Cancer Research and Treatment

Original Articles

Head/neck cancer

Nomogram for Predicting Central Lymph Node Metastasis in Papillary Thyroid Cancer: A Retrospective Cohort Study of Two Clinical Centers: Zheyu Yang, Yu Heng, Jianwei Lin, Chenghao Lu, Dingye Yu, Lei Tao, Wei Cai; Cancer Res Treat. 2020;52(4):1010-1018. Published online June 9, 2020; DOI: https://doi.org/10.4143/crt.2020.254

Purpose
Central lymph node metastasis (CNM) are highly prevalent but hard to detect preoperatively in papillary thyroid carcinoma (PTC) patients, while the significance of prophylactic compartment central lymph node dissection (CLND) remains controversial as a treatment option. We aim to establish a nomogram assessing risks of CNM in PTC patients, and explore whether prophylactic CLND should be recommended.
Materials and Methods
One thousand four hundred thirty-eight patients from two clinical centers that underwent thyroidectomy with CLND for PTC within the period 2016–2019 were retrospectively analyzed. Univariate and multivariate analysis were performed to examine risk factors associated with CNM. A nomogram for predicting CNM was established, thereafter internally and externally validated.
Results
Seven variables were found to be significantly associated with CNM and were used to construct the model. These were as follows: thyroid capsular invasion, multifocality, creatinine > 70 μmol/L, age < 40, tumor size > 1 cm, body mass index < 22, and carcinoembryonic antigen > 1 ng/mL. The nomogram had good discrimination with a concordance index of 0.854 (95% confidence interval [CI], 0.843 to 0.867), supported by an external validation point estimate of 0.825 (95% CI, 0.793 to 0.857). A decision curve analysis was made to evaluate nomogram and ultrasonography for predicting CNM.
Conclusion
A validated nomogram utilizing readily available preoperative variables was developed to predict the probability of central lymph node metastases in patients presenting with PTC. This nomogram may help surgeons make appropriate surgical decisions in the management of PTC, especially in terms of whether prophylactic CLND is warranted.

