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Breast cancer
Locoregional Recurrence in Adenoid Cystic Carcinoma of the Breast: A Retrospective, Multicenter Study (KROG 22-14)
Sang Min Lee, Bum-Sup Jang, Won Park, Yong Bae Kim, Jin Ho Song, Jin Hee Kim, Tae Hyun Kim, In Ah Kim, Jong Hoon Lee, Sung-Ja Ahn, Kyubo Kim, Ah Ram Chang, Jeanny Kwon, Hae Jin Park, Kyung Hwan Shin
Cancer Res Treat. 2025;57(1):150-158.   Published online July 12, 2024
DOI: https://doi.org/10.4143/crt.2024.201
AbstractAbstract PDFPubReaderePub
Purpose
This study aims to evaluate the treatment approaches and locoregional patterns for adenoid cystic carcinoma (ACC) in the breast, which is an uncommon malignant tumor with limited clinical data.
Materials and Methods
A total of 93 patients diagnosed with primary ACC in the breast between 1992 and 2022 were collected from multi-institutions. All patients underwent surgical resection, including breast-conserving surgery (BCS) or total mastectomy (TM). Recurrence patterns and locoregional recurrence-free survival (LRFS) were assessed.
Results
Seventy-five patients (80.7%) underwent BCS, and 71 of them (94.7%) received post-operative radiation therapy (PORT). Eighteen patients (19.3%) underwent TM, with five of them (27.8%) also receiving PORT. With a median follow-up of 50 months, the LRFS rate was 84.2% at 5 years. Local recurrence (LR) was observed in five patients (5.4%) and four cases (80%) of the LR occurred in the tumor bed. Three of LR (3/75, 4.0%) had a history of BCS and PORT, meanwhile, two of LR (2/18, 11.1%) had a history of mastectomy. Regional recurrence occurred in two patients (2.2%), and both cases had a history of PORT with (n=1) and without (n=1) irradiation of the regional lymph nodes. Partial breast irradiation (p=0.35), BCS (p=0.96) and PORT in BCS group (p=0.33) had no significant association with LRFS.
Conclusion
BCS followed by PORT was the predominant treatment approach for ACC of the breast and LR mostly occurred in the tumor bed. The findings of this study suggest that partial breast irradiation might be considered for PORT in primary breast ACC.
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No Association of Positive Superficial and/or Deep Margins with Local Recurrence in Invasive Breast Cancer Treated with Breast-Conserving Surgery
Tae In Yoon, Jong Won Lee, Sae Byul Lee, Guiyun Sohn, Jisun Kim, Il Young Chung, Hee Jeong Kim, Beom Seok Ko, Byung Ho Son, Gyungyub Gong, Sung-Bae Kim, Su Ssan Kim, Seung Do Ahn, Minsung Chung, Sei Hyun Ahn
Cancer Res Treat. 2018;50(1):275-282.   Published online April 14, 2017
DOI: https://doi.org/10.4143/crt.2017.041
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
We evaluated the effect of positive superficial and/or deep margin status on local recurrence (LR) in invasive breast cancer treated with breast-conserving surgery (BCS) followed by radiotherapy.
Materials and Methods
In total, 3,403 stage 1 and 2 invasive breast cancer patients treated with BCS followed by radiotherapy from January 2000 to December 2008 were included in this study. These patients were divided into three groups according to margin status: clear resection margin status for all sections (group 1, n=3,195); positive margin status in superficial and/or deep sections (group 2, n=121); and positive peripheral parenchymal margin regardless of superficial and/or deep margin involvement (group 3, n=87). The LR-free survival between these three groups was compared and the prognostic role of margin status was analyzed.
Results
Across all groups, age, tumor size, nodal status, and human epidermal growth factor receptor 2 status did not significantly differ. High grade, positive extensive intraductal component, hormone receptor positivity, hormone therapy received, and chemotherapy not received were more prevalent in groups 2 and 3 than in group 1. Five-year LR rates in groups 1, 2, and 3 were 1.9%, 1.7%, and 7.7%, respectively. Multivariate analysis revealed that group 3 was a significant predictor for LR (hazard ratio [HR], 4.78; p < 0.001), but that positive superficial and/or deep margin was not (HR, 0.66; p=0.57).
Conclusion
Superficial and/or deep margin involvement following BCS is not an important predictor for LR.

