KCA
Search
- Page Path
- HOME > Search
Original Articles
- Gastrointestinal cancer
- Development and Validation of Models to Predict Lymph Node Metastasis in Early Gastric Cancer Using Logistic Regression and Gradient Boosting Machine Methods
- Hae Dong Lee, Kyung Han Nam, Cheol Min Shin, Hye Seung Lee, Young Hoon Chang, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee, Sang-Hoon Ahn, Hyung-Ho Kim
- Cancer Res Treat. 2023;55(4):1240-1249. Published online March 21, 2023
- DOI: https://doi.org/10.4143/crt.2022.1330
-
Abstract
PDF
Supplementary Material
PubReader
ePub - Purpose
To identify important features of lymph node metastasis (LNM) and develop a prediction model for early gastric cancer (EGC) using a gradient boosting machine (GBM) method.
Materials and Methods
The clinicopathologic data of 2556 patients with EGC who underwent gastrectomy were used as training set and the internal validation set (set 1) at a ratio of 8:2. Additionally, 548 patients with EGC who underwent endoscopic submucosal dissection (ESD) as the initial treatment were included in the external validation set (set 2). The GBM model was constructed, and its performance was compared with that of the Japanese guidelines.
Results
LNM was identified in 12.6% (321/2556) of the gastrectomy group (training set & set 1) and 4.3% (24/548) of the ESD group (set 2). In the GBM analysis, the top five features that most affected LNM were lymphovascular invasion, depth, differentiation, size, and location. The accuracy, sensitivity, specificity, and the area under the receiver operating characteristics of set 1 were 0.566, 0.922, 0.516, and 0.867, while those of set 2 were 0.810, 0.958, 0.803, and 0.944, respectively. When the sensitivity of GBM was adjusted to that of Japanese guidelines (beyond the expanded criteria in set 1 [0.922] and eCuraC-2 in set 2 [0.958]), the specificities of GBM in sets 1 and 2 were 0.516 (95% confidence interval, 0.502-0.523) and 0.803 (0.795-0.805), while those of the Japanese guidelines were 0.502 (0.488-0.509) and 0.788 (0.780-0.790), respectively.
Conclusion
The GBM model showed good performance comparable with the eCura system in predicting LNM risk in EGCs. -
Citations
Citations to this article as recorded by
- Intratumoural and peritumoural CT-based radiomics for diagnosing lepidic-predominant adenocarcinoma in patients with pure ground-glass nodules: a machine learning approach
Y. Zou, Q. Mao, Z. Zhao, X. Zhou, Y. Pan, Z. Zuo, W. Zhang
Clinical Radiology.2024; 79(2): e211. CrossRef - eCura and W-eCura: different scores, different populations, same goal
Rui Morais, Diogo Libanio, João Santos-Antunes
Gut.2024; 73(11): e29. CrossRef - A machine learning model for predicting the lymph node metastasis of early gastric cancer not meeting the endoscopic curability criteria
Minoru Kato, Yoshito Hayashi, Ryotaro Uema, Takashi Kanesaka, Shinjiro Yamaguchi, Akira Maekawa, Takuya Yamada, Masashi Yamamoto, Shinji Kitamura, Takuya Inoue, Shunsuke Yamamoto, Takashi Kizu, Risato Takeda, Hideharu Ogiyama, Katsumi Yamamoto, Kenji Aoi,
Gastric Cancer.2024; 27(5): 1069. CrossRef - The Application of Artificial Intelligence to Cancer Research: A Comprehensive Guide
Amin Zadeh Shirazi, Morteza Tofighi, Alireza Gharavi, Guillermo A. Gomez
Technology in Cancer Research & Treatment.2024;[Epub] CrossRef - Computed Tomography-Based Radiomics Analysis of Different Machine Learning Approaches for Differentiating Pulmonary Sarcomatoid Carcinoma and Pulmonary Inflammatory Pseudotumor
An-Lin Zhang, Yan-Mei Fu, Zhi-Yang He
Iranian Journal of Radiology.2024;[Epub] CrossRef - Screening of gastric cancer diagnostic biomarkers in the homologous recombination signaling pathway and assessment of their clinical and radiomic correlations
Ahao Wu, Tengcheng Hu, Chao Lai, Qingwen Zeng, Lianghua Luo, Xufeng Shu, Pan Huang, Zhonghao Wang, Zongfeng Feng, Yanyan Zhu, Yi Cao, Zhengrong Li
Cancer Medicine.2024;[Epub] CrossRef
- Intratumoural and peritumoural CT-based radiomics for diagnosing lepidic-predominant adenocarcinoma in patients with pure ground-glass nodules: a machine learning approach
- 5,055 View
- 214 Download
- 6 Web of Science
- 6 Crossref
- Breast cancer
- Evaluation of a Direct Reverse Transcription Loop-Mediated Isothermal Amplification Method without RNA Extraction (Direct RT-LAMP) for the Detection of Lymph Node Metastasis in Early Breast Cancer
- In Hee Lee, Jin Hyang Jung, Soo Jung Lee, Jeeyeon Lee, Ho Yong Park, Ji-Young Park, Jee Young Park, Jae-hwan Jung, Hyunchul Lee, Hyo-Sung Jeon, Yee Soo Chae
- Cancer Res Treat. 2022;54(1):174-181. Published online April 26, 2021
- DOI: https://doi.org/10.4143/crt.2020.749
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
Assessing lymph node metastasis, tumor-derived DNA, or tumor-derived RNA has previously been studied in place of immunohistochemical assay. Because a direct reverse transcription loop-mediated isothermal amplification method (direct RT-LAMP) has been previously developed in order to rapidly identify viruses in place of RNA extraction, our team hypothesized that a direct RT-LAMP assay can be employed as a substitute in order to detect tumor involvement of lymph nodes within breast cancer patients.
