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Original Articles
Lung and Thoracic cancer
Strategies to Improve Smoking Cessation for Participants in Lung Cancer Screening Program: Analysis of Factors Associated with Smoking Cessation in Korean Lung Cancer Screening Project (K-LUCAS)
Yeol Kim, Jaeho Lee, Eunju Lee, Juntae Lim, Yonghyun Kim, Choon-Taek Lee, Seung Hun Jang, Yu-Jin Paek, Won-Chul Lee, Chan Wha Lee, Hyae Young Kim, Jin Mo Goo, Kui Son Choi, Boyoung Park, Duk Hyoung Lee, Hong Gwan Seo
Cancer Res Treat. 2024;56(1):92-103.   Published online August 7, 2023
DOI: https://doi.org/10.4143/crt.2022.1598
AbstractAbstract PDFPubReaderePub
Purpose
Smoking cessation intervention is one of the key components of successful lung cancer screening program. We investigated the effectiveness and related factors of smoking cessation services provided to the participants in a population-based lung cancer screening trial.
Materials and Methods
The Korean Lung Cancer Screening Project (K-LUCAS) is a nationwide, multi-center lung cancer screening trial that evaluates the feasibility of implementing population-based lung cancer screening. All 5,144 current smokers who participated in the K-LUCAS received a mandatory smoking cessation counseling. Changes in smoking status were followed up using a telephone survey in 6 months after lung cancer screening participation. The lung cancer screening’s impact on smoking cessation is analyzed by variations in the smoking cessation interventions provided in screening units.
Results
Among 4,136 survey responders, participant’s motivation to quit smoking increased by 9.4% on average after lung cancer screening. After 6 months from the initial screening, 24.3% of participants stopped smoking, and 10.6% of participants had not smoked continuously for at least 6 months after screening. Over 80% of quitters stated that participation in lung cancer screening motivated them to quit smoking. Low-cost public smoking cessation program combined with lung cancer screening increased the abstinence rates. The smokers were three times more likely to quit smoking when the smoking cessation counseling was provided simultaneously with low-dose computed tomography screening results than when provided separately.
Conclusion
A mandatory smoking cessation intervention integrated with screening result counselling by a physician after participation in lung cancer screening could be effective for increasing smoking cessation attempts.

Citations

Citations to this article as recorded by  
  • p53 Genetics and Biology in Lung Carcinomas: Insights, Implications and Clinical Applications
    Dixan A. Benitez, Guadalupe Cumplido-Laso, Marcos Olivera-Gómez, Nuria Del Valle-Del Pino, Alba Díaz-Pizarro, Sonia Mulero-Navarro, Angel Román-García, Jose Maria Carvajal-Gonzalez
    Biomedicines.2024; 12(7): 1453.     CrossRef
  • Problems and Alternatives for Korea National Lung Cancer Screening Program for Smoking Cessation: Analysis of a Survey Involving Experts
    Cheol Min Lee, Sil Vi Han Park, Jinri Kim, Bumjo Oh, Kiheon Lee, Yeol Kim, Yu-Jin Paek
    Journal of the Korean Society for Research on Nicotine and Tobacco.2024; 15(2): 49.     CrossRef
  • The pros and cons of lung cancer screening
    Roberta Eufrasia Ledda, Georg-Christian Funk, Nicola Sverzellati
    European Radiology.2024;[Epub]     CrossRef
  • Effective Smoking Cessation Counseling for Participants in a Lung Cancer Screening
    Choon-Young Kim, Yeol Kim, Cheol Min Lee
    Journal of the Korean Society for Research on Nicotine and Tobacco.2024; 15(3): 88.     CrossRef
  • 3,228 View
  • 215 Download
  • 2 Web of Science
  • 4 Crossref
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General
Longitudinal Changes in Smoking Behaviors and Cancer-Related Mortality Risk in Middle-Aged Korean Women
Thi Xuan Mai Tran, Soyeoun Kim, Seonju Kim, Boyoung Park
Cancer Res Treat. 2024;56(1):18-26.   Published online August 2, 2023
DOI: https://doi.org/10.4143/crt.2023.341
AbstractAbstract PDFPubReaderePub
Purpose
This study investigated association between smoking habit change and cancer-related mortality risk in Korean women.
Materials and Methods
Study population were women aged ≥ 40 years who underwent two biennial cancer screenings during 2009-2012 and were followed up until 2020. Participants were grouped into sustained nonsmokers, sustained quitters, new quitters, relapsers/smoking initiators, and sustained smokers. Outcomes included all-cause and cancer-related deaths. Cox regression and competing risk analysis was used to assess association between smoking habit change and mortality risk.
