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Review Article
- Applicability of Spatial Technology in Cancer Research
- Sangjeong Ahn, Hye Seung Lee
- Cancer Res Treat. 2024;56(2):343-356. Published online January 30, 2024
- DOI: https://doi.org/10.4143/crt.2023.1302
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Abstract
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PubReader
ePub - This review explores spatial mapping technologies in cancer research, highlighting their crucial role in understanding the complexities of the tumor microenvironment (TME). The TME, which is an intricate ecosystem of diverse cell types, has a significant impact on tumor dynamics and treatment outcomes. This review closely examines cutting-edge spatial mapping technologies, categorizing them into capture-, imaging-, and antibody-based approaches. Each technology was scrutinized for its advantages and disadvantages, factoring in aspects such as spatial profiling area, multiplexing capabilities, and resolution. Additionally, we draw attention to the nuanced choices researchers face, with capture-based methods lending themselves to hypothesis generation, and imaging/antibody-based methods that fit neatly into hypothesis testing. Looking ahead, we anticipate a scenario in which multi-omics data are seamlessly integrated, artificial intelligence enhances data analysis, and spatiotemporal profiling opens up new dimensions.
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Citations
Citations to this article as recorded by
- Distinctive Phenotypic and Microenvironmental Characteristics of Neuroendocrine Carcinoma and Adenocarcinoma Components in Gastric Mixed Adenoneuroendocrine Carcinoma
Yoonjin Kwak, Soo Kyung Nam, Yujun Park, Yun-Suhk Suh, Sang-Hoon Ahn, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Hyung-Ho Kim, Han-Kwang Yang, Hye Seung Lee
Modern Pathology.2024; 37(10): 100568. CrossRef - Effector Function Characteristics of Exhausted CD8+ T-Cell in Microsatellite Stable and Unstable Gastric Cancer
Dong-Seok Han, Yoonjin Kwak, Seungho Lee, Soo Kyung Nam, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Nak-Jung Kwon, Hye Seung Lee, Han-Kwang Yang
Cancer Research and Treatment.2024; 56(4): 1146. CrossRef - Prognostic significance of CD8 and TCF1 double positive T cell subset in microsatellite unstable gastric cancer
Juhyeong Park, Soo Kyung Nam, Yoonjin Kwak, Hyeon Jeong Oh, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Han-Kwang Yang, Hye Seung Lee
Scientific Reports.2024;[Epub] CrossRef
- Distinctive Phenotypic and Microenvironmental Characteristics of Neuroendocrine Carcinoma and Adenocarcinoma Components in Gastric Mixed Adenoneuroendocrine Carcinoma
- 4,034 View
- 239 Download
- 3 Web of Science
- 3 Crossref
Original Articles
- Genitourinary cancer
- Next-generation Proteomics-Based Discovery, Verification, and Validation of Urine Biomarkers for Bladder Cancer Diagnosis
- Jungyo Suh, Dohyun Han, Ja Hyeon Ku, Hyeon Hoe Kim, Cheol Kwak, Chang Wook Jeong
- Cancer Res Treat. 2022;54(3):882-893. Published online October 9, 2021
- DOI: https://doi.org/10.4143/crt.2021.642
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Abstract
PDF
Supplementary MaterialPubReaderePub - Purpose
We aimed to identify, verify, and validate a multiplex urinary biomarker-based prediction model for diagnosis and surveillance of urothelial carcinoma of bladder, using high-throughput proteomics methods.
Materials and Methods
Label-free quantification of data-dependent and data-independent acquisition of 12 and 24 individuals was performed in each of the discovery and verification phases using mass spectrometry, simultaneously using urinary exosome and proteins. Based on five scoring system based on proteomics data and statistical methods, we selected eight proteins. Enzyme-linked immunosorbent assay on urine from 120 patients with bladder mass lesions used for validation. Using multivariable logistic regression, we selected final candidate models for predicting bladder cancer.
Results
Comparing the discovery and verification cohorts, 38% (50/132 exosomal differentially expressed proteins [DEPs]) and 44% (109/248 urinary DEPs) are consistent at statistically significance, respectively. The 20 out of 50 exosome proteins and 27 out of 109 urinary proteins were upregulated in cancer patients. From eight selected proteins, we developed two diagnostic models for bladder cancer. The area under the receiver operating characteristic curve (AUROC) of two models were 0.845 and 0.842, which outperformed AUROC of urine cytology.
Conclusion
The results showed that the two diagnostic models developed here were more accurate than urine cytology. We successfully developed and validated a multiplex urinary protein-based prediction, which will have wide applications for the rapid diagnosis of urothelial carcinoma of the bladder. External validation for this biomarker panel in large population is required. -
Citations
Citations to this article as recorded by- A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes
Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
eLife.2024;[Epub] CrossRef - A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes
Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
eLife.2024;[Epub] CrossRef - Comprehensive Urinary Proteome Profiling Analysis Identifies Diagnosis and Relapse Surveillance Biomarkers for Bladder Cancer
Qi Chang, Yongqiang Chen, Jianjian Yin, Tao Wang, Yuanheng Dai, Zixin Wu, Yufeng Guo, Lingang Wang, Yufen Zhao, Hang Yuan, Dongkui Song, Lirong Zhang
Journal of Proteome Research.2024; 23(6): 2241. CrossRef - Construction of noninvasive prognostic model of bladder cancer patients based on urine proteomics and screening of natural compounds
Shun Wan, Jinlong Cao, Siyu Chen, Jianwei Yang, Huabin Wang, Chenyang Wang, Kunpeng Li, Li Yang
Journal of Cancer Research and Clinical Oncology.2023; 149(1): 281. CrossRef - Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?
Ana Teixeira-Marques, Catarina Lourenço, Miguel Carlos Oliveira, Rui Henrique, Carmen Jerónimo
International Journal of Molecular Sciences.2023; 24(7): 6757. CrossRef - Advances in the application of label‐free quantitative proteomics techniques in malignancy research
Xiao Meng, Dong Liu, Yan Guan
Biomedical Chromatography.2023;[Epub] CrossRef - Off the fog to find the optimal choice: Research advances in biomarkers for early diagnosis and recurrence monitoring of bladder cancer
Jiaxin Zhao, Jinming Li, Rui Zhang
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2023; 1878(4): 188926. CrossRef - An overview of metabolomic and proteomic profiling in bipolar disorder and its clinical value
Henrique Caracho Ribeiro, Flávia da Silva Zandonadi, Alessandra Sussulini
Expert Review of Proteomics.2023; 20(11): 267. CrossRef - Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia
Younggap Lim, Hyun Young Kim, Dohyun Han, Bong‐Kyu Choi
Journal of Extracellular Vesicles.2023;[Epub] CrossRef - A Liquid Biopsy in Bladder Cancer—The Current Landscape in Urinary Biomarkers
Milena Matuszczak, Adam Kiljańczyk, Maciej Salagierski
International Journal of Molecular Sciences.2022; 23(15): 8597. CrossRef - Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19
Takahiro Kawasaki, Yoshito Takeda, Ryuya Edahiro, Yuya Shirai, Mari Nogami-Itoh, Takanori Matsuki, Hiroshi Kida, Takatoshi Enomoto, Reina Hara, Yoshimi Noda, Yuichi Adachi, Takayuki Niitsu, Saori Amiya, Yuta Yamaguchi, Teruaki Murakami, Yasuhiro Kato, Tak
Inflammation and Regeneration.2022;[Epub] CrossRef
- A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes
- 8,103 View
- 279 Download
- 10 Web of Science
- 11 Crossref
- Proteomic Biomarkers for Bisphenol A–Early Exposure and Women’s Thyroid Cancer
- Ho-Sun Lee, Yunkyeong Kang, Kyung Tae, Gyu-Un Bae, Jong Y. Park, Yoon Hee Cho, Mihi Yang
- Cancer Res Treat. 2018;50(1):111-117. Published online March 8, 2017
- DOI: https://doi.org/10.4143/crt.2017.001
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Abstract
PDFPubReaderePub
- Purpose
For the target treatment and prevention of women’s increased thyroid cancer, we focused on risks of environmental exposure to endocrine disrupting chemicals, particularly bisphenol A (BPA), and its high susceptible exposure-timing, particularly early exposure in lives.
Materials and Methods
Female ICR mice were exposed to BPA in utero and in early life (15, 75, and 300 mg/L of drinking water via pregnant mice and lactation). We identified BPA-responsive proteins in mice thyroid by two-dimensional gel electrophoresis, image analyses, and electrospray ionization quadrupole time-of-flight mass spectrometry. We further analyzed expression of the BPA-responsive proteins in women thyroid cancer patients (n=28).
Results
We found the altered 17 proteins in BPA dose-dependent manner among the thyroid tissues of offspring mice and identified nine proteins of them, including Anxa6, Atp5b, Hspa5, and Vcp, etc. In addition, we observed the positive association between blood BPA levels and mRNA expression of the ANXA6 and VCP not in normal but thyroid cancer tissues.
Conclusion
Our study provides ANXA6 and VCP as proteomic biomarkers for BPA–early life exposure and their potential for women’s thyroid cancer. -
Citations
Citations to this article as recorded by- Predictive Value and Immunological Role of the HSPA5 Gene in Cervical Cancer
Yingying Bai, Yandong Miao, Jiangtao Wang, Jian Gan, Jiang Feng
Biochemical Genetics.2024;[Epub] CrossRef - Subchronic toxic effects of bisphenol A on the gut-liver-hormone axis in rats via intestinal flora and metabolism
Jiaqi Wang, Ce Su, Mingqin Qian, Xin Wang, Changlan Chen, Yangcheng Liu, Wei Liu, Zheng Xiang, Baoli Xu
Frontiers in Endocrinology.2024;[Epub] CrossRef - Annexin A protein family: Focusing on the occurrence, progression and treatment of cancer
Huhu Zhang, Zhe Zhang, Tingting Guo, Guang Chen, Guoxiang Liu, Qinghang Song, Guichun Li, Fenghua Xu, Xiaolei Dong, Fanghao Yang, Can Cao, Di Zhong, Shuang Li, Ya Li, Mengjun Wang, Bing Li, Lina Yang
Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef - Current Evidence on Bisphenol A Exposure and the Molecular Mechanism Involved in Related Pathological Conditions
Ylenia Della Rocca, Enrico Matteo Traini, Francesca Diomede, Luigia Fonticoli, Oriana Trubiani, Alessia Paganelli, Jacopo Pizzicannella, Guya Diletta Marconi
Pharmaceutics.2023; 15(3): 908. CrossRef - ANXA6: a key molecular player in cancer progression and drug resistance
Jinlong Cao, Shun Wan, Siyu Chen, Li Yang
Discover Oncology.2023;[Epub] CrossRef - Assessment of five typical environmental endocrine disruptors and thyroid cancer risk: a meta-analysis
Yuyao Yang, Xiaoyue Bai, Juan Lu, Ronghao Zou, Rui Ding, Xiaohui Hua
Frontiers in Endocrinology.2023;[Epub] CrossRef - Linking Late Endosomal Cholesterol with Cancer Progression and Anticancer Drug Resistance
Mai K. L. Nguyen, Jaimy Jose, Mohamed Wahba, Marc Bernaus-Esqué, Andrew J. Hoy, Carlos Enrich, Carles Rentero, Thomas Grewal
International Journal of Molecular Sciences.2022; 23(13): 7206. CrossRef - Oncoproteomics: insight into current proteomic technologies in cancer biomarker discovery and treatment
Shrestha Dutta, Swatilekha Ghosh, Abhishek Mishra, Rajgourab Ghosh
Journal of Proteins and Proteomics.2022;[Epub] CrossRef - A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence
Nadeem Ghani Khan, Jacinta Correia, Divya Adiga, Padmalatha Satwadi Rai, Herman Sunil Dsouza, Sanjiban Chakrabarty, Shama Prasada Kabekkodu
Environmental Science and Pollution Research.2021; 28(16): 19643. CrossRef - Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in Cancer
Susan Costantini, Francesca Capone, Andrea Polo, Palmina Bagnara, Alfredo Budillon
International Journal of Molecular Sciences.2021; 22(18): 10177. CrossRef - Bisphenol A Activates an Innate Viral Immune Response Pathway
Mark L. Sowers, Hui Tang, Bing Tian, Randall Goldblum, Terumi Midoro-Horiuti, Kangling Zhang
Journal of Proteome Research.2020; 19(2): 644. CrossRef - Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins
Edward P.C. Lai, Hendrik Kersten, Thorsten Benter
Molecules.2020; 25(3): 708. CrossRef - ANXA6 Contributes to Radioresistance by Promoting Autophagy via Inhibiting the PI3K/AKT/mTOR Signaling Pathway in Nasopharyngeal Carcinoma
Qianping Chen, Wang Zheng, Lin Zhu, Dan Yao, Chen Wang, Yimeng Song, Songling Hu, Hongxia Liu, Yang Bai, Yan Pan, Jianghong Zhang, Jian Guan, Chunlin Shao
Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef - Diverse Roles of Annexin A6 in Triple-Negative Breast Cancer Diagnosis, Prognosis and EGFR-Targeted Therapies
Olga Y. Korolkova, Sarrah E. Widatalla, Stephen D. Williams, Diva S. Whalen, Heather K. Beasley, Josiah Ochieng, Thomas Grewal, Amos M. Sakwe
Cells.2020; 9(8): 1855. CrossRef - Lapatinib-induced annexin A6 upregulation as an adaptive response of triple-negative breast cancer cells to EGFR tyrosine kinase inhibitors
Sarrah E Widatalla, Olga Y Korolkova, Diva S Whalen, J Shawn Goodwin, Kevin P Williams, Josiah Ochieng, Amos M Sakwe
Carcinogenesis.2019; 40(8): 998. CrossRef -
Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with
in Vitro
Testing and Adverse Outcome Pathway Approaches
Pamela D. Noyes, Katie Paul Friedman, Patience Browne, Jonathan T. Haselman, Mary E. Gilbert, Michael W. Hornung, Stan Barone, Kevin M. Crofton, Susan C. Laws, Tammy E. Stoker, Steven O. Simmons, Joseph E. Tietge, Sigmund J. Degitz
Environmental Health Perspectives.2019;[Epub] CrossRef - Isobaric tags for relative and absolute quantitation‑based proteomics reveals potential novel biomarkers for the early diagnosis of acute myocardial infarction within 3�h
Changqing Du, Yingzheng Weng, Jiangjie Lou, Guangzhong Zeng, Xiaowei Liu, Hongfeng Jin, Senna Lin, Lijiang Tang
International Journal of Molecular Medicine.2019;[Epub] CrossRef - Bisphenol A and estradiol impede myoblast differentiation through down-regulating Akt signaling pathway
Ga-Yeon Go, Sang-Jin Lee, Ayoung Jo, Jae-Rin Lee, Jong-Sun Kang, Mihi Yang, Gyu-Un Bae
Toxicology Letters.2018; 292: 12. CrossRef - Determination of Highly Sensitive Biological Cell Model Systems to Screen BPA-Related Health Hazards Using Pathway Studio
Do-Yeal Ryu, Md Rahman, Myung-Geol Pang
International Journal of Molecular Sciences.2017; 18(9): 1909. CrossRef
- Predictive Value and Immunological Role of the HSPA5 Gene in Cervical Cancer
- 12,899 View
- 441 Download
- 19 Web of Science
- 19 Crossref
Review Article
- Systems Biology Approaches to Decoding the Genome of Liver Cancer
- Ju-Seog Lee, Ji Hoon Kim, Yun-Yong Park, Gordon B. Mills
- Cancer Res Treat. 2011;43(4):205-211. Published online December 27, 2011
- DOI: https://doi.org/10.4143/crt.2011.43.4.205
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Abstract
PDFPubReaderePub
- Molecular classification of cancers has been significantly improved patient outcomes through the implementation of treatment protocols tailored to the abnormalities present in each patient's cancer cells. Breast cancer represents the poster child with marked improvements in outcome occurring due to the implementation of targeted therapies for estrogen receptor or human epidermal growth factor receptor-2 positive breast cancers. Important subtypes with characteristic molecular features as potential therapeutic targets are likely to exist for all tumor lineages including hepatocellular carcinoma (HCC) but have yet to be discovered and validated as targets. Because each tumor accumulates hundreds or thousands of genomic and epigenetic alterations of critical genes, it is challenging to identify and validate candidate tumor aberrations as therapeutic targets or biomarkers that predict prognosis or response to therapy. Therefore, there is an urgent need to devise new experimental and analytical strategies to overcome this problem. Systems biology approaches integrating multiple data sets and technologies analyzing patient tissues holds great promise for the identification of novel therapeutic targets and linked predictive biomarkers allowing implementation of personalized medicine for HCC patients.