Materials and Methods
A total amount of 92 lymph nodes removed across 40 patients possessing breast cancer were collected at Kyungpook National University Chilgok Hospital between the months of November 2015 and February 2016. All samples were then evaluated and contrasted via both a direct RT-LAMP assay and routine histopathologic examination.
Results
The sensitivity and specificity of the direct RT-LAMP assay were 85.7% and 100%, respectively. The positive predictive value and negative predictive value were 100% and 94.4%, respectively.
Conclusion
Direct RT-LAMP assay is capable of facilitating the detection of sentinel lymph node metastasis within breast cancer patients intraoperatively possessing an excellent sensitivity via a cost-effective and time-saving manner. -
Citations
Citations to this article as recorded by- Development and evaluation of an easy to use real-time reverse-transcription loop-mediated isothermal amplification assay for clinical diagnosis of West Nile virus
Marwa Khedhiri, Melek Chaouch, Kaouther Ayouni, Anissa Chouikha, Mariem Gdoura, Henda Touzi, Nahed Hogga, Alia Benkahla, Wasfi Fares, Henda Triki
Journal of Clinical Virology.2024; 170: 105633. CrossRef - Versatility of reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) from diagnosis of early pathological infection to mutation detection in organisms
Srishti Sen, Priyanka Bhowmik, Shubhangi Tiwari, Yoav Peleg, Boudhayan Bandyopadhyay
Molecular Biology Reports.2024;[Epub] CrossRef
- Development and evaluation of an easy to use real-time reverse-transcription loop-mediated isothermal amplification assay for clinical diagnosis of West Nile virus
- 6,926 View
- 219 Download
- 2 Web of Science
- 2 Crossref
- The Prognostic Impact of the Number of Metastatic Lymph Nodes and a New Prognostic Scoring System for Recurrence in Early-Stage Cervical Cancer with High Risk Factors: A Multicenter Cohort Study (KROG 15-04)
- Jeanny Kwon, Keun-Young Eom, Young Seok Kim, Won Park, Mison Chun, Jihae Lee, Yong Bae Kim, Won Sup Yoon, Jin Hee Kim, Jin Hwa Choi, Sei Kyung Chang, Bae Kwon Jeong, Seok Ho Lee, Jihye Cha
- Cancer Res Treat. 2018;50(3):964-974. Published online October 24, 2017
- DOI: https://doi.org/10.4143/crt.2017.346
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
We aimed to assess prognostic value of metastatic pelvic lymph node (mPLN) in early-stage cervical cancer treated with radical surgery followed by postoperative chemoradiotherapy. Also, we sought to define a high-risk group using prognosticators for recurrence.
Materials and Methods
A multicenter retrospective study was conducted using the data from 13 Korean institutions from 2000 to 2010. A total of 249 IB-IIA patients with high-risk factors were included. We evaluated distant metastasis-free survival (DMFS) and disease-free survival (DFS) in relation to clinicopathologic factors including pNstage, number of mPLN, lymph node (LN)ratio (number of positive LN/number of harvested LN), and log odds of mPLNs (log(number of positive LN+0.5/number of negative LN+0.5)).
Results
In univariate analysis, histology (squamous cell carcinoma [SqCC] vs. others), lymphovascular invasion (LVI), number of mPLNs (≤ 3 vs. > 3), LN ratio (≤ 17% vs. > 17%), and log odds of mPLNs (≤ ‒0.58 vs. > ‒0.58) were significant prognosticators for DMFS and DFS. Resection margin involvement only affected DFS. No significant survival difference was observed between pN0 patients and patients with 1-3 mPLNs. Multivariate analysis revealed that mPLN > 3, LVI, and non-SqCC were unfavorable index for both DMFS (p < 0.001, p=0.020, and p=0.031, respectively) and DFS (p < 0.001, p=0.017, and p=0.001, respectively). A scoring system using these three factors predicts risk of recurrence with relatively high concordance index (DMFS, 0.69; DFS, 0.71).
