Cancer Research and Treatment

Original Articles

Gastrointestinal cancer

A Phase II Study of Preoperative Chemoradiotherapy with Capecitabine Plus Simvastatin in Patients with Locally Advanced Rectal Cancer: Hyunji Jo, Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Jeong Il Yu, Hee Chul Park, Doo Ho Choi, Yoonah Park, Yong Beom Cho, Jung Wook Huh, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Won Ki Kang; Cancer Res Treat. 2023;55(1):189-195. Published online June 8, 2022; DOI: https://doi.org/10.4143/crt.2021.1527

Purpose
The purpose of this phase II trial was to evaluate whether the addition of simvastatin, a synthetic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, to preoperative chemoradiotherapy (CRT) with capecitabine confers a clinical benefit to patients with locally advanced rectal cancer (LARC).
Materials and Methods
Patients with LARC (defined by clinical stage T3/4 and/or lymph node positivity) received preoperative radiation (45-50.4 Gy in 25-28 daily fractions) with concomitant capecitabine (825 mg/m2 twice per day) and simvastatin (80 mg, daily). Curative surgery was planned 4-8 weeks after completion of the CRT regimen. The primary endpoint was pathologic complete response (pCR). The secondary endpoints included sphincter-sparing surgery, R0 resection, disease-free survival, overall survival, the pattern of failure, and toxicity.
Results
Between October 2014 and July 2017, 61 patients were enrolled; 53 patients completed CRT regimen and underwent total mesorectal excision. The pCR rate was 18.9% (n=10) by per-protocol analysis. Sphincter-sparing surgery was performed in 51 patients (96.2%). R0 resection was achieved in 51 patients (96.2%). One patient experienced grade 3 liver enzyme elevation. No patient experienced additional toxicity caused by simvastatin.
Conclusion
The combination of 80 mg simvastatin with CRT and capecitabine did not improve pCR in patients with LARC, although it did not increase toxicity.

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Short- and long-term outcomes of neoadjuvant chemotherapy compared with neoadjuvant chemoradiotherapy for locally advanced rectal cancer: an updated meta-analysis
Yue Guo, Zhifeng Guo, Jiaojiao Zhang, Guowu Qian, Wangquan Ji, Linlin Song, Zhe Guo, Zhuo Han
BMC Gastroenterology.2025;[Epub] CrossRef
A randomized phase II/III trial of rosuvastatin with neoadjuvant chemo-radiation in patients with locally advanced rectal cancer
Prachi S. Patil, Avanish Saklani, Naveena A. N. Kumar, Ashwin De’Souza, Rahul Krishnatry, Snehal Khanvilkar, Mufaddal Kazi, Reena Engineer, Vikas Ostwal, Anant Ramaswamy, Munita Bal, Priya Ranganathan, Ekta Gupta, Sanjeev Galande
Frontiers in Oncology.2025;[Epub] CrossRef
Effects of Hyperlipidemia on Osseointegration of Dental Implants and Its Strategies
Haiyang Sun, Shuhuai Meng, Junyu Chen, Qianbing Wan
Journal of Functional Biomaterials.2023; 14(4): 194. CrossRef

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Breast Cancer

Combination of Simvastatin and FAC Improves Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer: Erwin Danil Yulian, Nurjati Chairani Siregar, Bajuadji; Cancer Res Treat. 2021;53(4):1072-1083. Published online March 9, 2021; DOI: https://doi.org/10.4143/crt.2020.1024

Abstract PDF PubReader ePub

Purpose
The efficacy of neoadjuvant chemotherapy for locally advanced breast cancer (LABC) is limited due to drug resistance and cardiotoxic effects. Preclinical studies have shown that statin induces apoptosis and decreases breast cancer cell growth. This study aims to evaluate the role of statin in combination with fluorouracil, adriamycin, and cyclophosphamide (FAC) therapy in LABC patients.
Materials and Methods
We undertook a randomized, double-blinded, placebo-controlled trial in two centers of Indonesia. Patients were randomly assigned to FAC plus simvastatin (40 mg/day orally) or FAC plus placebo (40 mg/day) for 21 days. The FAC regimen was repeated every 3 weeks. We evaluated the clinical response, pathological response, and toxicities.
Results
The objective response rate (ORR) for FAC plus simvastatin was 90% (95% confidence interval [CI], 0.99 to 1.67) by per-protocol analysis. No complete responses (CR) were recorded, but there were 48 partial responses. No significant difference was observed between the two groups with the ORR (p=0.103). The pathological CR rate was 6.25% (2 in simvastatin group and 1 in placebo group). Adverse events in both arms were generally mild, mainly consisted of myotoxicity. Human epidermal growth factor receptor 2 (HER2) expression was a factor related to the success of therapeutic response (odds ratio, 4.2; 95% CI, 1.121 to 15.731; p=0.033).
Conclusion
This study suggests that simvastatin combined with FAC shows improvements in ORR and pathological response in patients with LABC. Although no statistically significant difference was documented, there was a trend for better activity and tolerability. The addition of 40 mg simvastatin may improve the efficacy of FAC in LABC patients with HER2 overexpression.