Citations

Citations to this article as recorded by

Risk nomogram for papillary thyroid microcarcinoma with central lymph node metastasis and postoperative thyroid function follow-up
Yuting Huang, Pengwei Lou, Hui Li, Yinhui Li, Li Ma, Kai Wang
Frontiers in Endocrinology.2024;[Epub] CrossRef
Ultrasonic Feature Prediction of Large-Number Central Lymph Node Metastasis in Clinically Node-Negative Solitary Papillary Thyroid Carcinoma
Weihan Xiao, Xiaomin Hu, Chaoxue Zhang, Xiachuan Qin
Endocrine Research.2023; 48(4): 112. CrossRef
Nomogram for predicting central lymph node metastasis in T1-T2 papillary thyroid cancer with no lateral lymph node metastasis
Yubo Sun, Wei Sun, Jingzhe Xiang, Hao Zhang
Frontiers in Endocrinology.2023;[Epub] CrossRef
An integrated nomogram combining deep learning, clinical characteristics and ultrasound features for predicting central lymph node metastasis in papillary thyroid cancer: A multicenter study
Luchen Chang, Yanqiu Zhang, Jialin Zhu, Linfei Hu, Xiaoqing Wang, Haozhi Zhang, Qing Gu, Xiaoyu Chen, Sheng Zhang, Ming Gao, Xi Wei
Frontiers in Endocrinology.2023;[Epub] CrossRef
Central and lateral neck involvement in papillary thyroid carcinoma patients with or without thyroid capsular invasion: A multi-center analysis
Zheyu Yang, Yu Heng, Jian Zhou, Lei Tao, Wei Cai
Frontiers in Endocrinology.2023;[Epub] CrossRef
Development and validation of nomograms for predicting the risk of central lymph node metastasis of solitary papillary thyroid carcinoma of the isthmus
Yonghao Li, Xuefei Gao, Tiantian Guo, Jing Liu
Journal of Cancer Research and Clinical Oncology.2023; 149(16): 14853. CrossRef
Development and validation of an individualized nomogram for predicting the high-volume (> 5) central lymph node metastasis in papillary thyroid microcarcinoma
X. Wei, Y. Min, Y. Feng, D. He, X. Zeng, Y. Huang, S. Fan, H. Chen, J. Chen, K. Xiang, H. Luo, G. Yin, D. Hu
Journal of Endocrinological Investigation.2022; 45(3): 507. CrossRef
Preoperative Prediction of Central Cervical Lymph Node Metastasis in Fine-Needle Aspiration Reporting Suspicious Papillary Thyroid Cancer or Papillary Thyroid Cancer Without Lateral Neck Metastasis
Kai Zhang, Lang Qian, Jieying Chen, Qian Zhu, Cai Chang
Frontiers in Oncology.2022;[Epub] CrossRef
Relationship between subgroups of central and lateral lymph node metastasis in clinically node-negative papillary thyroid carcinoma
Jing Zhou, Da-Xue Li, Han Gao, Xin-Liang Su
World Journal of Clinical Cases.2022; 10(12): 3709. CrossRef
Hashimoto’s Thyroiditis Is Associated With Central Lymph Node Metastasis in Classical Papillary Thyroid Cancer: Analysis from a High-Volume Single-Center Experience
Bin Zeng, Yu Min, Yang Feng, Ke Xiang, Hang Chen, Zijing Lin
Frontiers in Endocrinology.2022;[Epub] CrossRef
Nomogram model based on preoperative serum thyroglobulin and clinical characteristics of papillary thyroid carcinoma to predict cervical lymph node metastasis
Qungang Chang, Jieming Zhang, Yaqian Wang, Hongqiang Li, Xin Du, Daohong Zuo, Detao Yin
Frontiers in Endocrinology.2022;[Epub] CrossRef
Ultrasound-based radiomics nomogram combined with clinical features for the prediction of central lymph node metastasis in papillary thyroid carcinoma patients with Hashimoto’s thyroiditis
Peile Jin, Jifan Chen, Yiping Dong, Chengyue Zhang, Yajun Chen, Cong Zhang, Fuqiang Qiu, Chao Zhang, Pintong Huang
Frontiers in Endocrinology.2022;[Epub] CrossRef
Lateral Involvement in Different Sized Papillary Thyroid Carcinomas Patients with Central Lymph Node Metastasis: A Multi-Center Analysis
Yu Heng, Zheyu Yang, Pengyu Cao, Xi Cheng, Lei Tao
Journal of Clinical Medicine.2022; 11(17): 4975. CrossRef
Risk factors and prediction models of lymph node metastasis in papillary thyroid carcinoma based on clinical and imaging characteristics
Yanyuan Deng, Jie Zhang, Jiao Wang, Jinying Wang, Junping Zhang, Lulu Guan, Shasha He, Xiudan Han, Wei Cai, Jixiong Xu
Postgraduate Medicine.2022;[Epub] CrossRef
A prognostic nomogram for papillary thyroid cancer lymph node metastasis based on immune score
Yihua Lu, Kai Qian, Mengjia Fei, Kai Guo, Yuan Shi, Zhuoying Wang
Frontiers in Endocrinology.2022;[Epub] CrossRef
Risk factors for central and lateral lymph node metastasis in papillary thyroid carcinoma
Ji Hyun Ahn, Hee Kyung Chang
Kosin Medical Journal.2022; 37(4): 311. CrossRef
Construction and validation of a nomogram for predicting cervical lymph node metastasis in classic papillary thyroid carcinoma
Y. Feng, Y. Min, H. Chen, K. Xiang, X. Wang, G. Yin
Journal of Endocrinological Investigation.2021; 44(10): 2203. CrossRef
Application of Machine Learning Algorithms to Predict Central Lymph Node Metastasis in T1-T2, Non-invasive, and Clinically Node Negative Papillary Thyroid Carcinoma
Jiang Zhu, Jinxin Zheng, Longfei Li, Rui Huang, Haoyu Ren, Denghui Wang, Zhijun Dai, Xinliang Su
Frontiers in Medicine.2021;[Epub] CrossRef
Preoperative Predictors of Lymph Node Metastasis in Colon Cancer
Yansong Xu, Yi Chen, Chenyan Long, Huage Zhong, Fangfang Liang, Ling-xu Huang, Chuanyi Wei, Shaolong Lu, Weizhong Tang
Frontiers in Oncology.2021;[Epub] CrossRef
Preoperatively Predicting the Central Lymph Node Metastasis for Papillary Thyroid Cancer Patients With Hashimoto’s Thyroiditis
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Frontiers in Endocrinology.2021;[Epub] CrossRef
Reevaluation of Criteria and Establishment of Models for Total Thyroidectomy in Differentiated Thyroid Cancer
Zhenghao Wu, Yunxiao Xiao, Jie Ming, Yiquan Xiong, Shuntao Wang, Shengnan Ruan, Tao Huang
Frontiers in Oncology.2021;[Epub] CrossRef
Influencing Factors and Cumulative Risk Analysis of Cervical Lymph Node Metastasis of Papillary Thyroid Microcarcinoma
Yirong Yin, Xiang Xu, Liyan Shen, Wenjuan Zhao, Hongcui Diao, Chengqian Li
Frontiers in Oncology.2021;[Epub] CrossRef
A Specific Predicting Model for Screening Skip Metastasis From Patients With Negative Central Lymph Nodes Metastasis in Papillary Thyroid Cancer
Zheyu Yang, Yu Heng, Qiwu Zhao, Zichao Cao, Lei Tao, Weihua Qiu, Wei Cai
Frontiers in Endocrinology.2021;[Epub] CrossRef
Computed Tomography-Based Radiomics Model to Predict Central Cervical Lymph Node Metastases in Papillary Thyroid Carcinoma: A Multicenter Study
Jingjing Li, Xinxin Wu, Ning Mao, Guibin Zheng, Haicheng Zhang, Yakui Mou, Chuanliang Jia, Jia Mi, Xicheng Song
Frontiers in Endocrinology.2021;[Epub] CrossRef
Nomogram Including Elastography for Prediction of Contralateral Central Lymph Node Metastasis in Solitary Papillary Thyroid Carcinoma Preoperatively