Results
Of 2,892,590 women, 54,443 death cases were recorded (median follow-up of 9.0 years). Compared with sustained nonsmokers, mortality risk from all causes and cancer-related causes increased in all other smoking groups. Cancer-related risk increased 1.22-fold among sustained quitters (95% confidence interval [CI], 1.10 to 1.36), 1.56-fold (95% CI, 1.40 to 1.75) in new quitters, 1.40-fold (95% CI, 1.21 to 1.62) in relapsers/smoking initiators, and 1.61-fold (95% CI, 1.46 to 1.78) in sustained smokers compared with sustained nonsmokers. Women who were sustained smokers with higher smoking intensity had a higher mortality risk in terms of hazard ratios compared to nonsmokers (< 5 pack-years 2.12-fold, 5-10 pack-years 2.15-fold, and > 10 pack-years 2.27-fold).
Conclusion
Quitting smoking earlier is critical for preventing death from all causes and cancer among female smokers.
  • 3,157 View
  • 236 Download
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Adherence to Cancer Prevention Guidelines and Cancer Incidence and Mortality: A Population-Based Cohort Study
Jin-Kyoung Oh, Minji Han, Byungmi Kim, Eun Young Park
Cancer Res Treat. 2023;55(1):15-27.   Published online March 22, 2022
DOI: https://doi.org/10.4143/crt.2021.1031
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
This study aimed to estimate the risk of cancer incidence and mortality according to adherence to lifestyle-related cancer prevention guidelines.
Materials and Methods
Men and women who participated in the general health screening program in 2002 and 2003 provided by the National Health Insurance Service were included (n=8,325,492). Self-reported smoking, alcohol consumption, and physical activity habits and directly measured body mass index were collected. The participants were followed up until the date of cancer onset or death or 31 December 2018. The Cox proportional hazard model was used to evaluate the hazard ratio (HR) for cancer incidence and mortality according to different combinations of lifestyle behaviors.
Results
Only 6% of men and 15% of women engaged in healthy behavior at baseline, such as not smoking, not drinking alcohol, being moderately or highly physically active, and within a normal body mass index range. Compared to the best combination of healthy lifestyle behaviors, the weak and moderate associations with increased all cancer incidence (HR < 1.7) and mortality (HR < 2.5) were observed in those with heavy alcohol consumption and in former or current smokers. HRs of cancer mortality were significantly increased among current smokers in most combinations.
Conclusion
Compared to full adherence to cancer prevention recommendations, unhealthy behaviors increase cancer risk. As few people meet these recommendations, there is a great opportunity for cancer prevention.

Citations

Citations to this article as recorded by  
  • Increased risk of cardiovascular disease among kidney cancer survivors: a nationwide population-based cohort study
    Minji Jung, Eunjung Choo, Shufeng Li, Zhengyi Deng, Jinhui Li, Mingyi Li, Satvir Basran, Sukhyang Lee, Marvin E. Langston, Benjamin I. Chung
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Cancer survivors’ adherence to the American cancer society and American institute of cancer research dietary guidelines in Lebanon
    Jana Jabbour, Remie El Helou, Ruba Hadla, Riwa Azar, Maria Mezher, Farah Naja, Sally Temraz
    BMC Public Health.2024;[Epub]     CrossRef
  • Longitudinal Trends of Comorbidities and Survival Among Kidney Cancer Patients in Asian Population
    Minji Jung, Eunjung Choo, Jinhui Li, Zhengyi Deng, Marvin E. Langston, Sukhyang Lee, Benjamin I. Chung
    Cancer Medicine.2024;[Epub]     CrossRef
  • Combinations of lifestyle behaviors and cancer risk among Korean adults
    Ngoc Minh Luu, Thi Tra Bui, Thi Phuong Thao Tran, Thi Huyen Trang Nguyen, Jin-Kyoung Oh
    Scientific Reports.2023;[Epub]     CrossRef
  • Individual and joint effect of socioeconomic status and lifestyle factors on cancer in Korea
    Chi Lan Tran, Kui Son Choi, Sun‐Young Kim, Jin‐Kyoung Oh
    Cancer Medicine.2023; 12(16): 17389.     CrossRef
  • Tumorkachexie: die Bedeutung von Ernährung und Bewegung in der Onkologie
    Yurdagül Zopf, Hans Joachim Herrmann, Dejan Reljic, Luisa Marie Hardt
    Zeitschrift für Komplementärmedizin.2023; 15(06): 12.     CrossRef
  • Adherence to the World Cancer Research Fund/American Institute for Cancer Research and Korean Cancer Prevention Guidelines and cancer risk: a prospective cohort study from the Health Examinees-Gem study
    Jeeyoo Lee, Aesun Shin, Woo-Kyoung Shin, Ji-Yeob Choi, Daehee Kang, Jong-Koo Lee
    Epidemiology and Health.2023; 45: e2023070.     CrossRef
  • 6,254 View
  • 278 Download
  • 5 Web of Science
  • 7 Crossref
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Prevalence and Predictors of Sustained Smoking after a Cancer Diagnosis in Korean Men
Hye Yeon Koo, Kiheon Lee, Sang Min Park, Jooyoung Chang, Kyuwoong Kim, Seulggie Choi, Mi Hee Cho, Jihye Jun, Sung Min Kim
Cancer Res Treat. 2020;52(1):139-148.   Published online June 25, 2019
DOI: https://doi.org/10.4143/crt.2018.609
AbstractAbstract PDFPubReaderePub
Purpose
Although smoking has a significant impact on mortality and morbidity of cancer patients, many patients continue to smoke post-diagnosis. The purpose of this study was to investigate prevalence and predictors of sustained smoking among male cancer survivors.
