Cancer Research and Treatment

Original Articles

Unraveling the Impact of Sarcopenia-Induced Lymphopenia on Treatment Response and Prognosis in Patients with Stage III Non-Small Cell Lung Cancer: Insights for Optimizing Chemoradiation and Immune Checkpoint Inhibitor: Joongyo Lee, Kyung Hwan Kim, Jina Kim, Chang Geol Lee, Jaeho Cho, Hong In Yoon, Yeona Cho; Received May 23, 2024 Accepted October 29, 2024 Published online October 30, 2024; DOI: https://doi.org/10.4143/crt.2024.493 [Accepted]

Abstract PDF: Purpose
Sarcopenia is a poor prognostic factor in non-small cell lung cancer (NSCLC). However, its prognostic significance in patients with NSCLC receiving immune checkpoint inhibitors (ICIs) and its relationship with lymphopenia remain unclear. We aimed to investigate the prognostic role of sarcopenia and its effect on lymphocyte recovery in patients with stage III NSCLC treated with concurrent chemoradiotherapy (CCRT) followed by ICI.
Materials and Methods
We retrospectively evaluated 151 patients with stage III NSCLC who received definitive CCRT followed by maintenance ICI between January 2016 and June 2022. Sarcopenia was evaluated by measuring the skeletal muscle area at the L3 vertebra level using computed tomography scans. Lymphocyte level changes were assessed based on measurements taken before and during CCRT and at 1, 2, 3, 6, and 12 months post-CCRT completion.
Results
Even after adjusting for baseline absolute lymphocyte count through propensity score-matching, patients with pre-radiotherapy (RT) sarcopenia (n=86) exhibited poor lymphocyte recovery and a significantly high incidence of grade ≥3 lymphopenia during CCRT. Pre-RT sarcopenia and grade ≥3 lymphopenia during CCRT emerged as prognostic factors for overall survival and progression-free survival, respectively. Concurrent chemotherapy dose adjustments, objective response after CCRT, and discontinuation of maintenance ICI were also analyzed as independent prognostic factors.
Conclusion
Our results demonstrated an association between pre-RT sarcopenia and poor survival, concurrent chemotherapy dose adjustments, and impaired lymphocyte recovery after definitive CCRT. Moreover, CCRT-induced lymphopenia not only contributed to poor prognosis but may have also impaired the therapeutic efficacy of subsequent maintenance ICI, ultimately worsening treatment outcomes.

276 View
28 Download

General

Role of Interleukin-7 in the Development of and Recovery from Radiation-Induced Lymphopenia: A Post-hoc Analysis of a Prospective Cohort: Hwa Kyung Byun, Seung Yeun Chung, Kyoung-Jin Kim, Jinsil Seong; Cancer Res Treat. 2021;53(4):962-972. Published online January 26, 2021; DOI: https://doi.org/10.4143/crt.2020.1053

Abstract PDF Supplementary Material PubReader ePub

Purpose
Radiation-induced lymphopenia is associated with worse outcomes in solid tumors. We assessed the impact of interleukin-7 (IL-7), a key cytokine in lymphocyte homeostasis, on radiation-induced lymphopenia.
Materials and Methods
A post-hoc analysis was performed in a prospective cohort of 98 patients with hepatocellular carcinoma who were treated with radiotherapy in 2016-2018. Blood IL-7 levels were assayed before and at the end of radiotherapy. Acute severe lymphopenia (ASL) was defined as a total lymphocyte count of < 200/μL during radiotherapy. Cox and logistic regression analyses were performed to identify predictors of survival and ASL development, respectively.
Results
Patients with ASL (n=41) had significantly poorer overall survival than those without (12.0 months vs. 25.3 months, p=0.001). Patients with lymphocyte recovery showed significantly longer overall survival than those without (21.8 months vs. 10.3 months, p=0.042). ASL was an independent predictor of poor survival (hazard ratio, 2.07; p=0.015). Patients with ASL had significantly lower pre-radiotherapy IL-7 levels (2.07 pg/mL vs. 3.01 pg/mL, p=0.010). A high pre-radiotherapy IL-7 level was an independent predictor of a reduced risk of ASL development (hazard ratio, 0.40; p=0.004). IL-7 levels reflected a feedback response to ASL, with a higher ΔIL-7 in patients with ASL and a lower ΔIL-7 in those without ASL (0.48 pg/mL vs. –0.66 pg/mL, p < 0.001). Post-radiotherapy IL-7 levels were significantly positively correlated with the total lymphocyte counts at 2 months.
Conclusion
IL-7 is associated with the development of and recovery from ASL, which may impact survival. To overcome radiation-induced lymphopenia, a novel strategy using IL-7 may be considered.

