Cancer Research and Treatment

Conformationally constrained potent inhibitors for enhancer of zeste homolog 2 (EZH2)

Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li

Bioorganic & Medicinal Chemistry Letters.2024; 97: 129558. CrossRef

Development of a Cost-Efficient Process Toward a Key Synthetic Intermediate of the EZH2 Inhibitor PF-06821497

Christopher P. Ashcroft, Alexander M. Berne, Florian Blasberg, Kelly Catlin, Michael R. Collins, Doug J. Critcher, Jean-Nicolas Desrosiers, Adam Goetz, Cheryl Hayward, Ricky A. Jones, Michael J. Karmilowicz, Nandell Keene, Carlos A. Martinez, Sebastien Mo

Organic Process Research & Development.2024;[Epub] CrossRef

MicroRNAs and long non-coding RNAs during transcriptional regulation and latency of HIV and HTLV

Sergio P. Alpuche-Lazcano, Robert J. Scarborough, Anne Gatignol

Nuclear Biophysical Changes during Human Melanoma Plasticity

Maria Chiara Lionetti, Maria Rita Fumagalli, Caterina A.M. La Porta

The Role of H3K27me3-Mediated Th17 Differentiation in Ankylosing Spondylitis

Yuening Chen, Wanlin Liu, Xiaohan Xu, Hongying Zhen, Bo Pang, Zhe Zhao, Yanan Zhao, Hongxiao Liu

O‐GlcNAc regulates anti‐fibrotic genes in lung fibroblasts through EZH2

Qiuming P. Wu, Shia Vang, Jennifer Q. Zhou, Stefanie Krick, Jarrod W. Barnes, Yan Y. Sanders

Journal of Cellular and Molecular Medicine.2024;[Epub] CrossRef

CRISPR/Cas9-based genome editing for multimodal synergistic cancer nanotherapy

Yinying Pu, Wencheng Wu, Huijing Xiang, Yu Chen, Huixiong Xu

EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression

Zong-Shin Lin, Chiao-Chen Chung, Yu-Chia Liu, Chu-Han Chang, Hui-Chia Liu, Yung-Yi Liang, Teng-Le Huang, Tsung-Ming Chen, Che-Hsin Lee, Chih-Hsin Tang, Mien-Chie Hung, Ya-Huey Chen

Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies

Husheng Mei, Hong Wu, Jing Yang, Bin Zhou, Aoli Wang, Chen Hu, Shuang Qi, Zongru Jiang, Fengming Zou, Beilei Wang, Feiyang Liu, Yongfei Chen, Wenchao Wang, Jing Liu, Qingsong Liu

Signal Transduction and Targeted Therapy.2023;[Epub] CrossRef

SMARCB1(INI-1)-Deficient Sinonasal Carcinoma: An Evolving Entity

Sei Y. Chung, Parker Kenee, Tanner Mitton, Ashleigh Halderman

Journal of Neurological Surgery Reports.2023; 84(01): e1. CrossRef

Resistance to BRAF Inhibitors: EZH2 and Its Downstream Targets as Potential Therapeutic Options in Melanoma

Anne Uebel, Stefanie Kewitz-Hempel, Edith Willscher, Kathleen Gebhardt, Cord Sunderkötter, Dennis Gerloff

International Journal of Molecular Sciences.2023; 24(3): 1963. CrossRef

miRNA let-7a inhibits invasion, migration, anchorage-independent growth by suppressing EZH2 and promotes mesenchymal to epithelial transition in MDAMB-231

Nibedita Patel, Koteswara Rao Garikapati, Venkata Krishna Kanth Makani, Shreya Pal, Namratha Vangara, Manika Pal Bhadra

Inhibition of EZH2 exerts antitumorigenic effects in renal cell carcinoma via LATS1

Seong Hwi Hong, Hyun Ji Hwang, Da Hyeon Son, Eun Song Kim, Sung Yul Park, Young Eun Yoon

Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells

Y. Sbirkov, T. Schenk, C. Kwok, S. Stengel, R. Brown, G. Brown, L. Chesler, A. Zelent, M. J. Fuchter, K. Petrie

Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef

Dual role of enhancer of zeste homolog 2 in the regulation of ultraviolet radiation-induced matrix metalloproteinase-1 and type I procollagen expression in human dermal fibroblasts

Min-Kyoung Kim, Hye Sun Shin, Mi Hee Shin, Haesoo Kim, Dong Hun Lee, Jin Ho Chung

A patent review of EZH2 inhibitors from 2017 and beyond

Guoquan Wan, Huan Feng, Chang Su, Yongxia Zhu, Lidan Zhang, Qiangsheng Zhang, Luoting Yu

Expert Opinion on Therapeutic Patents.2023; 33(4): 293. CrossRef

Lysophosphatidic Acid Induces Podocyte Pyroptosis in Diabetic Nephropathy by an Increase of Egr1 Expression via Downregulation of EzH2

International Journal of Molecular Sciences.2023; 24(12): 9968. CrossRef

SMARCB1‐deficient basal cell carcinoma of the prostate controlled using radiation therapy

Shunta Makabe, Tomoyuki Koguchi, Kanako Matsuoka, Seiji Hoshi, Junya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Motohide Uemura, Yoshiyuki Kojima

JARID2 and EZH2, the eminent epigenetic drivers in human cancer

Design, synthesis and mechanism studies of dual EZH2/BRD4 inhibitors for cancer therapy

Xinye Chen, Cheng Wang, Dehua Lu, Heng Luo, Shang Li, Fucheng Yin, Zhongwen Luo, Ningjie Cui, Lingyi Kong, Xiaobing Wang

Bioorganic & Medicinal Chemistry.2023; 91: 117386. CrossRef

Jinhui Gao, Claire Fosbrook, Jane Gibson, Timothy J. Underwood, Juliet C. Gray, Zoë S. Walters

Cancer Treatment Reviews.2023; 119: 102600. CrossRef

Integrative Multi-Omics Analysis of Oncogenic EZH2 Mutants: From Epigenetic Reprogramming to Molecular Signatures

Julian Aldana, Miranda L. Gardner, Michael A. Freitas

International Journal of Molecular Sciences.2023; 24(14): 11378. CrossRef

The role of EZH2 in ocular diseases: a narrative review

Yu Peng, Christine HT Bui, Xiu J Zhang, Jian S Chen, Clement C Tham, Wai K Chu, Li J Chen, Chi P Pang, Jason C Yam

Targeting EZH2 in SMARCB1-deficient sarcomas: Advances and opportunities to potentiate the efficacy of EZH2 inhibitors

Cinzia Lanzi, Noemi Arrighetti, Sandro Pasquali, Giuliana Cassinelli

Biochemical Pharmacology.2023; 215: 115727. CrossRef

EZH2-mediated epigenetic silencing of tumor-suppressive let-7c/miR-99a cluster by hepatitis B virus X antigen enhances hepatocellular carcinoma progression and metastasis

Chen-Shiou Wu, Yi-Chung Chien, Chia‐Jui Yen, Jia-Yan Wu, Li-Yuan Bai, Yung-Luen Yu

SUZ12 inhibition attenuates cell proliferation of glioblastoma via post-translational regulation of CDKN1B