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Citations
Citations to this article as recorded by- Systems Challenges of Hepatic Carcinomas: A Review
Dhatri Madduru, Johny Ijaq, Sujata Dhar, Saumyadip Sarkar, Naresh Poondla, Partha S. Das, Silvia Vasquez, Prashanth Suravajhala
Journal of Clinical and Experimental Hepatology.2019; 9(2): 233. CrossRef - Epigenetic regulation of hepatocellular carcinoma in non-alcoholic fatty liver disease
Yuan Tian, Vincent Wai-Sun Wong, Henry Lik-Yuen Chan, Alfred Sze-Lok Cheng
Seminars in Cancer Biology.2013; 23(6): 471. CrossRef - The Impact of Network Medicine in Gastroenterology and Hepatology
György Baffy
Clinical Gastroenterology and Hepatology.2013; 11(10): 1240. CrossRef
- Systems Challenges of Hepatic Carcinomas: A Review
- 10,013 View
- 64 Download
- 3 Crossref
Erratum
- ERRATUM: Correction for Incorrect Citation of Reference and Wording in a Table
- Cancer Res Treat. 2011;43(3):204-204. Published online September 30, 2011
- DOI: https://doi.org/10.4143/crt.2011.43.3.204
- 6,499 View
- 42 Download
Original Articles
- Up-regulation of RhoGDI2 in Human Breast Cancer and Its Prognostic Implications
- Hyeong-Gon Moon, Sang-Ho Jeong, Young-Tae Ju, Chi-Young Jeong, Jong Sil Lee, Young-Joon Lee, Soon-Chan Hong, Sang-Kyung Choi, Woo-Song Ha, Soon-Tae Park, Eun-Jung Jung
- Cancer Res Treat. 2010;42(3):151-156. Published online September 30, 2010
- DOI: https://doi.org/10.4143/crt.2010.42.3.151
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Abstract
PDFPubReaderePub
Purpose Recent research has identified many genes and proteins that play specific roles in the process of systemic metastasis in various types of cancer. Rho GDP dissociation inhibitor 2 (RhoGDI2) has been shown to inhibit metastasis in human bladder cancer, but its role in breast cancer is controversial.
Materials and Methods We examined the regulation and clinical significance of RhoGDI2 in Korean breast cancer patients by using proteomic approaches.
Results By using a proteomic approach, we observed an increased expression of RhoGDI2 in human breast cancer tissues when compared to that of the normal breast tissues, and we validated its up-regulation in an independent cohort of 8 breast cancer patients. The clinical implication of a RhoGDI2 expression was investigated in 57 breast cancer patients by performing immunohistochemistry. RhoGDI2 did not show a significant association with the tumor size, lymph node metastasis, the histologic grade or the hormone receptor status. However, the patients with RhoGDI2-expressing tumors had significantly shorter disease-free survival (p=0.043; hazard ratio, 3.87) and distant metastasis-free survival (p=0.039; hazard ratio, 5.15).
Conclusion Our results demonstrated a potential role of RhoGDI2 as a poor prognostic marker as well as a potential therapeutic target. The pro-metastatic nature of RhoGDI2 shown in our study may indicate its organ-specific role in cancer metastasis.
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Citations
Citations to this article as recorded by- Differential functions of RhoGDIβ in malignant transformation and progression of urothelial cell following N-butyl-N-(4-hydmoxybutyl) nitrosamine exposure
Xiaohui Hua, Ronghao Zou, Xiaoyue Bai, Yuyao Yang, Juan Lu, Chuanshu Huang
BMC Biology.2023;[Epub] CrossRef - Systematic investigation of biomarker-like role of ARHGDIB in breast cancer
Xiaonan Wang, Xiaomin Bi, Xing Huang, Bijun Wang, Qianying Guo, Zhengsheng Wu
Cancer Biomarkers.2020; 28(1): 101. CrossRef - Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer
Stefan Steurer, Benjamin Hager, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Sarah Minner, Till S. Clauditz, Claudia Hube-Magg, Andreas M. Luebke, Ronald Simon, Jakob R. Izbicki, Eike Burandt, Guido Sauter, Christoph Fraune, Sören Weid
Aging.2019; 11(18): 7859. CrossRef - Prognostic value of Rho GDP dissociation inhibitors in patients with hepatocellular carcinoma following liver transplantation
Ming-Chun Lai, Qian-Qian Zhu, Kwabena-Gyabaah Owusu-Ansah, Yang-Bo Zhu, Zhe Yang, Hai-Yang Xie, Lin Zhou, Li-Ming Wu, Shu-Sen Zheng
Oncology Letters.2017; 14(2): 1395. CrossRef - RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasion of human lung cancer A549 cells via activating the PI3K/Akt pathway
Huiyan Niu, Baogang Wu, Yang Peng, Hongfang Jiang, Yi Zhang, Jiahe Wang, Yifei Zhang, Ping He
Tumor Biology.2015; 36(1): 409. CrossRef - Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors
Jonathan Hensel, Jason E. Duex, Charles Owens, Garrett M. Dancik, Michael G. Edwards, Henry F. Frierson, Dan Theodorescu
Molecular Cancer Research.2015; 13(9): 1306. CrossRef - Comparative proteomic profiling of triple-negative breast cancer reveals that up-regulation of RhoGDI-2 is associated to the inhibition of caspase 3 and caspase 9
Marcos A. Muñiz Lino, Yadira Palacios-Rodríguez, Sergio Rodríguez-Cuevas, Verónica Bautista-Piña, Laurence A. Marchat, Erika Ruíz-García, Horacio Astudillo-de la Vega, Ana E. González-Santiago, Ali Flores-Pérez, José Díaz-Chávez, Ángeles Carlos-Reyes, Eli
Journal of Proteomics.2014; 111: 198. CrossRef - Ectopic expression of miR-34a enhances radiosensitivity of non-small cell lung cancer cells, partly by suppressing the LyGDI signaling pathway
Weiming Duan, Yaxiang Xu, YuJin Dong, Lili Cao, Jian Tong, Xinwen Zhou
Journal of Radiation Research.2013; 54(4): 611. CrossRef - Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3
QINGHUA ZHAO, HAIFENG WANG, MINGYING YANG, DELIN YANG, YIGANG ZUO, JIANSONG WANG
Experimental and Therapeutic Medicine.2013; 5(3): 942. CrossRef - RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration
Neveen Said, Marta Sanchez-Carbayo, Steven C. Smith, Dan Theodorescu
Journal of Clinical Investigation.2012; 122(4): 1503. CrossRef - Overexpression of RhoGDI2 Correlates with Tumor Progression and Poor Prognosis in Colorectal Carcinoma
Xianzheng Li, Jianmei Wang, Xiaojing Zhang, Yuanfeng Zeng, Li Liang, Yanqing Ding
Annals of Surgical Oncology.2012; 19(1): 145. CrossRef - Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma
Haifeng Wang, Jiansong Wang, Yigang Zuo, Mingxia Ding, Ruping Yan, Delin Yang, Changxin Ke
Medical Oncology.2012; 29(3): 1921. CrossRef - The interrelationships between Src, Cav-1 and RhoGD12 in transitional cell carcinoma of the bladder
T Qayyum, G Fyffe, M Duncan, P A McArdle, M Hilmy, C Orange, G Halbert, M Seywright, P G Horgan, M A Underwood, J Edwards
British Journal of Cancer.2012; 106(6): 1187. CrossRef - The faces and friends of RhoGDI2
Erin M. Griner, Dan Theodorescu
Cancer and Metastasis Reviews.2012; 31(3-4): 519. CrossRef - Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade
MIGUEL A. FONSECA-SÁNCHEZ, SERGIO RODRÍGUEZ CUEVAS, GUILLERMO MENDOZA-HERNÁNDEZ, VERONICA BAUTISTA-PIÑA, ELENA ARECHAGA OCAMPO, ALFREDO HIDALGO MIRANDA, VALERIA QUINTANAR JURADO, LAURENCE A. MARCHAT, ELIZBETH ÁLVAREZ-SÁNCHEZ, CARLOS PÉREZ PLASENCIA, CÉSAR
International Journal of Oncology.2012; 41(2): 670. CrossRef - Reactive Center Loop Moiety Is Essential for the Maspin Activity on Cellular Invasion and Ubiquitin‐Proteasome Level
Chakkrit Khanaree, Kongthawat Chairatvit, Sittiruk Roytrakul, Ariyaphong Wongnoppavich
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics.2012; 20(9): 427. CrossRef - NFIB is a potential target for estrogen receptor‐negative breast cancers
Hyeong-Gon Moon, Ki-Tae Hwang, Jeong-Ah Kim, Hee Sung Kim, Min-Joo Lee, Eun-Mi Jung, Eunyoung Ko, Wonshik Han, Dong-Young Noh
Molecular Oncology.2011; 5(6): 538. CrossRef
- Differential functions of RhoGDIβ in malignant transformation and progression of urothelial cell following N-butyl-N-(4-hydmoxybutyl) nitrosamine exposure
- 11,403 View
- 73 Download
- 17 Crossref
- Overexpression of α1-protease Inhibitor and Galectin-1 in Radiation-induced Early Phase of Pulmonary Fibrosis
- Hee-Soon Im, Hyung-Doo Kim, Jie-Young Song, Youngsoo Han, Do-Youn Lee, Chan-Wha Kim, Yeon-Sook Yun
- Cancer Res Treat. 2006;38(2):92-98. Published online April 30, 2006
- DOI: https://doi.org/10.4143/crt.2006.38.2.92
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Abstract
PDFPubReaderePub
Purpose Radiation-induced pulmonary fibrosis (RIF) is a significant complication of radiotherapy for lung cancer. Despite the large number of studies, the molecular mechanisms of RIF are poorly understood. Therefore, the complex protein expression pattern in RIF was characterized by identifying the proteins with an altered expression level after thorax irradiation using two-dimensional electrophoresis (2-DE) and mass spectrometry.
Materials and Methods A mouse model of RIF was used to examine the alteration of the lung proteome because of availability of murine data related to human cases and the abundance of murine fibrotic lung samples. A mouse model of RIF was induced in radiosensitive C57BL/6 mice. Twenty-one weeks after 25 Gy irradiation, hematoxylin-eosin staining and hydroxyproline assay confirmed the early-phase pulmonary fibrosis.
Results Lung samples from the irradiated and age-matched control mice were used to generate 16 high quality 2-DE gels containing approximately 1,000 spots. Of the 31 significantly up- or down-regulated protein spots, 17 were identified by MALDI-TOF/MS.
Conclusions Two important upregulated proteins were found, the α1-protease inhibitor and galectin-1, which might be used as potential markers for the early phase of RIF.
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Citations
Citations to this article as recorded by- Gal-1-mediated cytochrome p450 activation promotes fibroblast into myofibroblast differentiation in pulmonary fibrosis
Jie Weng, Qianhui Cheng, Jingwen Yang, Haijuan Jin, Ran Zhang, Jiangan Guan, Yuan Ma, Liang Wang, Chan Chen, Zhiyi Wang
International Immunopharmacology.2024; 141: 112920. CrossRef - Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives
Chien-Hsiu Li, Yu-Chan Chang, Ming-Hsien Chan, Yi-Fang Yang, Shu-Mei Liang, Michael Hsiao
Biomedicines.2021; 9(9): 1159. CrossRef - Elevated level of Galectin-1 in bronchoalveolar lavage of patients with idiopathic pulmonary fibrosis
David Bennett, Elena Bargagli, Nicola Bianchi, Claudia Landi, Antonella Fossi, Annalisa Fui, Piersante Sestini, Rosa Metella Refini, Paola Rottoli
Respiratory Physiology & Neurobiology.2020; 273: 103323. CrossRef - Tissue- and cell-specific localization of galectins, β-galactose-binding animal lectins, and their potential functions in health and disease
Junko Nio-Kobayashi
Anatomical Science International.2017; 92(1): 25. CrossRef - Induction of galectin-1 by TGF-β1 accelerates fibrosis through enhancing nuclear retention of Smad2
Min Jin Lim, Jiyeon Ahn, Jae Youn Yi, Mi-Hyoung Kim, A-Rang Son, Sae-lo-oom Lee, Dae-Seog Lim, Sung Soo Kim, Mi Ae Kang, Youngsoo Han, Jie-Young Song
Experimental Cell Research.2014; 326(1): 125. CrossRef
- Gal-1-mediated cytochrome p450 activation promotes fibroblast into myofibroblast differentiation in pulmonary fibrosis
- 9,818 View
- 51 Download
- 5 Crossref
Review Article
- The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis
- Eun-Kyoung Yim, Jong-Sup Park
- Cancer Res Treat. 2005;37(6):319-324. Published online December 31, 2005
- DOI: https://doi.org/10.4143/crt.2005.37.6.319
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Abstract
PDFPubReaderePub
Cervical cancer is one of the leading world causes of cancer morbidity and mortality in woman, with more than 98% related to a human papillomavirus (HPV) infection origin. Infection with specific subtypes of HPV has been strongly implicated in cervical carcinogenesis. The identification and functional verification of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis and the development of cervical cancer-specific markers. The advent of functional genomics and proteomics has provided hope of discovering novel biological markers for use in the screening, early diagnosis, prognostication and prediction of response to therapy. Herein, we review the studies where the profiles of host proteins associated with HPV E6 and E7 oncoproteins in cervical cancer were generated.