Citations

Citations to this article as recorded by

Radiation Therapy and Myeloid-Derived Suppressor Cells: Breaking Down Their Cancerous Partnership
Kyra M. Boorsma Bergerud, Matthew Berkseth, Drew M. Pardoll, Sudipto Ganguly, Lawrence R. Kleinberg, Jessica Lawrence, David J. Odde, David A. Largaespada, Stephanie A. Terezakis, Lindsey Sloan
International Journal of Radiation Oncology*Biology*Physics.2024; 119(1): 42. CrossRef
The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for immunotherapy and oncolytic virotherapy
Aleksei A. Stepanenko, Anastasiia O. Sosnovtseva, Marat P. Valikhov, Anastasia A. Chernysheva, Olga V. Abramova, Victor A. Naumenko, Vladimir P. Chekhonin
Frontiers in Immunology.2024;[Epub] CrossRef
Prognostic value of lymphocytes in patients with breast cancer receiving radiotherapy after breast-conserving surgery: A post hoc analysis of a phase III randomized trial
Yu-Chun Song, Si-Ye Chen, Xu-Ran Zhao, Hao Jing, Hui Fang, Yu Tang, Shang-Ying Hu, Yong-Wen Song, Jing Jin, Yue-Ping Liu, Shu-Nan Qi, Guang-Yi Sun, Qiu-Zi Zhong, Xiang-Hui Du, Juan Liu, Ye-Xiong Li, Shu-Lian Wang
Radiotherapy and Oncology.2024; 199: 110390. CrossRef
The Role of PD-1/PD-L1 and IL-7 in Lymphocyte Dynamics and Sepsis Progression: A Biomarker Study in Critically Ill Patients
Oana Coman, Bianca-Liana Grigorescu, Adina Huțanu, Anca Bacârea, Anca Meda Văsieșiu, Raluca Ștefania Fodor, Marius Petrișor, Leonard Azamfirei
International Journal of Molecular Sciences.2024; 25(23): 12612. CrossRef
Compassionate use of recombinant human IL‐7‐hyFc as a salvage treatment for restoring lymphopenia in patients with recurrent glioblastoma
Stephen Ahn, Jae‐Sung Park, Heewon Kim, Minkyu Heo, Young Chul Sung, Sin‐Soo Jeun
Cancer Medicine.2023; 12(6): 6778. CrossRef

5,165 View
129 Download
4 Web of Science
5 Crossref

The Prognostic Value of Treatment-Related Lymphopenia in Nasopharyngeal Carcinoma Patients: Li-Ting Liu, Qiu-Yan Chen, Lin-Quan Tang, Shan-Shan Guo, Ling Guo, Hao-Yuan Mo, Ming-Yuan Chen, Chong Zhao, Xiang Guo, Chao-Nan Qian, Mu-Sheng Zeng, Jin-Xin Bei, Jing Tan, Shuai Chen, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma, Hai-Qiang Mai; Cancer Res Treat. 2018;50(1):19-29. Published online April 5, 2017; DOI: https://doi.org/10.4143/crt.2016.595

