Cancer Research and Treatment

Original Articles

Lung and Thoracic cancer

Long-term Survival Outcomes of Surgical Resection for Lung Adenocarcinoma with Intraoperatively Diagnosed Pleural Metastasis: Target Treatment Era: Yelee Kwon, Jae Kwang Yun, Geun Dong Lee, Se Hoon Choi, Yong-Hee Kim, Hyeong Ryul Kim; Cancer Res Treat. 2025;57(4):981-988. Published online December 30, 2024; DOI: https://doi.org/10.4143/crt.2024.993

Abstract PDF Supplementary Material PubReader ePub: Purpose
This study aimed to evaluate the clinical impact of main tumor resection on long-term survival compared with pleural biopsy alone in patients with lung adenocarcinoma who were intraoperatively diagnosed with pleural metastasis.
Materials and Methods
A total of 176 patients with adenocarcinoma who had unexpected pleural metastasis detected during surgery from 2002 to 2021 were retrospectively analyzed. Each surgeon decided whether to perform main tumor resection or pleural biopsy alone.
Results
The patients were grouped based on the surgical approaches: main tumor resection (resection group; n=83) and pleural biopsy only (O&C group; n=93). The resection group had better overall survival (OS; 10-year survival, 27.9% vs. 9.4%; median survival, 68.3 vs. 36.6 months; p < 0.01) and locoregional progression-free survival (10-year survival, 12.5% vs. 7.1%; median survival, 19.6 vs. 10.6 months; p < 0.01) than the O&C group. Similar results were found for OS in patients who received tyrosine kinase inhibitors (TKIs) as first-line therapy (10-year survival, 49.2% vs. 15.0%; median survival, 72.2 vs. 45.4 months; p=0.03), patients who did not undergo TKIs treatment (10-year survival, 29.4% vs. 9.2%; median survival, 82.4 vs. 23.8 months; p < 0.01), and patients with positive target gene mutation (10-year survival, 31.7% vs. 10.1%; median survival, 72.2 vs. 33.7 months; p < 0.01). In multivariate analysis, pleural biopsy only (hazard ratio, 1.73; p=0.04) was a significant predictor of OS.
Conclusion
Main tumor resection can improve survival in patients with lung adenocarcinoma who had unexpected pleural metastasis during operation.

3,644 View
84 Download

Usefulness of Pulmonary Rehabilitation in Non-Small Cell Lung Cancer Patients Based on Pulmonary Function Tests and Muscle Analysis Using Computed Tomography Images: Juwhan Choi, Zepa Yang, Jinhwan Lee, Jun Hee Lee, Hyun Koo Kim, Hwan Seok Yong, Sung Yong Lee; Cancer Res Treat. 2022;54(3):793-802. Published online October 20, 2021; DOI: https://doi.org/10.4143/crt.2021.769

Abstract PDF Supplementary Material PubReader ePub

Purpose
The usefulness of rehabilitation in patients with reduced lung function before lung surgery remains unclear, and there is no adequate method for evaluating the effect of rehabilitation. We aimed to evaluate the usefulness of rehabilitation in patients with non-small cell lung cancer (NSCLC) undergoing lung cancer surgery.
Materials and Methods
We retrospectively analyzed the medical records of NSCLC patients at Korea University Guro Hospital between 2018 and 2020. Patients were divided into two groups depending on whether they underwent rehabilitation. Pulmonary function test (PFT) data and muscle determined using chest computed tomography (CT) images were analyzed. Because the baseline characteristics were different between the two groups, propensity score matching was performed.
Results
Of 325 patients, 75 (23.1%) and 250 (76.9%) were included in the rehabilitation and non-rehabilitation (control) groups, respectively. The rehabilitation group had a worse general condition at baseline. After propensity score matching, 45 patients remained in each group. Pulmonary function (forced expiratory volume in 1 second, %) (p=0.001) and the Hounsfield unit of erector spinae muscle (p=0.001) were better preserved in the rehabilitation group. Muscle loss of 3.4% and 0.6% was observed in the control and rehabilitation groups, respectively (p=0.003). In addition, the incidence of embolic events was lower in the rehabilitation group (p=0.044).
Conclusion
Pulmonary rehabilitation is useful in patients with NSCLC undergoing lung surgery. Pulmonary rehabilitation preserves lung function, muscle and reduces embolic events after surgery. Pulmonary rehabilitation is recommended for patients with NSCLC undergoing surgery.