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Citations
Citations to this article as recorded by- Downregulation of LAMB3 Altered the Carcinogenic Properties of Human Papillomavirus 16-Positive Cervical Cancer Cells
Warattaya Wattanathavorn, Masahide Seki, Yutaka Suzuki, Supranee Buranapraditkun, Nakarin Kitkumthorn, Thanayod Sasivimolrattana, Parvapan Bhattarakosol, Arkom Chaiwongkot
International Journal of Molecular Sciences.2024; 25(5): 2535. CrossRef - It Is All about Probiotics to Control Cervical Cancer
Sumel Ashique, Abdul Faruk, Farhan Jalees Ahmad, Tasneem Khan, Neeraj Mishra
Probiotics and Antimicrobial Proteins.2024; 16(3): 979. CrossRef - Down-regulation of human papillomavirus E6 oncogene and antiproliferative effect of Schisandra chinensis and Pueraria lobata natural extracts on Hela cell line
Andrés Cardona-Mendoza, Angela Fonseca-Benitez, Diana Marcela Buitrago, Ericsson Coy-Barrera, Sandra J. Perdomo
Journal of Ethnopharmacology.2024; 319: 117225. CrossRef - HPV16 E6/E7-mediated regulation of PiwiL1 expression induces tumorigenesis in cervical cancer cells
Midhunaraj Kunnummal, Pooja Sherly Raveendran, Budhaditya Basu, Sheri Vidya Rani, Riya Ann Paul, Krithiga Kuppusamy, Mary Angelin, Joby Issac, Jackson James, Ani V. Das
Cellular Oncology.2024; 47(3): 917. CrossRef - Cis‐regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers
Anurag Kumar Singh, Kaivalya Walavalkar, Daniele Tavernari, Giovanni Ciriello, Dimple Notani, Radhakrishnan Sabarinathan
Molecular Oncology.2024; 18(5): 1189. CrossRef - The microbiome and gynecologic cancer: cellular mechanisms and clinical applications
Julia Chalif, Heather Wang, Daniel Spakowicz, Allison Quick, Elizabeth K Arthur, David O’Malley, Laura M Chambers
International Journal of Gynecologic Cancer.2024; 34(2): 317. CrossRef - Infectious pathogens and risk of esophageal, gastric and duodenal cancers and ulcers in China: A case‐cohort study
Christiana Kartsonaki, Pang Yao, Julia Butt, Rima Jeske, Catherine de Martel, Martyn Plummer, Dianjianyi Sun, Sarah Clark, Robin G. Walters, Yiping Chen, Jun Lv, Canqing Yu, Michael Hill, Richard Peto, Liming Li, Tim Waterboer, Zhengming Chen, Iona Y. Mil
International Journal of Cancer.2024; 154(8): 1423. CrossRef - Serum oxidative biomarkers associated with genital HPV infection and cervical lesions in women
Hui‐Yi Lin, Xiaodan Zhu, Harun Or Rashid Mazumder, Martin Ronis, Kim Brint Pedersen, Michael Hagensee
Journal of Medical Virology.2024;[Epub] CrossRef - Combined amplification-based single-molecule fluorescence in situ hybridization with immunofluorescence for simultaneous in situ detection of RNAs and proteins
Yinghui Qiu, Kaipeng Wei, Hui Lin, Yanxiu Liu, Chen Lin, Rongqin Ke
Biochemical and Biophysical Research Communications.2024; 696: 149508. CrossRef - PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation
Agnes Fütterer, Sara Rodriguez-Acebes, Juan Méndez, Julio Gutiérrez, Carlos Martínez-A
Cells.2024; 13(2): 159. CrossRef - Technologies of gene editing and related clinical trials for the treatment of genetic and acquired diseases: a systematic review
Wessam Sharaf-Eldin
Egyptian Journal of Medical Human Genetics.2024;[Epub] CrossRef - The role of viruses in cancer progression versus cancer treatment: A dual paradigm
Somya Ranjan Dash, Anushka Kundu, Chanakya Nath Kundu
Life Sciences.2024; 341: 122506. CrossRef - Epigallocatechin Gallate for the Treatment of Benign and Malignant Gynecological Diseases—Focus on Epigenetic Mechanisms
Marta Włodarczyk, Michał Ciebiera, Grażyna Nowicka, Tomasz Łoziński, Mohamed Ali, Ayman Al-Hendy
Nutrients.2024; 16(4): 559. CrossRef - Unveiling HPV's hidden link: Cardiovascular diseases and the viral intrigue
Preyangsee Dutta, Dwaipayan Saha, Mrudul Earle, Chandra Prakash Prasad, Mayank Singh, Mrinalini Darswal, Vipul Aggarwal, Nitish Naik, Rakesh Yadav, Abhishek Shankar, Abhijit Chakraborty
Indian Heart Journal.2024; 76(1): 1. CrossRef - Regulation and tumor‐suppressive function of the miR‐379/miR‐656 (C14MC) cluster in cervical cancer
Sriharikrishnaa Srinath, Padacherri Vethil Jishnu, Vinay Koshy Varghese, Vaibhav Shukla, Divya Adiga, Sandeep Mallya, Sanjiban Chakrabarty, Krishna Sharan, Deeksha Pandey, Aniruddha Chatterjee, Shama Prasada Kabekkodu
Molecular Oncology.2024; 18(6): 1608. CrossRef - Comprehensive analysis of a novel subtype of immune microenvironment-derived HPV-infected colorectal cancer
Jianlong Zhou, Yongfeng Liu, Yucheng Zhang, Fa Ling, Jiabin Zheng, Xueqing Yao, Zejian Lyu, Huolun Feng, Yong Li
Microbes and Infection.2024; 26(4): 105315. CrossRef - Evolution of Pathological Techniques for the Screening of Cervical Cancer: A Comprehensive Review
Priya B Chatterjee, Snehlata R Hingway, Kishor M Hiwale
Cureus.2024;[Epub] CrossRef - Therapeutic Response to Treatment of a Papillomatous Ocular Surface Squamous Neoplasia With Intramuscular Human Papillomavirus Vaccine
Mike Zein, Sofia De Arrigunaga, Mona M. Amer, Anat Galor, Anna J. Nichols, Tim Ioannides, Sander R. Dubovy, Carol L. Karp
Cornea.2024;[Epub] CrossRef - BRCA1 deficiency enhances the aggressiveness of breast cancer cells expressing HPV16 oncoproteins
Jariya Sangthong, Chanitra Thuwajit, Laran T. Jensen, Waraporn Komyod, Jirundon Yuvaniyama, Mathurose Ponglikitmongkol
Biology of the Cell.2024;[Epub] CrossRef - Exploring the Relationship between Ovarian Cancer and Genital Microbiota: A Systematic Review and Meta-Analysis
Vito Andrea Capozzi, Giosuè Giordano Incognito, Elisa Scarpelli, Marco Palumbo, Cinzia Lucia Randazzo, Alessandra Pino, Marco La Verde, Carlo Ronsini, Gaetano Riemma, Michela Gaiano, Paola Romeo, Vittorio Palmara, Roberto Berretta, Stefano Cianci
Journal of Personalized Medicine.2024; 14(4): 351. CrossRef - Virus-like Particles for Disease Diagnosis and Drug Delivery Applications
Rishav Sharma, Rishabha Malviya
Current Nanoscience.2024; 20(5): 613. CrossRef - Biplex quantitative PCR to detect transcriptionally active human papillomavirus 16 from patient saliva
Fiona Deutsch, Dayna Sais, Ni Keatinge, Meredith Hill, Ngoc Ha Tran, Michael Elliott, Nham Tran
BMC Cancer.2024;[Epub] CrossRef - Biochemical and toxicity evaluation of Retama sphaerocarpa extracts and in-silico investigation of phenolic compounds as potential inhibitors against HPV16 E6 oncoprotein
Soumia Moujane, Ismail Bouadid, Aziz Bouymajane, Filali Zegzouti Younes, Mohamed Benlyas, Bouachrine Mohammed, Francesco Cacciola, Roberto Laganà Vinci, Alessia Tropea, Luigi Mondello, Ammar B. Altemimi, Mohamed Eddouks, Benaissa Moualij
Fitoterapia.2024; 175: 105923. CrossRef - Viruses in glioblastoma: an update on evidence and clinical trials
Bavani Gunasegaran, Caroline L. Ashley, Felix Marsh-Wakefield, Gilles J. Guillemin, Benjamin Heng
BJC Reports.2024;[Epub] CrossRef - Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity
Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, T
iScience.2024; 27(5): 109693. CrossRef - Emerging biomarkers and molecular targets for precision medicine in cervical cancer
Pankaj Garg, Madhu Krishna, Ayalur Raghu Subbalakshmi, Sravani Ramisetty, Atish Mohanty, Prakash Kulkarni, David Horne, Ravi Salgia, Sharad S. Singhal
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2024; 1879(3): 189106. CrossRef - Unfurling the functional association between long intergenic noncoding RNAs (lincRNAs) and HPV16-related cervical cancer pathogenesis through weighted gene co-expression network analysis of differentially expressed lincRNAs and coding genes
Abarna Sinha, Sahana Ghosh, Abhisikta Ghosh, Arnab Ghosh, Sonia Mathai, Jaydip Bhaumik, Asima Mukhopadhyay, Arindam Maitra, Nidhan K Biswas, Sharmila Sengupta
Carcinogenesis.2024; 45(7): 451. CrossRef - Two Lineages of Papillomaviruses Identified from Caracals (Caracal caracal) in South Africa
Simona Kraberger, Laurel E. K. Serieys, Gabriella R. M. Leighton, Matthew D. De Koch, John S. Munday, Jacqueline M. Bishop, Arvind Varsani
Viruses.2024; 16(5): 701. CrossRef - Molecular Typing of Human Leukocyte Antigen-Class I (HLA-A, HLA-B) & Human Leukocyte Antigen-Class II (HLA-DR) in Carcinoma Cervix and Its Association with Staging
Sumanta Das, Mukul Singh, Anjali Sharma, R. Naveen Kumar, Adil Aziz Khan
Indian Journal of Gynecologic Oncology.2024;[Epub] CrossRef - Tumor-Derived Antigenic Peptides as Potential Cancer Vaccines
Stanislav Sotirov, Ivan Dimitrov
International Journal of Molecular Sciences.2024; 25(9): 4934. CrossRef - CRL4-DCAF1 Ubiquitin Ligase Dependent Functions of HIV Viral Protein R and Viral Protein X
Ashley Dobransky, Mary Root, Nicholas Hafner, Matty Marcum, H. John Sharifi
Viruses.2024; 16(8): 1313. CrossRef - Impact of human papillomavirus types on uterine cervical neoplasia
Ayumi Taguchi, Daisuke Yoshimoto, Misako Kusakabe, Satoshi Baba, Akira Kawata, Yuichiro Miyamoto, Mayuyo Mori, Kenbun Sone, Yasushi Hirota, Yutaka Osuga
Journal of Obstetrics and Gynaecology Research.2024; 50(8): 1283. CrossRef - Quantification of HPV16 E7 Oncoproteins in Urine Specimens from Women with Cervical Intraepithelial Neoplasia
Daiki Makioka, Mikio Inada, Masayuki Awano, Ema Saito, Takuya Shinoda, Satoko Abe, Teruki Yoshimura, Martin Müller, Toshiyuki Sasagawa, Etsuro Ito
Microorganisms.2024; 12(6): 1205. CrossRef - Assessing bias in the causal role of HPV in oral cancer: A systematic review and meta‐analysis
Gagandeep Kaur, Tami Yap, Rishi Ramani, Michael McCullough, Ankur Singh
Oral Diseases.2024; 30(8): 5379. CrossRef - Current status and future directions for the development of human papillomavirus vaccines
Rui Wang, Hongpeng Huang, Chulin Yu, Xuefeng Li, Yang Wang, Liangzhi Xie
Frontiers in Immunology.2024;[Epub] CrossRef - Exosome‐based therapy and targeted PROTAC delivery: A new nanomedicine frontier for HPV‐mediated cervical cancer treatment
Nobendu Mukerjee, Swastika Maitra, Arabinda Ghosh
Clinical and Translational Discovery.2024;[Epub] CrossRef - Human papillomavirus‐16 E6‐positive cervical cancer attenuated by potent 2‐(4‐biphenylyl)‐N‐(1‐ethyl‐4‐piperidinyl) acetamide second‐generation analogs with improved binding affinity
Ashish Kumar
Biotechnology and Applied Biochemistry.2024;[Epub] CrossRef - Transforming growth factor-β micro-environment mediated immune cell functions in cervical cancer
Jayapradha Gnanagurusamy, Sneha Krishnamoorthy, Sridhar Muthusami
International Immunopharmacology.2024; 140: 112837. CrossRef - Harnessing virulence factor-derived peptides for innovative oral cancer treatment
Karthikeyan Kandaswamy, Ajay Guru
Natural Product Research.2024; : 1. CrossRef - Oncoviral Infections and Small Extracellular Vesicles
Łukasz Ważny, Theresa L. Whiteside, Monika Pietrowska
Viruses.2024; 16(8): 1291. CrossRef - Therapeutic Strategies in Advanced Cervical Cancer Detection, Prevention and Treatment
Xolisiwe Sebutsoe, Nrateng Tsotetsi, Zodwa Jantjies, Portia Pheladi Raphela-Choma, Mpho Choene, lesetja R Motadi
OncoTargets and Therapy.2024; Volume 17: 785. CrossRef - Bovine papillomavirus gene expression and inflammatory pathway activation vary between equine sarcoid tumour subtypes
Nicholas J. Parkinson, Abby Ward, Alexandra J. Malbon, Richard J.M. Reardon, Padraig G. Kelly
Veterinary Immunology and Immunopathology.2024; 277: 110838. CrossRef - Small non-coding RNAs as diagnostic, prognostic and predictive biomarkers of gynecological cancers: an update
Marios A. Diamantopoulos, Panagiotis G. Adamopoulos, Andreas Scorilas
Expert Review of Molecular Diagnostics.2024; 24(11): 979. CrossRef - The role of transforming growth factor β in cervical carcinogenesis
Kleber Paiva Trugilo, Guilherme Cesar Martelossi Cebinelli, Eliza Pizarro Castilha, Mariane Ricciardi da Silva, Fernanda Costa Brandão Berti, Karen Brajão de Oliveira
Cytokine & Growth Factor Reviews.2024;[Epub] CrossRef - A Self-Amplifying Human Papillomavirus 16 Vaccine Candidate Delivered by Tobacco Mosaic Virus-Like Particles
Sweta Karan, Jessica Fernanda Affonso De Oliveira, Miguel A. Moreno-Gonzalez, Nicole F. Steinmetz
ACS Applied Bio Materials.2024; 7(11): 7675. CrossRef - A State‐of‐the‐Art Review on the Recent Advances in Exosomes in Oncogenic Virus
Fatemeh Ebrahimi, Ali Modaresi Movahedi, Mohammad Sabbaghian, Vahdat Poortahmasebi
Health Science Reports.2024;[Epub] CrossRef - Association between mutant E6 and E7 Human Papilloma Virus Type 16 oncogenes with cyclin D1 expression in cervical cancer: Observational study in Bali
I Nyoman Bayu Mahendra, I Nyoman Gede Budiana, I Gede Mega Putra, Anom Suardika, Anak Agung Gede Putra Wiradnyana, Alisza Novrita Sari
F1000Research.2023; 12: 257. CrossRef - Human papillomavirus infection, cervical cancer and the less explored role of trace elements
Anne Boyina Sravani, Vivek Ghate, Shaila Lewis
Biological Trace Element Research.2023; 201(3): 1026. CrossRef - Viral subversion of the cell polarity regulator Scribble
Airah Javorsky, Patrick O. Humbert, Marc Kvansakul
Biochemical Society Transactions.2023;[Epub] CrossRef - High nuclear expression of DNMT1 in correlation with inactivation of TET1 portray worst prognosis among the cervical carcinoma patients: clinical implications
Priyanka Dutta, Mukta Basu, Anup Roy, Ranajit Kumar Mandal, Chinmay Kumar Panda
Journal of Molecular Histology.2023; 54(1): 89. CrossRef - p15INK4B is an alternative marker of senescent tumor cells in colorectal cancer
Soon Sang Park, Young-Kyoung Lee, So Hyun Park, Su Bin Lim, Yong Won Choi, Jun Sang Shin, Young Hwa Kim, Jang-Hee Kim, Tae Jun Park
Heliyon.2023; 9(2): e13170. CrossRef - Evaluation of the proteomic landscape of HPV E7‑induced alterations in human keratinocytes reveal therapeutically relevant pathways for cervical cancer
Sivasangkary Gandhi, Muhammad Fazril Mohamad Razif, Shatrah Othman, Sajib Chakraborty, Nurshamimi Nor Rashid
Molecular Medicine Reports.2023;[Epub] CrossRef - Immune Environment and Immunotherapy in Endometrial Carcinoma and Cervical Tumors
Alexandra Lainé, Andrea M. Gonzalez-Lopez, Uzma Hasan, Ryotaro Ohkuma, Isabelle Ray-Coquard
Cancers.2023; 15(7): 2042. CrossRef - Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches
Faheem Ahmed, In Suk Kang, Kyung Hwan Kim, Arun Asif, Chethikkattuveli Salih Abdul Rahim, Anupama Samantasinghar, Fida Hussain Memon, Kyung Hyun Choi
Journal of Medical Virology.2023;[Epub] CrossRef - Protein–DNA Interactions Regulate Human Papillomavirus DNA Replication, Transcription, and Oncogenesis
Roxanne Evande, Anshul Rana, Esther E. Biswas-Fiss, Subhasis B. Biswas
International Journal of Molecular Sciences.2023; 24(10): 8493. CrossRef - Histopathologic and molecular characterization of Erethizon dorsatum papillomavirus 1 and Erethizon dorsatum papillomavirus 2 infection in North American porcupines (Erethizon dorsatum)
Zoe E. Mack, Leonardo C. Caserta, Randall W. Renshaw, Shotaro Nakagun, Rhea S. Gerdes, Diego G. Diel, Sara E. Childs-Sanford, Jeanine Peters-Kennedy
Veterinary Pathology.2023; 60(6): 898. CrossRef - Whole-Genome Doubling as a source of cancer: how, when, where, and why?