Citations

Citations to this article as recorded by  
  • Locoregional Recurrence-Free Survival in Postmastectomy Breast Cancer: A Comparative Longitudinal Study of Hypofractionated Versus Conventional Fractionated Radiation Therapy
    Suma Susan Meloot, Ciniraj Raveendran, IP Yadev
    Indian Journal of Surgical Oncology.2025;[Epub]     CrossRef
  • Assessment of Eligibility and Utilization of Accelerated Partial Breast Irradiation in Korean Breast Cancer Patients (KROG 22-15)
    Seok-Joo Chun, Ji Hwan Jo, Yong Bae Kim, Sangjoon Park, Sung-Ja Ahn, Su Ssan Kim, Kyubo Kim, Kyung Hwan Shin
    Cancer Research and Treatment.2024; 56(2): 549.     CrossRef
  • Surgical margin status and survival outcomes of breast cancer patients treated with breast-conserving surgery and whole-breast irradiation after neoadjuvant chemotherapy
    Jong-Ho Cheun, Young Joo Lee, Jun-Hee Lee, Yungil Shin, Jung Whan Chun, Soo Yeon Baek, Hong-Kyu Kim, Han-Byoel Lee, Jonghan Yu, Byung Joo Chae, Wonshik Han, Jeong Eon Lee
    Breast Cancer Research and Treatment.2022; 194(3): 683.     CrossRef
  • Comparison of Recurrence Rate Between Re-Excision With Radiotherapy and Radiotherapy-Only Groups in Surgical Margin Involvement of In Situ Carcinoma
    Jun-Hee Lee, Hyunjun Lee, Yoon Ju Bang, Jai Min Ryu, Se Kyung Lee, Jonghan Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Byung Joo Chae
    Journal of Breast Cancer.2022; 25(4): 288.     CrossRef
  • Updates and Debate Concerning Margin Adequacy and Management following Breast-Conserving Surgery
    Serena Bertozzi, Ambrogio P Londero, Jose Andres Diaz Nanez, Francesco Leone, Barbara Baita, Lucia La Verghetta, Milena Nobile, Daria Almesberger, Carla Cedolini
    Clinical and Experimental Obstetrics & Gynecology.2022;[Epub]     CrossRef
  • Feasibility and safety of breast-conserving surgery via a periareolar incision for cancers located far from the nipple–areolar complex: a retrospective study
    Joohyun Woo, Jihae Lee, Se Hyun Paek, Woosung Lim
    Journal of Cancer Research and Clinical Oncology.2021; 147(3): 893.     CrossRef
  • Breast-conserving surgery with 3D-printed surgical guide: a single-center, prospective clinical study
    Zhen-Yu Wu, Hee Jeong Kim, Jongwon Lee, Il Yong Chung, Jisun Kim, Saebyeol Lee, Byung Ho Son, Sei-Hyun Ahn, Hak Hee Kim, Joon Beom Seo, Jae Ho Jeong, Gyungyub Gong, Namkug Kim, BeomSeok Ko
    Scientific Reports.2021;[Epub]     CrossRef
  • Usefulness of 3D-surgical guides in breast conserving surgery after neoadjuvant treatment
    Han Shin Lee, Hee Jeong Kim, Il Yong Chung, Jisun Kim, Sae Byul Lee, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn, Hak Hee Kim, Joon Beom Seo, Jin Hee Ahn, Gyungyub Gong, Sangwook Lee, Namkug Kim, Beom Seok Ko
    Scientific Reports.2021;[Epub]     CrossRef
  • Partial chest wall radiation therapy for positive or close surgical margins after modified radical mastectomy for breast cancer without lymph node metastasis
    Naoya Ishibashi, Haruna Nishimaki, Toshiya Maebayashi, Keita Adachi, Kenichi Sakurai, Shinobu Masuda, Masaharu Hata, Masahiro Okada
    Asia-Pacific Journal of Clinical Oncology.2020; 16(1): 28.     CrossRef
  • Impact of Oncotype DX Recurrence Score on the Patterns of Locoregional Recurrence in Breast Cancer (Korean Radiation Oncology Group 19-06)
    Kyubo Kim, Jinhong Jung, Kyung Hwan Shin, Jin Ho Kim, Ji Hyun Chang, Su Ssan Kim, Haeyoung Kim, Won Park, Yong Bae Kim, Jee Suk Chang
    Journal of Breast Cancer.2020; 23(3): 314.     CrossRef
  • Magnetic resonance imaging based 3-dimensional printed breast surgical guide for breast-conserving surgery in ductal carcinoma in situ: a clinical trial
    Zhen-Yu Wu, Aisha Alzuhair, Heejeong Kim, Jong Won Lee, Il Yong Chung, Jisun Kim, Sae Byul Lee, Byung Ho Son, Gyungyub Gong, Hak Hee Kim, Joon Beom Seo, Sei Hyun Ahn, Namkug Kim, BeomSeok Ko
    Scientific Reports.2020;[Epub]     CrossRef
  • Aktuelle chirurgische Therapie des Mammakarzinoms
    Jasmin Zeindler, Fabienne Schwab
    InFo Hämatologie + Onkologie.2019; 22(4): 15.     CrossRef
  • Comparing long-term local recurrence rates of surgical and non-surgical management of close anterior margins in breast conserving surgery
    George Boundouki, Joseph Ryan Wong Sik Hee, Natalie Croghan, Katie Stocking, Andrew Pieri, Adam Critchley, Cliona C. Kirwan, James R. Harvey
    Breast Cancer Research and Treatment.2019; 176(2): 311.     CrossRef
  • Therapy of isolated locoregional recurrent carcinoma of the breast
    Lena Gabriel, Marina Schmidt, Stephanie Juhasz-Böss, Patrick Melchior, Anika von Heesen, Gilda Schmidt, Nicole Kranzhöfer, Erich-Franz Solomayer, Ingolf Juhasz-Böss, Georg-Peter Breitbach