Ning Li, Ju-hua He, Chao Song, Li-chun Yang, Hong-jiang Zhang, Zhi-hai Li
Cancer Management and Research.2020; Volume 12: 10789. CrossRef

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Active and Passive Smoking, BRAF^V600E Mutation Status, and the Risk of Papillary Thyroid Cancer: A Large-Scale Case-Control and Case-Only Study: Kyoung-Nam Kim, Yunji Hwang, Kyungsik Kim, Kyu Eun Lee, Young Joo Park, June Young Choi, Do Joon Park, BeLong Cho, Daehee Kang, Sue K. Park; Cancer Res Treat. 2019;51(4):1392-1399. Published online February 20, 2019; DOI: https://doi.org/10.4143/crt.2018.612

Abstract PDF Supplementary Material PubReader ePub

Purpose
The association between tobacco smoking and thyroid cancer remains uncertain. We evaluated the associations of active and passive smokingwith the risk of papillary thyroid cancer (PTC), the most common type of thyroid cancer, and with the BRAFV600E mutation, the most common oncogenic mutation in PTC related to poor prognosis.
Materials and Methods
We conducted this study with newly diagnosed PTC patients (n=2,142) and community controls (n=21,420) individually matched to cases for age and sex. Information on active and passive smoking and potential confounders were obtained from structured questionnaires, anthropometric measurements, and medical records. BRAF^V600E mutation status was assessed in PTC patients. We evaluated the associations of active and passive smoking with PTC and BRAF^V600E mutation risk using conditional and unconditional logistic regression models, respectively.
Results
We did not find associations between exposure indices of active and passive smoking and PTC risk in both men and women, except for the association between current smoking and lower PTC risk. Cumulative smoking ≥ 20 pack-years was associated with lower BRAFV600E mutation risk in male PTC patients (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.30 to 1.00). The CI for the association was wider in female PTC patients (OR, 0.23; 95% CI, 0.02 to 2.62), possibly owing to a smaller sample size in this stratum.
Conclusion
We did not find consistent associations between active and passive smoking and PTC risk. Cumulative smoking ≥ 20 pack-years was associated with lower BRAFV600E mutation risk in male PTC patients.

