Cancer Research and Treatment

Innate immune cells: Key players of orchestra in modulating tumor microenvironment (TME)

Mahvash Sadeghi, Sajad Dehnavi, Moosa Sharifat, Amir Mohammad Amiri, Ali Khodadadi

Anti-PD-1 antibody-activated Th17 cells subvert re-invigoration of antitumor cytotoxic T-lymphocytes via myeloid cell-derived COX-2/PGE2

Qingsheng Li, Kevin E. Goggin, SeonYeong Seo, Jonathan M. Warawa, Nejat K. Egilmez

Cancer Immunology, Immunotherapy.2023; 72(4): 1047. CrossRef

Candida albicans Promotes Oral Cancer via IL-17A/IL-17RA-Macrophage Axis

Xu Wang, Shuangshaung Wu, Wenjie Wu, Wenqing Zhang, Linman Li, Qian Liu, Zhimin Yan, Jianping Xu

Tumor Necrosis Factor-α Promotes the Tumorigenesis, Lymphangiogenesis, and Lymphatic Metastasis in Cervical Cancer via Activating VEGFC-Mediated AKT and ERK Pathways

Xiao Chen, Luping Lin, Qiaoling Wu, Sang Li, Huihui Wang, Yang Sun, Jinghua Pan

Depletion of enhancer zeste homolog 2 (EZH2) directs transcription factors associated with T cell differentiation through epigenetic regulation of Yin Yang 1(YY1) in combating non-small cell lung cancer (NSCLC)

Nikhil Chandnani, Vedika Shrirang Choudhari, Rajat Talukdar, Sudeshna Rakshit, Geetha Shanmugam, Shiuli Guchait, Ishika Gupta, Melvin George, Koustav Sarkar

Liping Liu, Renli Liu, Chaojie Wei, Dong Li, Xiuzhu Gao

IL-17A functions and the therapeutic use of IL-17A and IL-17RA targeted antibodies for cancer treatment

Meiying Song, Jie Liang, Luoyang Wang, Wei Li, Suli Jiang, Shuo Xu, Lei Tang, Qiaochu Du, Guixian Liu, Haining Meng, Dongchang Zhai, Shangheng Shi, Yanyan Yang, Li Zhang, Bei Zhang

International Immunopharmacology.2023; 123: 110757. CrossRef

Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress

Yinzhou Zhang, Junying Wei, Xinyuan Wu, Mengting Jiang, Wuhua Ma, Yuhui Li

Obesity-Modified CD4+ T-Cells Promote an Epithelial-Mesenchymal Transition Phenotype in Prostate Cancer Cells

Alejandra De Angulo, Peyton Travis, Gloria Cecilia Galvan, Christopher Jolly, Linda deGraffenried

Tumor immunotherapy: Mechanisms and clinical applications

Cheng Nong, Pengbo Guan, Li Li, Huiyuan Zhang, Hongbo Hu

Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway

Zhenzhen Lin, Qiumin Huang, Junrong Liu, Hao Wang, Xuexi Zhang, Zhiyan Zhu, Wei Zhang, Yiliang Wei, Zhe Liu, Wei Du

Prostate Infiltration by Treg and Th17 Cells as an Immune Response to Propionibacterium acnes Infection in the Course of Benign Prostatic Hyperplasia and Prostate Cancer

International Journal of Molecular Sciences.2022; 23(16): 8849. CrossRef

The roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors

Hamidreza Zalpoor, Fatemeh Aziziyan, Mahsa Liaghat, Maryam Bakhtiyari, Abdullatif Akbari, Mohsen Nabi-Afjadi, Razieh Forghaniesfidvajani, Nima Rezaei

Cell Communication and Signaling.2022;[Epub] CrossRef

Analysis of peripheral inflammatory T cell subsets and their effector function in patients with Birdshot Retinochoroiditis

Janine Trombke, Lucie Loyal, Julian Braun, Uwe Pleyer, Andreas Thiel, Dominika Pohlmann

MicroRNA-146a limits tumorigenic inflammation in colorectal cancer

Lucien P. Garo, Amrendra K. Ajay, Mai Fujiwara, Galina Gabriely, Radhika Raheja, Chantal Kuhn, Brendan Kenyon, Nathaniel Skillin, Ryoko Kadowaki-Saga, Shrishti Saxena, Gopal Murugaiyan