Conclusion
mPLN > 3 in early-stage cervical cancer affects DMFS and DFS. A scoring system using mPLNs > 3, LVI, and non-SqCC could stratify risk groups of recurrence in surgically resected early-stage cervix cancer with high-risk factors. -
Citations
Citations to this article as recorded by- Should all cervical cancer patients with positive lymph node receive definitive radiotherapy: a population-based comparative study
Yang Wang, Xingyu Liu, Jing Liu, Liying Liu, Yue Ma
Archives of Gynecology and Obstetrics.2025;[Epub] CrossRef - Significance of tumor size and number of positive nodes in patients with FIGO 2018 stage IIIC1 cervical cancer
Michihide Maeda, Seiji Mabuchi, Mina Sakata, Satoki Deguchi, Reisa Kakubari, Shinya Matsuzaki, Tsuyoshi Hisa, Shoji Kamiura
Japanese Journal of Clinical Oncology.2024; 54(2): 146. CrossRef - Internal Validation of Predictive Models for Recurrence-Free Survival and Risk of Recurrence in Patients with Figo Stages I–IV Cervical Cancer
Jorge Cea García, Francisco Márquez Maraver, M. Carmen Rubio Rodríguez, Laura Ríos-Pena, Inmaculada Rodríguez Jiménez
Indian Journal of Gynecologic Oncology.2024;[Epub] CrossRef - Prediction of recurrence-related factors for patients with early-stage cervical cancer following radical hysterectomy and adjuvant radiotherapy
Gui-Fen Ma, Gen-Lai Lin, Si-Tong Wang, Ya-Yu Huang, Chun-Li Xiao, Jing Sun, Ting-Yan Shi, Li-Bing Xiang
BMC Women's Health.2024;[Epub] CrossRef - Based on 3D-PDU and clinical characteristics nomogram for prediction of lymph node metastasis and lymph-vascular space invasion of early cervical cancer preoperatively
Shuang Dong, Yan-Qing Peng, Ya-Nan Feng, Xiao-Ying Li, Li-Ping Gong, Shuang Zhang, Xiao-Shan Du, Li-Tao Sun
BMC Women's Health.2024;[Epub] CrossRef - Predictive value of number of metastatic lymph nodes and lymph node ratio for prognosis of patients with FIGO 2018 stage IIICp cervical cancer: a multi-center retrospective study
Yanna Ye, Rui Lian, Zhiqiang Li, Xiaolin Chen, Yahong Huang, Jilong Yao, Anwei Lu, Jinghe Lang, Ping Liu, Chunlin Chen
BMC Cancer.2024;[Epub] CrossRef - Prognostic Factors for Cervical Cancer in Asian Populations: A Scoping Review of Research From 2013 to 2023
Syed S Abrar, Seoparjoo Azmel Mohd Isa, Suhaily Mohd Hairon, Najib M Yaacob, Mohd Pazudin Ismail
Cureus.2024;[Epub] CrossRef - New Classification of Tumor Microvessels and the Risk of Regional Metastasis in Squamous Cell and Glandular Cancers
Marina Senchukova
American Journal of Clinical and Experimental Medicine.2024; 12(5): 61. CrossRef - Analysis of prognostic factors for cervical mucinous adenocarcinoma and establishment and validation a nomogram: a SEER-based study
Yiping Hao, Qingqing Liu, Ruowen Li, Zhonghao Mao, Nan Jiang, Bingyu Wang, Wenjing Zhang, Baoxia Cui
Journal of Obstetrics and Gynaecology.2023;[Epub] CrossRef - Validation of the 2018 FIGO Staging System for Predicting the Prognosis of Patients With Stage IIIC Cervical Cancer
Xingtao Long, Misi He, Lingling Yang, Dongling Zou, Dong Wang, Yuemei Chen, Qi Zhou
Clinical Medicine Insights: Oncology.2023;[Epub] CrossRef - Development of novel tracers for sentinel node identification in cervical cancer
Keisuke Kodama, Chuya Tateishi, Tsuyoshi Oda, Lin Cui, Kazutaka Kuramoto, Hideaki Yahata, Kaoru Okugawa, Shoji Maenohara, Hiroshi Yagi, Masafumi Yasunaga, Ichiro Onoyama, Kazuo Asanoma, Takeshi Mori, Yoshiki Katayama, Kiyoko Kato
Cancer Science.2023; 114(11): 4216. CrossRef - Preoperative prediction of cervical cancer survival using a high-resolution MRI-based radiomics nomogram
Jia Li, Hao Zhou, Xiaofei Lu, Yiren Wang, Haowen Pang, Daniel Cesar, Aiai Liu, Ping Zhou
BMC Medical Imaging.2023;[Epub] CrossRef - Abdominal Radical Hysterectomy as an Alternative Treatment Option for Patients with Cervical Cancer without Access to Radiotherapy Facilities
Yanna Ye, Zhiqiang Li, Biliang Chen, Shan Kang, Bin Ling, Li Wang, Jilong Yao, Jinghe Lan, Ping Liu, Chunlin Chen
Clinical and Experimental Obstetrics & Gynecology.2023;[Epub] CrossRef - Canine anal sac gland carcinoma with regional lymph node metastases treated with sacculectomy and lymphadenectomy: Outcome and possible prognostic factors
Jean‐Benoit Tanis, Angharad B. Simlett‐Moss, Malgorzata Ossowksa, Thomas W. Maddox, James Guillem, Cristobal Lopez‐Jimenez, Gerry Polton, Rachel Burrow, Riccardo Finotello
