Cancer Research and Treatment

Original Articles

Lung and Thoracic cancer

The Additive Impact of Transbronchial Cryobiopsy Using a 1.1-mm Diameter Cryoprobe on Conventional Biopsy for Peripheral Lung Nodules: Soo Han Kim, Jeongha Mok, Eun-Jung Jo, Mi-Hyun Kim, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Jung Seop Eom; Cancer Res Treat. 2023;55(2):506-512. Published online November 1, 2022; DOI: https://doi.org/10.4143/crt.2022.1008

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Purpose
The diagnostic yield of transbronchial biopsy (TBB) using radial probe endobronchial ultrasound (RP-EBUS) is 71%, which is lower than that of transthoracic needle biopsy. We investigated the performance and safety of sequential transbronchial cryobiopsy (TBC) using a novel 1.1-mm diameter cryoprobe, after conventional TBB using RP-EBUS for the diagnosis of peripheral lung lesions (PLLs).
Materials and Methods
From April 2021 to November 2021, 110 patients who underwent bronchoscopy using RP-EBUS for the diagnosis of PLL ≤ 30 mm were retrospectively included in our study. All records were followed until June 2022.
Results
The overall diagnostic yield of combined TBB and TBC was 79.1%, which was higher than 60.9% of TBB alone (p=0.005). The diagnostic yield of sequential TBC was 65.5%, which increased the overall diagnostic yield by 18.2%. The surface area of tissues by TBC (mean area, 18.5 mm²) was significantly larger than those of TBB by 1.5-mm forceps (3.4 mm², p < 0.001) and 1.9-mm forceps (3.7 mm², p=0.011). In the multivariate analysis, PLLs with the longest diameter of ≤ 22 mm were found to be related to additional diagnostic benefits from sequential TBC (odds ratio, 3.51; 95% confidence interval, 1.043 to 11.775; p=0.042). Complications were found in 10.5% of the patients: pneumothorax (1.0%), infection (1.0%), and significant bleeding (8.6%). None of the patients developed any life-threatening complications.
Conclusion
Sequential TBC with a 1.1-mm cryoprobe improved the performance of conventional TBB using RP-EBUS without serious complications.

Citations

Citations to this article as recorded by

Complete resolution of non-tuberculous mycobacterial pulmonary nodule following cryobiopsy: The first case report
Sung Joon Han, Chaeuk Chung, Dongil Park
Diagnostic Pathology.2025;[Epub] CrossRef
Feasibility of a Modified Bronchoscopic Transparenchymal Nodule Access Technique (‘Essen Tunnel’) for Improving the Diagnosis of Intraparenchymal Pulmonary Lesions
Erik Büscher, Faustina Funke, Jane Winantea, Hanna Zellerhoff, Johannes Wienker, Marcel Opitz, Christian Taube, Kaid Darwiche
Respirology.2025;[Epub] CrossRef
Transbronchial lung cryobiopsy for peripheral pulmonary lesions. A narrative review
Y. Tang, S. Tian, H. Chen, X. Li, X. Pu, X. Zhang, Y. Zheng, Y. Li, H. Huang, C. Bai
Pulmonology.2024; 30(5): 475. CrossRef
Transbronchial Tumor Ablation
Russell Miller, George Cheng
Current Pulmonology Reports.2024; 13(1): 103. CrossRef
Using cryoprobes of different sizes combined with cone-beam computed tomography-derived augmented fluoroscopy and endobronchial ultrasound to diagnose peripheral pulmonary lesions: a propensity-matched study
Ching-Kai Lin, Sheng-Yuan Ruan, Hung-Jen Fan, Hao-Chun Chang, Yen-Ting Lin, Chao-Chi Ho
Respiratory Research.2024;[Epub] CrossRef
Next‐generation sequencing using tissue specimen collected with a 1.1 mm‐diameter cryoprobe in patients with lung cancer
Mi‐Hyun Kim, Soo Han Kim, Geewon Lee, Jeongha Mok, Min Ki Lee, Ju Sun Song, Jung Seop Eom
Respirology.2024; 29(4): 333. CrossRef
Development of the Korean Association for Lung Cancer Clinical Practice Guidelines: Recommendations on Radial Probe Endobronchial Ultrasound for Diagnosing Lung Cancer - An Updated Meta-Analysis
Soo Han Kim, Hyun Sung Chung, Jinmi Kim, Mi-Hyun Kim, Min Ki Lee, Insu Kim, Jung Seop Eom
Cancer Research and Treatment.2024; 56(2): 464. CrossRef
Navigational bronchoscopy with tranbronchial cryobiopsy in differential diagnosis of peripheral pulmonary lesions
Ya.O. Chesalina, I.Yu. Shabalina, L.A. Semenova, I.V. Sivokozov
Pirogov Russian Journal of Surgery.2024; (6): 36. CrossRef
Advanced Bronchoscopic Diagnostic Techniques in Lung Cancer
Dongil Park
Tuberculosis and Respiratory Diseases.2024; 87(3): 282. CrossRef
Clinical utility of rapid on-site evaluation of brush cytology during bronchoscopy using endobronchial ultrasound with a guide sheath
Kazuhiro Nishiyama, Kei Morikawa, Shotaro Kaneko, Makoto Nishida, Aya Matsushima, Yoshihiro Nishi, Yu Numata, Yusuke Shinozaki, Hajime Tsuruoka, Hirotaka Kida, Hiroshi Handa, Naoki Shimada, Chie Okawa, Nobuyuki Ohike, Junki Koike, Masamichi Mineshita
Scientific Reports.2024;[Epub] CrossRef
Bronchial branch tracing navigation in ultrathin bronchoscopy-guided radial endobronchial ultrasound for peripheral pulmonary nodule
Sze Shyang Kho, Shirin Hui Tan, Swee Kim Chan, Chan Sin Chai, Siew Teck Tie
BMC Pulmonary Medicine.2024;[Epub] CrossRef
The diagnosis of peripheral lung lesions: transbronchial biopsy using a radial probe endobronchial ultrasound
Jung Seop Eom
Journal of the Korean Medical Association.2023; 66(3): 166. CrossRef
Clinical outcomes of transbronchial cryobiopsy using a 1.1-mm diameter cryoprobe for peripheral lung lesions - A prospective pilot study
Soo Han Kim, Jeongha Mok, Saerom Kim, Wan Ho Yoo, Eun-Jung Jo, Mi-Hyun Kim, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Jung Seop Eom
Respiratory Medicine.2023; 217: 107338. CrossRef