Molecular insights into phytochemicals‐driven break function in tumor microenvironment

Assessment of the presence of interleukin 17+ macrophages and Th17 cells in situ in lip and oral tongue cancer

Thâmara Manoela Marinho Bezerra, Bárbara Vanessa de Brito Monteiro, Joabe dos Santos Pereira, Luiz Arthur Barbosa Silva, Cassiano Francisco Weege Nonaka, Éricka Janine Dantas da Silveira, Márcia Cristina da Costa Miguel

Dysregulated tumor-associated macrophages in carcinogenesis, progression and targeted therapy of gynecological and breast cancers

Journal of Hematology & Oncology.2021;[Epub] CrossRef

Danger matrix molecules orchestrate CD14/CD44 signaling in cancer development

Heiko Roedig, Roxana Damiescu, Jinyang Zeng-Brouwers, Iva Kutija, Jonel Trebicka, Malgorzata Wygrecka, Liliana Schaefer

IL-17A Modulates Peritoneal Macrophage Recruitment and M2 Polarization in Endometriosis

Jessica E. Miller, Soo Hyun Ahn, Ryan M. Marks, Stephany P. Monsanto, Asgerally T. Fazleabas, Madhuri Koti, Chandrakant Tayade

Interferon-Gamma Stimulated Murine MacrophagesIn Vitro: Impact of Ionic Composition and Osmolarity and Therapeutic Implications

Joshua Erndt-Marino, Daniel J. Yeisley, Hongyu Chen, Michael Levin, David L. Kaplan, Mariah S. Hahn

Pleiotropic Role and Bidirectional Immunomodulation of Innate Lymphoid Cells in Cancer

Zhengwen An, Fabian Flores-Borja, Sheeba Irshad, Jinhai Deng, Tony Ng

CD4+ T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion

Sen Liu, Fengli Liu, Bing Zhang, Peng Yan, Brian G. Rowan, Asim B. Abdel‐Mageed, Chad Steele, S. Michal Jazwinski, Krzysztof Moroz, Elizabeth B. Norton, Alun Wang, Leann Myers, Oliver Sartor, Qiuyang Zhang

Concanavalin-A stimulates IL-17 and nitric oxide production and induces macrophage polarization and resistance to Trypanosoma cruzi infection

Nágela Ghabdan Zanluqui, Maria Isabel Lovo-Martins, Aparecida Donizette Malvezi, Carolina Panis, Rosiane Valeriano da Silva, Vera Lucia Hideko Tatakihara, Ionice Felipe, Marli Cardoso Martins-Pinge, Pryscilla Fanini Wowk, Phileno Pinge-Filho

ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages

Jinlong Yin, Sung Soo Kim, Eunji Choi, Young Taek Oh, Weiwei Lin, Tae-Hoon Kim, Jason K. Sa, Jun Hee Hong, Se Hwan Park, Hyung Joon Kwon, Xiong Jin, Yeonhee You, Ji Hye Kim, Hyunggee Kim, Jaekyoung Son, Jeongwu Lee, Do-Hyun Nam, Kui Son Choi, Bingyang Shi

miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells

Dietary Supplementation of Foxtail Millet Ameliorates Colitis-Associated Colorectal Cancer in Mice via Activation of Gut Receptors and Suppression of the STAT3 Pathway

Bowei Zhang, Yingchuan Xu, Shuang Liu, Huan Lv, Yaozhong Hu, Yaya Wang, Zhi Li, Jin Wang, Xuemeng Ji, Hui Ma, Xiaowen Wang, Shuo Wang

Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research

Sirin Saranyutanon, Sachin Kumar Deshmukh, Santanu Dasgupta, Sachin Pai, Seema Singh, Ajay Pratap Singh

Innate Lymphoid Cells in the Malignant Melanoma Microenvironment

Aintzane Apraiz, Aitor Benedicto, Joana Marquez, Andrea Agüera-Lorente, Aintzane Asumendi, Elvira Olaso, Beatriz Arteta