Sojin Kim, Sungsin Jo, Sun Ha Paek, Sang Soo Kang, Heekyoung Chung

Advances in neuroendocrine prostate cancer research: From model construction to molecular network analyses

Xue Shui, Rong Xu, Caiqin Zhang, Han Meng, Jumei Zhao, Changhong Shi

Laboratory Investigation.2022; 102(4): 332. CrossRef

MicroRNA-217: a therapeutic and diagnostic tumor marker

Amir Abbas Hamidi, Malihe Zangoue, Daniel Kashani, Amir Sadra Zangouei, Hamid Reza Rahimi, Mohammad Reza Abbaszadegan, Meysam Moghbeli

Expert Review of Molecular Diagnostics.2022; 22(1): 61. CrossRef

Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2

Jing Yang, Ellen L. Weisberg, Shuang Qi, Wei Ni, Husheng Mei, Zuowei Wang, Chengcheng Meng, Shengzhe Zhang, Mingqi Hou, Ziping Qi, Aoli Wang, Yunyun Jiang, Zongru Jiang, Tao Huang, Qingwang Liu, Robert S. Magin, Laura Doherty, Wenchao Wang, Jing Liu, Sara

Mechanisms of Polycomb group protein function in cancer

Victoria Parreno, Anne-Marie Martinez, Giacomo Cavalli

Clinical Diagnosis and Treatment Analyses on SMARCB1 (Integrase Interactor 1)–Deficient Sinonasal Carcinoma: Case Series with Systematic Review of the Literature

Ru Wang, Lingwa Wang, Jugao Fang, Qi Zhong, Lizhen Hou, Hongzhi Ma, Ling Feng, Shizhi He, Chengshuo Wang, Luo Zhang

EZH2 Protein Expression in Triple-negative Breast Cancer Treated With Neoadjuvant Chemotherapy: An Exploratory Study of Association With Tumor Response and Prognosis

Susan Fineberg, Xuejun Tian, Della Makower, Malini Harigopal, Yungtai Lo

Applied Immunohistochemistry & Molecular Morphology.2022; 30(3): 157. CrossRef

Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma

Matthew L. Hedberg, Corbett T. Berry, Ata S. Moshiri, Yan Xiang, Christopher J. Yeh, Cem Attilasoy, Brian C. Capell, John T. Seykora

International Journal of Molecular Sciences.2022; 23(7): 3478. CrossRef

Identification of SET/EED dual binders as innovative PRC2 inhibitors

Raffaella Catalano, Annalisa Maruca, Roberta Rocca, Pierfrancesco Tassone, Giulia Panzarella, Giosuè Costa, Francesco Ortuso, Stefano Alcaro

Future Medicinal Chemistry.2022; 14(9): 609. CrossRef

METTL3 Accelerates Breast Cancer Progression via Regulating EZH2 m6A Modification

Shaojun Hu, Yang Song, Yu Zhou, Yu Jiao, Guopeng Li, Deepak Kumar Jain

Journal of Healthcare Engineering.2022; 2022: 1. CrossRef

IGF2BP1 Promotes Proliferation of Neuroendocrine Neoplasms by Post-Transcriptional Enhancement of EZH2

Florian Sperling, Danny Misiak, Stefan Hüttelmaier, Patrick Michl, Heidi Griesmann

KDM2B mediates the Wnt/β-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer

Xuedong Zhang, Zhongbo Yin, Chuanyi Li, Lishen Nie, Keyan Chen

Experimental Cell Research.2022; 417(2): 113208. CrossRef

Loss of H3K27 Trimethylation Promotes Radiotherapy Resistance in Medulloblastoma and Induces an Actionable Vulnerability to BET Inhibition

Nishanth Gabriel, Kumaresh Balaji, Kay Jayachandran, Matthew Inkman, Jin Zhang, Sonika Dahiya, Michael Goldstein

Pharmacologic Induction of BRCAness in BRCA-Proficient Cancers: Expanding PARP Inhibitor Use

Targeting EZH2 to overcome the resistance to immunotherapy in lung cancer

Daniel Sanghoon Shin, Kevin Park, Edward Garon, Steven Dubinett

SMARCB1 (INI-1)-Deficient Sinonasal Carcinoma: A Systematic Review and Pooled Analysis of Treatment Outcomes

Victor Ho-Fun Lee, Raymond King-Yin Tsang, Anthony Wing Ip Lo, Sum-Yin Chan, Joseph Chun-Kit Chung, Chi-Chung Tong, To-Wai Leung, Dora Lai-Wan Kwong

Degradable polyprodrugs: design and therapeutic efficiency

Farzad Seidi, Yajie Zhong, Huining Xiao, Yongcan Jin, Daniel Crespy

Chemical Society Reviews.2022; 51(15): 6652. CrossRef

PAR-Induced Harnessing of EZH2 to β-Catenin: Implications for Colorectal Cancer

Shoshana Sedley, Jeetendra Kumar Nag, Tatyana Rudina, Rachel Bar-Shavit

International Journal of Molecular Sciences.2022; 23(15): 8758. CrossRef

Insight into Thermodynamic and Kinetic Profiles in Small-Molecule Optimization

Wei Liu, Jingsheng Jiang, Yating Lin, Qidong You, Lei Wang

Journal of Medicinal Chemistry.2022; 65(16): 10809. CrossRef

EZH2 Protein Expression in Estrogen Receptor Positive Invasive Breast Cancer Treated With Neoadjuvant Endocrine Therapy: An Exploratory Study of Association With Tumor Response

Yujun Gan, Yungtai Lo, Della Makower, Celina Kleer, Jinyu Lu, Susan Fineberg

Applied Immunohistochemistry & Molecular Morphology.2022; 30(9): 614. CrossRef

Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting a Synergistic Effect for the Treatment of Hematological Malignancies

Dehua Lu, Cheng Wang, Lailiang Qu, Fucheng Yin, Shang Li, Heng Luo, Yonglei Zhang, Xingchen Liu, Xinye Chen, Zhongwen Luo, Ningjie Cui, Lingyi Kong, Xiaobing Wang

Journal of Medicinal Chemistry.2022; 65(19): 12838. CrossRef

EZH2 Inhibition and Cisplatin as a Combination Anticancer Therapy: An Overview of Preclinical Studies

Ivana Samaržija, Marko Tomljanović, Renata Novak Kujundžić, Koraljka Gall Trošelj

The role of transcription factors in the acquisition of the four latest proposed hallmarks of cancer and corresponding enabling characteristics

Seminars in Cancer Biology.2022; 86: 1203. CrossRef

EZH2 Promotes Cholangiocarcinoma Development and Progression through Histone Methylation and microRNA-Mediated Down-Regulation of Tumor Suppressor Genes

Jinqiang Zhang, Weina Chen, Wenbo Ma, Chang Han, Kyoungsub Song, Hyunjoo Kwon, Tong Wu

The American Journal of Pathology.2022; 192(12): 1712. CrossRef

Distinct binding pattern of EZH2 and JARID2 on RNAs and DNAs in hepatocellular carcinoma development

Zhili Wen, Ke He, Meixiao Zhan, Yong Li, Fei Liu, Xu He, Yanli Wei, Wei Zhao, Yu Zhang, Yaqiang Xue, Yong Xia, Fenfen Wang, Zhenglin Xia, Yongjie Xin, Yeye Wu, Xiaopeng Duan, Jing Xiao, Feng Shen, Yuliang Feng, Guoan Xiang, Ligong Lu