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Evaluation of Diagnostic Performance of Screening Thyroid Ultrasonography and Imaging Findings of Screening-Detected Thyroid Cancer: Jeongin Yoo, Hye Shin Ahn, Soo Jin Kim, Sung Hee Park, Mirinae Seo, Semin Chong; Cancer Res Treat. 2018;50(1):11-18. Published online February 24, 2017; DOI: https://doi.org/10.4143/crt.2016.600

Abstract PDF PubReader ePub

Purpose
The purpose of this study was to evaluate the diagnostic performance and cost of screening thyroid ultrasonography (US) in an asymptomatic population and determine the US features of screening-detected thyroid cancer.
Materials and Methods
This study included 1,845 asymptomatic participants who underwent screening thyroid US between March and August 2012 at the screening center in our hospital. We evaluated the diagnostic performance of screening thyroid US for thyroid cancer and the average cost of diagnosis for each patient. We also determined the characteristic US features of screening-detected thyroid cancer.
Results
Of the 1,845 subjects, 661 showed no abnormalities, 1,155 exhibited benign thyroid nodules, and 29 exhibited thyroid cancer. Imaging features such as solid composition, hypoechogenicity, taller-than-wide axis, and ill-defined or spiculated margins of nodules were suggestive of malignancy. The rate of detection of cancer was 1.6% (29/1,845), and the sensitivity, specificity, and positive and negative predictive values were 100% (18/18), 98.7% (1,051/1,065), 56.3% (18/32), and 100% (1,051/1,051), respectively. Of 18 patients who underwent thyroidectomy, three (16.7%) had a pathological tumor staging of T3, and four (22.2%) had a pathological nodal staging of N1a. The average cost of diagnosis for each patient with cancer was $7,319.
Conclusion
Screening thyroid US exhibited a good diagnostic performance, with a feasible social cost of use. This modality demonstrated significant differences in sonographic features between screening-detected cancer and benign nodules.