Abstract PDF Supplementary Material PubReader ePub

Purpose
This study was conducted to evaluate the prognostic value of treatment-related lymphopenia in patients with nasopharyngeal carcinoma (NPC).
Materials and Methods
A total of 413 consecutive stage II-IVb NPC patients treated with concurrent chemoradiotherapy (CCRT) were enrolled. The overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) were calculated with the Kaplan-Meier method, and differences were compared using the log-rank test.
Results
A minimum (mini)–absolute lymphocyte counts (ALC) of < 390 cells/μL or ALC after 3 months of CCRT (post3m-ALC) < 705 cells/μL was significantly associated with worse outcome than mini-ALC ≥ 390 cells/μL (OS, p=0.002; PFS, p=0.005; DMFS, p=0.004) or post3m-ALC ≥ 705 cells/μL (OS, p < 0.001; PFS, p < 0.001; DMFS, p=0.001). Patients with lymphopenia (mini-ALC < 390 cells/μL and post3m-ALC < 705 cells/μL) had a worse prognosis than those without lymphopenia (mini-ALC ≥ 390 cells/μL and post3m-ALC ≥ 705 cells/μL) (OS, p < 0.001; PFS, p < 0.001; DMFS, p < 0.001). Multivariate analysis revealed that post3m-ALC was an independent prognostic factor for OS (hazard ratio [HR], 1.76; 95% confidence interval [CI], 1.12 to 2.78; p=0.015), PFS (HR, 1.86; 95% CI, 1.23 to 2.82; p=0.003), and DMFS (HR, 1.87; 95% CI, 1.13 to 3.08; p=0.014). Multivariate analysis also revealed that patients with lymphopenia had a high risk of death (HR, 3.79; 95% CI, 1.75 to 8.19; p=0.001), disease progression (HR, 2.93; 95% CI, 1.59 to 5.41; p=0.001), and distant metastasis (HR, 3.89; 95% CI, 1.67 to 9.10; p=0.002). Multivariate analysis performed with time dependent Cox regression demonstrated ALC was an independent prognostic factor for OS (HR, 0.995; 95% CI, 0.991 to 0.999; p=0.025) and PFS (HR, 0.993; 95% CI, 0.988 to 0.998; p=0.006).
Conclusion
Treatment-related lymphopenia was a poor prognostic factor in NPC patients.

