Cancer Research and Treatment

Case Reports

A Case of Multiple Intussusceptions in the Small Intestine Caused by Metastatic Renal Cell Carcinoma: Wan Kyu Eo, Gou Young Kim, Sung Il Choi; Cancer Res Treat. 2008;40(2):97-99. Published online June 30, 2008; DOI: https://doi.org/10.4143/crt.2008.40.2.97

Renal cell carcinoma (RCC) may metastasize to almost any organ, but metastasis to the small bowel is rare. Small bowel metastasis from RCC can induce obstruction or bleeding, and perforation can also be induced in rare case. Yet RCC metastasis to the small bowel is unlikely to be a direct cause of intussusceptions. A few cases of intussusceptions caused by small intestinal metastasis of RCC have been reported, but multiple small intestinal intussusceptions are extremely rare. We report here on a 47-year-old male patient who presented to the emergency room with acute abdominal pain. He had undergone radical nephrectomy 2 years previously due to left RCC. The abdominal CT scan revealed enhanced masses with the "target" sign that suggested enteric intussusceptions in the jejunum. Eight pedunculated masses within the small intestinal lumen led to intussusceptions at 30 and 150 cm distal to Treitz ligament. Three segmental resections of the small intestine and functional end to end anastomosis were done. The patient recovered uneventfully from this operation. To the best of our knowledge, this is the 1^st report of metastases from RCC that presented as synchronous intraluminal polypoid tumors, and these tumors served as the lead points for two intussusceptions in the jejunum.

Citations

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Case Report: Pancreatic metastasis of renal cell carcinoma 16 years after nephrectomy
Yidan Lou, Kaibo Guo, Song Zheng
Frontiers in Oncology.2023;[Epub] CrossRef
Solitary metastasis of clear cell renal cell carcinoma in the small intestine 10 years after right nephrectomy
M.D. Budurova, N.V. Vorobyov, S.I. Poluektov, V.S. Surkova, N.A. Grishin, K.A. Turupaev, M.A. Chernichenko, A.B. Ryabov
Onkologiya. Zhurnal imeni P.A.Gertsena.2023; 12(6): 57. CrossRef
Metastatic disease masquerading as small intestinal tumoural masses: two case reports and literature review
Jovell Xing Yi Sim, Ilyana Huda Binte Mohamed Hussain, Wei Qiang Leow
Proceedings of Singapore Healthcare.2017; 26(4): 263. CrossRef
Severe blood loss anaemia and recurrent intussusceptions as first presentation of bowel metastatic renal cell carcinoma: A case report and review of the literature
Claudia Trojaniello, Maria Giuseppa Vitale, Biagio Trojaniello, Maria Luisa Lentini Graziano, Mariarosa Coccaro, Giacomo Cartenì, Vincenzo Montesarchio
Molecular and Clinical Oncology.2017; 7(4): 654. CrossRef
Small bowel intussusception from renal cell carcinoma metastasis: a case report and review of the literature
Gabriele Bellio, Tommaso Cipolat Mis, Gladiola Kaso, Roberto Dattola, Biagio Casagranda, Marina Bortul
Journal of Medical Case Reports.2016;[Epub] CrossRef
Small bowel metastasis from pancreatic cancer in a long-term survival patient with synchronous advanced malignant pleural mesothelioma: A case report and literature review
Morena Fasano, Carminia Maria Della Corte, Giovanni Vicidomini, Valerio Scotti, Pier Francesco Rambaldi, Alfonso Fiorelli, Marina Accardo, Ferdinando De Vita, Mario Santini, Fortunato Ciardiello, Floriana Morgillo
Oncology Letters.2016; 12(6): 4505. CrossRef
Triple jejuno-jejunal intussusception due to metastatic renal cell carcinoma
A.-S. Massy Budmiger, V. Nagy, S. Hurlimann, J. Metzger
Journal of Surgical Case Reports.2015; 2015(4): rjv047. CrossRef
An obscure cause of gastrointestinal bleeding: Renal cell carcinoma metastasis to the small bowel
Robyn L. Gorski, Salah Abdel Jalil, Manver Razick, Ala' Abdel Jalil
International Journal of Surgery Case Reports.2015; 15: 130. CrossRef
Recurrent Renal Cell Carcinoma with Synchronous Tumor Growth in Azygoesophageal Recess and Duodenum: A Rare Cause of Anemia and Upper Gastrointestinal Bleeding
Vamshidhar R. Vootla, Muhammad Kashif, Masooma Niazi, Suresh K. Nayudu
Case Reports in Oncological Medicine.2015; 2015: 1. CrossRef
Atypical Multiple Ileum Metastases of Renal Cell Carcinoma
Raffaele Longo, Domenico Gattuso, Roberto Luchetti, Carlo Giannetti, Alessandro Mero, Cinzia Bernardi, Giampietro Gasparini
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Enduring Response to Everolimus as Third-Line Therapy in a Patient With Advanced Renal Cell Carcinoma, Including Small-Bowel Metastases: Loss of FHIT but Normal VHL Gene Status
Reuben J. Broom, Imogen Caldwell, Fritha Hanning, Peter Fong, Sanjeev Deva, Paul Oei
Clinical Genitourinary Cancer.2012; 10(3): 202. CrossRef
A case of wedge resection of duodenum for massive gastrointestinal bleeding due to duodenal metastasis by renal cell carcinoma
Hongzhi Zhao, Keqiang Han, Jing Li, Ping Liang, Guohua Zuo, Yu Zhang, Hongyan Li
World Journal of Surgical Oncology.2012;[Epub] CrossRef
Malignant Pleural Mesothelioma Presenting as an Acute Surgical Abdomen due to Metastatic Jejunal Perforation
Kyoko Gocho, Kazutoshi Isobe, Kyohei Kaburaki, Yoshiko Honda, Aki Mitsuda, Yoshikiyo Akasaka, Nagato Shimada, Keigo Takagi, Sakae Homma
Internal Medicine.2010; 49(6): 597. CrossRef