Citations

Citations to this article as recorded by

Theoretical framework and emerging challenges of lipid metabolism in cancer
Qiuying Gu, Yuan Wang, Ping Yi, Chunming Cheng
Seminars in Cancer Biology.2025; 108: 48. CrossRef
Clinical significance of lipid pathway-targeted therapy in breast cancer
Dan Li, Pengcheng Jin, Yiqi Cai, Shijie Wu, Xianan Guo, Zhiyun Zhang, Kexin Liu, Panni Li, Yue Hu, Yunxiang Zhou
Frontiers in Pharmacology.2025;[Epub] CrossRef
Anticancer properties of histone deacetylase inhibitors – what is their potential?
Kajetan Kiełbowski, Agata Szwedkowicz, Paulina Plewa, Estera Bakinowska, Rafał Becht, Andrzej Pawlik
Expert Review of Anticancer Therapy.2025; 25(2): 105. CrossRef
Divide and Conquer—Targeted Therapy for Triple-Negative Breast Cancer
Milica Nedeljković, Ana Vuletić, Katarina Mirjačić Martinović
International Journal of Molecular Sciences.2025; 26(4): 1396. CrossRef
Factors Affecting Pathological Complete Response in Locally Advanced Breast Cancer Cases Receiving Neoadjuvant Therapy: A Comprehensive Literature Review
Munaser Alamoodi
European Journal of Breast Health.2024; 20(1): 8. CrossRef
Role of hydroxymethylglutharyl-coenzyme A reductase in the induction of stem-like states in breast cancer
María Paula Marks, Carla Alejandra Giménez, Luciana Isaja, Mariana Belén Vera, Francisco Raúl Borzone, Federico Pereyra-Bonnet, Leonardo Romorini, Guillermo Agustín Videla-Richardson, Norma Alejandra Chasseing, Juan Carlos Calvo, Luciano Vellón
Journal of Cancer Research and Clinical Oncology.2024;[Epub] CrossRef
Cardiovascular/anti‐inflammatory drugs repurposed for treating or preventing cancer: A systematic review and meta‐analysis of randomized trials
David J. Benjamin, Alyson Haslam, Vinay Prasad
Cancer Medicine.2024;[Epub] CrossRef
Are statins onco- suppressive agents for every type of tumor? A systematic review of literature
Luca Filaferro, Fabiana Zaccarelli, Giovanni Francesco Niccolini, Andrea Colizza, Federica Zoccali, Michele Grasso, Massimo Fusconi
Expert Review of Anticancer Therapy.2024; 24(6): 435. CrossRef
Post-surgery statin use contributes to favorable outcomes in patients with early breast cancer
María Belén Giorello, María Paula Marks, Tiago Martín Osinalde, María del Rosario Padin, Alejandra Wernicke, Juan Carlos Calvo, Norma Alejandra Chasseing, Luciano Vellón
Cancer Epidemiology.2024; 90: 102573. CrossRef
Unraveling the intricate relationship between lipid metabolism and oncogenic signaling pathways
Fahad Khan, Deena Elsori, Meenakshi Verma, Shivam Pandey, Safia Obaidur Rab, Samra Siddiqui, Nadiyah M. Alabdallah, Mohd Saeed, Pratibha Pandey
Frontiers in Cell and Developmental Biology.2024;[Epub] CrossRef
Obesity-Associated Colorectal Cancer
Lucia Gonzalez-Gutierrez, Omar Motiño, Daniel Barriuso, Juan de la Puente-Aldea, Lucia Alvarez-Frutos, Guido Kroemer, Roberto Palacios-Ramirez, Laura Senovilla
International Journal of Molecular Sciences.2024; 25(16): 8836. CrossRef
Statins inhibit paclitaxel-induced PD-L1 expression and increase CD8+ T cytotoxicity for better prognosis in breast cancer
Lei Li, Hongbin Wang, Shiyuan Zhang, Song Gao, Xiuxin Lu, You Pan, Wei Tang, Rong Huang, Kun Qiao, Shipeng Ning
International Journal of Surgery.2024; 110(8): 4716. CrossRef
Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target
Molly E. Muehlebach, Sarah A. Holstein
Clinical and Translational Medicine.2023;[Epub] CrossRef
The role of HMGCR expression in combination therapy of simvastatin and FAC treated locally advanced breast cancer patients