Veterinary and Comparative Oncology.2022; 20(1): 276. CrossRef - The prognostic value of the number of positive lymph nodes and the lymph node ratio in early‐stage cervical cancer
Ester P. Olthof, Constantijne H. Mom, Malou L. H. Snijders, Hans H. B. Wenzel, Jacobus van der Velden, Maaike A. van der Aa
Acta Obstetricia et Gynecologica Scandinavica.2022; 101(5): 550. CrossRef - Development and Validation of Novel Nomograms to Predict the Overall Survival and Cancer-Specific Survival of Cervical Cancer Patients With Lymph Node Metastasis
Jianying Yi, Zhili Liu, Lu Wang, Xingxin Zhang, Lili Pi, Chunlei Zhou, Hong Mu
Frontiers in Oncology.2022;[Epub] CrossRef - Treatment Strategies and Prognostic Factors of 2018 FIGO Stage IIIC Cervical Cancer: A Review
Fengying Qin, Huiting Pang, Tao Yu, Yahong Luo, Yue Dong
Technology in Cancer Research & Treatment.2022;[Epub] CrossRef - Tumoral Morphologic Features From Cervical Biopsies That Are Predictive of a Negligible Risk for Nodal Metastasis and Tumor Recurrence in Usual-type Cervical Adenocarcinomas
Yue Wang, Ruby Jean Chang, Rong-Zhen Luo, Jing Yu, Xiaofei Zhang, Xianghong Yang, M.R. Quddus, Li Li, Wentao Yang, Aijun Liu, Qingping Jiang, Ruijiao Zhao, Huiting Zhu, Feng Zhou, Yiying Wang, Xiujie Sheng, Li-Li Liu, Yan-Lin Wen, Natalie Banet, C.J. Sung
American Journal of Surgical Pathology.2022; 46(5): 713. CrossRef - Significance of the Number and the Location of Metastatic Lymph Nodes in Locally Recurrent or Persistent Cervical Cancer Patients Treated with Salvage Hysterectomy plus Lymphadenectomy
Seiji Mabuchi, Naoko Komura, Michiko Kodama, Michihide Maeda, Yuri Matsumoto, Shoji Kamiura
Current Oncology.2022; 29(7): 4856. CrossRef - Development and validation of a nomogram for predicting pelvic lymph node metastasis and prognosis in patients with cervical cancer
Mengting Wang, Min Ma, Liju Yang, Chengtong Liang
Frontiers in Oncology.2022;[Epub] CrossRef - High expression of PYK2 is associated with poor prognosis and cancer progression in early-stage cervical carcinoma
Can Zhang, Xinghua Zhu, Yong Li, Jia Shao, Haibo Xu, Lei Chen, Youli Dan, Hua Jin, Aiqin He
Medicine.2022; 101(41): e31178. CrossRef - Whether individualized dose escalation should be recommended for lymph nodes with different sizes in the definitive radiotherapy of cervical cancer?
Xiaojuan Lv, Huiting Rao, Tao Feng, Chufan Wu, Hanmei Lou
Radiation Oncology.2022;[Epub] CrossRef - Prognostic value of lymph node ratio in cervical cancer: A meta-analysis
Haixia Cui, Yuan Huang, Weibo Wen, Xiangdan Li, Dongyuan Xu, Lan Liu
Medicine.2022; 101(42): e30745. CrossRef - The Impact of Revised FIGO 2018 Staging System on Survival Outcomes in Patients with Carcinoma Cervix
Sharanya Sathish, Geeta Acharaya, Kiran Kulkarni, Gayatri Ravikumar
Indian Journal of Gynecologic Oncology.2022;[Epub] CrossRef - Lymph Node Ratio Is a Strong Prognostic Factor in Patients with Early-Stage Cervical Cancer Undergoing Minimally Invasive Radical Hysterectomy
Se Ik Kim, Tae Hun Kim, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Taek Sang Lee, Hye Won Jeon, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song
Yonsei Medical Journal.2021; 62(3): 231. CrossRef - Recurrence pattern and prognostic factors for survival in cervical cancer with lymph node metastasis
Cigdem Kilic, Gunsu Kimyon Comert, Caner Cakir, Dilek Yuksel, Bahadır Codal, Fatih Kilic, Osman Turkmen, Alper Karalok, Ozlem Moraloglu Tekin, Nurettin Boran, Taner Turan
Journal of Obstetrics and Gynaecology Research.2021; 47(6): 2175. CrossRef - Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: An EMBRACE analysis
Max Peters, Astrid A.C. de Leeuw, Christel N. Nomden, Kari Tanderup, Kathrin Kirchheiner, Jacob C. Lindegaard, Christian Kirisits, Christine Haie-Meder, Alina Sturdza, Lars Fokdal, Umesh Mahantshetty, Peter Hoskin, Barbara Segedin, Kjersti Bruheim, Bhavan
Radiotherapy and Oncology.2021; 163: 150. CrossRef - Prognostic Value of Lymph Node Characteristics in Patients with Cervical Cancer Treated with Radical Hysterectomy
Yoon Hee Lee, Gun Oh Chong, Su Jeong Kim, Ja Hyun Hwang, Jong Mi Kim, Nora Jee-Young Park, Dae Gy Hong
Cancer Management and Research.2021; Volume 13: 8137. CrossRef - The Combination of T Stage and the Number of Pathologic Lymph Nodes Provides Better Prognostic Discrimination in Early-Stage Cervical Cancer With Lymph Node Involvement