Dynamic‐shared Pharmacophore Approach as Tool to Design New Allosteric PRC2 Inhibitors, Targeting EED Binding Pocket

Jessica Lombino, Maria Rita Gulotta, Giada De Simone, Nedra Mekni, Maria De Rosa, Daniela Carbone, Barbara Parrino, Stella Maria Cascioferro, Patrizia Diana, Alessandro Padova, Ugo Perricone

Chain-shattering Pt(IV)-backboned polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic cancer therapy

Qingfei Zhang, Gaizhen Kuang, Shasha He, Sha Liu, Hongtong Lu, Xiaoyuan Li, Dongfang Zhou, Yubin Huang

Elevated EZH2 in ischemic heart disease epigenetically mediates suppression of NaV1.5 expression

Limei Zhao, Tao You, Yan Lu, Shin Lin, Faqian Li, Haodong Xu

Journal of Molecular and Cellular Cardiology.2021; 153: 95. CrossRef

Taxanes in cancer treatment: Activity, chemoresistance and its overcoming

Luciana Mosca, Andrea Ilari, Francesco Fazi, Yehuda G. Assaraf, Gianni Colotti

Drug Resistance Updates.2021; 54: 100742. CrossRef

MicroRNAs Involved in Inflammatory Breast Cancer: Oncogene and Tumor Suppressors with Possible Targets

Potential of enhancer of zeste homolog 2 inhibitors for the treatment of SWI/SNF mutant cancers and tumor microenvironment modulation

Karolina Pyziak, Agnieszka Sroka‐Porada, Tomasz Rzymski, Józef Dulak, Agnieszka Łoboda

Drug Development Research.2021; 82(6): 730. CrossRef

Jinhua Huang, Hongwei Gou, Jia Yao, Kaining Yi, Zhigang Jin, Masao Matsuoka, Tiejun Zhao

RePhine: An Integrative Method for Identification of Drug Response-related Transcriptional Regulators

Xujun Wang, Zhengtao Zhang, Wenyi Qin, Shiyi Liu, Cong Liu, Georgi Z. Genchev, Lijian Hui, Hongyu Zhao, Hui Lu

Genomics, Proteomics & Bioinformatics.2021; 19(4): 534. CrossRef

Diagnostic Utility of BAP1, EZH2 and Survivin in Differentiating Pleural Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia: Immunohistochemical Study

Pathology and Oncology Research.2021;[Epub] CrossRef

Clinical and Genomic Characteristics of Adult Diffuse Midline Glioma

Changhee Park, Tae Min Kim, Jeong Mo Bae, Hongseok Yun, Jin Wook Kim, Seung Hong Choi, Soon-Tae Lee, Joo Ho Lee, Sung-Hye Park, Chul-Kee Park

Cancer Research and Treatment.2021; 53(2): 389. CrossRef

Epigenomic and Metabolomic Integration Reveals Dynamic Metabolic Regulation in Bladder Cancer

Alba Loras, Cristina Segovia, José Luis Ruiz-Cerdá

The Biological Function, Mechanism, and Clinical Significance of m6A RNA Modifications in Head and Neck Carcinoma: A Systematic Review

Feng-Yang Jing, Li-Ming Zhou, Yu-Jie Ning, Xiao-Juan Wang, You-Ming Zhu

Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef

Clinical Perspectives to Overcome Acquired Resistance to Anti–Programmed Death-1 and Anti–Programmed Death Ligand-1 Therapy in Non-Small Cell Lung Cancer

Yong Jun Lee, Jii Bum Lee, Sang-Jun Ha, Hye Ryun Kim

Horizontal transfer of the stemness-related markers EZH2 and GLI1 by neuroblastoma-derived extracellular vesicles in stromal cells

Aranzazu Villasante, Amandine Godier-Furnemont, Alberto Hernandez-Barranco, Johanne Le Coq, Jasminka Boskovic, Hector Peinado, Jaume Mora, Josep Samitier, Gordana Vunjak-Novakovic

PBDEs affect inflammatory and oncosuppressive mechanisms via the EZH2 methyltransferase in airway epithelial cells

Giulia Anzalone, Monica Moscato, Angela Marina Montalbano, Giusy Daniela Albano, Rosalia Gagliardo, Roberto Marchese, Alberto Fucarino, Chiara Lo Nigro, Gaspare Drago, Mirella Profita

Overexpression of miR-378 Alleviates Chronic Sciatic Nerve Injury by Targeting EZH2

Pengfei Gao, Xin Zeng, Lin Zhang, Long Wang, Lu-Lu Shen, Ya-Yun Hou, Fang Zhou, Xianlong Zhang

Neurochemical Research.2021; 46(12): 3213. CrossRef

Involvement of EZH2 inhibition in lenalidomide and pomalidomide-mediated growth suppression in HTLV-1-infected cells

Nobuyo Kondo, Yoshiko Nagano, Atsuhiko Hasegawa, Miku Ishizawa, Kuniko Katagiri, Takeru Yoneda, Takao Masuda, Mari Kannagi

Biochemical and Biophysical Research Communications.2021; 574: 104. CrossRef

Discovery of IHMT-EZH2-115 as a Potent and Selective Enhancer of Zeste Homolog 2 (EZH2) Inhibitor for the Treatment of B-Cell Lymphomas

Bin Zhou, Xiaofei Liang, Husheng Mei, Shuang Qi, Zongru Jiang, Aoli Wang, Fengming Zou, Qingwang Liu, Juan Liu, Wenliang Wang, Chen Hu, Yongfei Chen, Zuowei Wang, Beilei Wang, Li Wang, Jing Liu, Qingsong Liu

Journal of Medicinal Chemistry.2021; 64(20): 15170. CrossRef

EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma

Yuko Kusakabe, Tetsuhiro Chiba, Motohiko Oshima, Shuhei Koide, Ola Rizq, Kazumasa Aoyama, Junjie Ao, Tatsuya Kaneko, Hiroaki Kanzaki, Kengo Kanayama, Takahiro Maeda, Tomoko Saito, Ryo Nakagawa, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Sadahis

Histone Demethylase UTX/KDM6A Regulates Glioblastoma Progression Through Modulating the Tumor Microenvironment

Yan Luan, Yingfei Liu, Jingwen Xue, Ke Wang, Kaige Ma, Xinlin Chen, Zhichao Zhang, Yong Liu

LncRNA-ANCR down-regulation suppresses invasion and migration of colorectal cancer cells by regulating EZH2 expression

Zhao-Yang Yang, Fang Yang, Ying-Li Zhang, Bao Liu, Meng Wang, Xuan Hong, Yan Yu, Yao-Hui Zhou, Hai Zeng

Targeting mTOR suppressed colon cancer growth through 4EBP1/eIF4E/PUMA pathway

Huanan Wang, Yeying Liu, Jie Ding, Yuan Huang, Jing Liu, Nannan Liu, Yue Ao, Yi Hong, Lefeng Wang, Lingling Zhang, Jiangang Wang, Yingjie Zhang

Utility of histone H3K27me3 and H4K20me as diagnostic indicators of melanoma

Genetic or pharmacologic blockade of enhancer of zeste homolog 2 inhibits the progression of peritoneal fibrosis