Citations

Citations to this article as recorded by

Geographic variation in the association between Hashimoto’s thyroiditis and Papillary thyroid carcinoma, a meta-analysis
Nabil W. G. Sweis, Ayman A. Zayed, Mira Al Jaberi, Lina AlQirem, Tala Basheer Hyasat, Farah A. Khraisat, Ward Maaita, Ahmad Moayad Naser, Abdullah Nimer, Mamoon Qatamin, Jaleel J. G. Sweis, Nadia Sweis, Abdallah T. Al-Ani, Ahmad M. Alghrabli, Alireza Hagh
Endocrine.2023; 81(3): 432. CrossRef
Sex-specific Associations between Body Mass Index and Thyroid Cancer Incidence among Korean Adults
Kyoung-Nam Kim, Kyungsik Kim, Sangjun Lee, Sue K. Park
Cancer Epidemiology, Biomarkers & Prevention.2023; 32(9): 1227. CrossRef
Effect of Cigarette Smoking on Thyroid Cancer: Meta-Analysis
Joon-Hyop Lee, Young Jun Chai, Ka Hee Yi
Endocrinology and Metabolism.2021; 36(3): 590. CrossRef
Tobacco smoking and risk of thyroid cancer according to BRAFV600E mutational subtypes
Sabbir T. Rahman, Nirmala Pandeya, Rachel E. Neale, Donald S. A. McLeod, Peter D. Baade, Philippa H. Youl, Roger Allison, Susan Leonard, Susan J. Jordan
Clinical Endocrinology.2021; 95(6): 891. CrossRef
circFAT1(e2) Promotes Papillary Thyroid Cancer Proliferation, Migration, and Invasion via the miRNA-873/ZEB1 Axis
Jiazhe Liu, Hongchang Li, Chuanchao Wei, Junbin Ding, Jingfeng Lu, Gaofeng Pan, Anwei Mao, Tao Huang
Computational and Mathematical Methods in Medicine.2020; 2020: 1. CrossRef

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The Role of Notch1 Signaling in Anaplastic Thyroid Carcinoma: Hyeon Jin Kim, Min-Jung Kim, Areumnuri Kim, Chang Won Jung, Sunhoo Park, Jae Soo Koh, Jae Kyung Myung; Cancer Res Treat. 2017;49(2):509-517. Published online September 1, 2016; DOI: https://doi.org/10.4143/crt.2016.214

Abstract PDF PubReader ePub

Purpose
The Notch signaling pathway is widely expressed in normal, reactive, and neoplastic tissues; however, its role in thyroid tissues has not been fully elucidated. Therefore, this study was conducted to characterize the expression of the Notch signaling pathway in papillary thyroid cancer (PTC) cells and anaplastic thyroid cancer (ATC) cells.
Materials and Methods
Expression of activated Notch1 in ATC and PTC paraffin-embedded tissues was determined by immunohistochemistry. The small interfering RNA techniquewas employed to knock down Notch1 expression in ATC and PTC cell lines.
Results
The expression of activated Notch1 was higher in ATC cases than in PTC cases. Inhibition of Notch1 significantly reduced proliferation and migration of ATC cells, but not PTC cells. In addition, inhibition of Notch1 in ATC cells significantly reduced the expression of key markers of epithelial-mesenchymal transition and cancer stem cells. Conversely, changes in the expression of these proteins were not observed in PTC cells.
Conclusion
The results of this study suggest that Notch1 expression plays different roles in tumor progression in ATC and PTC cells. We also found that Notch1 expression was significantly related to the highly invasive or proliferative activity of ATC cells.