Yongrui Bai, Ling Rong, Bin Hu, Xiumei Ma, Jiahui Wang, Haiyan Chen
Frontiers in Oncology.2021;[Epub] CrossRef - The prognostic value of lymph node ratio in stage IIIC cervical cancer patients triaged to primary treatment by radical hysterectomy with systematic pelvic and para-aortic lymphadenectomy
Koray Aslan, Mehmet Mutlu Meydanli, Murat Oz, Yusuf Aytac Tohma, Ali Haberal, Ali Ayhan
Journal of Gynecologic Oncology.2020;[Epub] CrossRef - Predictive value of preoperative serum squamous cell carcinoma antigen (SCC–Ag) level on tumor recurrence in cervical squamous cell carcinoma patients treated with radical surgery: A single-institution study
Qinhao Guo, Jun Zhu, Yong Wu, Hao Wen, Lingfang Xia, Xiaohua Wu, Xingzhu Ju
European Journal of Surgical Oncology.2020; 46(1): 131. CrossRef - Effects of preoperative radiotherapy or chemoradiotherapy on postoperative pathological outcome of cervical cancer——from the large database of 46,313 cases of cervical cancer in China
Weili Li, Ping Liu, Weidong Zhao, Zhaohong Yin, Zhong Lin, Xiaonong Bin, Jinghe Lang, Chunlin Chen
European Journal of Surgical Oncology.2020; 46(1): 148. CrossRef - DSG2 expression is correlated with poor prognosis and promotes early-stage cervical cancer
Shuhang Qin, Yuandong Liao, Qiqiao Du, Wei Wang, Jiaming Huang, Pan Liu, Chunliang Shang, Tianyu Liu, Meng Xia, Shuzhong Yao
Cancer Cell International.2020;[Epub] CrossRef - Should the Number of Metastatic Pelvic Lymph Nodes Be Integrated into the 2018 Figo Staging Classification of Early Stage Cervical Cancer?
Luigi Pedone Anchora, Vittoria Carbone, Valerio Gallotta, Francesco Fanfani, Francesco Cosentino, Luigi Carlo Turco, Camilla Fedele, Nicolò Bizzarri, Giovanni Scambia, Gabriella Ferrandina
Cancers.2020; 12(6): 1552. CrossRef - UGT1A1 polymorphism has a prognostic effect in patients with stage IB or II uterine cervical cancer and one or no metastatic pelvic nodes receiving irinotecan chemotherapy: a retrospective study
Hideki Matsuoka, Ryusuke Murakami, Kaoru Abiko, Ken Yamaguchi, Akihito Horie, Junzo Hamanishi, Tsukasa Baba, Masaki Mandai
BMC Cancer.2020;[Epub] CrossRef - Validation of the 2018 FIGO Classification for Cervical Cancer: Lymphovascular Space Invasion Should Be Considered in IB1 Stage
Vincent Balaya, Benedetta Guani, Laurent Magaud, Hélène Bonsang-Kitzis, Charlotte Ngô, Patrice Mathevet, Fabrice Lécuru
Cancers.2020; 12(12): 3554. CrossRef - Burden of lymphatic disease predicts efficacy of adjuvant radiation and chemotherapy in FIGO 2018 stage IIICp cervical cancer
Giorgio Bogani, Daniele Vinti, Ferdinando Murgia, Valentina Chiappa, Umberto Leone Roberti Maggiore, Fabio Martinelli, Antonino Ditto, Francesco Raspagliesi
International Journal of Gynecological Cancer.2019; 29(9): 1355. CrossRef - Prognostic factors for and pattern of lymph-node involvement in patients with operable cervical cancer
P. Widschwendter, W. Janni, C. Scholz, A. De Gregorio, N. De Gregorio, T W P Friedl
Archives of Gynecology and Obstetrics.2019; 300(6): 1709. CrossRef - Postoperative chemotherapy for node-positive cervical cancer: Results of a multicenter phase II trial (JGOG1067)
Maki Matoda, Nobuhiro Takeshima, Hirofumi Michimae, Takashi Iwata, Harushige Yokota, Yutaka Torii, Yorito Yamamoto, Kazuhiro Takehara, Shin Nishio, Hirokuni Takano, Mika Mizuno, Yoshiyuki Takahashi, Yuji Takei, Tetsuya Hasegawa, Mikio Mikami, Takayuki Eno
Gynecologic Oncology.2018; 149(3): 513. CrossRef
- Should all cervical cancer patients with positive lymph node receive definitive radiotherapy: a population-based comparative study
- 10,408 View
- 338 Download
- 47 Web of Science
- 39 Crossref
- Which Patients with Isolated Para-aortic Lymph Node Metastasis Will Truly Benefit from Extended Lymph Node Dissection for Colon Cancer?
- Sung Uk Bae, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
- Cancer Res Treat. 2018;50(3):712-719. Published online July 14, 2017
- DOI: https://doi.org/10.4143/crt.2017.100
-
Abstract
PDFPubReaderePub
- Purpose
The prognosis of patientswith colon cancer and para-aortic lymph node metastasis (PALNM) is poor. We analyzed the prognostic factors of extramesenteric lymphadenectomy for colon cancer patients with isolated PALNM.
