Cancer Research and Treatment

Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review: Pengcheng Zhu, Yaqi Duan, Qilin Ao, Guoping Wang; Cancer Res Treat. 2018;50(4):1452-1457. Published online November 24, 2017; DOI: https://doi.org/10.4143/crt.2017.414

Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case of a right-side testicular tumor in a 33-year-old Chinese male. The tumor is composed of predominantly lobulated cellular nodules separated by hyalinized fibrous stroma and they expressed CD10, β-catenin (nuclear), and cyclin D1. Molecular analysis identified a point mutation (c.110C>G) in exon 3 of CTNNB1. The histopathological features, immunohistochemistry profiles, and molecular analysis of this tumor were consistent with MCST of the ovary. Therefore, a diagnosis of MCST of the right testicle was determined. To the best of our knowledge, this is the first case of MCST occurring in the testicles. The study may provide new insights to the tumor biology of MCST and a better understanding of this rare entity.

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Ovarian Microcystic Stromal Tumor with Significant Nestin Expression: A Unique Case
Bao Wu, Chongming Wu, Dandan Li, Zhanmin Yang, Ying Liu, Hai-Xia Zhang, Hong-Wu Xin, Yuqin Bai
Internal Medicine.2024; 63(20): 2781. CrossRef
Microcystic stromal tumour of testis
Marije Hoogland, Ivar Bleumer, Albert Suurmeijer
BMJ Case Reports.2022; 15(3): e248498. CrossRef
A Morphologic and Immunohistochemical Comparison of Nuclear β-Catenin Expressing Testicular Sertoli Cell Tumors and Pancreatic Solid Pseudopapillary Neoplasms Supporting Their Continued Separate Classification
Chia-Sui Kao, Thomas M. Ulbright
American Journal of Surgical Pathology.2020; 44(8): 1082. CrossRef
Solid pseudopapillary neoplasm (SPN) of the testis: Comprehensive mutational analysis of 6 testicular and 8 pancreatic SPNs
Kvetoslava Michalova, Michael Michal, Monika Sedivcova, Dmitry V. Kazakov, Carlos Bacchi, Tatjana Antic, Marketa Miesbauerova, Ondrej Hes, Michal Michal
Annals of Diagnostic Pathology.2018; 35: 42. CrossRef

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Diffuse Large B-Cell Lymphoma with Involvement of the Breast and Testis in a Male Patient: Eunji Choi, Jae-Cheol Jo, Dok Hyun Yoon, Shin Kim, Kyoungmin Lee, Jooryung Huh, Chan-Sik Park, Sang Wook Lee, Cheolwon Suh; Cancer Res Treat. 2015;47(3):539-543. Published online September 11, 2014; DOI: https://doi.org/10.4143/crt.2013.245

Abstract PDF PubReader ePub

Here we report a case of a 76-year-old man with diffuse large B-cell lymphoma (DLBCL) with simultaneous involvement of the right breast and left testicle. The patient underwent complete resection of the involved testis, followed by immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) and prophylactic radiotherapy to the contralateral testis. Following this multimodal therapy, he achieved a complete response. This is a rare case of DLBCL involving both the breast and the testis in a male patient.

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Rare incidence of diffuse large B-cell lymphoma (DLBCL) with bilateral breast and testicular involvement in a male patient: A case report and review of the literature
Sarah Ayad, Anuraag Sah, Kirolos Gergis, Michelle Cholankeril
Current Problems in Cancer: Case Reports.2022; 5: 100142. CrossRef
Primary breast lymphoma in males: Incidence, demographics, prognostic factors, survival, and comparisons with females
Jie Zhang, Binbin Ma, Hong Ji, Rong Guo
Frontiers in Surgery.2022;[Epub] CrossRef
Diffuse Large B-Cell Breast Lymphoma: A Case Series
Afaf H Al Battah, Einas A Al Kuwari, Zsolt Hascsi, Abdulqadir J Nashwan, Halima Elomari, Hisham Elsabah, Safa Al Azawi, Samah Kohla, Dina Soliman, Mohamed A Yassin
Clinical Medicine Insights: Blood Disorders.2017; 10: 1179545X1772503. CrossRef

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Testis Tumor: A Review of 42 Cases: In Cheol Hwang, Dong Jin Yoon, Sung Hyun Jeon, Cheol Su Kim, Sung Goo Chang, Sun Ju Lee; J Korean Cancer Assoc. 2001;33(2):178-182.