Materials and Methods
The Korean National Health Insurance Service-National Health Screening Cohort database was used for this population-based, retrospective study. Study subjects were 15,141 men who were diagnosed with their first incident cancer between 2004 and 2011. Changes in smoking status before and after a cancer diagnosis were investigated. For patients who were current smokers pre-diagnosis, association between post-diagnosis sustained smoking and demographic, socioeconomic, and clinical variables were examined.
Results
Of the 4,657 pre-diagnosis smokers, 2,255 (48%) had quit after cancer diagnosis, while 2,402 (51.6%) continued to smoke. In a multivariate logistic regression analysis, younger age at cancer diagnosis (adjusted odds ratio [aOR], 1.37; 95% confidence interval [CI], 1.21 to 1.55; p < 0.001), low socioeconomic status (aOR, 1.29; 95% CI, 1.15 to 1.45; p ≤ 0.001), pre-diagnosis heavy smoking (aOR, 1.24; 95% CI, 1.09 to 1.41; p=0.001), diagnosis of non-smoking– related cancer (aOR, 1.67; 95% CI, 1.42 to 1.96; p < 0.001), and high serum glucose level (aOR, 1.23; 95% CI, 1.03 to 1.46; p=0.019) were associated with sustained smoking after a cancer diagnosis.
Conclusion
Almost half of the male smokers continue to smoke after a cancer diagnosis. Targeted interventions for smoking cessation should be considered for patients with younger age, low socioeconomic status, heavy smoking history, non-smoking–related cancer, and high blood glucose levels.

Citations

Citations to this article as recorded by  
  • Prevalence of Current Cigarette Smoking by Sociodemographic Characteristics in U.S. Cancer Survivors
    Liza M. González Ruiz, Lía I. Mondragón Márquez, Daniela L. Domínguez Bueso, Jason J. Liu
    Substance Use & Misuse.2024; 59(4): 486.     CrossRef
  • Healthy lifestyle and cancer survival: A multinational cohort study
    Zilong Bian, Rongqi Zhang, Shuai Yuan, Rong Fan, Lijuan Wang, Susanna C. Larsson, Evropi Theodoratou, Yimin Zhu, Shouling Wu, Yuan Ding, Xue Li
    International Journal of Cancer.2024; 154(10): 1709.     CrossRef
  • Smoking Cessation Support: A Marathon, Not a Sprint; The Perspectives of Cancer Patients Who Smoke
    Patricia Fox, Nancy Bhardwaj, Ailsa Lyons, Vikram Niranjan, Kate Frazer, Shiraz Syed, Amanda McCann, Sinead Brennan, Donal Brennan, Catherine Kelly, Michael Keane, Patricia Fitzpatrick
    Seminars in Oncology Nursing.2024; 40(2): 151584.     CrossRef
  • Association Between Cardiovascular Event Type and Smoking Cessation Rates Among Outpatients With Atherosclerotic Cardiovascular Disease: Insights From the NCDR PINNACLE Registry
    Vittal Hejjaji, Edward F. Ellerbeck, Philip G. Jones, Christina M. Pacheco, Ali O. Malik, Paul S. Chan, John A. Spertus, Suzanne V. Arnold
    Circulation: Cardiovascular Quality and Outcomes.2024;[Epub]     CrossRef
  • Determinants of persistent smoking among breast cancer survivors
    Kathleen Gali, Sita Aryal, Frederike Bokemeyer, Sabine Behrens, Petra Seibold, Nadia Obi, Heiko Becher, Jenny Chang-Claude
    Preventive Medicine Reports.2024; 48: 102913.     CrossRef
  • Factors associated with successful smoking cessation in men with or without cardiovascular disease or cancer: Nationwide Korean population analysis
    Youngmee Kim, Won-Kyung Cho
    Tobacco Induced Diseases.2023; 21(February): 1.     CrossRef
  • Mortality risk according to smoking trajectories after cancer diagnosis among Korean male cancer survivors: A population-based cohort study
    Thi Tra Bui, Minji Han, Ngoc Minh Luu, Thi Phuong Thao Tran, Sun Young Kim, Young Ae Kim, Min Kyung Lim, Jin-Kyoung Oh
    Tobacco Induced Diseases.2023; 21(May): 1.     CrossRef
  • Challenges posed by COVID‐19 in cancer patients: A narrative review
    Zeinab Mohseni Afshar, Rezvan Hosseinzadeh, Mohammad Barary, Soheil Ebrahimpour, Amirmasoud Alijanpour, Babak Sayad, Dariush Hosseinzadeh, Seyed Rouhollah Miri, Terence T. Sio, Mark J. M. Sullman, Kristin Carson‐Chahhoud, Arefeh Babazadeh