Materials and Methods
We retrospectively reviewed 49 patients with PALNM who underwent curative resection between October 1988 and December 2009.
Results
In univariate analyses, the 5-year overall survival (OS) and disease-free survival (DFS) rates were higher in patients with ≤ 7 positive para-aortic lymph node (PALN) (36.5% and 27.5%) than in those with > 7 PALN (14.3% and 14.3%; p=0.010 and p=0.027, respectively), and preoperative carcinoembryonic antigen (CEA) level > 5 was also correlated with a lower 5-year OS and DFS rate of 21.5% and 11.7% compared with those with CEA ≤ 5 (46.3% and 41.4%; p=0.122 and 0.039, respectively). Multivariate analysis found that the number of positive PALN (hazard ratio [HR], 3.291; 95% confidence interval [CI], 1.309 to 8.275; p=0.011) was an independent prognostic factor for OS and the number of positive PALN (HR, 2.484; 95% CI, 0.993 to 6.211; p=0.052) and preoperative CEA level (HR, 1.953; 95% CI, 0.940 to 4.057; p=0.073) were marginally independent prognostic factors for DFS. According to our prognostic model, the 5-year OS and DFS rate increased to 59.3% and 53.3%, respectively, in patients with ≤ 7 positive PALN and CEA level ≤ 5.
Conclusion
PALN dissection might be beneficial in carefully selected patients with a low CEA level and less extensive PALNM. -
Citations
Citations to this article as recorded by- Prognostic factors of para-aortic lymph node metastasis from colorectal cancer in highly selected patients undergoing para-aortic lymph node dissection
Shin Emoto, Yosuke Fukunaga, Manabu Takamatsu, Hiroshi Kawachi, Shuhei Sano, Tetsuro Tominaga, Toshiki Mukai, Tomohiro Yamaguchi, Toshiya Nagasaki, Takashi Akiyoshi, Tsuyoshi Konishi, Satoshi Nagayama, Masashi Ueno
Surgery Today.2024; 54(4): 356. CrossRef - Metastatic Colorectal Cancer Treated with Combined Liver Resection, Cytoreductive Surgery, and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Predictive Factors for Early Recurrence
Rémi Grange, Pascal Rousset, Nicolas Williet, Mathias Guesnon, Laurent Milot, Guillaume Passot, Jean-Marc Phelip, Bertrand Le Roy, Olivier Glehen, Vahan Kepenekian
Annals of Surgical Oncology.2024; 31(4): 2378. CrossRef - Para-aortic Lymph Node Dissection for Colorectal Cancer: Predicting Pathologic Lymph Node Positivity and Optimizing Outcomes
Neal Bhutiani, Kentaro Ochiai, Muhammad O. Awiwi, Miguel A. Rodriguez-Bigas, Abhineet Uppal, Oliver Peacock, Craig Messick, Michael G. White, John M. Skibber, Brian K. Bednarski, Y. Nancy You, George J. Chang, Harmeet Kaur, Tsuyoshi Konishi
Annals of Surgical Oncology.2024; 31(9): 5962. CrossRef - Surgery for Infrarenal Retroperitoneal Node Metastases from Colon Cancer
Anne-Sophie Dulac, Pietro Genova, Olivier Benoit, Cindy Neuzillet, Mostapha El Hajjam, Jean-François Emile, Frédérique Peschaud, Renato Micelli Lupinacci
Journal of Gastrointestinal Cancer.2024; 55(3): 1306. CrossRef - Long-term Outcome After Surgical Resection of Para-aortic Lymph Node Metastasis of Colorectal Cancer: A Multicenter Retrospective Study
Sono Ito, Yusuke Kinugasa, Shinichi Yamauchi, Hiroyuki Sato, Akihiro Hirakawa, Soichiro Ishihara, Akio Shiomi, Yukihide Kanemitsu, Takeshi Suto, Hiroki Takahashi, Michio Itabashi, Manabu Shiozawa, Masaya Hiyoshi, Takaya Kobatake, Koji Komori, Hiroyuki Egi
Diseases of the Colon & Rectum.2024; 67(11): 1423. CrossRef - Long-Term Outcome After Resection of Hepatic and Pulmonary Metastases in Multivisceral Colorectal Cancer
Christopher Berlin, Geoffroy Andrieux, Magdalena Menzel, Gabriel J. Stöger, Andreas Gengenbach, Luisa Schäfer, Hans C. Hillebrecht, Rebecca Kesselring, Uyen-Thao Le, Stefan Fichtner-Feigl, Philipp A. Holzner
Cancers.2024; 16(22): 3741. CrossRef - Role of Adjuvant Chemotherapy After Surgical Resection of Paraaortic Lymph Node Metastasis from Colorectal Cancer—A Multicenter Retrospective Study
Hiroaki Nozawa, Sono Ito, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Shinichi Yamauchi, Yusuke Kinugasa, Yoichi Ajioka, Soichiro Ishihara
Annals of Surgical Oncology.2024;[Epub] CrossRef - Survival outcomes after synchronous para‐aortic lymph node metastasis in colorectal cancer: A systematic review
Conor Aylward, Jawed Noori, Jack Tyrrell, Niall O'sullivan, Dara O. Kavanagh, John O. Larkin, Brian J. Mehigan, Paul H. McCormick, Michael E. Kelly
Journal of Surgical Oncology.2023; 127(4): 645. CrossRef - Retroperitoneal Lymph Node Dissection in Colorectal Cancer with Lymph Node Metastasis: A Systematic Review