Yingfeng Shi, Min Tao, Yi Wang, Xiujuan Zang, Xiaoyan Ma, Andong Qiu, Shougang Zhuang, Na Liu

The Journal of Pathology.2020; 250(1): 79. CrossRef

Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer

Shira Yomtoubian, Sharrell B. Lee, Akanksha Verma, Franco Izzo, Geoffrey Markowitz, Hyejin Choi, Leandro Cerchietti, Linda Vahdat, Kristy A. Brown, Eleni Andreopoulou, Olivier Elemento, Jenny Chang, Giorgio Inghirami, Dingcheng Gao, Seongho Ryu, Vivek Mit

HOXC10 promotes cell migration, invasion, and tumor growth in gastric carcinoma cells through upregulating proinflammatory cytokines

Jingzhang Li, Gangling Tong, Cheng Huang, Yunsheng Luo, Shubin Wang, Ying Zhang, Boran Cheng, Zhihong Zhang, Xuan Wu, Qiumei Liu, Min Li, Laiqing Li, Bingqiang Ni

Journal of Cellular Physiology.2020; 235(4): 3579. CrossRef

A TGF-β-MTA1-SOX4-EZH2 signaling axis drives epithelial–mesenchymal transition in tumor metastasis

Lina Li, Jian Liu, Hongsheng Xue, Chunxiao Li, Qun Liu, Yantong Zhou, Ting Wang, Haijuan Wang, Haili Qian, Tao Wen

Network-Based Genetic Profiling Reveals Cellular Pathway Differences Between Follicular Thyroid Carcinoma and Follicular Thyroid Adenoma

Md. Ali Hossain, Tania Akter Asa, Md. Mijanur Rahman, Shahadat Uddin, Ahmed A. Moustafa, Julian M. W. Quinn, Mohammad Ali Moni

International Journal of Environmental Research and Public Health.2020; 17(4): 1373. CrossRef

Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time

Avinash Khanna, Alexandre Côté, Shilpi Arora, Ludivine Moine, Victor S. Gehling, Jehrod Brenneman, Nico Cantone, Jacob I. Stuckey, Shruti Apte, Ashwin Ramakrishnan, Kamil Bruderek, William D. Bradley, James E. Audia, Richard T. Cummings, Robert J. Sims, P

ACS Medicinal Chemistry Letters.2020; 11(6): 1205. CrossRef

Archana P. Thankamony, Kritika Saxena, Reshma Murali, Mohit Kumar Jolly, Radhika Nair

Frontiers in Molecular Biosciences.2020;[Epub] CrossRef

Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model

Chidimma Agatha Akpa, Karsten Kleo, Elisabeth Oker, Nancy Tomaszewski, Clemens Messerschmidt, Cristina López, Rabea Wagener, Kathrin Oehl-Huber, Katja Dettmer, Anne Schoeler, Dido Lenze, Peter J. Oefner, Dieter Beule, Reiner Siebert, David Capper, Lora Di

Long noncoding RNA ANRIL promotes the malignant progression of cholangiocarcinoma by epigenetically repressing ERRFI1 expression

Yang Yu, Qiaoyu Chen, Xunlei Zhang, Jian Yang, Kaibo Lin, Congfei Ji, Aibing Xu, Lei Yang, Lin Miao

CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation

Si-Qi Wang, Jing Liu, Jing Qin, Yun Zhu, Vicky Pui-Chi Tin, Judy Wai Ping Yam, Maria Pik Wong, Zhi-Jie Xiao

INI-1 (SMARCB1)–Deficient Undifferentiated Sinonasal Carcinoma: Novel Paradigm of Molecular Testing in the Diagnosis and Management of Sinonasal Malignancies

Khvaramze Shaverdashvili, Elham Azimi-Nekoo, Perry Cohen, Nadeem Akbar, Thomas J. Ow, Balazs Halmos, Enrico Castellucci

Nature Reviews Nephrology.2020; 16(8): 435. CrossRef

The Roles of the Histone Protein Modifier EZH2 in the Uterus and Placenta

Ana M. Mesa, Cheryl S. Rosenfeld, Geetu Tuteja, Theresa I. Medrano, Paul S. Cooke

FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway

Cheng-Cao Sun, Wei Zhu, Shu-Jun Li, Wei Hu, Jian Zhang, Yue Zhuo, Han Zhang, Juan Wang, Yu Zhang, Shao-Xin Huang, Qi-Qiang He, De-Jia Li

The long non‐coding RNA SNHG1 promotes bladder cancer progression by interacting with miR‐143‐3p and EZH2

Wei Xiang, Lei Lyu, Tao Huang, Fuxin Zheng, Jingdong Yuan, Chuanhua Zhang, Guosong Jiang

Journal of Cellular and Molecular Medicine.2020; 24(20): 11858. CrossRef

Elevated expression of RUNX3 co-expressing with EZH2 in esophageal cancer patients from India

Asad Ur Rehman, Mohammad Askandar Iqbal, Real Sumayya Abdul Sattar, Snigdha Saikia, Mohammad Kashif, Wasif Mohammad Ali, Subhash Medhi, Sundeep Singh Saluja, Syed Akhtar Husain

MicroRNA-33b Suppresses Epithelial–Mesenchymal Transition Repressing the MYC–EZH2 Pathway in HER2+ Breast Carcinoma

Birlipta Pattanayak, Iris Garrido-Cano, Anna Adam-Artigues, Eduardo Tormo, Begoña Pineda, Paula Cabello, Elisa Alonso, Begoña Bermejo, Cristina Hernando, María Teresa Martínez, Ana Rovira, Joan Albanell, Federico Rojo, Octavio Burgués, Juan Miguel Cejalvo

Inhibition of EZH2 via the STAT3/HOTAIR signalling axis contributes to cell cycle arrest and apoptosis induced by polyphyllin I in human non-small cell lung cancer cells

EZH2 overexpression dampens tumor-suppressive signals via an EGR1 silencer to drive breast tumorigenesis

Xiaowen Guan, Houliang Deng, Un Lam Choi, Zhengfeng Li, Yiqi Yang, Jianming Zeng, Yunze Liu, Xuanjun Zhang, Gang Li

RETRACTED: Exosome-Delivered LncHEIH Promotes Gastric Cancer Progression by Upregulating EZH2 and Stimulating Methylation of the GSDME Promoter

Yan Lu, Kaiqing Hou, Mengsen Li, Xiaobin Wu, Shaochun Yuan

Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef

Impact of the Tumor Microenvironment on Tumor Heterogeneity and Consequences for Cancer Cell Plasticity and Stemness

The EZH2–PHACTR2–AS1–Ribosome Axis induces Genomic Instability and Promotes Growth and Metastasis in Breast Cancer

Wenhui Chu, Xi Zhang, Lihua Qi, Yenan Fu, Peng Wang, Wei Zhao, Juan Du, Jing Zhang, Jun Zhan, Yunling Wang, Wei-Guo Zhu, Yu Yu, Hongquan Zhang

Inhibition of EZH2 Enhances the Antitumor Efficacy of Metformin in Prostate Cancer

Yifan Kong, Yanquan Zhang, Fengyi Mao, Zhuangzhuang Zhang, Zhiguo Li, Ruixin Wang, Jinghui Liu, Xiaoqi Liu