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Metastatic Anaplastic Carcinoma of the Small Intestine Arising from The Lung: Dong Yi Kim, Jai Kyoon Joo, Seong Yeob Ryu, Young Jin Kim, Shin Kon Kim, Sang Woo Juhng; Cancer Res Treat. 2003;35(4):364-366. Published online August 31, 2003; DOI: https://doi.org/10.4143/crt.2003.35.4.364

Abstract PDF

A metastatic carcinoma of the small intestine is rare. Here, the case study of an 80-year-old lung carcinoma patient, with generalized peritonitis due to neoplastic perforation of the small intestine is reported. Pathological studies of a small intestinal mass revealed a metastatic anaplastic carcinoma arising from the lung. Patients with known lung carcinoma, who develop abdominal complaints, should be examined thoroughly. Although it is very difficult to diagnose and treat a metastatic carcinoma of the small intestine, in our judgment, with a greater awareness of this neoplasm, more cases may be diagnosed in the early stages, leading to improved rates of survival.

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Citations to this article as recorded by

Metástasis gastrointestinales de carcinoma pulmonar primario. Serie de casos y revisión sistemática de la literatura
Andrea Balla, José D. Subiela, Jesús Bollo, Carmen Martínez, Carlos Rodriguez Luppi, Pilar Hernández, Yuliana Pascual-González, Silvia Quaresima, Eduard M. Targarona
Cirugía Española.2018; 96(4): 184. CrossRef
Gastrointestinal Metastasis From Primary Lung Cancer. Case Series and Systematic Literature Review
Andrea Balla, José D. Subiela, Jesús Bollo, Carmen Martínez, Carlos Rodriguez Luppi, Pilar Hernández, Yuliana Pascual-González, Silvia Quaresima, Eduard M. Targarona
Cirugía Española (English Edition).2018; 96(4): 184. CrossRef

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Original Article

The Relationship between Radiation-induced Apoptosis and the Expression of Cytokines in the Small Intestine of Rats: Sung Sook Kim, Yeong Ju Woo, Jooryung Huh, Chung Sik Rhee, In Pyoi Choi; J Korean Cancer Assoc. 1997;29(6):921-929.

Abstract PDF: PURPOSE
It is well recognized that apoptosis is important in embryonic development, homeostatic control of normal tissues, carcinogenesis, tumor development and cancer therapy. Several papers have been reported the phenomenon of radiation-induced apoptosis and suggested its potential relevance to cancer radiotherapy. It has been shown that apoptosis is regulated by various cytokines. But the relationship between radiation induced apoptosis and cytokines have not fully understood in detail, yet.
MATERIALS AND METHODS
In this study, we performed to determine the role of cytokine in the radiation -induced apoptosis of rat's small intestine. The rats were divided into 6 groups according to the sacrifice day (1, 2, 3, 5, 7, 14 days) after whole body irradiation with single dose of 8 Gy.
RESULTS
Radiation induced intestinal damage was noted from first day of radiation and the most active regeneration was seen in the groups of 5 days after radiation. Abundant apoptosis were observed in damaged crypts of small intestine 1 day after radiation. Afterwards, the number of apoptosis was gradually diminished, but the second peak of apoptosis was noted in 5 days after radiation. On immunohistochemical study, IL-1, and TNF were expressed 1 day after radiation, but not expressed after that. IL-6 was expressed with strong positivity in 1, 3 days after radiation.
CONCLUSION
A apoptosis seems to be the important mechanism of radiation induced small intestinal damage, and is possibly induced by the release of cytokines, such as IL-1, IL-6, TNF, in view the simultaneously increased appearance of apoptosis and cytokines. The second peak of increased apoptosis is thought to be related to remodeling of active regenerative activity, and it is not associated with cytokine expression.

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