Erwin Danil Yulian, Nurjati Chairani Siregar, Bajuadji Sudijono, Lie Rebecca Yen Hwei
Breast Disease.2023; 42(1): 73. CrossRef
A phase 1 study of simvastatin in combination with topotecan and cyclophosphamide in pediatric patients with relapsed and/or refractory solid and CNS tumors
Thomas Cash, Hunter C. Jonus, Maya Tsvetkova, Jan H. Beumer, Arhanti Sadanand, Jasmine Y. Lee, Curtis J. Henry, Dolly Aguilera, R. Donald Harvey, Kelly C. Goldsmith
Pediatric Blood & Cancer.2023;[Epub] CrossRef
New insights into the therapeutic potentials of statins in cancer
Chengyu Liu, Hong Chen, Bicheng Hu, Jiajian Shi, Yuchen Chen, Kun Huang
Frontiers in Pharmacology.2023;[Epub] CrossRef
Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
Hao-Ran Jin, Jin Wang, Zi-Jing Wang, Ming-Jia Xi, Bi-Han Xia, Kai Deng, Jin-Lin Yang
Journal of Hematology & Oncology.2023;[Epub] CrossRef
Repositioning of HMG-CoA Reductase Inhibitors as Adjuvants in the Modulation of Efflux Pump-Mediated Bacterial and Tumor Resistance
Zsuzsanna Schelz, Hiba F. Muddather, István Zupkó
Antibiotics.2023; 12(9): 1468. CrossRef
Dysregulation of cholesterol metabolism in cancer progression
Xuesong Liu, Mengzhu Lv, Weimin Zhang, Qimin Zhan
Oncogene.2023; 42(45): 3289. CrossRef
p140Cap modulates the mevalonate pathway decreasing cell migration and enhancing drug sensitivity in breast cancer cells
Giorgia Centonze, Dora Natalini, Silvia Grasso, Alessandro Morellato, Vincenzo Salemme, Alessio Piccolantonio, Giacomo D’Attanasio, Aurora Savino, Olga Teresa Bianciotto, Matteo Fragomeni, Andrea Scavuzzo, Matteo Poncina, Francesca Nigrelli, Mario De Greg
Cell Death & Disease.2023;[Epub] CrossRef
Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer
Yoichi Morofuji, Shinsuke Nakagawa, Kenta Ujifuku, Takashi Fujimoto, Kaishi Otsuka, Masami Niwa, Keisuke Tsutsumi
Pharmaceuticals.2022; 15(2): 151. CrossRef
Long-term effectiveness of empiric cardio-protection in patients receiving cardiotoxic chemotherapies: A systematic review & bayesian network meta-analysis
Ahmed Sayed, Omar M. Abdelfattah, Malak Munir, Omar Shazly, Ahmed K. Awad, Hazem S. Ghaith, Khaled Moustafa, Maria Gerew, Avirup Guha, Ana Barac, Michael G. Fradley, George S. Abela, Daniel Addison
European Journal of Cancer.2022; 169: 82. CrossRef
Simvastatin in the Treatment of Colorectal Cancer: A Review
Hongliang Zang, Wei Yang, Xiaofeng Tian, Tian Jiao Wang
Evidence-Based Complementary and Alternative Medicine.2022; 2022: 1. CrossRef
Mutant p53, the Mevalonate Pathway and the Tumor Microenvironment Regulate Tumor Response to Statin Therapy
Madison Pereira, Kathy Matuszewska, Alice Glogova, Jim Petrik
Cancers.2022; 14(14): 3500. CrossRef
Repurposing of metabolic drugs and mitochondrial modulators as an emerging class of cancer therapeutics with a special focus on breast cancer
Versha Tripathi, Pooja Jaiswal, Khageswar Sahu, Shovan Kumar Majumder, Dharmendra Kashyap, Hem Chandra Jha, Amit Kumar Dixit, Hamendra Singh Parmar
Advances in Cancer Biology - Metastasis.2022; 6: 100065. CrossRef
Repurposing of Metabolic Drugs and Mitochondrial Modulators as an Emerging Class of Cancer Therapeutics with a Special Focus on Breast Cancer
Hamendra Singh Singh Parmar, Versha Tripathi, Pooja Jaiswal, Khageshwar Sahu, Shovan Kumar Majumder, Dharmendra Kashyap, Amit Kumar Dixit, Hem Chandra Jha
SSRN Electronic Journal .2022;[Epub] CrossRef
Statins: a repurposed drug to fight cancer
Wen Jiang, Jin-Wei Hu, Xu-Ran He, Wei-Lin Jin, Xin-Yang He
Journal of Experimental & Clinical Cancer Research.2021;[Epub] CrossRef

