji Hye Kim, Jong-Hoon Kim, Young-Su Yi, Jae Youl Cho

Journal of Ginseng Research.2018; 42(3): 248. CrossRef

Synthesis and Characterization of the Hemi‐Salen Ligands and Their Triboron Complexes: Spectroscopy and Examination of Anticancer Properties

Ahmet Kilic, Ismail Koyuncu, Mustafa Durgun, Ismail Ozaslan, İbrahim Halil Kaya, Ataman Gönel

Chemistry & Biodiversity.2018;[Epub] CrossRef

Role of ginsenosides in reactive oxygen species-mediated anticancer therapy

Islam M.D. Sodrul, Chenying Wang, Xiangfeng Chen, Jing Du, Hongxiang Sun

Anticancer effect of joboksansam, Korean wild ginseng germinated from bird feces

Jae Gwang Park, Wie-Soo Kang, Kyung Tae Park, Dong Jun Park, Adithan Aravinthan, Jong-Hoon Kim, Jae Youl Cho

Journal of Ginseng Research.2016; 40(3): 304. CrossRef

Korean Red Ginseng water extract arrests growth of xenografted lymphoma cells

Jae Gwang Park, Young-Jin Son, Adithan Aravinthan, Jong-Hoon Kim, Jae Youl Cho

Journal of Ginseng Research.2016; 40(4): 431. CrossRef

Isolation and identification of antiproliferative substances from ginseng fermented using Ganoderma lucidum mycelia

Gwi Yeong Jang, Eun Mi Joung, Sang Hoon Lee, Jae-Hyun Jeong, Bang Yeon Hwang, Jin Tae Hong, Junsoo Lee, Heon Sang Jeong

Food Science and Biotechnology.2015; 24(2): 567. CrossRef

Ginsenoside compound K induces apoptosis in nasopharyngeal carcinoma cells via activation of apoptosis-inducing factor

Carmen Ka-Man Law, Hoi-Hin Kwok, Po-Ying Poon, Chi-Chiu Lau, Zhi-Hong Jiang, William Chi-Shing Tai, Wendy Wen-Luan Hsiao, Nai-Ki Mak, Patrick Ying-Kit Yue, Ricky Ngok-Shun Wong

Effects of compound K on hyperglycemia and insulin resistance in rats with type 2 diabetes mellitus

Shuang Jiang, Dayong Ren, Jianrui Li, Guangxin Yuan, Hongyu Li, Guangyu Xu, Xiao Han, Peige Du, Liping An

20‐O‐β‐d‐Glucopyranosyl‐20(S)‐Protopanaxadiol Suppresses UV‐Induced MMP‐1 Expression Through AMPK‐Mediated mTOR Inhibition as a Downstream of the PKA‐LKB1 Pathway

Dong Joo Shin, Jong‐Eun Kim, Tae‐Gyu Lim, Eun Hee Jeong, Gaeun Park, Nam Joo Kang, Jun‐Seong Park, Myeong‐Hun Yeom, Deok Kun Oh, Ann M. Bode, Zigang Dong, Hyong Joo Lee, Ki Won Lee

Journal of Cellular Biochemistry.2014; 115(10): 1702. CrossRef

Compound K Induces Apoptosis of Bladder Cancer T24 Cells Via Reactive Oxygen Species-Mediated p38 MAPK Pathway

Han Wang, Dandan Jiang, Jing Liu, Shuhong Ye, Shan Xiao, Wenwen Wang, Zhongyan Sun, Yuping Xie, Jihui Wang

Cancer Biotherapy and Radiopharmaceuticals.2013; 28(8): 607. CrossRef

20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx

Jeong Ah Hwang, Mun Kyung Hwang, Yongwoo Jang, Eun Jung Lee, Jong-Eun Kim, Mi Hyun Oh, Dong Joo Shin, Semi Lim, Geun og Ji, Uhtaek Oh, Ann M. Bode, Zigang Dong, Ki Won Lee, Hyong Joo Lee