Natalia Sanz-Gómez, María González-Álvarez, Javier De Las Rivas, Guillermo de Cárcer
Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef - Retrospective Phylodynamic and Phylogeographic Analysis of the Human Papillomavirus 16 E6 Gene in the Mediterranean Region
Oussama Souiai, Ameni Sallemi
Bioinformatics and Biology Insights.2023;[Epub] CrossRef - MicroRNAs as Potential Biomarkers in Gynecological Cancers
Joanna Miśkiewicz, Aleksandra Mielczarek-Palacz, Joanna Magdalena Gola
Biomedicines.2023; 11(6): 1704. CrossRef - Impact of Dietary Quality on Genital Oncogenic Human Papillomavirus Infection in Women
Hui-Yi Lin, Qiufan Fu, Tung-sung Tseng, Xiaodan Zhu, Krzysztof Reiss, L Joseph Su, Michael E Hagensee
The Journal of Infectious Diseases.2023; 228(10): 1385. CrossRef - Prevalence of P16 Immunohistochemistry Positive Staining and Its Correlation to Clinical and Radiological Staging of Squamous Cell Carcinoma of the Cervix
Hossam H. El Sokkary, Eman Sheta
The Journal of Obstetrics and Gynecology of India.2023; 73(S1): 142. CrossRef - HPV-associated cancers: insights into the mechanistic scenario and latest updates
Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Rama Jayaraj, Ramkumar Katturajan, Sandra Kannampuzha, Reshma Murali, Arunraj Namachivayam, Sabina Evan Prince, Balachandar Vellingiri, Abhijit Dey, Kaviyarasi Renu
Medical Oncology.2023;[Epub] CrossRef - Genome editing mRNA nanotherapies inhibit cervical cancer progression and regulate the immunosuppressive microenvironment for adoptive T-cell therapy
Kaijian Ling, Yin Dou, Neng Yang, Li Deng, Yanzhou Wang, Yudi Li, Leiyan Yang, Cheng Chen, Lupin Jiang, Qingchun Deng, Chenwen Li, Zhiqing Liang, Jianxiang Zhang
Journal of Controlled Release.2023; 360: 496. CrossRef - Viral manipulation of cell polarity signalling
Airah Javorsky, Patrick O. Humbert, Marc Kvansakul
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2023; 1870(7): 119536. CrossRef - The Undefinable Links: Unraveling the Mysterious Relationships Between Viruses and the Human
Yuening Li
Highlights in Science, Engineering and Technology.2023; 54: 397. CrossRef - Herpes Simplex Virus, Human Papillomavirus, and Cervical Cancer: Overview, Relationship, and Treatment Implications
Daniel Sausen, Oren Shechter, Elisa Gallo, Harel Dahari, Ronen Borenstein
Cancers.2023; 15(14): 3692. CrossRef - The potential role of the microbiota in prostate cancer pathogenesis and treatment
Nicolò Pernigoni, Christina Guo, Lewis Gallagher, Wei Yuan, Manuel Colucci, Martina Troiani, Lei Liu, Luisa Maraccani, Ilaria Guccini, Denis Migliorini, Johann de Bono, Andrea Alimonti
Nature Reviews Urology.2023; 20(12): 706. CrossRef - Clinicopathologic and Molecular Characterization of Anorectal Neuroendocrine Carcinomas Reveals Human Papillomavirus, p53, and c-Myc as Alternative Mechanisms of Carcinogenesis
Allison J. Cox, William E. Crowe, Qi Yang, Bin Zhang, Zoltán N. Oltvai, Xiaoyan Liao
Modern Pathology.2023; 36(11): 100295. CrossRef - An updated systemic review and meta-analysis on human papillomavirus in breast carcinogenesis
Usman Ayub Awan, Aamer Ali Khattak, Noman Ahmed, Xingyi Guo, Sohail Akhtar, Shehrish Kamran, Zhao Yongjing, Jianbo Liu, Suliman Khan
Frontiers in Oncology.2023;[Epub] CrossRef - Role of MLH1 and MSH2 deficiency in the development of tumorigenesis and chemo-tolerance of cervical Carcinoma: Clinical implications
Priyanka Dutta, Debolina Pal, Anup Roy, Ranajit Kumar Mandal, Chinmay Kumar Panda
Gene.2023; 888: 147746. CrossRef - Detection of High-Grade Cervical Intraepithelial Neoplasia by Electrical Impedance Spectroscopy in Women Diagnosed with Low-Grade Cervical Intraepithelial Neoplasia in Cytology
Georgios Panagakis, Ioannis K. Papapanagiotou, Charalampos Theofanakis, Paraskevi Tsetsa, Adamantia Kontogeorgi, Nikolaos Thomakos, Alexandros Rodolakis, Dimitrios Haidopoulos
Life.2023; 13(11): 2139. CrossRef - MULTİPL SKLEROZ HASTALARINDA SERVİKAL DİSPLAZİ RİSKİ
Özlem Kayacık Günday, Gökçe Zeytin Demiral, Şerafettin Baysal, Tacettin Sevim, Selin Yoldaş, Berkay Çelebi, Ensar Çam
Kocatepe Tıp Dergisi.2023; 24(4): 493. CrossRef - p16/Ki67 dual stain triage versus cytology in primary human papillomavirus‐based cervical cancer screening with limited genotyping
Martyna Trzeszcz, Maciej Mazurec, Robert Jach, Karolina Mazurec, Izabela Kotkowska‐Szeps, Magdalena Kania, Mariola Wantuchowicz, Jolanta Wasowska, Monika Duczek‐Polakiewicz, Patrycja Rozmus, Joanna Streb, Agnieszka Halon
Journal of Medical Virology.2023;[Epub] CrossRef - From Diagnosis to Treatment: Exploring the Latest Management Trends in Cervical Intraepithelial Neoplasia
Saloni Gupta, Nikhilesh Nagtode, Vaibhav Chandra, Kavita Gomase
Cureus.2023;[Epub] CrossRef - Regulatory Effect of Ficus carica Latex on Cell Cycle Progression in Human Papillomavirus-Positive Cervical Cancer Cell Lines: Insights from Gene Expression Analysis
Muharrem Cakir, Ugur Bilge, Arshia Ghanbari, G. Ashrafi
Pharmaceuticals.2023; 16(12): 1723. CrossRef - Leveraging innovative therapies with an evolving understanding of the molecular pathogenesis of penile squamous cell carcinoma
Ali Hajiran, Taylor Bracco, Logan Zemp, Philippe E. Spiess
Urologic Oncology: Seminars and Original Investigations.2022; 40(5): 173. CrossRef - Antioxidant and Cytotoxic Activities of Exopolysaccharides from Alcaligenes faecalis Species Isolated from the Marine Environment of Mauritius
Aadil Ahmad Aullybux, Daneshwar Puchooa, Theeshan Bahorun, Rajesh Jeewon, Xuesong Wen, Poona Matin
Journal of Polymers and the Environment.2022; 30(4): 1462. CrossRef - Molecular landscape of vulvovaginal squamous cell carcinoma: new insights into molecular mechanisms of HPV-associated and HPV-independent squamous cell carcinoma
Abeer M. Salama, Amir Momeni-Boroujeni, Chad Vanderbilt, Marc Ladanyi, Robert Soslow
Modern Pathology.2022; 35(2): 274. CrossRef - Haemophilus pittmaniae and Leptotrichia spp. Constitute a Multi-Marker Signature in a Cohort of Human Papillomavirus-Positive Head and Neck Cancer Patients
Jean-Luc C. Mougeot, Micaela F. Beckman, Holden C. Langdon, Rajesh V. Lalla, Michael T. Brennan, Farah K. Bahrani Mougeot
Frontiers in Microbiology.2022;[Epub] CrossRef - Therapeutic DNA Vaccines against HPV-Related Malignancies: Promising Leads from Clinical Trials
Jianming Tang, Mingzhu Li, Chao Zhao, Danhua Shen, Lei Liu, Xiujun Zhang, Lihui Wei
Viruses.2022; 14(2): 239. CrossRef - Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming
Stefanie Koster, Rajendra Kumar Gurumurthy, Naveen Kumar, Pon Ganish Prakash, Jayabhuvaneshwari Dhanraj, Sofia Bayer, Hilmar Berger, Shilpa Mary Kurian, Marina Drabkina, Hans-Joachim Mollenkopf, Christian Goosmann, Volker Brinkmann, Zachary Nagel, Mandy M
Nature Communications.2022;[Epub] CrossRef - Peptide-Based Nanovaccines in the Treatment of Cervical Cancer: A Review of Recent Advances
Jiahui Zhang, Jingyi Fan, Mariusz Skwarczynski, Rachel J Stephenson, Istvan Toth, Waleed M Hussein
International Journal of Nanomedicine.2022; Volume 17: 869. CrossRef - Cancer Therapy With TCR-Engineered T Cells: Current Strategies, Challenges, and Prospects
Paul Shafer, Lauren M. Kelly, Valentina Hoyos
Frontiers in Immunology.2022;[Epub] CrossRef - Human Papillomavirus E6/E7 oncogene transcripts as biomarkers for the early detection of cervical cancer
Sadhana M Gupta, Himangi Warke, Hemangi Chaudhari, Padmaja Mavani, Rajshree D. Katke, Shilpa C. Kerkar, Jayanti Mania‐Pramanik
Journal of Medical Virology.2022; 94(7): 3368. CrossRef - Targeting metabolism: A potential strategy for hematological cancer therapy
Xue Tang, Fen Chen, Li-Chun Xie, Si-Xi Liu, Hui-Rong Mai
World Journal of Clinical Cases.2022; 10(10): 2990. CrossRef - Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia
Tafadzwa Chihanga, Sara Vicente-Muñoz, Sonya Ruiz-Torres, Bidisha Pal, Mathieu Sertorio, Paul R. Andreassen, Ruby Khoury, Parinda Mehta, Stella M. Davies, Andrew N. Lane, Lindsey E. Romick-Rosendale, Susanne I. Wells
Cancers.2022; 14(8): 2040. CrossRef - Current and future direction in treatment of HPV-related cervical disease
Niloofar Khairkhah, Azam Bolhassani, Reza Najafipour
Journal of Molecular Medicine.2022; 100(6): 829. CrossRef - Parent Attitudes regarding Orthodontists’ Role as Potential Administrators of Human Papilloma Virus (HPV) Vaccines
Gloria Lee, Jessica Begley, Kavita Ahluwalia, Jaffer A Shariff, Sunil Wadhwa, Christine O’Hea, Gaetano Isola
International Journal of Dentistry.2022; 2022: 1. CrossRef - Graphene Quantum Dots – Hydrothermal Green Synthesis, Material Characterization and Prospects for Cervical Cancer Diagnosis Applications: A Review
Raghavv Raghavender Suresh, Arockia Jayalatha Kulandaisamy, Noel Nesakumar, Saisubramanian Nagarajan, Jung Heon Lee, John Bosco Balaguru Rayappan
ChemistrySelect.2022;[Epub] CrossRef - Interplay between cellular metabolism and DNA viruses
Milad Zandi, Somayeh Shokri, Shahab Mahmoudvand, Ahmad Hosseinzadeh Adli, Ramin Mohammadi, Azita Haddadi
Journal of Medical Virology.2022; 94(11): 5163. CrossRef - Breast Cancer Risk and Human Papillomavirus Infection: A Bradford Hill Criteria Based Evaluation
Muhammad Usman, Yasir Hameed, Mukhtiar Ahmad, Jalil Ur Rehman, Hamad Ahmed, Muhammad Safdar Hussain, Rizwan Asif, Muhammad Ghulam Murtaza, Muhammad Tayyab Jawad, Muhammad Junaid Iqbal
Infectious Disorders - Drug Targets.2022;[Epub] CrossRef - Sensor detection in gynaecological medicine
Michael Thompson, Soha Ahmadi, Katharina Davoudian, Brian De La Franier, Navina Lotay, Marcus Q. Bernardini
Sensors & Diagnostics.2022; 1(5): 877. CrossRef - Cervical cancer screening, treatment and prophylaxis in Brazil: Current and future perspectives for cervical cancer elimination
Flávia M. Corrêa, Arn Migowski, Liz M. de Almeida, Marcelo A. Soares
Frontiers in Medicine.2022;[Epub] CrossRef - HPV-mediated Cervical Cancer: A Systematic Review on Immunological
Basis, Molecular Biology, and Immune Evasion Mechanisms
Ramar Vanajothi, Natarajan Srikanth, Rajendran Vijayakumar, Manikandan Palanisamy, Sundaresan Bhavaniramya, Kumpati Premkumar
Current Drug Targets.2022; 23(8): 782. CrossRef - Potential role of human papillomavirus proteins associated with the development of cancer
Dhanvee Balaji, Iyshwarya Bhaskar Kalarani, Vajagathali Mohammed, Ramakrishnan Veerabathiran
VirusDisease.2022; 33(3): 322. CrossRef - Proton-induced DNA damage promotes integration of foreign plasmid DNA into human genome
Meghri Katerji, Antonella Bertucci, Valery Filippov, Marcelo Vazquez, Xin Chen, Penelope J. Duerksen-Hughes
Frontiers in Oncology.2022;[Epub] CrossRef - Anti-cancer properties of Caulerpa racemosa by altering expression of Bcl-2, BAX, cleaved caspase 3 and apoptosis in HeLa cancer cell culture
Happy Kurnia Permatasari, Defny Silvia Wewengkang, Nur Iedha Tertiana, Farida Zharfani Muslim, Muhammad Yusuf, Shintya Octaviana Baliulina, Vanessa Pradna Adyana Daud, Aurielle Annalicia Setiawan, Fahrul Nurkolis
Frontiers in Oncology.2022;[Epub] CrossRef - Does Lactobacillus Exert a Protective Effect on the Development of Cervical and Endometrial Cancer in Women?