Citations

Citations to this article as recorded by

Nomograms containing body dose parameters for predicting survival in patients with nasopharyngeal carcinoma
Jianyun Jiang, Ruiping Zhai, Fangfang Kong, Chengrun Du, Hongmei Ying
European Archives of Oto-Rhino-Laryngology.2024; 281(1): 181. CrossRef
Radiotherapy alone versus concurrent chemoradiotherapy in patients with stage II and T3N0 nasopharyngeal carcinoma with adverse features: A propensity score-matched cohort study
Wei-Wei Zhang, Jia-Yi Lin, Gao-Yuan Wang, Cheng-Long Huang, Ling-Long Tang, Yan-Ping Mao, Guan-Qun Zhou, Li-Zhi Liu, Li Tian, Ji-Bin Li, Jun Ma, Rui Guo
Radiotherapy and Oncology.2024; 194: 110189. CrossRef
Reduced-Volume Irradiation of Uninvolved Neck in Patients With Nasopharyngeal Cancer: Updated Results From an Open-Label, Noninferiority, Multicenter, Randomized Phase III Trial
Cheng-Long Huang, Ning Zhang, Wei Jiang, Fang-Yun Xie, Xiao-Qing Pei, Shao Hui Huang, Xue-Yan Wang, Yan-Ping Mao, Kun-Peng Li, Qing Liu, Ji-Bin Li, Shao-Qiang Liang, Guan-Jie Qin, Wei-Han Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Lei Chen, Ling-Long Tang
Journal of Clinical Oncology.2024; 42(17): 2021. CrossRef
Immunological effects of radiopharmaceutical therapy
Amanda G. Shea, Malick Bio Idrissou, Ana Isabel Torres, Tessa Chen, Reiner Hernandez, Zachary S. Morris, Quaovi H. Sodji
Frontiers in Nuclear Medicine.2024;[Epub] CrossRef
Current Status and Future Directions of Proton Therapy for Head and Neck Carcinoma
Sara Lillo, Alfredo Mirandola, Alessandro Vai, Anna Maria Camarda, Sara Ronchi, Maria Bonora, Rossana Ingargiola, Barbara Vischioni, Ester Orlandi
Cancers.2024; 16(11): 2085. CrossRef
Treatment-Related Lymphopenia is Possibly a Marker of Good Prognosis in Nasopharyngeal Carcinoma: a Propensity-Score Matching Analysis
Ke-gui Weng, Hai-ke Lei, De-Song Shen, Ying Wang, Xiao-Dong Zhu
Cancer Management and Research.2024; Volume 16: 603. CrossRef
A prognostic nomogram for patients with III–IV nasopharyngeal carcinoma based on dynamic changes in the inflammatory and nutrition index
Guangyi Cheng, Shiwang Yuan, Jiang Wang, Sijia Deng, Yang Wu, Yuyan Wang, Yu Shen, Liantao Li
Clinical and Translational Oncology.2024;[Epub] CrossRef
Impact of Radiation Dose to Circulating Immune Cells on Tumor Control and Survival in Esophageal Cancer
Shang Cai, Yawen Fan, Qi Guo, Yanze Sun, Peifeng Zhao, Ye Tian, Qiuhong Fan
Cancer Biotherapy and Radiopharmaceuticals.2023; 38(6): 380. CrossRef
Meta-analysis and Critical Review: Association Between Radio-induced Lymphopenia and Overall Survival in Solid Cancers
Yasmine El Houat, Christophe Massard, Veronique Quillien, Renaud de Crevoisier, Joël Castelli
Advances in Radiation Oncology.2023; 8(2): 101038. CrossRef
The prognostic predictive value of systemic immune index and systemic inflammatory response index in nasopharyngeal carcinoma: A systematic review and meta-analysis
Li Wang, Xianfei Qin, Yu Zhang, Shouyu Xue, Xicheng Song
Frontiers in Oncology.2023;[Epub] CrossRef
Prognostic Significance of the Post-Treatment Neutrophil-to-Lymphocyte Ratio in Pharyngeal Cancers Treated with Concurrent Chemoradiotherapy