Molecular Cancer Therapeutics.2020; 19(12): 2490. CrossRef

Aberrant differential expression of EZH2 and H3K27me3 in extranodal NK/T-cell lymphoma, nasal type, is associated with disease progression and prognosis

Jumei Liu, Li Liang, Sixia Huang, Lin Nong, Dong Li, Bo Zhang, Ting Li

Retracted: Long noncoding RNA TALNEC2 plays an oncogenic role in breast cancer by binding to EZH2 to target p57KIP2 and involving in p‐p38 MAPK and NF‐κB pathways

Enqi Qiao, Daobao Chen, Qinglin Li, Weiliang Feng, Xingfei Yu, Xiping Zhang, Liang Xia, Ju Jin, Hongjian Yang

Journal of Cellular Biochemistry.2019; 120(3): 3978. CrossRef

Interaction of EZH2 and P65 is involved in the arsenic trioxide-induced anti-angiogenesis in human triple-negative breast cancer cells

Cell Biology and Toxicology.2019; 35(4): 361. CrossRef

lncRNA SNHG6 regulates EZH2 expression by sponging miR-26a/b and miR-214 in colorectal cancer

Mu Xu, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Xueni Xu, Bei Pan, Tao Xu, Li Sun, Bangshun He, Yuqin Pan, Huiling Sun, Shukui Wang

Journal of Hematology & Oncology.2019;[Epub] CrossRef

Genome-wide expression analysis reveals six contravened targets of EZH2 associated with breast cancer patient survival

Kanchan Kumari, Biswajit Das, Amit K. Adhya, Arabinda K. Rath, Sandip K. Mishra

LncRNA ADAMTS9-AS2 promotes tongue squamous cell carcinoma proliferation, migration and EMT via the miR-600/EZH2 axis

Yingru Li, Quan Wan, Weiwei Wang, Lianxi Mai, Liujuan Sha, Mubarak Mashrah, Zhaoyu Lin, Chaobin Pan

Biomedicine & Pharmacotherapy.2019; 112: 108719. CrossRef

New directions in treating peripheral T-cell lymphomas (PTCL): leveraging epigenetic modifiers alone and in combination

Expert Review of Hematology.2019; 12(3): 137. CrossRef

iPS-Cell Technology and the Problem of Genetic Instability—Can It Ever Be Safe for Clinical Use?

Journal of Clinical Medicine.2019; 8(3): 288. CrossRef

Protein dynamics analysis reveals that missense mutations in cancer‐related genes appear frequently on hinge‐neighboring residues

Jan Fehmi Sayılgan, Türkan Haliloğlu, Mehmet Gönen

Proteins: Structure, Function, and Bioinformatics.2019; 87(6): 512. CrossRef

Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity

Xin Fang, Nan Ni, John P. Lydon, Ivan Ivanov, Kayla J. Bayless, Monique Rijnkels, Qinglei Li

The American Journal of Pathology.2019; 189(6): 1212. CrossRef

Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets

Mark E Pepin, Hayden H Bickerton, Maigen Bethea, Chad S Hunter, Adam R Wende, Ronadip R Banerjee

Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation

Jie Zhou, Shuo Huang, Zhongyu Wang, Jiani Huang, Liang Xu, Xuefeng Tang, Yisong Y. Wan, Qi-jing Li, Alistair L. J. Symonds, Haixia Long, Bo Zhu

Silencing of microRNA-708 promotes cell growth and epithelial-to-mesenchymal transition by activating the SPHK2/AKT/β-catenin pathway in glioma

Yan Chen, Xubin Deng, Weiquan Chen, Pengwei Shi, Mei Lian, Hongxiao Wang, Kewan Wang, Dadi Qian, Dong Xiao, Hao Long

EZH2 upregulates the PI3K/AKT pathway through IGF1R and MYC in clinically aggressive chronic lymphocytic leukaemia

Subazini Thankaswamy Kosalai, Mohammad Hamdy Abdelrazak Morsy, Nikos Papakonstantinou, Larry Mansouri, Niki Stavroyianni, Chandrasekhar Kanduri, Kostas Stamatopoulos, Richard Rosenquist, Meena Kanduri

Current state of melanoma diagnosis and treatment

Cancer Biology & Therapy.2019; 20(11): 1366. CrossRef

DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations

Chidimma Agatha Akpa, Karsten Kleo, Dido Lenze, Elisabeth Oker, Lora Dimitrova, Michael Hummel, Francesco Bertolini

HO-1 promotes resistance to an EZH2 inhibitor through the pRB-E2F pathway: correlation with the progression of myelodysplastic syndrome into acute myeloid leukemia

Zhengchang He, Siyu Zhang, Dan Ma, Qin Fang, Liping Yang, Shaoxian Shen, Ying Chen, Lingli Ren, Jishi Wang

Journal of Translational Medicine.2019;[Epub] CrossRef

Hematopoietic Differentiation of Human Pluripotent Stem Cells: HOX and GATA Transcription Factors as Master Regulators

Khaled Alsayegh, Lorena V. Cortés-Medina, Gerardo Ramos-Mandujano, Heba Badraiq, Mo Li

Long non‐coding small nucleolar RNA host genes in digestive cancers

Huan Yang, Zheng Jiang, Shuang Wang, Yongbing Zhao, Xiaomei Song, Yufeng Xiao, Shiming Yang

Aberrant Expression of EZH2 in Pediatric Patients with Myelodysplastic Syndrome: A Potential Biomarker of Leukemic Evolution

Teresa de Souza Fernandez, Tatiana Fonseca Alvarenga, Elaiza Almeida Antônio de Kós, Viviane Lamim Lovatel, Rita de Cássia Tavares, Elaine Sobral da Costa, Cecília de Souza Fernandez, Eliana Abdelhay

BioMed Research International.2019; 2019: 1. CrossRef

Epigenetics of Bladder Cancer: Where Biomarkers and Therapeutic Targets Meet

Victor G. Martinez, Ester Munera-Maravilla, Alejandra Bernardini, Carolina Rubio, Cristian Suarez-Cabrera, Cristina Segovia, Iris Lodewijk, Marta Dueñas, Mónica Martínez-Fernández, Jesus Maria Paramio

Cigarette smoke affects the onco-suppressor DAB2IP expression in bronchial epithelial cells of COPD patients

Giulia Anzalone, Giuseppe Arcoleo, Fabio Bucchieri, Angela M. Montalbano, Roberto Marchese, Giusy D. Albano, Caterina Di Sano, Monica Moscato, Rosalia Gagliardo, Fabio L. M. Ricciardolo, Mirella Profita

Stratifying nonfunctional pituitary adenomas into two groups distinguished by macrophage subtypes

Garima Yagnik, Martin J. Rutowski, Sumedh S. Shah, Manish K. Aghi

Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review)

EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer

H Yamaguchi, Y Du, K Nakai, M Ding, S-S Chang, J L Hsu, J Yao, Y Wei, L Nie, S Jiao, W-C Chang, C-H Chen, Y Yu, G N Hortobagyi, M-C Hung

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-d

Pei-Pei Kung, Patrick Bingham, Alexei Brooun, Michael Collins, Ya-Li Deng, Dac Dinh, Connie Fan, Ketan S. Gajiwala, Rita Grantner, Hovhannes J. Gukasyan, Wenyue Hu, Buwen Huang, Robert Kania, Susan E. Kephart, Cody Krivacic, Robert A. Kumpf, Penney Khamph