Citations

Citations to this article as recorded by

Temporal Trends in Thyroid Nodule Size on Ultrasonography
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JAMA Otolaryngology–Head & Neck Surgery.2025; 151(1): 47. CrossRef
Thyroid Ultrasonography Screening of a Cohort of Male University Students
Mahmoud S. Babiker, Fathelrehman A. Alamin, Mohammed Almteri, Abdullah Alradaddi, Waleed Alharbi
Journal of Diagnostic Medical Sonography.2025; 41(3): 225. CrossRef
Ultrasonographic study on the prevalence of thyroid abnormalities in asymptomatic females
Meaad Elbashir, Sara Ali, Sawsan Saidahmed, Awatif M. Omer, Rania Mohammed Ahmed, Aishah Hakami, Asala Jammah, Nuha Hazmi, Areej Faqihi, Ali Abdelrazig
Journal of Radiation Research and Applied Sciences.2025; 18(3): 101645. CrossRef
A nomogram based on clinicopathological and ultrasound characteristics to predict central neck lymph node metastases in papillary thyroid cancer
Fei Chen, Shuiping Jiang, Fan Yao, Yixi Huang, Jiaxi Cai, Jia Wei, Chengxu Li, Yanxuan Wu, Xiaolin Yi, Zhen Zhang
Frontiers in Endocrinology.2024;[Epub] CrossRef
Comparison of the value of ultrasound-guided fine needle aspiration biopsy and contrast-enhanced ultrasound in different sizes of thyroid nodules
Qi Liu, Liquan Ouyang, Shengchu Zhang, Yuxia Yang
Medicine.2024; 103(39): e39843. CrossRef
Diagnostic performance of six ultrasound-based risk stratification systems in thyroid follicular neoplasm: A retrospective multi-center study
Jingjing Yang, Yu Sun, Xingjia Li, Yueting Zhao, Xue Han, Guofang Chen, Wenbo Ding, Ruiping Li, Jianhua Wang, Fangsen Xiao, Chao Liu, Shuhang Xu
Frontiers in Oncology.2022;[Epub] CrossRef
Clinical and ultrasonography evaluation of thyroid tumor screening in symptomatic patient of Bajulmati primary care center, Banyuwangi, East Java, Indonesia
Rosy Setiawati, Tri Wulanhandarini, Fierly Hayati, Dyah Erawati, Merlin Guntur Jaya, Andi Ahmad Thoriq, Triana Mediyawati Wijaya, Galih Nur Ismiyati, Dyan Wahyu Kusumaningrum, Belinda Koesmarsono, Agnes Triana Basja, M. Ikhsan Nugroho, Silvi Yuliana, Syad
Medicine.2022; 101(52): e32546. CrossRef
The use of computed tomography as a first-line imaging modality in patients with primary hyperparathyroidism
Mechteld C. de Jong, K. Jamal, S. Morley, T. Beale, T. Chung, S. Jawad, S. Hurel, H. Simpson, U. Srirangalingam, S. E. Baldeweg, V. Rozalén García, S. Otero, M. Shawky, T. E. Abdel-Aziz, T. R. Kurzawinski
Hormones.2021; 20(3): 499. CrossRef
Sex Bias in Differentiated Thyroid Cancer
Valentine Suteau, Mathilde Munier, Claire Briet, Patrice Rodien
International Journal of Molecular Sciences.2021; 22(23): 12992. CrossRef
Hashimoto Thyroiditis in Primary Thyroid Non-Hodgkin Lymphoma
Antonio Travaglino, Mirella Pace, Silvia Varricchio, Luigi Insabato, Claudia Giordano, Marco Picardi, Fabrizio Pane, Stefania Staibano, Massimo Mascolo
American Journal of Clinical Pathology.2020; 153(2): 156. CrossRef
Changes in the Diagnostic Efficiency of Thyroid Fine-Needle Aspiration Biopsy during the Era of Increased Thyroid Cancer Screening in Korea
Young Ki Lee, Kyeong Hye Park, Young Duk Song, Taemi Youk, Joo Young Nam, Sun Ok Song, Dong Yeob Shin, Eun Jig Lee
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Sonographic Criteria Predictive of Malignant Thyroid Nodules
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Academic Radiology.2017;[Epub] CrossRef

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Clinical Significance of Endometrial Cavity Fluid Detected by Ultrasonography in Patients with Gynecologic Neoplasm: Keun Jai Yoo, Soo Nyung Kim, In Jae Cho, Doo Ho Kim, Hae g Jeon, Jeong Hee Park; J Korean Cancer Assoc. 1994;26(3):460-466.

Abstract PDF: There are a number of different causes of endometrial fluid collections. Hematometra, hematocolpos, pregnancy and its complications, pelvic inflammatory disease, menstruation or exogenous estrogen administration have been reported to cause uterine fluid collections. The sonographically detected endometrial cavity fluid in the postmenopausal women has been described as indicative of uterine malignancy. The purpose of this study was to determine whether sonographic detection of the endometrial cavity fluid might be useful in the evaluation of gynecologic neoplasm. The results were as follows; 1) The sonographic detection rate of endometrial fluid in endometrial hyperplasia, endome- trial cancerm uterine myoma, cervical cancer, benign ovarian tumor were 33%(8/24), 50% (3/6), 11%(7/66), 9%(1/l1), 10%(l/10) respectively. 2) The sonographic detection rate of endometrial cavity fluid in vaginal bleeding was 56%(66/ 117) which was not significantly higher than that of other sy mptoms. 3) The sonographic detection rate(37%) of endometrial fluid in endometrial hyperplasia and cancer was significantly higher than that of other gynecologic neoplasms(10%)(P<0.05). 4) The frequency(10/1l) of vaginal bleeding in endometrial hyperplasia and cancer with endometrial cavity fluid detected by ultrasonography was significantly higher than that of other gynecologic neoplasms(P < 0.05). 5) The amounts of endometrial cavity fluid(mean+1SD) were 1.76+-1.35ml in endometrial hyperplasia, 2.33+-1.16m1 in endometrial cancer, 1.76+-1.35ml in uterine myoma, 8.00+-0.00ml in cervical cancer and 1.000.00ml in benign ovarian tumor. 6) In premenopausal and postmenopausal women, endometrial fluid collections were found in 15(18%) and 5(15%) cases respectively and there was no significant difference between the two groups.

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