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Original Article
- Hematologic malignancy
- Incidence and Features of Lymphoid Proliferation and Lymphomas after Solid Organ or Hematopoietic Stem Cell Transplantation in a National Database Cohort
- Seung Min Hahn, Myeongjee Lee, JongHoon Hyun, Sungmin Lim, Ji-Man Kang, Jong Gyun Ahn, Dong Jin Joo, Inkyung Jung, Kyong Ihn
- Cancer Res Treat. 2024;56(1):305-313. Published online July 18, 2023
- DOI: https://doi.org/10.4143/crt.2023.647
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Abstract
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Supplementary Material
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ePub - Purpose
Post-transplantation lymphoproliferative disorders (PTLDs) after hematopoietic stem transplantation (HCT) or solid organ transplantation (SOT) result in poorer outcomes, including death. There are limited large cohort data on the incidence and natural course of PTLD in Asians.
Materials and Methods
We investigated PTLD using Korean national health insurance claims data of 47,518 patients who underwent HCT or SOT in 2008-2020. Patient demographics, time and type of PTLD diagnosis, type of PTLD treatment, and death data were collected. We used Fine and Gray subdistribution hazard models to calculate the cumulative incidence and risk factors for PTLD.
Results
During median follow-up of 5.32 years, PTLD occurred in 294 of 36,945 SOT patients (0.79%) and 235 of 10,573 HCT patients (2.22%). Cumulative incidence of PTLD were 0.49% at 1 year, 1.02% at 5 years, and 1.50% at 10 years post-transplantation. Age < 20 years (subdistribution hazard ratio [SHR] of 1.67 in age 10-19, SHR 1.51 in age 0-9), HCT (SHR 3.02), heart transplantation (SHR 2.27), and liver transplantation (SHR 1.47) were significant risk factors for PTLD. The presence of PTLD was associated with an increased risk of death (hazard ratio of 2.84). Overall, 5-year survival of PTLD patients was 68.9% (95% confidence interval, 64.9 to 73.2).
Conclusion
We observed a steady increase in PTLD over 10 years after HCT or SOT in this large cohort study. Pediatric age group, HCT, liver transplantation, and heart transplantation were suggested to be risk factors for PTLD, and PTLD was associated with a higher risk of death. -
Citations
Citations to this article as recorded by
- Insights into the Current Clinical Features of Posttransplant Lymphoproliferative Disorders in Pediatric Liver Transplantation
Yi Luo, Chen Chen, Zhifeng Xi, Tao Zhou, Jianjun Zhang, Kang He, Qiang Xia
Indian Journal of Transplantation.2026; 20(1): 47. CrossRef - The Impact of Posttransplant Lymphoproliferative Disease in High-risk Kidney Transplant Recipients: Benefits of Prevention
Bryce A. Kiberd, Christopher J.A. Daley
Transplantation Direct.2025; 11(5): e1792. CrossRef - Does the Organ Matter in PTLD Development in Solid Organ Transplant Recipients? A Multicenter Observational Study of Risk and Prognostic Factors
Rafał Staros, Bartosz Foroncewicz, Dorota Kamińska, Dominika Dęborska-Materkowska, Sławomir Lizakowski, Izabela Zakrocka, Joanna Raszeja-Wyszomirska, Anita Stanjek-Cichoracka, Anna Pawłowska, Emilia Knioła, Paweł Poznański, Jolanta Gozdowska, Alicja Dębsk
Cancers.2025; 17(11): 1770. CrossRef - Malignancies After Renal Transplantation: Frequency, Etiology, and Prognosis—A Single Center Experience
Fatih Atalah, Aydın Acarbay, Akgün Karakök, Mehmet Beşiroğlu, Fatih Kuş, Huzeyfe Arıcı, Ahmet Burak Dirim, Vafa Suleymanova, Aydın Türkmen, Halil Yazıcı
Journal of Clinical Medicine.2025; 14(16): 5858. CrossRef - Post-Transplant Double Malignancy: Multiple Myeloma and Papillary Renal Cell Carcinoma—A Case Report
Aleksandar Petrov, Miroslava Benkova, Yavor Petrov, Yana Dimieva, Mari Ara Hachmeriyan
Reports.2025; 9(1): 13. CrossRef
- Insights into the Current Clinical Features of Posttransplant Lymphoproliferative Disorders in Pediatric Liver Transplantation
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