Journal of Medicinal Chemistry.2018; 61(3): 650. CrossRef

Nicotine associated breast cancer in smokers is mediated through high level of EZH2 expression which can be reversed by methyltransferase inhibitor DZNepA

Kanchan Kumari, Biswajit Das, Amit Adhya, Sanjib Chaudhary, Shantibhusan Senapati, Sandip K. Mishra

Long noncoding RNA GAS5 promotes bladder cancer cells apoptosis through inhibiting EZH2 transcription

Miao Wang, Chen Guo, Liang Wang, Gang Luo, Chao Huang, Yawei Li, Dong Liu, Fuqing Zeng, Guosong Jiang, Xingyuan Xiao

Valproic Acid Promotes Apoptosis and Cisplatin Sensitivity Through Downregulation of H19 Noncoding RNA in Ovarian A2780 Cells

Zahre Sajadpoor, Zeinab Amini-Farsani, Hossein Teimori, Mehdi Shamsara, Mohammad Hossein Sangtarash, Payam Ghasemi-Dehkordi, Farrokh Yadollahi

Applied Biochemistry and Biotechnology.2018; 185(4): 1132. CrossRef

Epigenetic dysregulation of key developmental genes in radiation‐induced rat mammary carcinomas

Kazuhiro Daino, Mayumi Nishimura, Tatsuhiko Imaoka, Masaru Takabatake, Takamitsu Morioka, Yukiko Nishimura, Yoshiya Shimada, Shizuko Kakinuma

International Journal of Cancer.2018; 143(2): 343. CrossRef

The role of enhancer of zeste homolog 2: From viral epigenetics to the carcinogenesis of hepatocellular carcinoma

Luca Sanna, Irene Marchesi, Mariarosa A. B. Melone, Luigi Bagella

Journal of Cellular Physiology.2018; 233(9): 6508. CrossRef

Decreased expression of microRNA-26b in locally advanced and inflammatory breast cancer

Qingqing Ding, Yan Wang, Zhuang Zuo, Yun Gong, Savitri Krishnamurthy, Chia-Wei Li, Yun-Ju Lai, Wei Wei, Jing Wang, Ganiraju C. Manyam, Lixia Diao, Xinna Zhang, Feng Lin, William F. Symmans, Li Sun, Chang-Gong Liu, Xiuping Liu, Bisrat G. Debeb, Naoto T. Ue

EZH2 induces the expression of miR-1301 as a negative feedback control mechanism in triple negative breast cancer

Qiuju Wu, Zekun Chen, Guihua Zhang, Wenhui Zhou, You Peng, Rong Liu, Ceshi Chen, Jing Feng

Acta Biochimica et Biophysica Sinica.2018; 50(7): 693. CrossRef

Impact of OGT deregulation on EZH2 target genes FOXA1 and FOXC1 expression in breast cancer cells

Ewa Forma, Paweł Jóźwiak, Piotr Ciesielski, Agnieszka Zaczek, Katarzyna Starska, Magdalena Bryś, Anna Krześlak, Gokul M. Das

Anti-tumor and anti-metastasis activities of honey bee larvae powder by suppressing the expression of EZH2

Masakatsu Kageyama, Kejuan Li, Shuang Sun, Guoqing Xing, Ran Gao, Zhongfang Lei, Zhenya Zhang

Biomedicine & Pharmacotherapy.2018; 105: 690. CrossRef

Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma

Yang Yu, Mingjiong Zhang, Ni Wang, Quanpeng Li, Jian Yang, Shuai Yan, Xuezhi He, Guozhong Ji, Lin Miao

Emerging roles of Myc in stem cell biology and novel tumor therapies

Journal of Experimental & Clinical Cancer Research.2018;[Epub] CrossRef

The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p

Mu Xu, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Bei Pan, Xueni Xu, Tao Xu, Xiuxiu Hu, Li Sun, Bangshun He, Yuqin Pan, Huiling Sun, Shukui Wang

Long noncoding RNA PCAT6 functions as an oncogene by binding to EZH2 and suppressing LATS2 in non-small-cell lung cancer

Xuefei Shi, Zhili Liu, Zhicong Liu, Xueren Feng, Feng Hua, Xixian Hu, Bin Wang, Kaihua Lu, Fengqi Nie

DUXAP8, a pseudogene derived lncRNA, promotes growth of pancreatic carcinoma cells by epigenetically silencing CDKN1A and KLF2

Yifan Lian, Jiebin Yang, Yikai Lian, Chuangxing Xiao, Xuezhen Hu, Hongzhi Xu

EZH2, HIF-1, and Their Inhibitors: An Overview on Pediatric Cancers

Marco Papale, Elisabetta Ferretti, Giuseppe Battaglia, Diana Bellavia, Antonello Mai, Marco Tafani

Long Noncoding RNA ANRIL Supports Proliferation of Adult T-Cell Leukemia Cells through Cooperation with EZH2

Zaowen Song, Wencai Wu, Mengyun Chen, Wenzhao Cheng, Juntao Yu, Jinyong Fang, Lingling Xu, Jun-ichirou Yasunaga, Masao Matsuoka, Tiejun Zhao, Viviana Simon

MET/ERK and MET/JNK Pathway Activation Is Involved in BCR-ABL Inhibitor-resistance in Chronic Myeloid Leukemia

EZH2 inhibitors sensitize myeloma cell lines to panobinostat resulting in unique combinatorial transcriptomic changes

The untold stories of the speech gene, the FOXP2 cancer gene

SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer

W Lu, S Liu, B Li, Y Xie, M G Izban, B R Ballard, S A Sathyanarayana, S E Adunyah, R J Matusik, Z Chen

Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis

Junchao Xue, Yang Liu, Fei Luo, Xiaolin Lu, Hui Xu, Xinlu Liu, Lu Lu, Qianlei Yang, Chao Chen, Weimin Fan, Qizhan Liu

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2017; 1863(3): 753. CrossRef

Regulation of cancer epigenomes with a histone-binding synthetic transcription factor

David B. Nyer, Rene M. Daer, Daniel Vargas, Caroline Hom, Karmella A. Haynes

Rosalia de Necochea-Campion, Lee M. Zuckerman, Hamid R. Mirshahidi, Shahrzad Khosrowpour, Chien-Shing Chen, Saied Mirshahidi

Interplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to β-elemene-inhibited growth of nasopharyngeal carcinoma cells

JingJing Wu, Qing Tang, LiJuan Yang, YuQing Chen, Fang Zheng, Swei Sunny Hann

Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3

Maureen M. Sherry-Lynes, Sejuti Sengupta, Shreya Kulkarni, Brent H. Cochran, Anita B. Hjelmeland

Modulation of HAT activity by the BRCA2 N372H variation is a novel mechanism of paclitaxel resistance in breast cancer cell lines

Woo Sun Kwon, Sun Young Rha, Hei-Cheul Jeung, Tae Soo Kim, Hyun Cheol Chung

Expression and inhibition of BRD4, EZH2 and TOP2A in neurofibromas and malignant peripheral nerve sheath tumors