Ji Min Yun, Man Ki Chung, Chung Hwan Baek, Young Ik Son, Myung Ju Ahn, Dongryul Oh, Ki Won Kim, Yoon Kyoung So
Cancers.2023; 15(4): 1248. CrossRef
Analysis of risk characteristics for metachronous metastasis in different period of nasopharyngeal carcinoma
Zhaodong Fei, Huiling Hong, Ting Xu, Yiying Xu, Jiawei Chen, Xiufang Qiu, Jianming Ding, Ye Feng, Chaoxiong Huang, Li Li, Mengying Li, Chuanben Chen
BMC Cancer.2023;[Epub] CrossRef
Higher radiation dose on immune cells is associated with radiation-induced lymphopenia and worse prognosis in patients with locally advanced esophageal squamous cell carcinoma
Jianjian Qiu, Hancui Lin, Dongmei Ke, Yilin Yu, Jiaying Xu, Hejin Qiu, Qunhao Zheng, Hui Li, Hongying Zheng, Lingyun Liu, Zhiping Wang, Qiwei Yao, Jiancheng Li
Frontiers in Immunology.2023;[Epub] CrossRef
Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma
Rema Shah, Christina Liu, Hemali P. Shah, Benjamin L. Judson
Laryngoscope Investigative Otolaryngology.2023; 8(4): 870. CrossRef
Dosimetric Effect of Thymus and Thoracic Duct on Radiation-Induced Lymphopenia in Patients With Primary Lung Cancer Who Received Thoracic Radiation
Jinliang Zhang, Li Yang, Hui Li, Jeff W. Chan, Eric K.W. Lee, Min Liu, Lingyu Ma, Qin Liu, Jian-Yue Jin, Pingfu Fu, Zhiyuan Xu, Feng-Ming (Spring) Kong
Advances in Radiation Oncology.2023; 8(6): 101260. CrossRef
Lymphopénie radio-induite : les lymphocytes comme nouvel organe à risque
P.A. Laurent, É. Deutsch
Cancer/Radiothérapie.2023; 27(6-7): 511. CrossRef
Impact of chemotherapeutic agents on liver microenvironment: oxaliplatin create a pro-metastatic landscape
Yuanyuan Ma, Chang Guo, Xijun Wang, Xundong Wei, Jie Ma
Journal of Experimental & Clinical Cancer Research.2023;[Epub] CrossRef
CT-based dosiomics and radiomics model predicts radiation-induced lymphopenia in nasopharyngeal carcinoma patients
Qingfang Huang, Chao Yang, Jinmeng Pang, Biao Zeng, Pei Yang, Rongrong Zhou, Haijun Wu, Liangfang Shen, Rong Zhang, Fan Lou, Yi Jin, Albert Abdilim, Hekun Jin, Zijian Zhang, Xiaoxue Xie
Frontiers in Oncology.2023;[Epub] CrossRef
Developing the POTOMAC Model: A Novel Prediction Model to Study the Impact of Lymphopenia Kinetics on Survival Outcomes in Head and Neck Cancer Via an Ensemble Tree-Based Machine Learning Approach
Carmen Kut, Doug Midthune, Emerson Lee, Peyton Fair, Tia Cheunkarndee, Todd McNutt, Theodore DeWeese, Carole Fakhry, Victor Kipnis, Harry Quon
JCO Clinical Cancer Informatics.2023;[Epub] CrossRef
Preoperative prognostic nutritional index predicts prognosis of patients with oral cavity cancer
Ku‐Hao Fang, Sheng‐Wei Chang, Yi‐Chan Lee, Ethan I. Huang, Chia‐Hsuan Lai, Geng‐He Chang, Ming‐Shao Tsai, Cheng‐Ming Hsu, Yao‐Te Tsai
Oral Diseases.2022; 28(7): 1816. CrossRef
A comprehensive model based on temporal dynamics of peripheral T cell repertoire for predicting post-treatment distant metastasis of nasopharyngeal carcinoma
Yajing Zhang, Yujie Zhu, Jiaqi Wang, Yi Xu, Zekun Wang, Yang Liu, Xuebing Di, Lin Feng, Ye Zhang
Cancer Immunology, Immunotherapy.2022; 71(3): 675. CrossRef
Identifying distinct risks of treatment failure in nasopharyngeal carcinoma: Study based on the dynamic changes in peripheral blood lymphocytes, monocytes, N classification, and plasma Epstein‐Barr virus DNA