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27 Web of Science
27 Crossref

A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-Line Chemotherapy in Metastatic Colorectal Cancer Patients: Youjin Kim, Tae Won Kim, Sae Won Han, Joong Bae Ahn, Seung Tae Kim, Jeeyun Lee, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang; Cancer Res Treat. 2019;51(3):1128-1134. Published online November 21, 2018; DOI: https://doi.org/10.4143/crt.2018.379

Abstract PDF PubReader ePub

Purpose
Simvastatin has demonstrated anti-tumor activity in preclinical studies via tumor cell senescence, apoptosis, and anti-angiogenesis. This phase II trial evaluated the efficacy and toxicity profile of conventional XELOX and bevacizumab chemotherapy plus simvastatin in metastatic colorectal cancer patients (MCRC).
Materials and Methods
Patients with MCRC received first-line XELOX in 3-week treatment cycles of intravenous oxaliplatin 130 mg/m² plus bevacizumab 7.5 mg/kg (day 1), followed by oral capecitabine 1,000 mg/m² twice daily (day 1-14). Simvastatin 80 mg tablets were taken orally once daily every day during the period of chemotherapy. The primary endpoint was progression-free survival (PFS). Secondary endpoints were response rate, duration of response, overall survival (OS), time to progression, and toxicity.
Results
From January 2014 to April 2015, 60 patients were enrolled and 55 patients were evaluable for tumor response. The median follow-up duration was 30.1 months (range, 28.5 to 31.7 months). The median PFS was 10.4 months (95% confidence interval [CI], 9.6 to 11.1). The median OS of all patients was 19.0 months (95% CI, 11.9 to 26.0). The disease-control rate and overall response rate were 88.3% (95% CI, 74 to 96) and 58.3% (95% CI, 44 to 77), respectively, by intent-to-treat protocol analysis. There was one complete response and 34 partial responses. One patient experienced grade 3 creatine kinase elevation and liver enzyme elevation.
Conclusion
Based on the current study, the addition of 80 mg simvastatin to XELOX and bevacizumab showed comparable clinical efficacy in patients with MCRC as first-line chemotherapy and did not increase toxicity.