Azadeh Amirnasr, Rob M. Verdijk, Patricia F. van Kuijk, Walter Taal, Stefan Sleijfer, Erik A. C. Wiemer, Marta M. Alonso

Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options

Robert E. Brown, Syed Naqvi, Mary F. McGuire, Jamie Buryanek, Ron J. Karni

Journal of Otolaryngology - Head & Neck Surgery.2017;[Epub] CrossRef

Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation

Hyunjoo Kwon, Kyoungsub Song, Chang Han, Jinqiang Zhang, Lu Lu, Weina Chen, Tong Wu

The American Journal of Pathology.2017; 187(10): 2288. CrossRef

The role of EZH2 in overall survival of colorectal cancer: a meta-analysis

Laura Vilorio-Marqués, Vicente Martín, Cristina Diez-Tascón, María Francisca González-Sevilla, Tania Fernández-Villa, Emiliano Honrado, Veronica Davila-Batista, Antonio J. Molina

Identification of coexistence of BRAF V600E mutation and EZH2 gain specifically in melanoma as a promising target for combination therapy

Huan Yu, Meng Ma, Junya Yan, Longwen Xu, Jiayi Yu, Jie Dai, Tianxiao Xu, Huan Tang, Xiaowen Wu, Siming Li, Bin Lian, Lili Mao, Zhihong Chi, Chuanliang Cui, Jun Guo, Yan Kong

Journal of Translational Medicine.2017;[Epub] CrossRef

Decreased expression of JMJD3 predicts poor prognosis of patients with clear cell renal cell carcinoma

Jiajun Wang, Li Liu, Qilai Long, Qi Bai, Yu Xia, Wei Xi, Jiejie Xu, Jianming Guo

Contributions of MET activation to BCR-ABL1 tyrosine kinase inhibitor resistance in chronic myeloid leukemia cells

Masanobu Tsubaki, Tomoya Takeda, Toshiki Kino, Kazuko Sakai, Tatsuki Itoh, Motohiro Imano, Takashi Nakayama, Kazuto Nishio, Takao Satou, Shozo Nishida

Methylation-mediated silencing of microRNA-211 promotes cell growth and epithelial to mesenchymal transition through activation of the AKT/β-catenin pathway in GBM

Weidong Li, Xiaobo Miao, Lingling Liu, Yue Zhang, Xuejun Jin, Xiaojun Luo, Hai Gao, Xubin Deng

EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis

Kei Ihira, Peixin Dong, Ying Xiong, Hidemichi Watari, Yosuke Konno, Sharon JB Hanley, Masayuki Noguchi, Noriyuki Hirata, Futoshi Suizu, Takahiro Yamada, Masataka Kudo, Noriaki Sakuragi

Inhibition of enhancer of zeste homolog 2 increases the expression of p16 and suppresses the proliferation and migration of ovarian carcinoma cells inï¿½vitro and inï¿½vivo

Fangfang Lu, Hong Xu, Qi Wang, Meiyi Li, Jiahua Meng, Yan Kuang

miR-202 Diminishes TGFβ Receptors and Attenuates TGFβ1-Induced EMT in Pancreatic Cancer

Hardik R. Mody, Sau Wai Hung, Rakesh K. Pathak, Jazmine Griffin, Zobeida Cruz-Monserrate, Rajgopal Govindarajan

Molecular Cancer Research.2017; 15(8): 1029. CrossRef

TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis

Min Deng, Ruixin Zhang, Zhengxi He, Qinwei Qiu, Xihong Lu, Jiang Yin, Hao Liu, Xiaoting Jia, Zhimin He

The role of the polycomb repressive complex pathway in T and NK cell lymphoma: biological and prognostic implications

Soo Hee Kim, Woo Ick Yang, Yoo Hong Min, Young Hyeh Ko, Sun Och Yoon

Interference with endogenous EZH2 reverses the chemotherapy drug resistance in cervical cancer cells partly by up-regulating Dicer expression

The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane

Matthew L. Fisher, Gautam Adhikary, Dan Grun, David M. Kaetzel, Richard L. Eckert

Molecular Carcinogenesis.2016; 55(12): 2024. CrossRef

Problems of glioblastoma multiforme drug resistance

A. A. Stavrovskaya, S. S. Shushanov, E. Yu. Rybalkina

High EZH2 Protein Expression Is Associated with Poor Overall Survival in Patients with Luminal A Breast Cancer

Si-Hyong Jang, Jong Eun Lee, Mee-Hye Oh, Ji-Hye Lee, Hyun Deuk Cho, Kyung-Ju Kim, Sung Yong Kim, Sun Wook Han, Han Jo Kim, Sang Byung Bae, Hyun Ju Lee

Journal of Breast Cancer.2016; 19(1): 53. CrossRef

Expression of miRNA-26b in the diagnosis and prognosis of patients with non-small-cell lung cancer

Targeting NK Cells for Anticancer Immunotherapy: Clinical and Preclinical Approaches

Role of EZH2 histone methyltrasferase in melanoma progression and metastasis

Fade Mahmoud, Bradley Shields, Issam Makhoul, Laura F. Hutchins, Sara C. Shalin, Alan J. Tackett

Cancer Biology & Therapy.2016; 17(6): 579. CrossRef

Prognostic value of UTX expression in patients with clear cell renal cell carcinoma

Jiajun Wang, Li Liu, Wei Xi, Qilai Long, Yiwei Wang, Qi Bai, Yu Xia, Jiejie Xu, Jianming Guo

Urologic Oncology: Seminars and Original Investigations.2016; 34(8): 338.e19. CrossRef

Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

Balabhadrapatruni V.S.K. Chakravarthi, Saroj Nepal, Sooryanarayana Varambally

The American Journal of Pathology.2016; 186(7): 1724. CrossRef

Epigenetic mechanisms of cell adhesion-mediated drug resistance in multiple myeloma

International Journal of Hematology.2016; 104(3): 281. CrossRef

Down-Regulation of TSLP After EZH2 Silencing in ESCC Cell Line

Gholamreza Karami Madani, Abolfazl Rad, Mohammad Mahdi Forghanifard

High EZH2 expression is correlated to metastatic disease in pediatric soft tissue sarcomas

Maria Ramaglia, Velia D’Angelo, Adriana Iannotta, Daniela Di Pinto, Elvira Pota, Maria Carmen Affinita, Vittoria Donofrio, Maria Elena Errico, Angela Lombardi, Cristiana Indolfi, Fiorina Casale, Michele Caraglia

DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity

Y Wang, H Sun, J Wang, H Wang, L Meng, C Xu, M Jin, B Wang, Y Zhang, Y Zhang, T Zhu

Significance of EZH2 expression in canine mammary tumors

Hyun-Ji Choi, Sungwoong Jang, Jae-Eun Ryu, Hyo-Ju Lee, Han-Byul Lee, Woo-Sung Ahn, Hye-Jin Kim, Hyo-Jin Lee, Hee Jin Lee, Gyung-Yub Gong, Woo-Chan Son

Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitabl

Rishi G. Vaswani, Victor S. Gehling, Les A. Dakin, Andrew S. Cook, Christopher G. Nasveschuk, Martin Duplessis, Priyadarshini Iyer, Srividya Balasubramanian, Feng Zhao, Andrew C. Good, Robert Campbell, Christina Lee, Nico Cantone, Richard T. Cummings, Emm