Karolina Frąszczak, Bartłomiej Barczyński, Adrianna Kondracka
Cancers.2022; 14(19): 4909. CrossRef - Cervical cancer screening: Past, present and outlook
Radomir Živadinović, Aleksandra Petrić, Aleksandar Živadinović, Sonja Pop-Trajković, Lazar Živadinović, Dušan Simić
Glasnik javnog zdravlja.2022; 96(3): 333. CrossRef - HPV-18 E7 Interacts with Elk-1 Leading to Elevation of the Transcriptional Activity of Elk-1 in Cervical Cancer
Sung-Ho Go, Seung Bae Rho, Dong-Wha Yang, Boh-Ram Kim, Chang Hoon Lee, Seung-Hoon Lee
Biomolecules & Therapeutics.2022; 30(6): 593. CrossRef - A Reverse Structure-based Design of HPV E7 Inhibitor
Wan Chein Tan, Shatrah Othman, See Khai Lim, Nurshamimi Nor Rashid, Choon Han Heh
Current Computer-Aided Drug Design.2022; 18(4): 318. CrossRef - Investigation of Curcumin-Loaded OA400 Nanoparticle’s Effect on the Expression of E6 and E7 Human Papilloma-Virus Oncogenes and P53 and Rb Factors in HeLa Cell Line
Rezvaneh Vahedian Sadeghi, Masoud Parsania, Majid Sadeghizadeh, Setareh Haghighat
Iranian Journal of Pharmaceutical Research.2022;[Epub] CrossRef - Enhancing the Effect of Nucleic Acid Vaccines in the Treatment of HPV-Related Cancers: An Overview of Delivery Systems
Ingrid Andrêssa de Moura, Anna Jéssica Duarte Silva, Larissa Silva de Macêdo, Maria da Conceição Viana Invenção, Mylenna Máyra Gois de Sousa, Antonio Carlos de Freitas
Pathogens.2022; 11(12): 1444. CrossRef - Effects of Human Papilloma Virus E6/E7 Oncoproteins on Genomic Structure in Head and Neck Squamous Cell Carcinoma
Matthew Uzelac, Armon Barakchi, Varsha Beldona, Daniel John, Jaideep Chakladar, Wei Tse Li, Weg M. Ongkeko
Cancers.2022; 14(24): 6190. CrossRef - Towards Novel Gene and Cell Therapy Approaches for Cervical Cancer
Robert Polten, Ivana Kutle, Jens Hachenberg, Rüdiger Klapdor, Michael Morgan, Axel Schambach
Cancers.2022; 15(1): 263. CrossRef - The Presence of Human Papillomavirus and Epstein-Barr Virus Infection in Gastric Cancer: A Systematic Study
Abolfazl Jafari-Sales, Afsoon Shariat, Hossein Bannazadeh Baghi, Behzad Baradaran, Behboud Jafari
Oncologie.2022; 24(3): 413. CrossRef - Immunology of HPV-mediated cervical cancer: current understanding
Babban Jee, Renu Yadav, Sangeeta Pankaj, Shivendra Kumar Shahi
International Reviews of Immunology.2021; 40(5): 359. CrossRef - The role of human papillomavirus in the pathogenesis of sinonasal inverted papilloma: a narrative review
Rohit Gupta, Peter L. Rady, Andrew G. Sikora, Stephen K. Tyring
Reviews in Medical Virology.2021;[Epub] CrossRef - The role of HPV gene expression and selected cellular MiRNAs in lung cancer development
Bashdar Mahmud Hussen, Gelavizh Ahmadi, Havva Marzban, Maryam Ebadi Fard Azar, Saba Sorayyayi, Romina Karampour, Javid Sadri Nahand, Hazha Jamal Hidayat, Mohsen Moghoofei
Microbial Pathogenesis.2021; 150: 104692. CrossRef - Adjunctive testing by cytology, p16/Ki‐67 dual‐stained cytology or HPV16/18 E6 oncoprotein for the management of HPV16/18 screen‐positive women
Leticia Torres‐Ibarra, Attila T. Lorincz, Cosette M. Wheeler, Jack Cuzick, Rubí Hernández‐López, Donna Spiegelman, Leith León‐Maldonado, Berenice Rivera‐Paredez, Pablo Méndez‐Hernández, Eduardo Lazcano‐Ponce, Jorge Salmerón
International Journal of Cancer.2021; 148(9): 2264. CrossRef - EGFR Protein Expression Relates with Tumor Histology, Methylation Status of EGFR and HPV16 E6 Viral Load in Oropharyngeal Carcinoma
Yo Suzuki, Yuki Fukumura, Miki Asahina, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Isao Kurahayashi, Takashi Yao, Katsuhisa Ikeda
Head and Neck Pathology.2021; 15(3): 743. CrossRef - An internal class III PDZ binding motif in HPV16 E6* protein is required for Dlg degradation activity
Wareerat Umnajvijit, Jariya Sangthong, Fabien Loison, Kulthida Vaeteewoottacharn, Mathurose Ponglikitmongkol
Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(5): 129850. CrossRef - Microbiota Effects on Carcinogenesis: Initiation, Promotion, and Progression
Lacey R. Lopez, Rachel M. Bleich, Janelle C. Arthur
Annual Review of Medicine.2021; 72(1): 243. CrossRef - Ovulatory Follicular Fluid Facilitates the Full Transformation Process for the Development of High-Grade Serous Carcinoma
Che-Fang Hsu, Pao-Chu Chen, Vaishnavi Seenan, Dah-Ching Ding, Tang-Yuan Chu
Cancers.2021; 13(3): 468. CrossRef - Is There a Carcinogenic Risk Attached to Vitamin B12 Deficient Diets and What Should We Do About It? Reviewing the Facts
Alexandra K. Loedin, Dave Speijer
Molecular Nutrition & Food Research.2021;[Epub] CrossRef - Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers
Saghi Nooraei, Howra Bahrulolum, Zakieh Sadat Hoseini, Camellia Katalani, Abbas Hajizade, Andrew J. Easton, Gholamreza Ahmadian
Journal of Nanobiotechnology.2021;[Epub] CrossRef - Focus on HPV Infection and the Molecular Mechanisms of Oral Carcinogenesis
Luigi Santacroce, Michele Di Cosola, Lucrezia Bottalico, Skender Topi, Ioannis Alexandros Charitos, Andrea Ballini, Francesco Inchingolo, Angela Pia Cazzolla, Gianna Dipalma
Viruses.2021; 13(4): 559. CrossRef - An Emerging Anti-p16 Antibody-BC42 Clone as an Alternative to the Current E6H4 for Use in the Female Genital Tract Pathological Diagnosis: Our Experience and a Review on p16ink4a Functional Significance, Role in Daily-Practice Diagnosis, Prognostic Potent
Giuseppe Angelico, Angela Santoro, Frediano Inzani, Patrizia Straccia, Saveria Spadola, Damiano Arciuolo, Michele Valente, Nicoletta D’Alessandris, Roberta Benvenuto, Antonio Travaglino, Antonio Raffone, Gian Franco Zannoni
Diagnostics.2021; 11(4): 713. CrossRef - Dynamic crosstalk within the tumor microenvironment of uterine cervical carcinoma: baseline network, iatrogenic alterations, and translational implications
Rosalba De Nola, Vera Loizzi, Ettore Cicinelli, Gennaro Cormio
Critical Reviews in Oncology/Hematology.2021; 162: 103343. CrossRef - Meet the Insidious Players: Review of Viral Infections in Head and Neck Cancer Etiology with an Update on Clinical Trials
Lejla Mahmutović, Esma Bilajac, Altijana Hromić-Jahjefendić
Microorganisms.2021; 9(5): 1001. CrossRef - Degradation of p53 by HPV16-E6 variants isolated from cervical cancer specimens of Moroccan women
Khaoula HADAMI, Charles SABY, Nadia DAKKA, Guillaume COLLIN, Mohammed ATTALEB, Meriem KHYATTI, Abdelkarim FILALI-MALTOUF, Hamid MORJANI, Mohammed EL MZIBRI
Gene.2021; 791: 145709. CrossRef - The potential applications of T cell receptor (TCR)-like antibody in cervical cancer immunotherapy
Sylvia Annabel Dass, Rehasri Selva Rajan, Gee Jun Tye, Venugopal Balakrishnan
Human Vaccines & Immunotherapeutics.2021; 17(9): 2981. CrossRef - UVB Inhibits Proliferation, Cell Cycle and Induces Apoptosis via p53, E2F1 and Microtubules System in Cervical Cancer Cell Lines
Angelica Judith Granados-López, Eduardo Manzanares-Acuña, Yamilé López-Hernández, Julio Enrique Castañeda-Delgado, Ixamail Fraire-Soto, Claudia Araceli Reyes-Estrada, Rosalinda Gutiérrez-Hernández, Jesús Adrián López
International Journal of Molecular Sciences.2021; 22(10): 5197. CrossRef - Novel Affibody Molecules Targeting the HPV16 E6 Oncoprotein Inhibited the Proliferation of Cervical Cancer Cells
Jinshun Zhu, Saidu Kamara, Qi Wang, Yanru Guo, Qingfeng Li, Linlin Wang, Jingjing Chen, Qianqian Du, Wangqi Du, Shao Chen, Shanli Zhu, Jun Chen, Maoping Chu, Lifang Zhang
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef - Recent Progress in Electrochemical Detection of Human Papillomavirus (HPV) via Graphene‐Based Nanosensors
Seyyed Mojtaba Mousavi, Gity Behbudi, Seyyed Alireza Hashemi, Aziz Babapoor, Wei-Hung Chiang, Seeram Ramakrishna, Mohammed Muzibur Rahman, Chin Wei Lai, Ahmad Gholami, Navid Omidifar, Khadije Yousefi, Bruno C. Janegitz
Journal of Sensors.2021;[Epub] CrossRef - Antioxidants Associated With Oncogenic Human Papillomavirus Infection in Women
Hui-Yi Lin, Qiufan Fu, Yu-Hsiang Kao, Tung-sung Tseng, Krzysztof Reiss, Jennifer E Cameron, Martin J Ronis, Joseph Su, Navya Nair, Hsiao-Man Chang, Michael E Hagensee
The Journal of Infectious Diseases.2021; 224(9): 1520. CrossRef - The Microbiome and Gynecologic Cancer: Current Evidence and Future Opportunities
Laura M. Chambers, Parker Bussies, Roberto Vargas, Emily Esakov, Surabhi Tewari, Ofer Reizes, Chad Michener
Current Oncology Reports.2021;[Epub] CrossRef - Interpretations on the Interaction between Protein Tyrosine Phosphatase and E7 Oncoproteins of High and Low-Risk HPV: A Computational Perception
Murali Aarthy, Sanjeev Kumar Singh
ACS Omega.2021; 6(25): 16472. CrossRef - Validation of Potential Protein Markers Predicting Chemoradioresistance in Early Cervical Cancer by Immunohistochemistry
Soo Young Jeong, Joon-Yong Chung, Sun-Ju Byeon, Chul Jung Kim, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Ye Lin Chae, So Young Oh, Chel Hun Choi
Frontiers in Oncology.2021;[Epub] CrossRef - Viral load and interaction of HPV oncoprotein E6 and E7 with host cellular markers in the progression of cervical cancer
Bilal Ahmad Mir, P. F. Rahaman, Arif Ahmad
AIMS Molecular Science.2021; 8(3): 184. CrossRef - Integrin alpha 6 as a stemness driver is a novel promising target for HPV (+) head and neck squamous cell carcinoma
Jin Seol An, Jung Hwa Moon, Chayeon Kim, Joo Kyung No, Young Gyu Eun, Young Chang Lim
Experimental Cell Research.2021; 407(2): 112815. CrossRef - Reduced MAGI3 level by HPV18E6 contributes to Wnt/β‐catenin signaling activation and cervical cancer progression
Zhuoli Yang, Hua Liu, Ran Song, Wenxiu Lu, Haibo Wang, Siyu Gu, Xuedi Cao, Yibin Chen, Jihuan Liang, Qiong Qin, Xiaomei Yang, Duiping Feng, Junqi He
FEBS Open Bio.2021; 11(11): 3051. CrossRef - An Integrated View of Virus-Triggered Cellular Plasticity Using Boolean Networks
Jenny Paola Alfaro-García, María Camila Granados-Alzate, Miguel Vicente-Manzanares, Juan Carlos Gallego-Gómez
Cells.2021; 10(11): 2863. CrossRef - Role of interleukin-17 in human papillomavirus infection and associated malignancies
Utkarsha Sahu, Prashant Khare
Microbial Pathogenesis.2021; 161: 105294. CrossRef - FNDC3B and BPGM Are Involved in Human Papillomavirus-Mediated Carcinogenesis of Cervical Cancer
Luhan Zhang, Hong Yu, Tian Deng, Li Ling, Juan Wen, Mingfen Lv, Rongying Ou, Qiaozhi Wang, Yunsheng Xu
Frontiers in Oncology.2021;[Epub] CrossRef - Investigating host-virus interaction mechanism and phylogenetic analysis of viral proteins involved in the pathogenesis
Ahmad Abu Turab Naqvi, Farah Anjum, Alaa Shafie, Sufian Badar, Abdelbaset Mohamed Elasbali, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan, Timir Tripathi
PLOS ONE.2021; 16(12): e0261497. CrossRef - Potential anticancer effect of aspirin and 2'‑hydroxy‑2,3,5'‑trimethoxychalcone‑linked polymeric micelles against cervical cancer through apoptosis
Kang Lee, Suji Baek, Myeong Yoon, Ji Park, Bok Hong, Sang Lee, Seung Oh, Seung Kwon, Ruda Lee, Dae Lee, Kang-Seo Park, Byung Moon
Oncology Letters.2021;[Epub] CrossRef - HPVE6-USP46 Mediated Cdt2 Stabilization Reduces Set8 Mediated H4K20-Methylation to Induce Gene Expression Changes
Shashi Kiran, Briana Wilson, Shekhar Saha, Julia Ann Graff, Anindya Dutta
Cancers.2021; 14(1): 30. CrossRef - Translatable gene therapy for lung cancer using Crispr CAS9—an exploratory review
Jishnu Nair, Abhishek Nair, Soundaram Veerappan, Dwaipayan Sen
Cancer Gene Therapy.2020; 27(3-4): 116. CrossRef - Cancer signaling by plasmonic quantum probes
Ayushi Agarwal, Krishnan Venkatakrishnan, Bo Tan
Applied Materials Today.2020; 18: 100465. CrossRef - Multistate Markov Model to Predict the Prognosis of High-Risk Human Papillomavirus-Related Cervical Lesions
Ayumi Taguchi, Konan Hara, Jun Tomio, Kei Kawana, Tomoki Tanaka, Satoshi Baba, Akira Kawata, Satoko Eguchi, Tetsushi Tsuruga, Mayuyo Mori, Katsuyuki Adachi, Takeshi Nagamatsu, Katsutoshi Oda, Toshiharu Yasugi, Yutaka Osuga, Tomoyuki Fujii
Cancers.2020; 12(2): 270. CrossRef - Early-stage cervical cancer diagnosis based on an ultra-sensitive electrochemical DNA nanobiosensor for HPV-18 detection in real samples
Pegah Mahmoodi, Majid Rezayi, Elisa Rasouli, Amir Avan, Mehrdad Gholami, Majid Ghayour Mobarhan, Ehsan Karimi, Yatima Alias
Journal of Nanobiotechnology.2020;[Epub] CrossRef - Cervical Cancer Screening: Past, Present, and Future
Sarah L. Bedell, Lena S. Goldstein, Amelia R. Goldstein, Andrew T. Goldstein
Sexual Medicine Reviews.2020; 8(1): 28. CrossRef - Potential oncogenic roles of mutant-p53-derived exosomes in the tumor–host interaction of head and neck cancers
Etti Ester Azulay, Tomer Cooks, Moshe Elkabets
Cancer Immunology, Immunotherapy.2020; 69(2): 285. CrossRef - Extracellular Vesicles from Human Papilloma Virus-Infected Cervical Cancer Cells Enhance HIV-1 Replication in Differentiated U1 Cell Line
Sabina Ranjit, Sunitha Kodidela, Namita Sinha, Subhash Chauhan, Santosh Kumar
Viruses.2020; 12(2): 239. CrossRef - Preparation, Characterization and Diagnostic Valuation of Two Novel Anti-HPV16 E7 Oncoprotein Monoclonal Antibodies
Renjian Hu, Zhen Dong, Kui Zhang, Guangzhao Pan, Chongyang Li, Hongjuan Cui
Viruses.2020; 12(3): 333. CrossRef - Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics
Patrick Herr, Johan Boström, Eric Rullman, Sean G. Rudd, Mattias Vesterlund, Janne Lehtiö, Thomas Helleday, Gianluca Maddalo, Mikael Altun
Molecular & Cellular Proteomics.2020; 19(4): 608. CrossRef - HPV Infection Significantly Accelerates Glycogen Metabolism in Cervical Cells with Large Nuclei: Raman Microscopic Study with Subcellular Resolution
Katarzyna Sitarz, Krzysztof Czamara, Joanna Bialecka, Malgorzata Klimek, Barbara Zawilinska, Slawa Szostek, Agnieszka Kaczor
International Journal of Molecular Sciences.2020; 21(8): 2667. CrossRef - Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
Shaian Tavakolian, Hossein Goudarzi, Ebrahim Faghihloo
Infectious Agents and Cancer.2020;[Epub] CrossRef - Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment
Mohsen Keshavarz, Mir Saeed Ebrahimzadeh, Seyed Mohammad Miri, Hassan Dianat-Moghadam, Seyedeh Sara Ghorbanhosseini, Seyed Reza Mohebbi, Hossein Keyvani, Amir Ghaemi
Virology Journal.2020;[Epub] CrossRef - Virus-Specific T Cells for the Treatment of Malignancies—Then, Now, and the Future
Sandhya Sharma, Wingchi K Leung, Helen E Heslop
Current Stem Cell Reports.2020; 6(2): 17. CrossRef - The Relationship between Estrogen-Related Signaling and Human Papillomavirus Positive Cancers
Claire D. James, Iain M. Morgan, Molly L. Bristol
Pathogens.2020; 9(5): 403. CrossRef - Combination Vaccination With Tetanus Toxoid and Enhanced Tumor-Cell Based Vaccine Against Cervical Cancer in a Mouse Model
Donia Alson, Scott C. Schuyler, Bo-Xin Yan, Karthika Samimuthu, Jiantai Timothy Qiu
Frontiers in Immunology.2020;[Epub] CrossRef - HPV‐related methylation‐based reclassification and risk stratification of cervical cancer
Si Yang, Ying Wu, Shuqian Wang, Peng Xu, Yujiao Deng, Meng Wang, Kang Liu, Tian Tian, Yuyao Zhu, Na Li, Linghui Zhou, Zhijun Dai, Huafeng Kang
Molecular Oncology.2020; 14(9): 2124. CrossRef - Anti-tumor activities of probiotics in cervical cancer
Moghaddaseh Jahanshahi, Parisa Maleki Dana, Bita Badehnoosh, Zatollah Asemi, Jamal Hallajzadeh, Mohammad Ali Mansournia, Bahman Yousefi, Bahram Moazzami, Shahla Chaichian
Journal of Ovarian Research.2020;[Epub] CrossRef - Dysregulation of Stemness Pathways in HPV Mediated Cervical Malignant Transformation Identifies Potential Oncotherapy Targets
Megha Budhwani, Samuel W. Lukowski, Sandro V. Porceddu, Ian H. Frazer, Janin Chandra
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef - Bee venom inhibits the proliferation and migration of cervical-cancer cells in an HPV E6/E7-dependent manner
Da-Hyun Kim, Hyun-Woo Lee, Hyun-Woo Park, Han-Woong Lee, Kyung-Hee Chun
BMB Reports.2020; 53(8): 419. CrossRef - The association between HPV gene expression, inflammatory agents and cellular genes involved in EMT in lung cancer tissue
Marzieh Rezaei, Shayan Mostafaei, Amir Aghaei, Nayyerehalsadat Hosseini, Hassan Darabi, Majid Nouri, Ashkan Etemadi, Andrew O’. Neill, Javid Sadri Nahand, Hamed Mirzaei, Seamas C. Donnelly, Mohammad Doroudian, Mohsen Moghoofei
BMC Cancer.2020;[Epub] CrossRef - The role of viruses in adenocarcinoma development
Mohsen Nakhaie, Javad Charostad, Gholam Abbas Kaydani, Ebrahim Faghihloo
Infection, Genetics and Evolution.2020; 86: 104603. CrossRef - Use of Cap Analysis Gene Expression to detect human papillomavirus promoter activity patterns at different disease stages
Ayumi Taguchi, Kazunori Nagasaka, Charles Plessy, Hiroe Nakamura, Yoshiko Kawata, Sachi Kato, Kosuke Hashimoto, Takeshi Nagamatsu, Katsutoshi Oda, Iwao Kukimoto, Kei Kawana, Piero Carninci, Yutaka Osuga, Tomoyuki Fujii
Scientific Reports.2020;[Epub] CrossRef - Potential therapeutic and pharmacological effects of Wogonin: an updated review
Do Luong Huynh, Tran Hoang Ngau, Nguyen Hoai Nguyen, Gia-Buu Tran, Cuong Thach Nguyen
Molecular Biology Reports.2020; 47(12): 9779. CrossRef - The Molecular and Pathophysiological Functions of Members of the LNX/PDZRN E3 Ubiquitin Ligase Family
Jeongkwan Hong, Minho Won, Hyunju Ro
Molecules.2020; 25(24): 5938. CrossRef - Investigating the aetiology of adverse events following HPV vaccination with systems vaccinology
Joan Campbell-Tofte, Aristidis Vrahatis, Knud Josefsen, Jesper Mehlsen, Kaj Winther
Cellular and Molecular Life Sciences.2019; 76(1): 67. CrossRef - DNA methyltransferases in virus‐associated cancers
Javad Charostad, Akram Astani, Hossein Goudarzi, Ebrahim Faghihloo
Reviews in Medical Virology.2019;[Epub] CrossRef - Identification and characterization of an alternative cancer-derived PD-L1 splice variant
Nadia B. Hassounah, Venkat S. Malladi, Yi Huang, Samuel S. Freeman, Ellen M. Beauchamp, Shohei Koyama, Nicholas Souders, Sunil Martin, Glenn Dranoff, Kwok-Kin Wong, Chandra S. Pedamallu, Peter S. Hammerman, Esra A. Akbay
Cancer Immunology, Immunotherapy.2019; 68(3): 407. CrossRef - What is the potential of p53 isoforms as a predictive biomarker in the treatment of cancer?
Liam Hayman, Wajeeh Raza Chaudhry, Victor V. Revin, Nikolai Zhelev, Jean-Christophe Bourdon
Expert Review of Molecular Diagnostics.2019; 19(2): 149. CrossRef - Transforming properties of ovine papillomaviruses E6 and E7 oncogenes
Gessica Tore, Gian Mario Dore, Carla Cacciotto, Rosita Accardi, Antonio G. Anfossi, Luisa Bogliolo, Marco Pittau, Salvatore Pirino, Tiziana Cubeddu, Massimo Tommasino, Alberto Alberti
Veterinary Microbiology.2019; 230: 14. CrossRef - Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins
Niloofar Khodabandehlou, Shayan Mostafaei, Ashkan Etemadi, Amir Ghasemi, Mehrdad Payandeh, Shima Hadifar, Amir Hossein Norooznezhad, Anoshirvan Kazemnejad, Mohsen Moghoofei
BMC Cancer.2019;[Epub] CrossRef - HPVE6/E7,hTERT, andKi67mRNA RT-qPCR Assay for Detecting High-Grade Cervical Lesion with Microscope Slides
Geehyuk Kim, Jemberu Taye, Kwangmin Yu, Sunyoung Park, Jungho Kim, Sunghyun Kim, Dongsup Lee, Hye-young Wang, Kwang Hwa Park, Hyeyoung Lee
Analytical Cellular Pathology.2019; 2019: 1. CrossRef - A high-risk papillomavirus 18 E7 affibody-enabled in vivo imaging and targeted therapy of cervical cancer
Ledan Wang, Wangqi Du, Shanli Zhu, Pengfei Jiang, Lifang Zhang
Applied Microbiology and Biotechnology.2019; 103(7): 3049. CrossRef -
HOXC6
promotes cervical cancer progression
via
regulation of
Bcl‐2
Yongsheng Wang, Cong Wang, Na Liu, Jun Hou, Wenjing Xiao, Hui Wang
The FASEB Journal.2019; 33(3): 3901. CrossRef - Meta‐analysis of the accuracy of p16 or p16/Ki‐67 immunocytochemistry versus HPV testing for the detection of CIN2+/CIN3+ in triage of women with minor abnormal cytology
Eliana Peeters, Nicolas Wentzensen, Christine Bergeron, Marc Arbyn
Cancer Cytopathology.2019; 127(3): 169. CrossRef - Long non-coding RNA FAM83H-AS1 is regulated by human papillomavirus 16 E6 independently of p53 in cervical cancer cells
Jamie A. Barr, Karen E. Hayes, Tayvia Brownmiller, Abby D. Harold, Rajaganapathi Jagannathan, Paul R. Lockman, Saleem Khan, Ivan Martinez
Scientific Reports.2019;[Epub] CrossRef - Pongapin and Karanjin, furanoflavanoids of Pongamia pinnata, induce G2/M arrest and apoptosis in cervical cancer cells by differential reactive oxygen species modulation, DNA damage, and nuclear factor kappa‐light‐chain‐enhancer of activated B cell signal
Rituparna Roy, Debolina Pal, Subhayan Sur, Suvra Mandal, Prosenjit Saha, Chinmay Kumar Panda
Phytotherapy Research.2019; 33(4): 1084. CrossRef - Effect of Multiple Vaccinations with Tumor Cell-Based Vaccine with Codon-Modified GM-CSF on Tumor Growth in a Mouse Model
Jiantai Qiu, Donia Alson, Ta-Hsien Lee, Ching-Chou Tsai, Ting-Wei Yu, Yu-Sing Chen, Ya-Fang Cheng, Chu-Chi Lin, Scott Schuyler
Cancers.2019; 11(3): 368. CrossRef - Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer
Rashmi Deshpande, Prerna Raina, Kavita Shinde, Prakash Mansara, Manjiri Karandikar, Ruchika Kaul-Ghanekar
Prostaglandins & Other Lipid Mediators.2019; 143: 106332. CrossRef - The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions
Predrag Kukic, Giuseppe Mattia Lo Piccolo, Marcela O. Nogueira, Dmitri I. Svergun, Michele Vendruscolo, Isabella C. Felli, Roberta Pierattelli
Scientific Reports.2019;[Epub] CrossRef - Immune Signature-Based Subtypes of Cervical Squamous Cell Carcinoma Tightly Associated with Human Papillomavirus Type 16 Expression, Molecular Features, and Clinical Outcome
Xiaofan Lu, Liyun Jiang, Liya Zhang, Yue Zhu, Wenjun Hu, Jiashuo Wang, Xinjia Ruan, Zhengbao Xu, Xiaowei Meng, Jun Gao, Xiaoping Su, Fangrong Yan
Neoplasia.2019; 21(6): 591. CrossRef - How to Steer and Control ERK and the ERK Signaling Cascade Exemplified by Looking at Cardiac Insufficiency
Tim Breitenbach, Kristina Lorenz, Thomas Dandekar
International Journal of Molecular Sciences.2019; 20(9): 2179. CrossRef - Dietary Polyphenols, Resveratrol and Pterostilbene Exhibit Antitumor Activity on an HPV E6-Positive Cervical Cancer Model: An in vitro and in vivo Analysis
Kaushiki Chatterjee, Sumit Mukherjee, Jonathan Vanmanen, Probal Banerjee, Jimmie E. Fata
Frontiers in Oncology.2019;[Epub] CrossRef - Human papilloma virus DNA-biomarker analysis for cervical cancer: Signal enhancement by gold nanoparticle-coupled tetravalent streptavidin-biotin strategy
Qingfeng Lv, Yongmei Wang, Cuijin Su, Thangavel Lakshmipriya, Subash C.B. Gopinath, Kannaiyan Pandian, Veeradasan Perumal, Ying Liu
International Journal of Biological Macromolecules.2019; 134: 354. CrossRef - RNA-seq analysis in equine papillomavirus type 2-positive carcinomas identifies affected pathways and potential cancer markers as well as viral gene expression and splicing events
Anna Sophie Ramsauer, Jakub Kubacki, Claude Favrot, Mathias Ackermann, Cornel Fraefel, Kurt Tobler
Journal of General Virology .2019; 100(6): 985. CrossRef - Different expression of GSK3β and pS9GSK3β depending on phenotype of cervical cancer: possible association of GSK3β with squamous cell carcinoma and pS9GSK3β with adenocarcinoma
Kwanghee Ahn, Sojung Kweon, Dae Woon Kim, Hojung Lee
Obstetrics & Gynecology Science.2019; 62(3): 157. CrossRef - Delivery of microRNAs by Extracellular Vesicles in Viral Infections: Could the News be Packaged?
Fabio Seiti Yamada Yoshikawa, Franciane Mouradian Emidio Teixeira, Maria Notomi Sato, Luanda Mara da Silva Oliveira
Cells.2019; 8(6): 611. CrossRef - The high-risk HPV oncogene E7 upregulates miR-182 expression through the TGF-β/Smad pathway in cervical cancer
Jiao Chen, Yan Deng, Liangfei Ao, Yi Song, Yan Xu, Chi Chiu Wang, Kwong Wai Choy, Kwok Hung Tony Chung, Quan Du, Yi Sui, Tao Yang, Jing Yang, Hu Li, Chang Zou, Tao Tang
Cancer Letters.2019; 460: 75. CrossRef - A unique insert in the genomes of high-risk human papillomaviruses with a predicted dual role in conferring oncogenic risk
Noam Auslander, Yuri I. Wolf, Svetlana A. Shabalina, Eugene V. Koonin
F1000Research.2019; 8: 1000. CrossRef - Papillomavirus DNA not detected in canine lobular orbital adenoma and normal conjunctival tissue
Elizabeth A. F. Schaefer, Shirley Chu, Jacqueline W. Pearce, Jeffrey N. Bryan, Brian K. Flesner
BMC Veterinary Research.2019;[Epub] CrossRef - Phenotype-based discovery of a HeLa-specific cytotoxic molecule that downregulates HPV-mediated signaling pathwaysviaoxidative damage
Sanghee Lee, Wansang Cho, Sungyoul Hong, Sihyeong Yi, Heejun Kim, Soo Yeon Baek, Hankum Park, Jinjoo Jung, Young Kee Shin, Seung Bum Park
Organic & Biomolecular Chemistry.2019; 17(31): 7388. CrossRef - High Incidence of Human Papillomavirus Types 16 and 18 in Cervical Carcinoma Patients in a Tertiary Care Unit, Jabalpur, MP, India
Shyamji Rawat, Sulekha Yadav, Pranjil Mandloi, Chinkal Panihar, P. V. Barde
Indian Journal of Gynecologic Oncology.2019;[Epub] CrossRef - Advances in technologies for cervical cancer detection in low-resource settings
Kathryn A. Kundrod, Chelsey A. Smith, Brady Hunt, Richard A. Schwarz, Kathleen Schmeler, Rebecca Richards-Kortum
Expert Review of Molecular Diagnostics.2019; 19(8): 695. CrossRef - Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System
Chenhao Zhou, Zewen Kelvin Tuong, Ian Hector Frazer
Frontiers in Oncology.2019;[Epub] CrossRef - Identification of potential binding pocket on viral oncoprotein HPV16 E6: a promising anti-cancer target for small molecule drug discovery
Srikanth Kolluru, Rosemary Momoh, Lydia Lin, Jayapal Reddy Mallareddy, John L. Krstenansky
BMC Molecular and Cell Biology.2019;[Epub] CrossRef - The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1
Jennifer L. McCann, Madeline M. Klein, Evelyn M. Leland, Emily K. Law, William L. Brown, Daniel J. Salamango, Reuben S. Harris
Journal of Biological Chemistry.2019; 294(32): 12099. CrossRef - LncRNA SRA1 is down-regulated in HPV-negative cervical squamous cell carcinoma and regulates cancer cell behaviors
Yunyong Liu, Mengdan Li, Huihui Yu, Haozhe Piao
Bioscience Reports.2019;[Epub] CrossRef - Diagnosis and management of vulvar cancer: A review
Andrea Tan, Amy K. Bieber, Jennifer A. Stein, Miriam K. Pomeranz
Journal of the American Academy of Dermatology.2019; 81(6): 1387. CrossRef - Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter
Nobumaru Hirao, Takashi Iwata, Kohsei Tanaka, Hiroshi Nishio, Masaru Nakamura, Tohru Morisada, Kenji Morii, Natsuki Maruyama, Yuki Katoh, Tomonori Yaguchi, Shigeki Ohta, Iwao Kukimoto, Daisuke Aoki, Yutaka Kawakami
Gynecologic Oncology.2019; 155(2): 340. CrossRef - Phase 1 Safety and Immunogenicity Trial of Recombinant Lactococcus lactis Expressing Human Papillomavirus Type 16 E6 Oncoprotein Vaccine
Sedigheh Taghinezhad-S, Amir Hossein Mohseni, Hossein Keyvani, Mohammad Reza Razavi
Molecular Therapy - Methods & Clinical Development.2019; 15: 40. CrossRef - Cloning and expression of the L1 immunogenic protein of human papillomavirus genotype 16 by using Lactobacillus expression system
Masumeh Haj Hodaei, Rudabeh Behzadi Anduhjerdi, Jalil Fallah Mehrabadi, Davoud Esmaeili
Gene Reports.2019; 17: 100521. CrossRef - Relationship between p16 expression and prognosis in different anatomic subsites of OSCC
Yanhong Ni, Xiaoxin Zhang, Yunxia Wan, Kai Dun Tang, Yin Xiao, Yue Jing, Yuxian Song, Xiaofeng Huang, Chamindie Punyadeera, Qingang Hu
Cancer Biomarkers.2019; 26(3): 375. CrossRef - A unique insert in the genomes of high-risk human papillomaviruses with a predicted dual role in conferring oncogenic risk
Noam Auslander, Yuri I. Wolf, Svetlana A. Shabalina, Eugene V. Koonin
F1000Research.2019; 8: 1000. CrossRef - A Current Update on Human Papillomavirus-Associated Head and Neck Cancers
Ebenezer Tumban
Viruses.2019; 11(10): 922. CrossRef - Current Perspectives in Human Papilloma Virus: Where We are and What We Need?