Role of interleukin-17 in acute myocardial infarction

Mónica Daniela Mora-Ruíz, Francisco Blanco-Favela, Adriana Karina Chávez Rueda, María Victoria Legorreta-Haquet, Luis Chávez-Sánchez

The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer

Qun Wang, Alexander Steger, Sven Mahner, Udo Jeschke, Helene Heidegger

International Journal of Molecular Sciences.2019; 20(13): 3310. CrossRef

IL-17A improves the efficacy of mesenchymal stem cells in ischemic-reperfusion renal injury by increasing Treg percentages by the COX-2/PGE2 pathway

Ming Bai, Li Zhang, Bo Fu, Jiuxu Bai, Yingjie Zhang, Guangyan Cai, Xueyuan Bai, Zhe Feng, Shiren Sun, Xiangmei Chen

Mucosa-associated invariant T cells in malignancies: a faithful friend or formidable foe?

S. M. Mansour Haeryfar, Christopher R. Shaler, Patrick T. Rudak

Cancer Immunology, Immunotherapy.2018; 67(12): 1885. CrossRef

Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy

Adriana Albini, Antonino Bruno, Douglas M. Noonan, Lorenzo Mortara

Prostaglandin E2 Secreted by Thyroid Cancer Cells Contributes to Immune Escape Through the Suppression of Natural Killer (NK) Cell Cytotoxicity and NK Cell Differentiation

Arum Park, Yunhee Lee, Mi Sun Kim, Young Ju Kang, Young-Jun Park, Haiyoung Jung, Tae-Don Kim, Hee Gu Lee, Inpyo Choi, Suk Ran Yoon

β-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC

Canadian Journal of Gastroenterology and Hepatology.2018; 2018: 1. CrossRef

The promotion of tissue engineering blood vessel patency by CGS21680 through regulating pro‐inflammatory activities of endothelial progenitor cell

Wen Chen, Li Xiao, Jian Bai, Wen Zeng, Mingcan Yang, Bingyi Shi, Chuhong Zhu

Journal of Biomedical Materials Research Part A.2018; 106(10): 2634. CrossRef

ST2/IL-33 signaling promotes malignant development of experimental squamous cell carcinoma by decreasing NK cells cytotoxicity and modulating the intratumoral cell infiltrate

Nádia Ghinelli Amôr, Carine Ervolino de Oliveira, Thaís Helena Gasparoto, Vanessa Garcia Vilas Boas, Graziela Perri, Ramon Kaneno, Vanessa Soares Lara, Gustavo Pompermaier Garlet, João Santana da Silva, Gislâine A. Martins, Cory Hogaboam, Karen A. Cavassa

Interleukin-17 acts as double-edged sword in anti-tumor immunity and tumorigenesis

Xin Qian, Hankui Chen, Xiaofeng Wu, Ling Hu, Qi Huang, Yang Jin

Metformin inhibits castration-induced EMT in prostate cancer by repressing COX2/PGE2/STAT3 axis

Dali Tong, Qiuli Liu, Gaolei Liu, Jing Xu, Weihua Lan, Yao Jiang, Hualiang Xiao, Dianzheng Zhang, Jun Jiang

Juan-juan Dai, Ming-jie Jiang, Xing-Peng Wang, Ling Tian

The paradox of Th17 cell functions in tumor immunity

Zahra Asadzadeh, Hamed Mohammadi, Elham Safarzadeh, Maryam Hemmatzadeh, Ahmad Mahdian-shakib, Farhad Jadidi-Niaragh, Gholamreza Azizi, Behzad Baradaran

IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection

Jaleesa M. Garth, Kristen M. Reeder, Matthew S. Godwin, Joseph J. Mackel, Chad W. Dunaway, Jonathan P. Blackburn, Chad Steele

The Journal of Immunology.2017; 199(6): 2140. CrossRef

Apolipoprotein A-I mimetic peptide 4F suppresses tumor-associated macrophages and pancreatic cancer progression

Meiyu Peng, Qi Zhang, Yingnan Cheng, Shuyu Fu, Huipeng Yang, Xiangdong Guo, Jieyou Zhang, Lina Wang, Lijuan Zhang, Zhenyi Xue, Yan Li, Yurong Da, Zhi Yao, Liang Qiao, Rongxin Zhang