Journal of Medicinal Chemistry.2016; 59(21): 9928. CrossRef

MiR-101 Targets the EZH2/Wnt/β-Catenin the Pathway to Promote the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

Hongrui Wang, Yake Meng, Quanjun Cui, Fujun Qin, Haisong Yang, Yu Chen, Yajun Cheng, Jiangang Shi, Yongfei Guo

EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells

Ming-Quan Sha, Xiao-Li Zhao, Liang Li, Li-Hui Li, Yi Li, Tian-Geng Dong, Wei-Xin Niu, Li-Jun Jia, Rong-Guang Shao, Yong-Su Zhen, Zhen Wang

Marginal zone lymphoma-derived interfollicular diffuse large B-cell lymphoma harboring 20q12 chromosomal deletion and missense mutation of BIRC3 gene: a case report

Joseph Hatem, April M. Schrank-Hacker, Christopher D. Watt, Jennifer J. D. Morrissette, Adam I. Rubin, Ellen J. Kim, Sunita D. Nasta, Mariusz A. Wasik, Agata M. Bogusz

Expression Profile and Function Analysis of LncRNAs during Priming Phase of Rat Liver Regeneration

Jun Li, Wei Jin, Yanli Qin, Weiming Zhao, Cuifang Chang, Cunshuan Xu, Klaus Roemer

Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer

Identification of Polycomb Group Protein EZH2-Mediated DNA Mismatch Repair Gene MSH2 in Human Uterine Fibroids

Qiwei Yang, Archana Laknaur, Lelyand Elam, Nahed Ismail, Larisa Gavrilova-Jordan, John Lue, Michael P. Diamond, Ayman Al-Hendy

Reproductive Sciences.2016; 23(10): 1314. CrossRef

The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway

Hiroyoshi Kurihara, Reo Maruyama, Kazuya Ishiguro, Shinichi Kanno, Itaru Yamamoto, Keisuke Ishigami, Kei Mitsuhashi, Hisayoshi Igarashi, Miki Ito, Tokuma Tanuma, Yasutaka Sukawa, Kenji Okita, Tadashi Hasegawa, Kohzoh Imai, Hiroyuki Yamamoto, Yasuhisa Shin

The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia

Nikos Papakonstantinou, Stavroula Ntoufa, Elisavet Chartomatsidou, Konstantia Kotta, Andreas Agathangelidis, Lefki Giassafaki, Tzeni Karamanli, Panagiota Bele, Theodoros Moysiadis, Panagiotis Baliakas, Lesley Ann Sutton, Niki Stavroyianni, Achilles Anagno

Proximal and distal regulation of the HYAL1 gene cluster by the estrogen receptor α in breast cancer cells

Lydia Edjekouane, Samira Benhadjeba, Maïka Jangal, Hubert Fleury, Nicolas Gévry, Euridice Carmona, André Tremblay

Overexpression of EZH2 is associated with the poor prognosis in osteosarcoma and function analysis indicates a therapeutic potential

Ranran Sun, Jacson Shen, Yan Gao, Yubing Zhou, Zujiang Yu, Francis Hornicek, Quancheng Kan, Zhenfeng Duan

GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers

How-Wen Ko, Heng-Huan Lee, Longfei Huo, Weiya Xia, Cheng-Chieh Yang, Jennifer L. Hsu, Long-Yuan Li, Chien-Chen Lai, Li-Chuan Chan, Chien-Chia Cheng, Adam M. Labaff, Hsin-Wei Liao, Seung-Oe Lim, Chia-Wei Li, Yongkun Wei, Lei Nie, Hirohito Yamaguchi, Mien-C

Upregulation of the long noncoding RNA TUG1 promotes proliferation and migration of esophageal squamous cell carcinoma

Youtao Xu, Jie Wang, Mantang Qiu, Lei Xu, Ming Li, Feng Jiang, Rong Yin, Lin Xu

Role of the ubiquitin proteasome system in hematologic malignancies

Anagh A. Sahasrabuddhe, Kojo S. J. Elenitoba‐Johnson

The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer

The role of aberrant proteolysis in lymphomagenesis

Current Opinion in Hematology.2015; 22(4): 369. CrossRef

Small molecule inhibitors of EZH2: the emerging translational landscape

Enhancer of zeste homolog 2 silencing inhibits tumor growth and lung metastasis in osteosarcoma

Yang-Fan Lv, Guang-Ning Yan, Gang Meng, Xi Zhang, Qiao-Nan Guo

Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma

Mehnaz Khan, Laura L Walters, Qiang Li, Dafydd G Thomas, Jason M L Miller, Qitao Zhang, Andrew P Sciallis, Yu Liu, Brian J Dlouhy, Patrice E Fort, Steven M Archer, Hakan Demirci, Yali Dou, Rajesh C Rao

Laboratory Investigation.2015; 95(11): 1278. CrossRef

Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer

Emmi I. Joensuu, Taina T. Nieminen, Johanna E. Lotsari, Walter Pavicic, Wael M. Abdel‐Rahman, Päivi Peltomäki

Genes, Chromosomes and Cancer.2015; 54(12): 776. CrossRef

Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma

Jiro Kikuchi, Daisuke Koyama, Taeko Wada, Tohru Izumi, Peter O. Hofgaard, Bjarne Bogen, Yusuke Furukawa

Journal of Clinical Investigation.2015; 125(12): 4375. CrossRef

Overexpression of enhancer of zeste homolog 2 (EZH2) characterizes an aggressive subset of prostate cancers and predicts patient prognosis independently from pre- and postoperatively assessed clinicopathological parameters

Nathaniel Melling, Erik Thomsen, Maria Christina Tsourlakis, Martina Kluth, Claudia Hube-Magg, Sarah Minner, Christina Koop, Markus Graefen, Hans Heinzer, Corinna Wittmer, Guido Sauter, Waldemar Wilczak, Hartwig Huland, Ronald Simon, Thorsten Schlomm, Ste

EZH2 in Bladder Cancer, a Promising Therapeutic Target

Mónica Martínez-Fernández, Carolina Rubio, Cristina Segovia, Fernando López-Calderón, Marta Dueñas, Jesús Paramio

International Journal of Molecular Sciences.2015; 16(11): 27107. CrossRef

siRNA Silencing EZH2 Reverses Cisplatin-resistance of Human Non-small Cell Lung and Gastric Cancer Cells

Wen Zhou, Jian Wang, Wang-Ying Man, Qing-Wei Zhang, Wen-Gui Xu

Asian Pacific Journal of Cancer Prevention.2015; 16(6): 2425. CrossRef

H3K27me3 is an Epigenetic Mark of Relevance in Endometriosis

Mariano Colón-Caraballo, Janice B. Monteiro, Idhaliz Flores

A Gene Regulatory Program in Human Breast Cancer

MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells

Xiaoping Liu, Qianqian Lei, Zhibin Yu, Gang Xu, Hailin Tang, Wei Wang, Zeyou Wang, Guiyuan Li, Minghua Wu

Enhancer of zeste acts as a major developmental regulator ofCiona intestinalisembryogenesis

Emilie Le Goff, Camille Martinand-Mari, Marianne Martin, Jérôme Feuillard, Yvan Boublik, Nelly Godefroy, Paul Mangeat, Stephen Baghdiguian, Giacomo Cavalli