B.S Anjali Devi, Venugopal Reddy Bovilla, SubbaRao V. Madhunapantula
Biomedical and Pharmacology Journal.2019; 12(04): 1683. CrossRef - Plant viral and bacteriophage delivery of nucleic acid therapeutics
Patricia Lam, Nicole F. Steinmetz
WIREs Nanomedicine and Nanobiotechnology.2018;[Epub] CrossRef - Prevalence of human papillomavirus in benign and malignant laryngeal lesions in Egyptian patients: Cross‐sectional study
P. Milad, H. Kassamy, A. Askoura, S. Abuelela, R. Salem, D. Ragab
Clinical Otolaryngology.2018; 43(1): 312. CrossRef - Human papillomavirus E7 induces p63 expression to modulate DNA damage response
Sahar Eldakhakhny, Qing Zhou, Emma J. Crosbie, Berna S. Sayan
Cell Death & Disease.2018;[Epub] CrossRef - ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer
Nam-phuong D Nguyen, Viraj Deshpande, Jens Luebeck, Paul S Mischel, Vineet Bafna
Nucleic Acids Research.2018; 46(7): 3309. CrossRef - Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells
Kaushiki Chatterjee, Dina AlSharif, Christina Mazza, Palwasha Syar, Mohamed Al Sharif, Jimmie E. Fata
Nutrients.2018; 10(2): 243. CrossRef - Use of protein-based biomarkers of exfoliated cervical cells for primary screening of cervical cancer
Yingji Jin, Seung Cheol Kim, Hyoung Jin Kim, Woong Ju, Yun Hwan Kim, Hong-Jin Kim
Archives of Pharmacal Research.2018; 41(4): 438. CrossRef - ARFHPV E7 oncogene, lncRNA HOTAIR, miR‐331‐3p and its target, NRP2, form a negative feedback loop to regulate the apoptosis in the tumorigenesis in HPV positive cervical cancer
Min Zhang, Yinghui Song, Furui Zhai
Journal of Cellular Biochemistry.2018; 119(6): 4397. CrossRef - Lupeol induces S-phase arrest and mitochondria-mediated apoptosis in cervical cancer cells
Nupoor Prasad, Akash Sabarwal, Umesh C S Yadav, Rana P Singh
Journal of Biosciences.2018; 43(2): 249. CrossRef - Deregulated TNF-Alpha Levels Along with HPV Genotype 16 Infection Are Associated with Pathogenesis of Cervical Neoplasia in Northeast Indian Patients
Chandana Ray Das, Diptika Tiwari, Anita Dongre, Mohammad Aasif Khan, Syed Akhtar Husain, Anirudha Sarma, Sujoy Bose, Purabi Deka Bose
Viral Immunology.2018; 31(4): 282. CrossRef -
Lactobacillus
Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens
Jonathan S. LeCureux, Gregg A. Dean, Christopher J. Papasian
mSphere.2018;[Epub] CrossRef - SALL2 represses cyclins D1 and E1 expression and restrains G1/S cell cycle transition and cancer‐related phenotypes
Viviana E. Hermosilla, Ginessa Salgado, Elizabeth Riffo, David Escobar, Matías I. Hepp, Carlos Farkas, Mario Galindo, Violeta Morín, María A. García‐Robles, Ariel F. Castro, Roxana Pincheira
Molecular Oncology.2018; 12(7): 1026. CrossRef - The combinational effect of E6/E7 siRNA and anti-miR-182 on apoptosis induction in HPV16-positive cervical cells
Hamidreza Javadi, Abbas Sahebghadam Lotfi, Saman Hosseinkhani, Hossein Mehrani, Jafar Amani, Zahra Soheila Soheili, Zahra Hojati, Mehdi Kamali
Artificial Cells, Nanomedicine, and Biotechnology.2018; 46(sup2): 727. CrossRef - A Cu2+ complex induces the aggregation of human papillomavirus oncoprotein E6 and stabilizes p53
Amit Kumar, Lars T. Kuhn, Jochen Balbach
The FEBS Journal.2018; 285(16): 3013. CrossRef - The Myb-related protein MYPOP is a novel intrinsic host restriction factor of oncogenic human papillomaviruses
Elena Wüstenhagen, Fatima Boukhallouk, Inka Negwer, Krishnaraj Rajalingam, Frank Stubenrauch, Luise Florin
Oncogene.2018; 37(48): 6275. CrossRef - Targeting Cyclin-Dependent Kinases for Treatment of Gynecologic Cancers
Z. Ping Lin, Yong-Lian Zhu, Elena S. Ratner
Frontiers in Oncology.2018;[Epub] CrossRef - Development and validation of a multiplex reverse transcript real-time PCR for E6/E7 mRNA detection of high-risk human papillomavirus
Caixia Pan, Jing Zhou, Jiangfeng Lyu, Xuyi Ren
Journal of Medical Microbiology.2018; 67(10): 1509. CrossRef - High-affinity binding with specific peptides endows EuW10a good luminescence probe for HPV E6 detection
Yuxue Liu, Xinxin Yuan, Weixian Wang, Yuqing Wu, Lixin Wu
New Journal of Chemistry.2018; 42(21): 17339. CrossRef - Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53-binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus-induced DNA damage response
Diletta Francesca Squarzanti, Rita Sorrentino, Manuela Miriam Landini, Andrea Chiesa, Sabrina Pinato, Francesca Rocchio, Martina Mattii, Lorenza Penengo, Barbara Azzimonti
Virology Journal.2018;[Epub] CrossRef - Do Human Papilloma Viruses Play a Role in the Genesis of Cutaneous Malignancies?
Mohamed JEMF Mabruk
Journal of Dermatology & Cosmetology.2018;[Epub] CrossRef - Nicotinic acetylcholine receptor gene polymorphism is not associated with tobacco-related oral squamous cell carcinoma
Deepa Rajesh, SM Azeem Mohiyuddin, Sharath Balakrishna, AV Moideen Kutty
Indian Journal of Cancer.2018; 55(4): 399. CrossRef - Immune Checkpoint Inhibition in the Treatment of Gynecologic Cancer
Kristen Anderson, Ramez N. Eskander
Current Obstetrics and Gynecology Reports.2018; 7(1): 6. CrossRef - Identification of fatal outcome in a childhood nasopharyngeal carcinoma patient by protein expression profiling
Mohamed Saeed, Rolf Mertens, Rupert Handgretinger, Thomas Efferth
International Journal of Oncology.2018;[Epub] CrossRef - Integration of Oncogenes via Sleeping Beauty as a Mouse Model of HPV16+ Oral Tumors and Immunologic Control
Yi-Hsin Lin, Ming-Chieh Yang, Ssu-Hsueh Tseng, Rosie Jiang, Andrew Yang, Emily Farmer, Shiwen Peng, Talia Henkle, Yung-Nien Chang, Chien-Fu Hung, T.-C. Wu
Cancer Immunology Research.2018; 6(3): 305. CrossRef - Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers
Jialing Zhang, Tony Chen, Xinping Yang, Hui Cheng, Stephan S. Späth, Paul E. Clavijo, Jianhong Chen, Christopher Silvin, Natalia Issaeva, Xiulan Su, Wendell G. Yarbrough, Christina M. Annunziata, Zhong Chen, Carter Van Waes
Cancer Research.2018; 78(16): 4613. CrossRef - Relevant Allelic Frequency of Gene Polymorphism and Genetic Predisposition of Human Papillomavirus in Patients with Cervical Cancer
Nikta Sajjadi, Reza Mirnejad, Malike Sharif, Vahhab Piranfar, Davood Zaeifi
Modern Medical Laboratory Journal.2018; 1(2): 50. CrossRef - Epidemiology and biology of cutaneous human papillomavirus
Emily M Nunes, Valéria Talpe-Nunes, Laura Sichero
Clinics.2018; 73: e489s. CrossRef - Genome characterization of a bovine papillomavirus type 5 from cattle in the Amazon region, Brazil
Flavio R. C. da Silva, Cíntia Daudt, Samuel P. Cibulski, Matheus N. Weber, Ana Paula M. Varela, Fabiana Q. Mayer, Paulo M. Roehe, Cláudio W. Canal
Virus Genes.2017; 53(1): 130. CrossRef - Exploring the potential of genome editing CRISPR-Cas9 technology
Vijai Singh, Darren Braddick, Pawan Kumar Dhar
Gene.2017; 599: 1. CrossRef - Two-step chromatographic purification of glutathione S-transferase-tagged human papillomavirus type 16 E6 protein and its application for serology
Mei Ling Xu, Seung Cheol Kim, Hyoung Jin Kim, Woong Ju, Yun Hwan Kim, Hong-Jin Kim
Protein Expression and Purification.2017; 132: 19. CrossRef - Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene Therapy
Christian Bressy, Eric Hastie, Valery Z. Grdzelishvili
Molecular Therapy - Oncolytics.2017; 5: 20. CrossRef - MiR-23b controls ALDH1A1 expression in cervical cancer stem cells
Weiwen Wang, Yang Li, Na Liu, Yu Gao, Long Li
BMC Cancer.2017;[Epub] CrossRef - Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit
Daniel Henry Marks, Rozario Thomas, Yvette Chin, Riddhi Shah, Christine Khoo, Robert Benezra
Cell Reports.2017; 19(9): 1832. CrossRef - Genomic abnormalities in invasive endocervical adenocarcinoma correlate with pattern of invasion: biologic and clinical implications
Anjelica Hodgson, Yutaka Amemiya, Arun Seth, Matthew Cesari, Bojana Djordjevic, Carlos Parra-Herran
Modern Pathology.2017; 30(11): 1633. CrossRef - Enhancing antitumor immunogenicity of HPV16-E7 DNA vaccine by fusing DNA encoding E7-antigenic peptide to DNA encoding capsid protein L1 of Bovine papillomavirus
Andrew Yang, Shiwen Peng, Emily Farmer, Qi Zeng, Max A. Cheng, Xiaowu Pang, T. -C. Wu, Chien-Fu Hung
Cell & Bioscience.2017;[Epub] CrossRef - Virus like particles as a platform for cancer vaccine development
Hui Kian Ong, Wen Siang Tan, Kok Lian Ho
PeerJ.2017; 5: e4053. CrossRef - Expression of cell cycle-related proteins in oropharyngeal squamous cell carcinoma based on human papilloma virus status
Koudai Tsuchida, Tamotsu Sugai, Noriyuki Uesugi, Kazuyuki Ishida, Kazuto Matsuura, Ikuro Sato, Kiyoto Shiga, Hiroaki Sato
Oncology Reports.2017; 38(2): 908. CrossRef - Correlation of hTERT Expression with Cervical Cytological Abnormalities and Human Papillomavirus Infection
Vjosa A. Zejnullahu, Valon A. Zejnullahu, Slavica Josifovska, Nikola Vukovik, Kiril Pakovski, Sasho Panov
PRILOZI.2017; 38(3): 143. CrossRef - TAT‑mediated si‑hWAPL inhibits the invasion and metastasis of cervical cancer stem cells
Pijun Gong, Chunyan Hu, Xi Zhou, Renxiao Wang, Zhao Duan
Experimental and Therapeutic Medicine.2017;[Epub] CrossRef - Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer (Review)
Prakriti Sen, Pooja Ganguly, Niladri Ganguly
Oncology Letters.2017;[Epub] CrossRef - Decision management in transoral robotic surgery: Indications, individual patient selection, and role in the multidisciplinary treatment for head and neck cancer from a European perspective
Balazs B. Lörincz, Nathan Jowett, Rainald Knecht
Head & Neck.2016;[Epub] CrossRef - The Role of p53 Gene in Cervical Carcinogenesis
Garima, Sulekha Pandey, L. K. Pandey, A. K. Saxena, Nidhi Patel
The Journal of Obstetrics and Gynecology of India.2016; 66(S1): 383. CrossRef - Biological implications and therapeutic significance of DNA methylation regulated genes in cervical cancer
Samatha Bhat, Shama Prasada Kabekkodu, Ashish Noronha, Kapaettu Satyamoorthy
Biochimie.2016; 121: 298. CrossRef - Human papillomavirus integration pattern and demographic, clinical, and survival characteristics of patients with oropharyngeal squamous cell carcinoma
Ming Yann Lim, Kristina R. Dahlstrom, Erich M. Sturgis, Guojun Li
Head & Neck.2016; 38(8): 1139. CrossRef - A Giant Vulvar Mass: A Case Study of Cellular Angiofibroma
Ümit Aydın, Hasan Terzi, Ünal Turkay, Ahmet Tuğrul Eruyar, Ahmet Kale
Case Reports in Obstetrics and Gynecology.2016; 2016: 1. CrossRef - Aptima HR-HPV testing from Diff-Quick-stained fine-needle aspiration smears of oropharyngeal squamous cell carcinoma
Min Han, Cory T. Bernadt, Benjamin Murray, Steven M. Johnson, Jalal B. Jalaly, Telly Garcia, Laura J. Adhikari
Journal of the American Society of Cytopathology.2016; 5(4): 221. CrossRef - Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm
Wan-Hsiang Hu, Katsumi Miyai, Judith C Sporn, Linda Luo, Jean Y J Wang, Bard Cosman, Sonia Ramamoorthy
Journal of Clinical Pathology.2016; 69(7): 627. CrossRef - Targeting HPV‐infected cervical cancer cells with PEGylated liposomes encapsulating siRNA and the role of siRNA complexation with polyethylenimine
Rachel M. Levine, Christina V. Dinh, Michael A. Harris, Efrosini Kokkoli
Bioengineering & Translational Medicine.2016; 1(2): 168. CrossRef - New Strategies for Multimodality Therapy in Treating Locally Advanced Cervix Cancer
Jonathan Verma, Bradley J. Monk, Aaron H. Wolfson
Seminars in Radiation Oncology.2016; 26(4): 344. CrossRef - A Low-Cost HPV Immunochromatographic Assay to Detect High-Grade Cervical Intraepithelial Neoplasia
Vânia Sammartino Mariano, Adriana Tarlá Lorenzi, Cristovam Scapulatempo-Neto, Maíra Degiovani Stein, Julio Cesar Possati Resende, Márcio Antoniazzi, Luisa Lina Villa, José Eduardo Levi, Adhemar Longatto-Filho, José Humberto Tavares Guerreiro Fregnani, Kal
PLOS ONE.2016; 11(10): e0164892. CrossRef - Inhibition of endoplasmic reticulum (ER) stress sensors sensitizes cancer stem-like cells to ER stress-mediated apoptosis
Asaha Fujimoto, Kei Kawana, Ayumi Taguchi, Katsuyuki Adachi, Masakazu Sato, Hiroe Nakamura, Juri Ogishima, Mitsuyo Yoshida, Tomoko Inoue, Haruka Nishida, Kensuke Tomio, Aki Yamashita, Yoko Matsumoto, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, T
Oncotarget.2016; 7(32): 51854. CrossRef - The potential of plants for the production and delivery of human papillomavirus vaccines
Sergio Rosales-Mendoza, Dania O Govea-Alonso
Expert Review of Vaccines.2015; 14(7): 1031. CrossRef - NGS-based approach to determine the presence of HPV and their sites of integration in human cancer genome
P Chandrani, V Kulkarni, P Iyer, P Upadhyay, R Chaubal, P Das, R Mulherkar, R Singh, A Dutt
British Journal of Cancer.2015; 112(12): 1958. CrossRef - An overview of new biomolecular pathways in pathogen-related cancers
Maria Lina Tornesello, Luigi Buonaguro, Franco M Buonaguro
Future Oncology.2015; 11(11): 1625. CrossRef - Cellular angiofibroma in women: a review of the literature
Vincenzo Dario Mandato, Susanna Santagni, Alberto Cavazza, Lorenzo Aguzzoli, Martino Abrate, Giovanni Battista La Sala
Diagnostic Pathology.2015;[Epub] CrossRef - Human papillomavirus and host genetic polymorphisms in carcinogenesis: A systematic review and meta-analysis
Steven Habbous, Vincent Pang, Wei Xu, Eitan Amir, Geoffrey Liu
Journal of Clinical Virology.2014; 61(2): 220. CrossRef - Human papillomavirus therapeutic vaccines: targeting viral antigens as immunotherapy for precancerous disease and cancer
Matthew P Morrow, Jian Yan, Niranjan Y Sardesai
Expert Review of Vaccines.2013; 12(3): 271. CrossRef - ProExC is a novel marker for distinguishing between primary endometrial and endocervical adenocarcinomas
Ghada E. Esheba
Journal of the Egyptian National Cancer Institute.2013; 25(2): 87. CrossRef - Canine distemper virus induces apoptosis in cervical tumor derived cell lines
Helen L Del Puerto, Almir S Martins, Amy Milsted, Elaine M Souza-Fagundes, Gissandra F Braz, Barbara Hissa, Luciana O Andrade, Fabiana Alves, Daniela S Rajão, Rômulo C Leite, Anilton C Vasconcelos
Virology Journal.2011;[Epub] CrossRef
- Downregulation of LAMB3 Altered the Carcinogenic Properties of Human Papillomavirus 16-Positive Cervical Cancer Cells
- 23,253 View
- 476 Download
- 260 Crossref
Original Articles
- Identification of CLP36 as a Tumor Antigen that Induces an Antibody Response in Pancreatic Cancer
- Su-Hyung Hong
- Cancer Res Treat. 2005;37(1):71-77. Published online February 28, 2005
- DOI: https://doi.org/10.4143/crt.2005.37.1.71
-
Abstract
PDFPubReaderePub
Purpose Pancreatic cancer has a poor prognosis, due in part to the lack of an effective approach for its early detection. The identification of tumor antigens potentially provides a means for the early diagnosis. The purpose of this study was to use a proteomic approach for the identification of proteins that commonly induce a humoral response in patients with pancreatic cancer.