Li‐Ting Liu, Yu‐Jing Liang, Shan‐Shan Guo, Yao Xie, Guo‐Dong Jia, Dong‐Xiang Wen, Lin‐Quan Tang, Qiu‐Yan Chen, Hai‐Qiang Mai
Head & Neck.2022; 44(1): 34. CrossRef
Taxane/gemcitabine-containing chemotherapy plus locoregional IMRT for patients with de novo metastatic nasopharyngeal carcinoma: the treatment outcomes and prognostic factors analysis
Chengrun Du, Mengshan Ni, Jianyun Jiang, Fangfang Kong, Ruiping Zhai, Yingchen Lv, Chaosu Hu, Hongmei Ying
European Archives of Oto-Rhino-Laryngology.2022; 279(8): 3947. CrossRef
The impact of radiation induced lymphopenia in the prognosis of head and neck cancer: A systematic review and meta-analysis
Dongjun Dai, Qiaoying Tian, Yongjie Shui, Jinfan Li, Qichun Wei
Radiotherapy and Oncology.2022; 168: 28. CrossRef
Systematic construction and external validation of an immune‐related prognostic model for nasopharyngeal carcinoma
Weiqun Lin, Di Cao, Annan Dong, Shaobo Liang, Yongyi Zhao, Cuibing Liu, Yinghua Yan, Xiaoliu Luo, Lizhi Liu, Xinchen Zeng, Qiaowen Ou
Head & Neck.2022; 44(5): 1086. CrossRef
Radiation Induced Lymphopenia Is Associated With the Effective Dose to the Circulating Immune Cells in Breast Cancer
Fang Chen, Jian-Yue Jin, Timothy S.K. Hui, Haiman Jing, Hong Zhang, Yaqing Nong, Ying Han, Weili Wang, Lingyu Ma, Fan Yi, Qingqing Chen, Yongsheng Zhang, Pingfu Fu, Li Yang, Zhiyuan Xu, Feng-Ming Spring Kong
Frontiers in Oncology.2022;[Epub] CrossRef
RuleFit-Based Nomogram Using Inflammatory Indicators for Predicting Survival in Nasopharyngeal Carcinoma, a Bi-Center Study
Chao Luo, Shuqi Li, Qin Zhao, Qiaowen Ou, Wenjie Huang, Guangying Ruan, Shaobo Liang, Lizhi Liu, Yu Zhang, Haojiang Li
Journal of Inflammation Research.2022; Volume 15: 4803. CrossRef
Head and neck cancers volume reduction: should we reduce our prophylactic node radiation to spare the antitumor immune response?
Y. El Houat, L. Bouvier, M. Baty, X. Palard-Novello, Y. Pointreau, R. de Crevoisier, J. Castelli
Cancer/Radiothérapie.2022; 26(6-7): 916. CrossRef
Establishment of a prognostic nomogram for patients with locoregionally advanced nasopharyngeal carcinoma incorporating clinical characteristics and dynamic changes in hematological and inflammatory markers
Qin Liu, Lingyu Ma, Huangrong Ma, Li Yang, Zhiyuan Xu
Frontiers in Oncology.2022;[Epub] CrossRef
The Current and Future Promises of Combination Radiation and Immunotherapy for Genitourinary Cancers
Ava Saidian, Isabella Dolendo, Andrew Sharabi, Tyler F. Stewart, Brent Rose, Rana R. McKay, Aditya Bagrodia, Amirali Salmasi
Cancers.2022; 15(1): 127. CrossRef
Hypofractionated concurrent chemoradiotherapy related lymphopenia and its association with survival in locally advanced non-small cell lung cancer patients
FangJie Liu, YingJia Wu, JianHui Shao, Bo Qiu, SuPing Guo, QiaoTing Luo, JinYu Guo, DaQuan Wang, Chu Chu, Rui Zhou, NaiBin Chen, XinLei Ai, Hui Liu
Frontiers in Oncology.2022;[Epub] CrossRef
Combined radiotherapy and immunotherapy in urothelial bladder cancer: harnessing the full potential of the anti-tumor immune response
Mame Daro-Faye, Wassim Kassouf, Luis Souhami, Gautier Marcq, Fabio Cury, Tamim Niazi, Paul Sargos