    Cancer Medicine.2022; 11(4): 1119.     CrossRef
  • Quitting Smoking At or Around Diagnosis Improves the Overall Survival of Lung Cancer Patients: A Systematic Review and Meta-Analysis
    Saverio Caini, Marco Del Riccio, Virginia Vettori, Vieri Scotti, Chiara Martinoli, Sara Raimondi, Giulio Cammarata, Domenico Palli, Marco Banini, Giovanna Masala, Sara Gandini
    Journal of Thoracic Oncology.2022; 17(5): 623.     CrossRef
  • Cessation experiences and quitting perspectives of Jordanian cancer patients who smoke
    Feras I. Hawari, Minas A. Abu Alhalawa, Rasha H. Alshrideh, Ahmad M. Al Nawaiseh, Alia Khamis, Yasmeen I. Dodin, Nour A. Obeidat
    Cancer Epidemiology.2022; 79: 102207.     CrossRef
  • Changes in cigarette smoking behavior among breast cancer and unaffected women – A prospective study in the MARIE cohort
    Kathleen Gali, Frederike Bokemeyer, Sabine Behrens, Annika Möhl, Nadia Obi, Heiko Becher, Jenny Chang-Claude
    Cancer Epidemiology.2022; 81: 102282.     CrossRef
  • Supporting Smokers in Difficult Settings: Suggestions for Better Education and Counseling in Cancer Centers in Jordan
    Feras I. Hawari, Minas A. Abu Alhalawa, Rasha H. Alshraiedeh, Ahmad M. Al Nawaiseh, Alia Khamis, Yasmeen I. Dodin, Nour A. Obeidat
    Current Oncology.2022; 29(12): 9335.     CrossRef
  • Efficacy of an inpatient smoking cessation program at a single regional cancer center
    Ha-Young Park, Yu-Ri Choe, In-Jae Oh, Min-Seok Kim, Bo Gun Kho, Hong-Joon Shin, Cheol Kyu Park, Yu-Il Kim, Young-Chul Kim, Hye-Ran Ahn, Sun-Seog Kweon
    Medicine.2021; 100(6): e24745.     CrossRef
  • Smoking Cessation in Cancer Survivors
    Young Gyu Cho
    Korean Journal of Family Medicine.2021; 42(4): 258.     CrossRef
  • Impact of Family and Social Network on Tobacco Cessation Amongst Cancer Patients
    Melissa Neumann, Neal Murphy, Nagashree Seetharamu
    Cancer Control.2021;[Epub]     CrossRef
  • 6,374 View
  • 188 Download
  • 15 Web of Science
  • 15 Crossref
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Active and Passive Smoking, BRAFV600E Mutation Status, and the Risk of Papillary Thyroid Cancer: A Large-Scale Case-Control and Case-Only Study
Kyoung-Nam Kim, Yunji Hwang, Kyungsik Kim, Kyu Eun Lee, Young Joo Park, June Young Choi, Do Joon Park, BeLong Cho, Daehee Kang, Sue K. Park
Cancer Res Treat. 2019;51(4):1392-1399.   Published online February 20, 2019
DOI: https://doi.org/10.4143/crt.2018.612
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The association between tobacco smoking and thyroid cancer remains uncertain. We evaluated the associations of active and passive smokingwith the risk of papillary thyroid cancer (PTC), the most common type of thyroid cancer, and with the BRAFV600E mutation, the most common oncogenic mutation in PTC related to poor prognosis.
Materials and Methods
We conducted this study with newly diagnosed PTC patients (n=2,142) and community controls (n=21,420) individually matched to cases for age and sex. Information on active and passive smoking and potential confounders were obtained from structured questionnaires, anthropometric measurements, and medical records. BRAFV600E mutation status was assessed in PTC patients. We evaluated the associations of active and passive smoking with PTC and BRAFV600E mutation risk using conditional and unconditional logistic regression models, respectively.
Results
We did not find associations between exposure indices of active and passive smoking and PTC risk in both men and women, except for the association between current smoking and lower PTC risk. Cumulative smoking ≥ 20 pack-years was associated with lower BRAFV600E mutation risk in male PTC patients (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.30 to 1.00). The CI for the association was wider in female PTC patients (OR, 0.23; 95% CI, 0.02 to 2.62), possibly owing to a smaller sample size in this stratum.