Citations

Citations to this article as recorded by

TMEM252 inhibits epithelial–mesenchymal transition and progression in papillary thyroid carcinoma by regulating Notch1 expression
Shuyong Zhang, Rong Xie, Liuhuan Wang, Guoxue Fu, Chenxi Zhang, Yang Zhang, Jichun Yu
Head & Neck.2024;[Epub] CrossRef
BRAFV600E Overrides NOTCH Signaling in Thyroid Cancer
Florian Traversi, Amandine Stooss, Matthias S. Dettmer, Roch-Philippe Charles
Thyroid.2021; 31(5): 787. CrossRef
Thyroid Carcinoma: Phenotypic Features, Underlying Biology and Potential Relevance for Targeting Therapy
Jinwei Hu, Isabella J. Yuan, Saied Mirshahidi, Alfred Simental, Steve C. Lee, Xiangpeng Yuan
International Journal of Molecular Sciences.2021; 22(4): 1950. CrossRef
The Knockdown of Nrf2 Suppressed Tumor Growth and Increased the Sensitivity to Lenvatinib in Anaplastic Thyroid Cancer
Zhongqin Gong, Lingbin Xue, Minghui Wei, Zhimin Liu, Alexander C. Vlantis, C. Andrew van Hasselt, Jason Y. K. Chan, Dongcai Li, Xianhai Zeng, Michael C. F. Tong, George G. Chen, Sander Bekeschus
Oxidative Medicine and Cellular Longevity.2021;[Epub] CrossRef
Notch1 regulates tongue cancer cells proliferation, apoptosis and invasion
Rui-Huan Gan, Hua Wei, Jing Xie, Dan-Ping Zheng, Er-Ling Luo, Xiao-Yu Huang, Jian Xie, Yong Zhao, Lin-Can Ding, Bo-Hua Su, Li-Song Lin, Da-Li Zheng, You-Guang Lu
Cell Cycle.2018; 17(2): 216. CrossRef

11,307 View
277 Download
11 Web of Science
5 Crossref

Case Report

A Case of Pancreatic Serous Cystadenoma Associated with Papillary Thyroid Cancer: Jin Hong Park, Chang Ryoul Lee, Jun Ho Lee, So Jin Choi, Seong Ho Choi, Seong Pyo Son; J Korean Cancer Assoc. 1999;31(1):201-207.

Abstract PDF: The most common pancreatic cystic lesion is pancreatic pseudocyst which represents about 85%. Primary cystic neoplasms represent about 10 to 15% of the lesion. Pathologically cystic neoplasms can be classified into serous cystadenoma, mucinous cystadenoma and papillary cystic neoplasm by epithelial lining-cell, whereas pseudocyst is characterized by fibrotic capsules. Mucinous form is known to be premalignant or malignant and serous cystadenoma was known to be benign in the past, but recently 4 cases of malignant transformation have been reported. Serous cystadenoma is described under a variety of names, including microcystic adenoma and glycogen-rich cystadenoma but recently macroqystic variants have been reported. Serous cystadenoma is most commonly seen in middle aged women with symptoms of vague upper abdominal pain or palpable mass. It is sometimes associated with extra- pancreatic diseases such as gallstones, diabetes mellitus, hypertension, duodenal ulcers, sterility, obesity and thymic dysfunction, but coexisting papillary thyroid cancer have been reported in only 2 cases to our knowledge. The pathogenesis of associated diseases is unknown and appears to be due to function of age of the patients or incidental occurrence. Herein, we report a patient who had a pancreatic serous cystadenoma coexisting with papillary thyroid cancer. Since pancreatic serous cystadenoma can occur in association with papaillary thyroid cancer, examination of thyroid seems to be advisable when pancreatic serous cystadenoma is found.

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