World Journal of Urology.2021; 39(5): 1331. CrossRef
Lymphopenia During Definitive Chemoradiotherapy in Esophageal Squamous Cell Carcinoma: Association with Dosimetric Parameters and Patient Outcomes
Hui Xu, Maosheng Lin, Yingying Hu, Li Zhang, Qiaoqiao Li, Jinhan Zhu, Shi Wang, Mian Xi
The Oncologist.2021; 26(3): e425. CrossRef
Lymphopenia and intratumoral lymphocytic balance in the era of cancer immuno-radiotherapy
Michael I. Koukourakis, Alexandra Giatromanolaki
Critical Reviews in Oncology/Hematology.2021; 159: 103226. CrossRef
Hematological toxicity in patients with solid malignant tumors treated with radiation – Temporal analysis, dose response and impact on survival
Cynthia Terrones-Campos, Bruno Ledergerber, Ivan Richter Vogelius, Marie Helleberg, Lena Specht, Jens Lundgren
Radiotherapy and Oncology.2021; 158: 175. CrossRef
Prognosis of severe lymphopenia after postoperative radiotherapy in non-small cell lung cancer: Results of a long-term follow up study
Wang Jing, Yufei Liu, Hui Zhu, James Welsh, Saumil Gandhi, Melenda Jeter, Quynh Nguyen, Aileen B. Chen, Michael O'Reilly, Zhongxing Liao, Joe Y. Chang, Percy Lee, Steven H. Lin
Clinical and Translational Radiation Oncology.2021; 28: 54. CrossRef
Prognostic value of neutrophils for patients with nasopharyngeal carcinoma
Lisha Chen, Mengying Li, Ting Xu, Xiufang Qiu, Chuanben Chen
Laryngoscope Investigative Otolaryngology.2021; 6(2): 219. CrossRef
The Influence of Severe Radiation-Induced Lymphopenia on Overall Survival in Solid Tumors: A Systematic Review and Meta-Analysis
Pim J.J. Damen, Tiuri E. Kroese, Richard van Hillegersberg, Ewoud Schuit, Max Peters, Joost J.C. Verhoeff, Steven H. Lin, Peter S.N. van Rossum
International Journal of Radiation Oncology*Biology*Physics.2021; 111(4): 936. CrossRef
Prognostic Significance of Circulating Lymphocyte Subsets Before Treatment in Patients with Nasopharyngeal Carcinoma
De-Song Shen, Chang Yan, Yu Liang, Kai-Hua Chen, Xiao-Dong Zhu
Cancer Management and Research.2021; Volume 13: 8109. CrossRef
Proton therapy for locally advanced non-small cell lung cancer
Olsi Gjyshi, Zhongxing Liao
The British Journal of Radiology.2020;[Epub] CrossRef
Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis
Jiawen Zhao, Weijia Huang, Yongxian Wu, Yihuan Luo, Bo Wu, Jiwen Cheng, Junqiang Chen, Deyun Liu, Chengyang Li
Cancer Cell International.2020;[Epub] CrossRef
Prognosis and Risk Factors of Radiation-Induced Lymphopenia in Early-Stage Lung Cancer Treated With Stereotactic Body Radiation Therapy
Qianqian Zhao, Tingting Li, Gang Chen, Zhaochong Zeng, Jian He
Frontiers in Oncology.2020;[Epub] CrossRef
Prediction of Severe Lymphopenia During Chemoradiation Therapy for Esophageal Cancer: Development and Validation of a Pretreatment Nomogram
Peter S.N. van Rossum, Wei Deng, David M. Routman, Amy Y. Liu, Cai Xu, Yutaka Shiraishi, Max Peters, Kenneth W. Merrell, Christopher L. Hallemeier, Radhe Mohan, Steven H. Lin
Practical Radiation Oncology.2020; 10(1): e16. CrossRef
Radiation-induced lymphopenia correlates with survival in nasopharyngeal carcinoma: impact of treatment modality and the baseline lymphocyte count