Conclusion
We did not find consistent associations between active and passive smoking and PTC risk. Cumulative smoking ≥ 20 pack-years was associated with lower BRAFV600E mutation risk in male PTC patients.

Citations

Citations to this article as recorded by  
  • Geographic variation in the association between Hashimoto’s thyroiditis and Papillary thyroid carcinoma, a meta-analysis
    Nabil W. G. Sweis, Ayman A. Zayed, Mira Al Jaberi, Lina AlQirem, Tala Basheer Hyasat, Farah A. Khraisat, Ward Maaita, Ahmad Moayad Naser, Abdullah Nimer, Mamoon Qatamin, Jaleel J. G. Sweis, Nadia Sweis, Abdallah T. Al-Ani, Ahmad M. Alghrabli, Alireza Hagh
    Endocrine.2023; 81(3): 432.     CrossRef
  • Sex-specific Associations between Body Mass Index and Thyroid Cancer Incidence among Korean Adults
    Kyoung-Nam Kim, Kyungsik Kim, Sangjun Lee, Sue K. Park
    Cancer Epidemiology, Biomarkers & Prevention.2023; 32(9): 1227.     CrossRef
  • Effect of Cigarette Smoking on Thyroid Cancer: Meta-Analysis
    Joon-Hyop Lee, Young Jun Chai, Ka Hee Yi
    Endocrinology and Metabolism.2021; 36(3): 590.     CrossRef
  • Tobacco smoking and risk of thyroid cancer according to BRAFV600E mutational subtypes
    Sabbir T. Rahman, Nirmala Pandeya, Rachel E. Neale, Donald S. A. McLeod, Peter D. Baade, Philippa H. Youl, Roger Allison, Susan Leonard, Susan J. Jordan
    Clinical Endocrinology.2021; 95(6): 891.     CrossRef
  • circFAT1(e2) Promotes Papillary Thyroid Cancer Proliferation, Migration, and Invasion via the miRNA-873/ZEB1 Axis
    Jiazhe Liu, Hongchang Li, Chuanchao Wei, Junbin Ding, Jingfeng Lu, Gaofeng Pan, Anwei Mao, Tao Huang
    Computational and Mathematical Methods in Medicine.2020; 2020: 1.     CrossRef
  • 6,301 View
  • 187 Download
  • 5 Web of Science
  • 5 Crossref
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Effect of Smoking Cessation and Reduction on the Risk of Cancer in Korean Men: A Population Based Study
Seulggie Choi, Jooyoung Chang, Kyuwoong Kim, Sang Min Park, Kiheon Lee
Cancer Res Treat. 2018;50(4):1114-1120.   Published online November 24, 2017
DOI: https://doi.org/10.4143/crt.2017.326
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The purpose of this study was to investigate the effect of smoking habit change on the risk of cancer.
Materials and Methods
From the Korean National Health Insurance Service database, we determined the change in smoking habit between the first (2002 and 2003) and second (2004 and 2005) health examination periods. A total of 143,071 men were categorized into baseline heavy (≥ 20 cigarettes per day), moderate (10-19 cigarettes per day), light (< 10 cigarettes per day) smokers, quitters, and never smokers, after which the change in smoking status was determined during the second health examination. The participants were then followed up from 2006 to 2013 for all cancer, smoking related cancer, and lung cancer.
Results
Compared to heavy continual smokers, heavy smokers who quit had reduced risk of smoking related cancer (hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.56 to 0.97) and tended to have reduced risk of all cancer (HR, 0.87; 95% CI, 0.75 to 1.00). Moderate smokers who reduced the amount of smoking to light levels had decreased risk of all cancer (HR, 0.82; 95% CI, 0.72 to 0.94), smoking related cancer (HR, 0.74; 95% CI, 0.59 to 0.93), and lung cancer (HR, 0.55; 95% CI, 0.38 to 0.79) compared to heavy continual smokers.
Conclusion
Smoking reduction decreases the risk of all cancer, smoking related cancer, and lung cancer. While smoking cessation should be the treatment of choice for smokers, smoking reduction may serve as an alternative strategy for those who cannot quit.

