Tae Ryool Koo, Hong-Gyun Wu, J. Hun Hah, Myung-Whun Sung, Kwang-Hyun Kim, Bhumsuk Keam, Tae Min Kim, Se-Hoon Lee, Dong-Wan Kim, Dae-Seog Heo, Charn Il Park
Cancer Res Treat. 2012;44(4):227-234. Published online December 31, 2012
PURPOSE The purpose of this study is to analyze treatment outcome of radiotherapy (RT) in patients with stage III-IV tonsil cancer managed by surgery followed by postoperative RT (SRT) and definitive chemoradiotherapy (CRT), and to thereby evaluate the most feasible treatment modality. MATERIALS AND METHODS Of 124 patients, 67 underwent CRT, and 57 underwent SRT. We compared survival and complication rates in both groups. RESULTS The median follow-up time was 57 months (range, 19 to 255 months) for surviving patients. At five years, locoregional progression-free survival (LRPFS) and overall survival (OS) were 88% and 80%, respectively. No significant difference in LRPFS (p=0.491) and OS (p=0.177) was observed between CRT and SRT. In multivariate analysis, old age and higher T stage showed a significant association with poor LRPFS, PFS, and OS; higher N stage showed an association with poor PFS and a trend of poor LRPFS, while no association with OS was observed; treatment modality (CRT and SRT) showed no association with LRFPS, PFS, and OS.
Grade 3 or higher mucositis was observed in 12 patients (21%) in the SRT group, and 25 patients (37%) in the CRT group. CONCLUSION Definitive CRT and SRT have similar treatment outcomes for patients with stage III-IV tonsil cancer.
Although acute complication rate appears to be higher in the CRT group, it should be noted that not all data on complications were included in this retrospective study. To determine the most feasible treatment modality, not only mucositis and xerostomia, but also emotional aspect and quality of life, should be considered.
Citations
Citations to this article as recorded by
Risk of lymph node metastasis in T1 tonsil squamous cell carcinomas patients according to age stratification at diagnosis Yujiao Li, Chaosu Hu American Journal of Otolaryngology.2024; 45(6): 104452. CrossRef
Detection of the high-risk factors for synchronous bone metastasis in tonsillar squamous cell carcinoma Yujiao Li, Chaosu Hu European Archives of Oto-Rhino-Laryngology.2023; 280(10): 4619. CrossRef
The treatment of tonsillar squamous cell carcinoma at Hue Central Hospital Phuong Nam Tran Journal of Clinical Medicine- Hue Central Hospital.2021;[Epub] CrossRef
Chemoradiotherapy versus surgery followed by postoperative radiotherapy in tonsil cancer: Korean Radiation Oncology Group (KROG) study Sanghyuk Song, Hong-Gyun Wu, Chang Geol Lee, Ki Chang Keum, Mi Sun Kim, Yong Chan Ahn, Dongryul Oh, Hyo Jung Park, Sang-Wook Lee, Geumju Park, Sung Ho Moon, Kwan Ho Cho, Yeon-Sil Kim, Yongkyun Won, Young-Taek Oh, Won-Taek Kim, Jae-Uk Jeong BMC Cancer.2017;[Epub] CrossRef
Long-term results of ipsilateral radiotherapy for tonsil cancer Tae Ryool Koo, Hong-Gyun Wu Radiation Oncology Journal.2013; 31(2): 66. CrossRef
Impact of Postoperative Chemoradiotherapy and Chemoradiotherapy Alone for Esophageal Cancer in North-West Iran Seyed Kazem Mirinezhad, Mohammad Hossein Somi, Masoud Shirmohamadi, Farshad Seyednejad, Amir Ghasemi Jangjoo, Morteza Ghojazadeh, Mohammad Mohammadzadeh, Ali Reza Naseri, Behnam Nasiri Asian Pacific Journal of Cancer Prevention.2013; 14(6): 3921. CrossRef