Citations

Citations to this article as recorded by

Anticancer properties of histone deacetylase inhibitors – what is their potential?
Kajetan Kiełbowski, Agata Szwedkowicz, Paulina Plewa, Estera Bakinowska, Rafał Becht, Andrzej Pawlik
Expert Review of Anticancer Therapy.2025; 25(2): 105. CrossRef
Therapeutic Effects of Statins: Promising Drug for Topical and Transdermal Administration
Fatemeh Zahedipour, Seyede Atefe Hosseini, Željko Reiner, Eugenia Tedeschi-Reiner, Tannaz Jamialahmadi, Amirhossein Sahebkar
Current Medicinal Chemistry.2024; 31(21): 3149. CrossRef
Are statins onco- suppressive agents for every type of tumor? A systematic review of literature
Luca Filaferro, Fabiana Zaccarelli, Giovanni Francesco Niccolini, Andrea Colizza, Federica Zoccali, Michele Grasso, Massimo Fusconi
Expert Review of Anticancer Therapy.2024; 24(6): 435. CrossRef
Cholesterol synthesis is essential for the growth of liver metastasis‐prone colorectal cancer cells
Kumiko Taniguchi, Kei Sugihara, Takashi Miura, Daisuke Hoshi, Susumu Kohno, Chiaki Takahashi, Eishu Hirata, Etsuko Kiyokawa
Cancer Science.2024; 115(11): 3817. CrossRef
Statins in Mitigating Anticancer Treatment-Related Cardiovascular Disease
Rong Jiang, Lian Lou, Wen Shi, Yuxiao Chen, Zhaoming Fu, Shuo Liu, Thida Sok, Zhihang Li, Xuan Zhang, Jian Yang
International Journal of Molecular Sciences.2024; 25(18): 10177. CrossRef
Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients
Claes R. Andersson, Jiawei Ye, Kristin Blom, Mårten Fryknäs, Rolf Larsson, Peter Nygren
Anti-Cancer Drugs.2023; 34(1): 92. CrossRef
A phase 1 study of simvastatin in combination with topotecan and cyclophosphamide in pediatric patients with relapsed and/or refractory solid and CNS tumors
Thomas Cash, Hunter C. Jonus, Maya Tsvetkova, Jan H. Beumer, Arhanti Sadanand, Jasmine Y. Lee, Curtis J. Henry, Dolly Aguilera, R. Donald Harvey, Kelly C. Goldsmith
Pediatric Blood & Cancer.2023;[Epub] CrossRef
New insights into the therapeutic potentials of statins in cancer
Chengyu Liu, Hong Chen, Bicheng Hu, Jiajian Shi, Yuchen Chen, Kun Huang
Frontiers in Pharmacology.2023;[Epub] CrossRef
The Association of Metformin, Other Antidiabetic Medications, and Statins With the Prognosis of Colon Cancer in Patients With Type 2 Diabetes: A Retrospective Cohort Study
Sami Erkinantti, Ari Hautakoski, Reijo Sund, Martti Arffman, Elina Urpilainen, Ulla Puistola, Arja Jukkola, Karihtala Peeter, Esa Läärä
Cancer Control.2022;[Epub] CrossRef
Performance of capecitabine in novel combination therapies in colorectal cancer
Fahima Danesh Pouya, Yousef Rasmi, Irem Yalim Camci, Yusuf Tutar, Mohadeseh Nemati
Journal of Chemotherapy.2021; 33(6): 375. CrossRef
The potential use of simvastatin for cancer treatment: A review
Jaqueline Aparecida Duarte, Andre Luis Branco de Barros, Elaine Amaral Leite
Biomedicine & Pharmacotherapy.2021; 141: 111858. CrossRef
Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis
Navneet Kumar, Chandi C. Mandal
Frontiers in Genetics.2021;[Epub] CrossRef
Targeting Inflammatory Signaling in Prostate Cancer Castration Resistance
Shangwei Zhong, Changhao Huang, Zhikang Chen, Zihua Chen, Jun-Li Luo
Journal of Clinical Medicine.2021; 10(21): 5000. CrossRef
Osteolytic metastasis in breast cancer: effective prevention strategies
Chandi C Mandal
Expert Review of Anticancer Therapy.2020; 20(9): 797. CrossRef

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223 Download
18 Web of Science
14 Crossref

Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through AKT-Dependent Downregulation of Survivin: Young-Suk Kim, Chang-Hwan Seol, Jae-Wan Jung, Su-Jin Oh, Ki-Eun Hwang, Hwi-Jung Kim, Eun-Taik Jeong, Hak-Ryul Kim; Cancer Res Treat. 2015;47(1):90-100. Published online October 27, 2014; DOI: https://doi.org/10.4143/crt.2013.194

Abstract PDF PubReader ePub

Purpose
Non-steroidal anti-inflammatory drugs (NSAIDs) and statins are potential chemopreventive or chemotherapeutic agents. The mechanism underlying the deregulation of survivin by NSAIDs and statins in human non-small cell lung cancer cells has not been elucidated. In this study, we investigated the synergistic interaction of sulindac and simvastatin in lung cancer A549 cells.
Materials and Methods
Cell viability was measured by an MTT assay, while the expression of apoptotic markers, AKT, and survivin in response to sulindac and simvastatin was examined by Western blotting. DNA fragmentation by apoptosis was analyzed by flow cytometry in A549 cells. Reactive oxygen species (ROS) generation was measured by flow cytometry using H2DCFDA and MitoSOX Red, and the effects of pretreatment with N-acetylcysteine were tested. The effects of AKT on survivin expression in sulindac- and simvastatin-treated cells were assessed. Survivin was knocked down or overexpressed to determine its role in apoptosis induced by sulindac and simvastatin.
Results
Sulindac and simvastatin synergistically augmented apoptotic activity and intracellular ROS production in A549 cells. Inhibition of AKT by siRNA or LY294002 inhibited survivin, while AKT overexpression markedly increased survivin expression, even in the presence of sulindac and simvastatin. Moreover, survivin siRNA enhanced sulindac- and simvastatininduced apoptosis. In contrast, survivin upregulation protected against sulindac- and simvastatin-induced apoptosis.
Conclusion
Combined treatment with sulindac and simvastatin augmented their apoptotic potential in lung cancer cells through AKT signaling-dependent downregulation of survivin. These results indicate that sulindac and simvastatin may be clinically promising therapies for the prevention of lung cancer.