The Journal of Nutritional Biochemistry.2013; 24(6): 1096. CrossRef

Recent Methodology in Ginseng Analysis

Seung-Hoon Baek, Ok-Nam Bae, Jeong-Hill Park

Journal of Ginseng Research.2012; 36(2): 119. CrossRef

Identification and Characterization of the Rhizobium sp. Strain GIN611 Glycoside Oxidoreductase Resulting in the Deglycosylation of Ginsenosides

Eun-Mi Kim, Juhan Kim, Joo-Hyun Seo, Jun-Seong Park, Duck-Hee Kim, Byung-Gee Kim

Applied and Environmental Microbiology.2012; 78(1): 242. CrossRef

Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathway

Yasuo M. Tsutsumi, Rie Tsutsumi, Kazuaki Mawatari, Yutaka Nakaya, Michiko Kinoshita, Katsuya Tanaka, Shuzo Oshita

Life Sciences.2011; 88(15-16): 725. CrossRef

Synthesis of 20S-protopanaxadiol β-D-galactopyranosides

Chemistry of Natural Compounds.2011; 47(1): 79. CrossRef

TRAIL promotes caspase-dependent pro-inflammatory responses via PKCδ activation by vascular smooth muscle cells

Cell Death & Disease.2011; 2(11): e223. CrossRef

Compound K, a Metabolite of Ginseng Saponin, Induces Mitochondria-Dependent and Caspase-Dependent Apoptosis via the Generation of Reactive Oxygen Species in Human Colon Cancer Cells

In Kyung Lee, Kyoung Ah Kang, Chae Moon Lim, Ki Cheon Kim, Hee Sun Kim, Dong Hyun Kim, Bum Joon Kim, Weon Young Chang, Jae Hyuck Choi, Jin Won Hyun

International Journal of Molecular Sciences.2010; 11(12): 4916. CrossRef

Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase

Areum Daseul Kim, Kyoung Ah Kang, Rui Zhang, Chae Moon Lim, Hee Sun Kim, Dong Hyun Kim, You Jin Jeon, Chang Hyun Lee, Jinny Park, Weon Young Chang, Jin Won Hyun

Environmental Toxicology and Pharmacology.2010; 30(2): 134. CrossRef

Compound K Inhibits Basic Fibroblast Growth Factor-Induced Angiogenesis via Regulation of p38 Mitogen Activated Protein Kinaseand AKT in Human Umbilical Vein Endothelial Cells

Arong Jeong, Hyo-Jung Lee, Soo-Jin Jeong, Hyo-Jeong Lee, Eun-Ok Lee, Hyunsu Bae, Sung-Hoon Kim

Biological and Pharmaceutical Bulletin.2010; 33(6): 945. CrossRef

Caspase-dependent generation of reactive oxygen species in human astrocytoma cells contributes to resistance to TRAIL-mediated apoptosis

K Choi, S-W Ryu, S Song, H Choi, S W Kang, C Choi

Cell Death & Differentiation.2010; 17(5): 833. CrossRef

Intestinal Metabolite Compound K of Ginseng Saponin Potently Attenuates Metastatic Growth of Hepatocellular Carcinoma by Augmenting Apoptosis via a Bid-Mediated Mitochondrial Pathway

Gang Song, Shiguang Guo, Weiwei Wang, Chun Hu, Yubing Mao, Bing Zhang, Hong Zhang, Tianhui Hu

Journal of Agricultural and Food Chemistry.2010; 58(24): 12753. CrossRef

Aqueous extract of the medicinal plant Patrinia villosa Juss. Induces angiogenesis via activation of focal adhesion kinase

Jongwook Jeon, Jungwhoi Lee, Chaehyun Kim, Yuri An, Chulhee Choi

Microvascular Research.2010; 80(3): 303. CrossRef