Citations

Citations to this article as recorded by  
  • Cancer Risk Following Smoking Cessation in Korea
    Eunjung Park, Hee-Yeon Kang, Min Kyung Lim, Byungmi Kim, Jin-Kyoung Oh
    JAMA Network Open.2024; 7(2): e2354958.     CrossRef
  • Impact of smoking reduction on lung cancer risk in patients with COPD who smoked fewer than 30 pack-years: a nationwide population-based cohort study
    Sun Hye Shin, Taeyun Kim, Hyunsoo Kim, Juhee Cho, Danbee Kang, Hye Yun Park
    Respiratory Research.2024;[Epub]     CrossRef
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    Daniela S Gutiérrez-Torres, Sungduk Kim, Demetrius Albanes, Stephanie J Weinstein, Maki Inoue-Choi, Paul S Albert, Neal D Freedman
    JNCI: Journal of the National Cancer Institute.2024; 116(6): 895.     CrossRef
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    Pojsakorn Danpanichkul, Thanida Auttapracha, Siwanart Kongarin, Ben Ponvilawan, Daniel M. Simadibrata, Kwanjit Duangsonk, Supitchaya Jaruvattanadilok, Sakditad Saowapa, Kanokphong Suparan, Rashid N. Lui, Suthat Liangpunsakul, Michael B. Wallace, Karn Wija
    Journal of Gastroenterology and Hepatology.2024; 39(9): 1856.     CrossRef
  • Smoking cessation rate and predictors of successful quitting in Jordan: A cross-sectional study
    Nuha W. Qasem, Batool H. Al-Omoush, Sami K. Altbeinat, Moutasem M. Al-Dlaijem, Reham I. Salahat, Samer A. Okour
    Medicine.2024; 103(27): e38708.     CrossRef
  • Smoking-attributable Mortality in Korea, 2020: A Meta-analysis of 4 Databases
    Eunsil Cheon, Yeun Soo Yang, Suyoung Jo, Jieun Hwang, Keum Ji Jung, Sunmi Lee, Seong Yong Park, Kyoungin Na, Soyeon Kim, Sun Ha Jee, Sung-il Cho
    Journal of Preventive Medicine and Public Health.2024; 57(4): 327.     CrossRef
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    Xudong Wang, Zihan Wang, Xujie Wang
    PeerJ.2024; 12: e18017.     CrossRef
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    Jung Eun Yoo, Kyungdo Han, Jin‐Hyung Jung, Yang‐Im Hur, Yang Hyun Kim, Eun Sook Kim, Jang Won Son, Eun‐Jung Rhee, Won‐Young Lee, Ga Eun Nam
    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 369.     CrossRef
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    Jing-Rong Jhuang, Po-Chun Chiu, Tung-Che Hsieh, Chung-Hsin Chen, Yeong-Shiau Pu, Wen-Chung Lee
    Frontiers in Public Health.2023;[Epub]     CrossRef
  • Association between smoking and obstructive sleep apnea based on the STOP-Bang index
    Yun Seo Jang, Nataliya Nerobkova, Kyungduk Hurh, Eun-Cheol Park, Jaeyong Shin
    Scientific Reports.2023;[Epub]     CrossRef
  • The effects of smoking habit change on the risk of depression–Analysis of data from the Korean National Health Insurance Service
    Ga Eun Kim, Min-ho Kim, Weon-Jeon Lim, Soo In Kim
    Journal of Affective Disorders.2022; 302: 293.     CrossRef
  • Effect of smoking reduction, cessation, and resumption on cancer risk: A nationwide cohort study
    Jung Eun Yoo, Kyungdo Han, Dong Wook Shin, Wonyoung Jung, Dahye Kim, Cheol Min Lee, Hyuktae Kwon, Kyu‐Won Jung, Yun‐Mi Song
    Cancer.2022; 128(11): 2126.     CrossRef
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    Ananyaa Mohan, Inge Huybrechts, Nathalie Michels
    European Journal of Cancer Prevention.2022; 31(6): 585.     CrossRef
  • Smoking trajectory and cancer risk: A population-based cohort study
    Minh Luu, Minji Han, Tra Bui, Phuong Thao Tran, Min-Kyung Lim, Jin Oh
    Tobacco Induced Diseases.2022; 20(August): 1.     CrossRef
  • Longitudinal Changes in Smoking Habits in Women and Subsequent Risk of Cancer
    Thi Xuan Mai Tran, Soyeoun Kim, Huiyeon Song, Boyoung Park
    American Journal of Preventive Medicine.2022; 63(6): 894.     CrossRef
  • Health promotion: the essence of primary healthcare
    Sung Sunwoo
    Journal of the Korean Medical Association.2022; 65(12): 772.     CrossRef
  • Cigarette Smoking Reduction and Health Risks: A Systematic Review and Meta-analysis
    Joanne T Chang, Gabriella M Anic, Brian L Rostron, Manju Tanwar, Cindy M Chang
    Nicotine & Tobacco Research.2021; 23(4): 635.     CrossRef
  • Decreased Levels of Soluble CD44 in a High-Risk Population following a Smoking Cessation Program
    Drew H. Smith, Shahm Raslan, Isildinha M. Reis, Abdurrahman Al-Awady, Isabella Buitron, Melanie Perez, Huaping Liu, Jerri Halgowich, Claudia Gordon, Monica Webb Hooper, Noël C. Barengo, Elizabeth J. Franzmann