Michael G. Fadel, Mosab Ahmed, Gianluca Pellino, Shahnawaz Rasheed, Paris Tekkis, David Nicol, Christos Kontovounisios, Erik Mayer
Cancers.2023; 15(2): 455. CrossRef - The management of clinically suspicious para‐aortic lymph node metastasis in colorectal cancer: A systematic review
Michelle Zhiyun Chen, Yeng Kwang Tay, Swetha Prabhakaran, Joseph C Kong
Asia-Pacific Journal of Clinical Oncology.2023; 19(6): 596. CrossRef - Survival benefits of para-aortic lymphadenectomy in colorectal cancer with clinically suspected para-aortic lymph node metastasis: a meta-analysis and systematic review
Rong-Chang Wang, Jian-Qi Wang, Xiao-Yu Zhou, Chu-lin Zhong, Jin-Xu Chen, Jing-Song Chen
World Journal of Surgical Oncology.2023;[Epub] CrossRef - Influence of Extraperitoneal Metastases on the Curative-Intent Management of Colorectal Peritoneal Metastases
Frédéric Schell, Amaniel Kefleyesus, Nazim Benzerdjeb, Guillaume Passot, Pascal Rousset, Alhadeedi Omar, Laurent Villeneuve, Julien Péron, Olivier Glehen, Vahan Kepenekian
Annals of Surgical Oncology.2023; 30(7): 4444. CrossRef - Lymph nodes primary staging of colorectal cancer in 18F-FDG PET/MRI: a systematic review and meta-analysis
Qingwei Ren, Yanyan Chen, Xuejun Shao, Lanzhong Guo, Xinxin Xu
European Journal of Medical Research.2023;[Epub] CrossRef - Oncologic Outcomes after Surgical Resection for Para-aortic Lymph Node Metastasis in Colorectal Cancer
Takayuki Okuno, Masaya Hiyoshi, Yuusuke Kyoden, Junji Yamamoto
Nippon Daicho Komonbyo Gakkai Zasshi.2023; 76(7): 460. CrossRef - Multicenter study of prognostic factors in paraaortic lymph node dissection for metastatic colorectal cancer
Jun Woo Bong, Sanghee Kang, Pyoungjae Park
Annals of Surgical Treatment and Research.2023; 105(5): 271. CrossRef - Outcomes of metachronous para-aortic lymphadenectomy in colorectal cancer: a systematic review of the literature
Oluwatobi O. Onafowokan, Jennifer Redfern, Agastya Patel, Thomas Satyadas, Minas Baltatzis
Langenbeck's Archives of Surgery.2023;[Epub] CrossRef - Predictive factors of survival of colorectal cancer patients after para-aortic lymph node metastasis
Hiroaki Nozawa, Kazushige Kawai, Kazuhito Sasaki, Shigenobu Emoto, Shinya Abe, Hirofumi Sonoda, Koji Murono, Junko Kishikawa, Yuzo Nagai, Yuichiro Yokoyama, Hiroyuki Anzai, Soichiro Ishihara
International Journal of Clinical Oncology.2022; 27(3): 520. CrossRef - Long-Term Outcomes of Surgical Resection of Pathologically Confirmed Isolated Para-Aortic Lymph Node Metastases in Colorectal Cancer: A Systematic Review
Maurizio Zizzo, Maria Pia Federica Dorma, Magda Zanelli, Francesca Sanguedolce, Maria Chiara Bassi, Andrea Palicelli, Stefano Ascani, Alessandro Giunta
Cancers.2022; 14(3): 661. CrossRef - Effect of radical lymphadenectomy in colorectal cancer with para-aortic lymph node metastasis: a systematic review and meta-analysis
Pengyue Zhao, Xingpeng Yang, Yang Yan, Jiaqi Yang, Songyan Li, Xiaohui Du
BMC Surgery.2022;[Epub] CrossRef - Prognostic significance of enlarged paraaortic lymph nodes detected during left-sided colorectal cancer surgery: a single-center retrospective cohort study
Jaram Lee, Hyeong-min Park, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim
World Journal of Surgical Oncology.2021;[Epub] CrossRef - Risk factors for local recurrence and long term survival after minimally invasive intersphincteric resection for very low rectal cancer: Multivariate analysis in 161 patients
G.N. Piozzi, H. Park, T.H. Lee, J.S. Kim, H.B. Choi, S.J. Baek, J.M. Kwak, J. Kim, S.H. Kim
European Journal of Surgical Oncology.2021; 47(8): 2069. CrossRef - Effect of lymphadenectomy in colorectal cancer with isolated synchronous para‐aortic lymph node metastasis
Sung Chul Lee, Hee Cheol Kim, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park, Jung Kyong Shin
Colorectal Disease.2021; 23(10): 2584. CrossRef - Robotic Intersphincteric Resection for Low Rectal Cancer: Technical Controversies and a Systematic Review on the Perioperative, Oncological, and Functional Outcomes
Guglielmo Niccolò Piozzi, Seon Hahn Kim
Annals of Coloproctology.2021; 37(6): 351. CrossRef - Is 18F-FDG PET/CT an Accurate Way to Detect Lymph Node Metastasis in Colorectal Cancer: A Systematic Review and Meta-Analysis
Hamid Dahmarde, Fateme Parooie, Morteza Salarzaei