Citations

Citations to this article as recorded by

Regulatory effects of statins on Akt signaling for prevention of cancers
Fatemeh Sadat Hosseini, Abdolreza Ahmadi, Prashant Kesharwani, Hossein Hosseini, Amirhossein Sahebkar
Cellular Signalling.2024; 120: 111213. CrossRef
Sulindac exhibits anti-proliferative and anti-invasive effects in uterine serous carcinoma cells
Shuning Chen, Weimin Kong, Xiaochang Shen, Boer Deng, Jennifer Haag, Nikita Sinha, Catherine John, Wenchuan Sun, Chunxiao Zhou, Victoria L. Bae-Jump
Journal of Cancer Research and Clinical Oncology.2024;[Epub] CrossRef
BAPST. A Combo of Common Use Drugs as Metabolic Therapy for Cancer: A Theoretical Proposal
Adriana Romo-Perez, Guadalupe Dominguez-Gomez, Alma Chavez-Blanco, Lucia Taja-Chayeb, Aurora Gonzalez-Fierro, Elisa Garcia-Martinez, Jose Correa-Basurto, Alfonso Duenas-Gonzalez
Current Molecular Pharmacology.2022; 15(6): 815. CrossRef
Cholesterol-Lowering Drugs on Akt Signaling for Prevention of Tumorigenesis
Navneet Kumar, Chandi C. Mandal
Frontiers in Genetics.2021;[Epub] CrossRef
Small molecules regulating reactive oxygen species homeostasis for cancer therapy
Junmin Zhang, Dongzhu Duan, Zi‐Long Song, Tianyu Liu, Yanan Hou, Jianguo Fang
Medicinal Research Reviews.2021; 41(1): 342. CrossRef
Lanthanum(III) and neodymium(III) complexes with anti-inflammatory drug sulindac: Synthesis, characterization, thermal investigation using coupled techniques TG-FTIR, and in vitro biological studies
Renan B. Guerra, Thais Fernanda de Campos Fraga-Silva, Julia Aguiar, Paula B. Oshiro, Bruno B.C. Holanda, James Venturini, Gilbert Bannach
Inorganica Chimica Acta.2020; 503: 119408. CrossRef
A remarkable in vitro cytotoxic, cell cycle arresting and proapoptotic characteristics of low-dose mixed micellar simvastatin combined with alendronate sodium
Sandip A. Bandgar, Namdeo R. Jadhav, Arehalli S. Manjappa
Drug Delivery and Translational Research.2020; 10(4): 1122. CrossRef
Repositioning of drugs for intervention in tumor progression and metastasis: Old drugs for new targets
Giridhar Mudduluru, Wolfgang Walther, Dennis Kobelt, Mathias Dahlmann, Christoph Treese, Yehuda G. Assaraf, Ulrike Stein
Drug Resistance Updates.2016; 26: 10. CrossRef
Simvastatin Reduces Cancerogenic Potential of Renal Cancer Cells via Geranylgeranyl Pyrophosphate and Mevalonate Pathway
Mathias Woschek, Niels Kneip, Katrin Jurida, Ingo Marzi, Borna Relja
Nutrition and Cancer.2016; 68(3): 420. CrossRef
Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1
Byong-Ki Cha, Young-Suk Kim, Ki-Eun Hwang, Kyung-Hwa Cho, Seon-Hee Oh, Byoung-Ryun Kim, Hong-Young Jun, Kwon-Ha Yoon, Eun-Taik Jeong, Hak-Ryul Kim
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Ultra-structure changes and survivin expression in uterine fibroids after radiofrequency ablation
Shan-rong Shu, Xin Luo, Wen-Xia Song, Pei-Wen Chen
International Journal of Hyperthermia.2015; 31(8): 896. CrossRef

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