Abstract PDF: PURPOSE
This study was performed in order to evaluate the clinical characteristics, effect of treatment and prognosis in patients with testicular tumors.
MATERIALS AND METHODS
We retrospectively reviewed 42 patients with testicular tumor treated at our hospital. We analyzed the pathologic classification, clinical stage, preoperative tumor markers, treatment methods, clinical characteristics, and prognosis.
RESULTS
The histologic type was seminoma in 11, teratoma in 10, yolk sac tumor in 5, embryonal cell carcinoma in 4, mixed type in 8 and secondary neoplasm in 4. Clinically, 31 patients were stage I, 2 stage IIa, 2 stage IIb, 1 stage IIc, 6 stage IV. Following orchiectomy, 22 patients underwent surveillance, 12 chemotherapy, 4 radiation therapy, 1 retroperitoneal lymph node dissection (RPLND), 2 radiation plus chemotherapy, and 1 radiation plus chemotherapy and RPLND. The 10-year survival rate was 90.9% in the cases of seminoma. Similarly, the 10-year survival rate was 96.0% in the cases of non-seminomatous germ cell tumors (NSGCT).
CONCLUSION
In our study, patients with testicular tumor revealed an excellent survival rate. Testicular tumors are solid tumors that have a possibility of complete remission by additional chemotherapy or radiation following radical surgery. Therefore, early detection and aggressive treatment were mandatory.

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A Case of Metastatic Epididymal and the Other Metastatic Testicular Carcinoma from Sigmoid Carcinoma: Yon Sil Jung, Dong Kyeong Yang, Pill Woon Kim, Chan Il Moon, Seung Won Lee, Hyeon Gyoo Ji, Ji Ho Choi, Jae Hun Lee, Dong Bok Shin, Seung Phil Cho, Jeong Cheol Yoon; J Korean Cancer Assoc. 1997;29(4):706-706.

Abstract PDF: Metastatic tumor of the epididymis is a rare tumor. There are around 31 cases in the literature until now. The primary tumor was from the prostate in 18 cases, large and small intestine in 6 cases, kidney in 4 cases, stomach in 2 cases and pancreas in 1 case. We recently experienced a case of metastatic carcinoma to the epididymis from a primary cancer in the sigmoid colon and the other case of metastatic carcinoma to the testis and the liver from a sigmoid adenocarcinoma.

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A Case of Malignant Testicular Lymphoma with Diffuse Bilateral Renal Involvement: Hyug Chan Suh, Sug Kyun Shin, Young Goo Song, Heon Soo Kim, Kwang Hwa Park, Se Joong Kim, Hugh Chul Kim; J Korean Cancer Assoc. 1995;27(4):686-692.

Abstract PDF: Involvement of testis by malignant lymphoma is rare in young age, comprising only 2% of testicular cancers under 50 years old and 25% of over 50 years old. Testicular lymphoma is frequently bilateral and has a poor prognosis. Testicular lymphoma has a propensity to involve the skin, the central nervous system, Waldeyers ring and adjacent structures. Renal involvement in lymphoma is often manifested as multinodular masses, whereas diffuse renal infiltration is less freguent. Most often, renal involvement of malignant lymphoma is asymptomatic. Of the reported cases of renal insufficiency secondary to diffuse renal infiltration with lymphoma, few have presented with acute renal failure. We present a patient with acute renal failure secondary to diffuse bilateral renal infi1tration and unilateral testicular non-Hodgkin's lymphoma.

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