Materials and Methods Proteins from the pancreatic adenocarcinoma cell line, BxPC3, were subjected to two-dimensional polyacrylamide gel electrophoresis, followed by Western blot analysis, where individual sera were tested for autoantibodies. Sera from 36 patients with pancreatic adenocarcinoma, and 68 from control groups (14 from lung adenocarcinoma, 19 from colon adenocarcinoma and 35 from healthy subjects) were analyzed. CLP36 expression was evaluated by immunohistochemical analysis and real-time PCR. The cellular localization of CLP36 as an autoantigen was investigated by Western blot analysis.
Results The autoantibody was detected against a protein, identified by mass spectrometry as CLP36, in 14 of the 36 sera (38.9%) from patients with a pancreatic adenocarcinoma, and 3 of the 68 controls (4.4%). Immunohistochemical analysis of CLP36 in a tissue array demonstrated diffuse and consistent immunoreactivity in the pancreatic adenocarcinomas. The levels of CLP36 mRNA were highest in the pancreatic cancer cell lines of the different cells analyzed. The molecular weight of the protein displayed in the membrane-rich fraction was larger than that in the cytosolic fraction, which is likely attributable to a post-translational modification.
Conclusion CLP36 was identified as a tumor autoantigen inducing a humoral immune response in pancreatic adenocarcinomas. More detailed studies need to be undertaken to understand whether the humoral response by CLP36 is tumor-specific.
-
Citations
Citations to this article as recorded by- PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development
Xinyuan Jiang, Zhiyong Xu, Sujing Jiang, Huan Wang, Mingshu Xiao, Yueli Shi, Kai Wang
Cancers.2023; 15(20): 5042. CrossRef - miR-187/PDLIM1 Gets Involved in Gastric Cancer Progression and Cisplatin Sensitivity of Cisplatin by Mediating the Hippo-YAP Signaling Pathway
Yeru Tan, Yuehua Li, Hongbo Zhu, Xiaoping Wu, Kai Mei, Pian Li, Qiao Yang, Zhongjie Shi
Journal of Oncology.2022; 2022: 1. CrossRef - Serum Anti-PDLIM1 Autoantibody as Diagnostic Marker in Ovarian Cancer
Cuipeng Qiu, Yaru Duan, Bofei Wang, Jianxiang Shi, Peng Wang, Hua Ye, Liping Dai, Jianying Zhang, Xiao Wang
Frontiers in Immunology.2021;[Epub] CrossRef - Autoantibodies against TYMS and PDLIM1 proteins detected as circulatory signatures in Indian breast cancer patients
Prachi Gupta, Shankar Suman, Manisha Mishra, Sanjay Mishra, Nidhi Srivastava, Vijay Kumar, Pradhyumna Kumar Singh, Yogeshwer Shukla
PROTEOMICS - Clinical Applications.2016; 10(5): 564. CrossRef - Identification of Novel Gene Targets and Functions of p21-Activated Kinase 1 during DNA Damage by Gene Expression Profiling
Mona Motwani, Da-Qiang Li, Anelia Horvath, Rakesh Kumar, Wei-Guo Zhu
PLoS ONE.2013; 8(8): e66585. CrossRef - Immunogenicity of SEREX-identified antigens and disease outcome in pancreatic cancer
A. Heller, I. Zörnig, T. Müller, K. Giorgadze, C. Frei, T. Giese, F. Bergmann, J. Schmidt, J. Werner, M. W. Buchler, D. Jaeger, N. A. Giese
Cancer Immunology, Immunotherapy.2010; 59(9): 1389. CrossRef
- PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development
- 8,653 View
- 50 Download
- 6 Crossref
- Proteome Analysis of Differential Protein Expression in Cervical Cancer Cells after Paclitaxel Treatment
- Eun-Kyoung Yim, Jun-Sang Bae, Seung-Bak Lee, Keun-Ho Lee, Chan-Joo Kim, Sung-Eun Namkoong, Soo-Jong Um, Jong-Sup Park
- Cancer Res Treat. 2004;36(6):395-399. Published online December 31, 2004
- DOI: https://doi.org/10.4143/crt.2004.36.6.395
-
Abstract
PDFPubReaderePub
Purpose It is well known that infection with HPV (human papillomavirus) is the main cause of cervical cancer and certain types of HPV are recognized as carcinogens. At present, there is little information regarding the antineoplastic mechanism of paclitaxel against cervical carcinoma cells. We thus tried to analyze differential protein expression and antineoplastic mechanism-related proteins after paclitaxel treatment on cervical cancer cells by using a proteomic analysis and to investigate the mechanism of action.
Materials and Methods Using proteomics analysis including 2-DE and MALDI-TOF-MS, we detected the antineoplastic mechanism-related proteins. Then, we performed western blot analysis for apoptosis- and transformation-related proteins to confirm expression patterns derived from proteome analysis after paclitaxel treatment.
Results We identified several cellular proteins that are responsive to paclitaxel treatment in HeLa cells using proteomics methods. Paclitaxel treatment elevated mainly apoptosis, immune response and cell cycle check point-related proteins. On the other hand, paclitaxel treatment diminished growth factor/oncogene-related proteins and transcription regulation-related proteins. Also, in the HPV-associated cervical carcinoma cells, paclitaxel demonstrated anti-proliferative activity through the membrane death receptor-mediated apoptotic pathway and the mitochondrial-mediated pathway.
Conclusion Identification and characterization of functionally modulated proteins involved in anti-cancer regulatory events should lead to a better understanding of the long-term actions of paclitaxel at the molecular level and will contribute to the future development of novel therapeutic drug treatments based upon current therapies.
-
Citations
Citations to this article as recorded by- Proteomic Analysis of Thermus thermophilus Cells after Treatment with Antimicrobial Peptide
Alexey K. Surin, Anna I. Malykhina, Michail V. Slizen, Alexey P. Kochetov, Mariya Yu. Suvorina, Vadim E. Biryulyov, Sergei Y. Grishin, Oxana V. Galzitskaya
Bacteria.2024; 3(4): 299. CrossRef - Proteomics approaches in cervical cancer: focus on the discovery of biomarkers for diagnosis and drug treatment monitoring
Georgia Kontostathi, Jerome Zoidakis, Nicholas P. Anagnou, Kalliopi I. Pappa, Antonia Vlahou, Manousos Makridakis
Expert Review of Proteomics.2016; 13(8): 731. CrossRef - PKM2 enhances chemosensitivity to cisplatin through interaction with the mTOR pathway in cervical cancer
Haiyan Zhu, Jun Wu, Wenwen Zhang, Hui Luo, Zhaojun Shen, Huihui Cheng, Xueqiong Zhu
Scientific Reports.2016;[Epub] CrossRef - Proteomic Analysis of Anticancer TCMs Targeted at Mitochondria
Yang Wang, Ru-Yuan Yu, Qing-Yu He
Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1. CrossRef - Mass Spectrometry-Based Proteomics in Molecular Diagnostics: Discovery of Cancer Biomarkers Using Tissue Culture
Debasish Paul, Avinash Kumar, Akshada Gajbhiye, Manas K. Santra, Rapole Srikanth
BioMed Research International.2013; 2013: 1. CrossRef - Identification of Cervical Cancer Proteins Associated With Treatment With Paclitaxel and Cisplatin in Patients
Huiling Liu, Yin Han, Ruoran Mi, Ying Zhang, Gang Su, Hailin Wang, Xin Zhou, Xiangwen Liu, Bingdong Zhu
International Journal of Gynecological Cancer.2011; 21(8): 1452. CrossRef - Impact of taxol on dermal papilla cells — A proteomics and bioinformatics analysis
Pei-Hsiu Chen, Chih-Yuan Wang, Ching-Wu Hsia, Ming-Yi Ho, Ann Chen, Min-Jen Tseng, Yung-Fu Wu, Han-Min Chen, Tzu-Hao Huang, Hung-Te Liu, Hao-Ai Shui
Journal of Proteomics.2011; 74(12): 2760. CrossRef
- Proteomic Analysis of Thermus thermophilus Cells after Treatment with Antimicrobial Peptide
- 10,488 View
- 64 Download
- 7 Crossref
- Expression Profiling of the Cellular Processes in Uterine Leiomyomas: Omic Approaches and IGF-2 Association with Leiomyosarcomas
- Su Mi Bae, Yong-Wan Kim, Joon Mo Lee, Sung Eun Namkoong, Chong Kook Kim, Woong Shick Ahn
- Cancer Res Treat. 2004;36(1):31-42. Published online February 29, 2004
- DOI: https://doi.org/10.4143/crt.2004.36.1.31
-
Abstract
PDFPubReaderePub
Purpose This study utilized both cDNA microarray and 2D protein gel electrophoresis technology to investigate the multiple interactions of the genes and proteins involved in the pathophysiology of uterine leiomyomas. Also, Gene Ontology (GO) analysis was used to systematically characterize the global expression profiles, which were found to correlate with the leiomyosarcomas.
Materials and Methods The uterine leiomyoma biopsies were obtained from patients in the Department of Obstetrics and Gynecology, The Catholic University of Korea. Differentially expressed transcriptome and proteome, in 6 paired leiomyoma and normal myometrium, were profiled. The total RNAs from the leiomyoma and normal myometrium were labeled with Cy5 and Cy3. All specimens were punch-biopsy-obtained, and frozen in liquid nitrogen.
Results Screening of up to 17,000 genes identified 71 that were either up-regulated or down-regulated (21 and 50, respectively). The gene expression profiles were classified into 420 mutually dependent functional sets, resulting in 611 cellular processes, according to the gene ontology. Also, the protein analysis, using 2D gel electrophoresis, identified 33 proteins (17 up-regulated and 16 down-regulated) with more than 500 total spots, which were classified into 302 cellular processes. O f these functional profilings, transcriptomes and proteoms down-regulations were shown in the cell adhesion, cell m otility, organogenesis, enzyme regulator, structural molecule activity and responses to external stimulus functional activities, which are supposed to play important roles in the pathophysiology. In contrast, up-regulation was only shown in the nucleic acid binding activity. The CDKN2A, ADH1A, DCX, IGF2, CRABP2 and KIF5C were found to increase the reliability of this study, and correlate with the leiomyosarcomas.
Conclusion Potentially significant pathogenetic cellular processes showed that down-regulated functional profiling has an important impact on the discovery of the pathogenic pathways in leiomyomas and leiomyosarcomas. GO analysis can also overcome the complexity of the expression profiles of cDNA microarrays and 2D protein analyses, via a cellular process level approach. Thereby, a valuable prognostic candidate gene, with real relevance to disease-specific pathogenesis, can be found at cellular process levels.
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Citations
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Journal of Obstetrics and Gynaecology Research.2017; 43(1): 149. CrossRef - Association of chloride intracellular channel 4 and Indian hedgehog proteins with survival of patients with pancreatic ductal adenocarcinoma
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International Journal of Experimental Pathology.2016; 97(6): 422. CrossRef - Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets
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Biochimica et Biophysica Acta (BBA) - Biomembranes.2015; 1848(10): 2523. CrossRef - Two-dimensional gel electrophoresis analysis of the leiomyoma interstitial fluid reveals altered protein expression with a possible involvement in pathogenesis
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Oncology Reports.2015; 33(5): 2219. CrossRef - CLIC4 is a tumor suppressor for cutaneous squamous cell cancer
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- H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/β-catenin and TGF-β pathways
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