Xiaoxue Xie, Shenglan Gong, Hekun Jin, Pei Yang, Ting Xu, Yilong Cai, Chengxian Guo, Rong Zhang, Fan Lou, Wenjuan Yang, Hui Wang
Radiation Oncology.2020;[Epub] CrossRef
Lymphopenia after induction chemotherapy correlates with incomplete surgical resection in patients with advanced ovarian cancer
Yasunori Yoshino, Ayumi Taguchi, Maki Takao, Tomoko Kashiyama, Akiko Furusawa, Masaya Uno, Satoshi Okada, Nao Kino, Toshiharu Yasugi
International Journal of Clinical Oncology.2019; 24(4): 428. CrossRef
Radiation-related Lymphopenia after Pelvic Nodal Irradiation for Prostate Cancer
Michael D. Schad, Sunil W. Dutta, Donald M. Muller, Krishni Wijesooriya, Timothy N. Showalter
Advances in Radiation Oncology.2019; 4(2): 323. CrossRef
Clinical predictors of radiation-induced lymphopenia in patients receiving chemoradiation for glioblastoma: clinical usefulness of intensity-modulated radiotherapy in the immuno-oncology era
Hwa Kyung Byun, Nalee Kim, Hong In Yoon, Seok-Gu Kang, Se Hoon Kim, Jaeho Cho, Jong Geol Baek, Jong Hee Chang, Chang-Ok Suh
Radiation Oncology.2019;[Epub] CrossRef
Acute severe lymphopenia by radiotherapy is associated with reduced overall survival in hepatocellular carcinoma
Hwa Kyung Byun, Nalee Kim, Sangjoon Park, Jinsil Seong
Strahlentherapie und Onkologie.2019; 195(11): 1007. CrossRef
Treatment-Related Lymphopenia Predicts Pathologic Complete Response and Recurrence in Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemoradiotherapy
Qiaoqiao Li, Sha Zhou, Shiliang Liu, Songran Liu, Hong Yang, Lei Zhao, Mengzhong Liu, Yonghong Hu, Mian Xi
Annals of Surgical Oncology.2019; 26(9): 2882. CrossRef
Assessing the interactions between radiotherapy and antitumour immunity
Clemens Grassberger, Susannah G. Ellsworth, Moses Q. Wilks, Florence K. Keane, Jay S. Loeffler
Nature Reviews Clinical Oncology.2019; 16(12): 729. CrossRef
Overview of Hematopoietic Stem Cells in Systemic Cancer Treatment, Aging, Pregnancy, and Radiation Hormesis
Aleksei N. Shoutko
Advances in Molecular Imaging.2019; 09(02): 19. CrossRef
Irradiation-Related Lymphopenia for Bone Metastasis from Hepatocellular Carcinoma
Sangjoon Park, Hwa Kyung Byun, Jinsil Seong
Liver Cancer.2019; 8(6): 468. CrossRef
Neutropenia during the First Cycle of Induction Chemotherapy Is Prognostic for Poor Survival in Locoregionally Advanced Nasopharyngeal Carcinoma: A Real-World Study in an Endemic Area
Cheng Xu, Shi-Ping Yang, Yuan Zhang, Ling-Long Tang, Guan-Qun Zhou, Xu Liu, Yan-Ping Mao, Rui Guo, Wen-Fei Li, Lei Chen, Ai-Hua Lin, Ying Sun, Jun Ma
Cancer Research and Treatment.2018; 50(3): 777. CrossRef
Field size effects on the risk and severity of treatment-induced lymphopenia in patients undergoing radiation therapy for solid tumors
Susannah G. Ellsworth
Advances in Radiation Oncology.2018; 3(4): 512. CrossRef
Turning cold tumors into hot tumors: harnessing the potential of tumor immunity using nanoparticles
Anne Rodallec, Guillaume Sicard, Raphaelle Fanciullino, Sébastien Benzekry, Bruno Lacarelle, Gerard Milano, Joseph Ciccolini
Expert Opinion on Drug Metabolism & Toxicology.2018; : 1. CrossRef

11,662 View
355 Download
61 Web of Science
55 Crossref

First
Prev
Page of 1
Next
Last

Search