Myeloid-derived cells in prostate cancer progression: phenotype and prospective therapies

Journal of Leukocyte Biology.2017; 102(2): 393. CrossRef

hnRNPA2/B1 activates cyclooxygenase‐2 and promotes tumor growth in human lung cancers

Yang Xuan, Jingshu Wang, Liying Ban, Jian-Jun Lu, Canhui Yi, Zhenglin Li, Wendan Yu, Mei Li, Tingting Xu, Wenjing Yang, Zhipeng Tang, Ranran Tang, Xiangsheng Xiao, Songshu Meng, Yiming Chen, Quentin Liu, Wenlin Huang, Wei Guo, Xiaonan Cui, Wuguo Deng

Culture supernatants of cervical cancer cells induce an M2 phenotypic profile in THP-1 macrophages

Eliza Julia Pedraza-Brindis, Karina Sánchez-Reyes, Georgina Hernández-Flores, Alejandro Bravo-Cuellar, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy, Paulina Gómez-Lomelí, Brenda Anahí López-López, Pablo Cesar Ortiz-Lazareno

15-Lipoxygenase metabolites of α-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome

Naresh Kumar, Geetika Gupta, Kotha Anilkumar, Naireen Fatima, Roy Karnati, Gorla Venkateswara Reddy, Priyanka Voori Giri, Pallu Reddanna

Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment

Fabian Flores-Borja, Sheeba Irshad, Peter Gordon, Felix Wong, Ibrahim Sheriff, Andrew Tutt, Tony Ng

Journal of Immunology Research.2016; 2016: 1. CrossRef

Phytomedicine—Modulating oxidative stress and the tumor microenvironment for cancer therapy

Feng Wu, Juanjuan Xu, Qi Huang, Jieli Han, Limin Duan, Jinshuo Fan, Zhilei Lv, Mengfei Guo, Guorong Hu, Lian Chen, Shuai Zhang, Xiaonan Tao, Wanli Ma, Yang Jin

Calreticulin Promotes Proliferation and Migration But Inhibits Apoptosis in Schwann Cells

Gui Huang, Zhulei Sun, Jiang Wu, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li

The immunopathogenesis of birdshot chorioretinopathy; a bird of many feathers

Jonas Kuiper, Aniki Rothova, Joke de Boer, Timothy Radstake

Progress in Retinal and Eye Research.2015; 44: 99. CrossRef

Genetic basis of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs

Francisca Gómez, James R. Perkins, Elena García-Martín, Gabriela Canto, José A. Cornejo-García

Current Opinion in Allergy & Clinical Immunology.2015; 15(4): 285. CrossRef

CD4, IL-17, and COX-2 Are Associated With Subclinical Inflammation in Malar Melasma

Adriana Rodríguez-Arámbula, Bertha Torres-Álvarez, Diego Cortés-García, Cornelia Fuentes-Ahumada, Juan Pablo Castanedo-Cázares

The American Journal of Dermatopathology.2015; 37(10): 761. CrossRef

Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity

M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss, and elevated blood pressure

Jeffrey P. Moore, Antony Vinh, Kellie L. Tuck, Samy Sakkal, Shalini M. Krishnan, Christopher T. Chan, Maggie Lieu, Chrishan S. Samuel, Henry Diep, Barbara K. Kemp-Harper, Marianne Tare, Sharon D. Ricardo, Tomasz J. Guzik, Christopher G. Sobey, Grant R. Dr

American Journal of Physiology-Heart and Circulatory Physiology.2015; 309(5): H906. CrossRef

Macrophage depletion reduces postsurgical tumor recurrence and metastatic growth in a spontaneous murine model of melanoma

Muly Tham, Karen Khoo, Kim Pin Yeo, Masashi Kato, Amelle Prevost-Blondel, Veronique Angeli, Jean-Pierre Abastado

Interleukin-17A Promotes Arginase-1 Production and 2,4-Dinitrochlorobenzene-Induced Acute Hyperinflammation in Human Papillomavirus E7 Oncoprotein-Expressing Skin

Le Son Tran, Deepak Mittal, Stephen R. Mattarollo, Ian H. Frazer

Journal of Innate Immunity.2015; 7(4): 392. CrossRef