    Archives of Gynecology and Obstetrics.2019; 300(2): 365.     CrossRef
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Nomogram for Predicting Breast Conservation after Neoadjuvant Chemotherapy
Min Kyoon Kim, Wonshik Han, Hyeong-Gon Moon, Soo Kyung Ahn, Jisun Kim, Jun Woo Lee, Ju-Yeon Kim, Taeryung Kim, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, In Ae Park, Dong-Young Noh
Cancer Res Treat. 2015;47(2):197-207.   Published online September 4, 2014
DOI: https://doi.org/10.4143/crt.2013.247
AbstractAbstract PDFPubReaderePub
Purpose
The ability to accurately predict the likelihood of achieving breast conservation surgery (BCS) after neoadjuvant chemotherapy (NCT) is important in deciding whether NCT or surgery should be the first-line treatment in patients with operable breast cancers. Materials and Methods We reviewed the data of 513 women, who had stage II or III breast cancer and received NCT and surgery from a single institution. The ability of various clinicopathologic factors to predict the achievement of BCS and tumor size reduction to ≤ 3 cm was assessed. Nomograms were built and validated in an independent cohort. Results BCS was performed in 50.1% of patients, with 42.2% of tumors reduced to ≤ 3 cm after NCT. A multivariate logistic regression analysis showed that smaller initial tumor size, longer distance between the lesion and the nipple, absence of suspicious calcifications on mammography, and a single tumor were associated with BCS rather than mastectomy (p < 0.05). Negative estrogen receptor, smaller initial tumor size, higher Ki-67 level, and absence of in situ component were associated with residual tumor size ≤ 3 cm (p < 0.05). Two nomograms were developed using these factors. The areas under the receiver operating characteristic curves for nomograms predicting BCS and residual tumor ≤ 3 cm were 0.800 and 0.777, respectively. The calibration plots showed good agreement between the predicted and actual probabilities. Conclusion We have established a model with novel factors that predicts BCS and residual tumor size after NCT. This model can help in making treatment decisions for patients who are candidates for NCT.

Citations

Citations to this article as recorded by  
  • Risk scoring system for predicting breast conservation after neoadjuvant chemotherapy
    Lobna Ouldamer, Sofiane Bendifallah, Joseph Pilloy, Flavie Arbion, Gilles Body, Caroline Brisson, Vincent Lavoué, Jean Lévêque, Emile Daraï
    The Breast Journal.2019; 25(4): 696.     CrossRef
  • Score for the Survival Probability in Metastasis Breast Cancer: A Nomogram-Based Risk Assessment Model
    Zhenchong Xiong, Guangzheng Deng, Xinjian Huang, Xing Li, Xinhua Xie, Jin Wang, Zeyu Shuang, Xi Wang
    Cancer Research and Treatment.2018; 50(4): 1260.     CrossRef
  • Development of Nomogram to Predict the Best Military Category Using Physical Fitness Variables: A Model Development in Navy Trainees
    Milad Nazarzadeh, Ali Reza Khoshdel, Abolfazl Goodarzi, Alireza Mosavi Jarrahi
    Journal of Archives in Military Medicine.2018;[Epub]     CrossRef
  • Predicting Successful Conservative Surgery after Neoadjuvant Chemotherapy in Hormone Receptor-Positive, HER2-Negative Breast Cancer
    Chang Seok Ko, Kyu Min Kim, Jong Won Lee, Han Shin Lee, Sae Byul Lee, Guiyun Sohn, Jisun Kim, Hee Jeong Kim, Il Yong Chung, Beom Seok Ko, Byung Ho Son, Seung Do Ahn, Sung-Bae Kim, Hak Hee Kim, Sei Hyun Ahn
    Journal of Breast Disease.2018; 6(2): 52.     CrossRef
  • External validation of a published nomogram for prediction of brain metastasis in patients with extra-cerebral metastatic breast cancer and risk regression analysis
    Ludivine Genre, Henri Roché, Léonel Varela, Dorra Kanoun, Monia Ouali, Thomas Filleron, Florence Dalenc
    European Journal of Cancer.2017; 72: 200.     CrossRef
  • Facteurs prédictifs de traitement conservateur après chimiothérapie néo-adjuvante dans le cancer du sein
    J. Pilloy, C. Fleurier, M. Chas, L. Bédouet, M.L. Jourdan, F. Arbion, G. Body, L. Ouldamer
    Gynécologie Obstétrique Fertilité & Sénologie .2017; 45(9): 466.     CrossRef
  • Actual Conversion Rate from Total Mastectomy to Breast Conservation after Neoadjuvant Chemotherapy for Stages II–III Breast Cancer Patients
    Hyejin Mo, Yumi Kim, Jiyoung Rhu, Kyung-Hun Lee, Tae-Yong Kim, Seock-Ah Im, Eun-Shin Lee, Han-Byoel Lee, Hyeong-Gon Moon, Dong-Young Noh, Wonshik Han
    Journal of Breast Disease.2017; 5(2): 51.     CrossRef
  • 14,426 View
  • 101 Download
  • 4 Web of Science
  • 7 Crossref
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