Citations

Citations to this article as recorded by

Efficacy of a smartphone application assisting home-based rehabilitation and symptom management for patients with lung cancer undergoing video-assisted thoracoscopic lobectomy: a prospective, single-blinded, randomised control trial (POPPER study)
Chao Lv, Fangliang Lu, Xiugeng Zhou, Xiang Li, Wenhua Yu, Chune Zhang, Kaishen Chen, Songtao Du, Chao Han, Jia Wang, Yuzhao Wang, Shaolei Li, Liang Wang, Yinan Liu, Shanyuan Zhang, Miao Huang, Dongdong Song, Dachuan Zhao, Bing Liu, Yaqi Wang, Xinrun Cui,
International Journal of Surgery.2025; 111(1): 597. CrossRef
The impact of lung surgery, with or without (neo-)adjuvant therapy, on physical functioning in patients with nonsmall cell lung cancer: a scoping review
Sarah Haesevoets, Eva Arents, Dries Cops, Kirsten Quadflieg, Maarten Criel, David Ruttens, Marc Daenen, Dieter Stevens, Veerle Surmont, Heleen Demeyer, Chris Burtin
European Respiratory Review.2025; 34(175): 240156. CrossRef
Effects of Bojungikki-Tang on immune response and clinical outcomes in NSCLC patients receiving immune checkpoint inhibitors: a randomized pilot study
Mi Mi Ko, Se Won Na, Jin-Mu Yi, Ho Jang, Chang Min Choi, Seung Hyeun Lee, Sung Yong Lee, Mi-Kyung Jeong
BMC Cancer.2025;[Epub] CrossRef
Comprehensive pulmonary rehabilitation for a 90-year-old patient with intertrochanteric fracture complicated by chronic obstructive pulmonary disease: a case report
Hui Teng, Jun Tian, Qing Shu
Physiotherapy Theory and Practice.2024; 40(11): 2712. CrossRef
Impact of pulmonary rehabilitation on exercise capacity, health-related quality of life, and cardiopulmonary function in lung surgery patients: a retrospective propensity score-matched analysis
Chunlai Niu, Huan Lin, Zinan Zhang, Qing Wang, Yingjun Wei
Frontiers in Medicine.2024;[Epub] CrossRef
Changes in the Glittre-ADL test in patients with non-small cell lung cancer: Pre- and postoperative analysis after home-based rehabilitation: A preliminary study
Isabelle da Nobrega Ferreira, Joao Pedro Lima de Almeida, Mel Portugal Cabral Santos, Beatriz Martins Gomes Cruz, Thiago Thomaz Mafort, Agnaldo José Lopes
Heliyon.2024; 10(23): e40646. CrossRef
Safety and Efficacy of Bojungikki-Tang in Advanced NSCLC Patients Receiving Treatment with Immune Checkpoint Inhibitors: Protocol for a Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Trial
Mi Mi Ko, Mi-Kyung Jeong, Chang Min Choi, Seung Hyeun Lee, Jaemoo Chun, Jin-Mu Yi, Ho Jang, Sung Yong Lee
International Journal of Environmental Research and Public Health.2023; 20(5): 4507. CrossRef
Association of Preoperative Rehabilitation With Postoperative Length of Hospital Stay for Elderly Lung Cancer Patients
Kohei FUNATSU, Ryutaro MATSUGAKI, Hanaka IMAMURA, Masaru TAKENAKA, Fumihiro TANAKA, Kiyohide FUSHIMI, Shinya MATSUDA, Satoru SAEKI
Journal of UOEH.2023; 45(3): 155. CrossRef
Research Status and Progress of Lung Rehabilitation after Lung Cancer Operation
莉袁
Advances in Clinical Medicine.2023; 13(09): 14955. CrossRef
Rapid Recovery of Postoperative Pulmonary Function in Patients With Lung Cancer and Influencing Factors
Yang Fuzhi, Tang Dongfang, Fu Wentao, Wang Jing, Wu Yingting, Mo Nianping, Gao Wen, Shen Xiaoyong
Frontiers in Oncology.2022;[Epub] CrossRef
Bilan fonctionnel préopératoire du cancer bronchique
J. Frija-Masson
Revue des Maladies Respiratoires Actualités.2022; 14(2): 2S75. CrossRef

8,239 View
173 Download
8 Web of Science
11 Crossref

First
Prev
Page of 1
Next
Last

Search