    International Journal of Environmental Research and Public Health.2021; 18(24): 13174.     CrossRef
  • Exposure to oral bisphosphonates and risk of gastrointestinal cancer
    D. Choi, S. Choi, J. Chang, S. M. Park
    Osteoporosis International.2020; 31(4): 775.     CrossRef
  • Smoking Cessation Improves the Symptoms and the Findings of Laryngeal Irritation
    A. Secil Kayalı Dinc, Melih Cayonu, Tijen Sengezer, M. Melih Sahin
    Ear, Nose & Throat Journal.2020; 99(2): 124.     CrossRef
  • Association between Post-Diagnosis Particulate Matter Exposure among 5-Year Cancer Survivors and Cardiovascular Disease Risk in Three Metropolitan Areas from South Korea
    Seulggie Choi, Kyae Hyung Kim, Kyuwoong Kim, Jooyoung Chang, Sung Min Kim, Seong Rae Kim, Yoosun Cho, Gyeongsil Lee, Joung Sik Son, Sang Min Park
    International Journal of Environmental Research and Public Health.2020; 17(8): 2841.     CrossRef
  • Cigarette Smoking Is Associated with Increased Risk of Malignant Gliomas: A Nationwide Population-Based Cohort Study
    Stephen Ahn, Kyung-Do Han, Yong-Moon Park, Jung Min Bae, Sang Uk Kim, Sin-Soo Jeun, Seung Ho Yang
    Cancers.2020; 12(5): 1343.     CrossRef
  • The Association of Smoking Exposure at Home with Attempts to Quit Smoking and Cessation Success: A Survey of South Korean Adolescents Who Smoke
    Wonjeong Jeong, Yun Kyung Kim, Jae Hong Joo, Sung-In Jang, Eun-Cheol Park
    International Journal of Environmental Research and Public Health.2020; 17(11): 4129.     CrossRef
  • Exploring smoking cessation behaviors of outpatients in outpatient clinics
    Ching-Yi Hsu, Hung-En Liao, Li-Chun Huang
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Risk Factors for Thyroid Cancer: A Hospital-Based Case-Control Study in Korean Adults
Seung-Kwon Myung, Chan Wha Lee, Jeonghee Lee, Jeongseon Kim, Hyeon Suk Kim
Cancer Res Treat. 2017;49(1):70-78.   Published online June 23, 2016
DOI: https://doi.org/10.4143/crt.2015.310
AbstractAbstract PDFPubReaderePub
Purpose
Although the incidence of thyroid cancer in Korea has rapidly increased over the past decade, few studies have investigated its risk factors. This study examined the risk factors for thyroid cancer in Korean adults.
Materials and Methods
The study design was a hospital-based case-control study. Between August 2002 and December 2011, a total of 802 thyroid cancer cases out of 34,211 patients screened from the Cancer Screenee. Cohort of the National Cancer Center in South Korea were included in the analysis. A total of 802 control cases were selected from the same cohort, and matched individually (1:1) by age (±2 years) and area of residence for control group 1 and additionally by sex for control group 2.
Results
Multivariate conditional logistic regression analysis using the control group 1 showed that females and those with a family history of thyroid cancer had an increased risk of thyroid cancer, whereas ever-smokers and those with a higher monthly household income had a decreased risk of thyroid cancer. On the other hand, the analysis using control group 2 showed that a family history of cancer and alcohol consumption were associated with a decreased risk of thyroid cancer, whereas higher body mass index (BMI) and family history of thyroid cancer were associated with an increased risk of thyroid cancer.
Conclusion
These findings suggest that females, those with a family history of thyroid cancer, those with a higher BMI, non-smokers, non-drinkers, and those with a lower monthly household income have an increased risk of developing thyroid cancer.

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Effects of Polymorphisms of Innate Immunity Genes and Environmental Factors on the Risk of Noncardia Gastric Cancer
Jeongseon Kim, Young Ae Cho, Il Ju Choi, Yeon-Su Lee, Sook-Young Kim, Jung-Ah Hwang, Soo-Jeong Cho, Myeong-Cherl Kook, Chan Gyoo Kim, Young-Woo Kim
Cancer Res Treat. 2013;45(4):313-324.   Published online December 31, 2013
DOI: https://doi.org/10.4143/crt.2013.45.4.313
AbstractAbstract PDFPubReaderePub
PURPOSE
Increasing evidence suggests that polymorphisms in innate immunity genes are associated with Helicobacter pylori-induced inflammation and may influence susceptibility in developing noncardia gastric cancer. Therefore, we investigate the effect of polymorphisms of innate immunity genes and interactions with environmental factors in the Korean population.
MATERIALS AND METHODS
We genotyped four polymorphisms of TLR2 (rs1898830), TLR4 (rs10983755 and rs10759932), and CD14 (rs2569190) in a case-control study of 487 noncardia gastric cancer patients and 487 sex- and age-matched healthy controls. Polytomous logistic regression models were used to detect the effects of genetic polymorphisms and environmental factors, which were stratified by the histological type of gastric cancer.
RESULTS
TLR4 rs10983755 A carriers were found to have higher risk of intestinal-type noncarida gastric cancer than G homozygotes (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.01 to 1.97), but other genetic variants showed no association with the risk of noncardia gastric cancer. Among H. pylori-positive participants, smokers carrying TLR4 rs10983755 A had a higher risk of intestinal-type gastric cancer than nonsmoking TLR4 rs10983755 G homozygotes (OR, 4.28; 95% CI, 2.12 to 8.64). In addition, compared with tap water, other drinking water sources during childhood were found to be associated with the elevated risk of intestinal-type gastric cancer, and these associations were slightly stronger among TLR4 rs10983755 A carriers.
CONCLUSION
The genetic polymorphisms of innate immunity genes are associated with the development of intestinal-type noncardia gastric cancer and these associations may differ in accordance to an exposure to certain environmental factors.

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Review Article
Passive Smoking and Lung Cancer
Hwangbo Bin, Jin Soo Lee
Cancer Res Treat. 2003;35(2):90-95.   Published online April 30, 2003
DOI: https://doi.org/10.4143/crt.2003.35.2.90
AbstractAbstract PDF
Passive smoking is an important risk factor for lung cancer and its impact might be more significant than generally appreciated in Korea. We reviewed the literatures that support the biologic plausibility of Environmental Tobacco Smoke (ETS) causing lung cancer and summarized epidemiological evidences. Because ETS exposure is a preventable risk factor, more social efforts should be directed to reduce ETS exposure.
  • 3,226 View
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Original Articles
Interaction between Genetic Polymorphisms of CYP2E1 & NAT1 and Smoking in Lung Cancer Development (Preliminary report)
Kyoung Mu Lee, Seung Joon Lee, Sue Kyung Park, Sang Yun Lee, Hyung June Im, Ki Jung Yoon, In Mi Choi, Young Ju Lee, Soo Ung Kim, Hwang Choi, Seung Ho Choi, Young Whan Kim, Soo Han Cho, Daehee Kang
J Korean Cancer Assoc. 2001;33(1):41-48.
AbstractAbstract PDF
PURPOSE
The interactive effects of genetic polymorphisms of cytochrome P4502E1 (CYP2E1) & N-acetyltransferase 1 (NAT1) and smoking on lung cancer development were evaluated in hospital based case-control study.
MATERIALS AND METHODS
Male lung cancer patients (N= 157) and the male patients with no present or previous history of systemic illnesses who visited the urology department (N=138) were recruited (1998-1999). CYP2E1 & NAT1 genotypes were determined by PCR-RFLP method using RsaI and MboII digestion, respectively.
RESULTS
CYP2E1 c2 or NAT1 *10 allele did not increased the risk of lung cancer. Heavy smokers (35CONCLUSION
These results suggest the gene-environment interaction between genetic polymorphisms of CYP2E1 & NAT1 and smoking in lung cancer development.
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p 53 Expression in Non - Small Cell Lung Cancer: Its relationship to the clinical prognostic factor and smoking history
Moon Kyung Kim, Han Kyeom Kim, In Sun Kim, Joung Ho Han, Seung Jae Huh, Yong Chan Ahn, Dae Yong Kim, Young Mok Shim
J Korean Cancer Assoc. 1999;31(6):1219-1226.
AbstractAbstract PDF
PURPOSE
p53 mutations are one of the most common genetic alterations in human lung cancer. Although the prognostic value of mutant p53 is still debated, it is widely accepted as a relatively early genetic event in the development and progression of lung cancer. Moreover, there are growing reports about an association between smoking and p53 mutation, suggesting that the p53 gene could be a target of the smoking associated carcino- genesis in the lung cancer.
MATERIALS AND METHODS
Surgically resected 89 primary non-small cell lung cancers were obtained from May of 1995 to May of 1997. p53 expression and Ki-67 expression were measured by immunohistochemistry, and each p53 expression and smoking amount were compared with Ki-67 expression and other clinical prognostic factors.
RESULTS
Positive p53 expressions were found in 52 (58%) specimens, including 38 (69%) squamous cell carcinomas, 11 (39%) adenocarcinomas, and 3 (50%) large cell carcinomas, and closely associated with male and squamous cell carcinoma. Also close correlation was observed between smoking amount and p53 expression by the regression analysis. But p53 and Ki-67 expression showed no associations in pathologic stage and survival, and there was no association between p53 expression and survival after adjuvant radiotherapy.
CONCLUSION
Smoking seems to affect p53 mutations in non-small cell lung cancer, and additional efforts are needed to evaluate the carcinogesis of lung cancer.
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