Contrast Media & Molecular Imaging.2020; 2020: 1. CrossRef - Oncologic outcomes after resection of para-aortic lymph node metastasis in left-sided colon and rectal cancer
Junichi Sakamoto, Heita Ozawa, Hiroki Nakanishi, Shin Fujita, Norikatsu Miyoshi
PLOS ONE.2020; 15(11): e0241815. CrossRef - Long-term outcome and prognostic factors for patients with para-aortic lymph node dissection in left-sided colorectal cancer
Kota Sahara, Jun Watanabe, Atsushi Ishibe, Yusuke Suwa, Hirokazu Suwa, Mitsuyoshi Ota, Chikara Kunisaki, Itaru Endo
International Journal of Colorectal Disease.2019; 34(6): 1121. CrossRef
- Prognostic factors of para-aortic lymph node metastasis from colorectal cancer in highly selected patients undergoing para-aortic lymph node dissection
- 16,214 View
- 329 Download
- 25 Web of Science
- 26 Crossref
- Molecular Signature for Lymphatic Invasion Associated with Survival of Epithelial Ovarian Cancer
- E Sun Paik, Hyun Jin Choi, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae, Chel Hun Choi
- Cancer Res Treat. 2018;50(2):461-473. Published online May 22, 2017
- DOI: https://doi.org/10.4143/crt.2017.104
-
Abstract
PDFSupplementary MaterialPubReaderePub
- Purpose
We aimed to develop molecular classifier that can predict lymphatic invasion and their clinical significance in epithelial ovarian cancer (EOC) patients.
Materials and Methods
We analyzed gene expression (mRNA, methylated DNA) in data from The Cancer Genome Atlas. To identify molecular signatures for lymphatic invasion, we found differentially expressed genes. The performance of classifier was validated by receiver operating characteristics analysis, logistic regression, linear discriminant analysis (LDA), and support vector machine (SVM). We assessed prognostic role of classifier using random survival forest (RSF) model and pathway deregulation score (PDS). For external validation,we analyzed microarray data from 26 EOC samples of Samsung Medical Center and curatedOvarianData database.
Results
We identified 21 mRNAs, and seven methylated DNAs from primary EOC tissues that predicted lymphatic invasion and created prognostic models. The classifier predicted lymphatic invasion well, which was validated by logistic regression, LDA, and SVM algorithm (C-index of 0.90, 0.71, and 0.74 for mRNA and C-index of 0.64, 0.68, and 0.69 for DNA methylation). Using RSF model, incorporating molecular data with clinical variables improved prediction of progression-free survival compared with using only clinical variables (p < 0.001 and p=0.008). Similarly, PDS enabled us to classify patients into high-risk and low-risk group, which resulted in survival difference in mRNA profiles (log-rank p-value=0.011). In external validation, gene signature was well correlated with prediction of lymphatic invasion and patients’ survival.
Conclusion
Molecular signature model predicting lymphatic invasion was well performed and also associated with survival of EOC patients. -
Citations
Citations to this article as recorded by- Identifying Stage II Colorectal Cancer Recurrence Associated Genes by Microarray Meta-Analysis and Building Predictive Models with Machine Learning Algorithms
Wei Lu, Xiang Pan, Siqi Dai, Dongliang Fu, Maxwell Hwang, Yingshuang Zhu, Lina Zhang, Jingsun Wei, Xiangxing Kong, Jun Li, Qian Xiao, Kefeng Ding, Quan Cheng
Journal of Oncology.2021; 2021: 1. CrossRef
- Identifying Stage II Colorectal Cancer Recurrence Associated Genes by Microarray Meta-Analysis and Building Predictive Models with Machine Learning Algorithms
- 9,923 View
- 249 Download
- 5 Web of Science
- 1 Crossref
- Anti-proliferative Effect of Engineered Neural Stem Cells Expressing Cytosine Deaminase and Interferon-β against Lymph Node–Derived Metastatic Colorectal Adenocarcinoma in Cellular and Xenograft Mouse Models
- Geon-Tae Park, Seung U. Kim, Kyung-Chul Choi
- Cancer Res Treat. 2017;49(1):79-91. Published online May 3, 2016
- DOI: https://doi.org/10.4143/crt.2015.503
-
Abstract
PDFPubReaderePub
- Purpose
Genetically engineered stem cells may be advantageous for gene therapy against various human cancers due to their inherent tumor-tropic properties. In this study, genetically engineered human neural stem cells (HB1.F3) expressing Escherichia coli cytosine deaminase (CD) (HB1.F3.CD) and human interferon-β (IFN-β) (HB1.F3.CD.IFN-β) were employed against lymph node–derived metastatic colorectal adenocarcinoma.
Materials and Methods
CD can convert a prodrug, 5-fluorocytosine (5-FC), to active 5-fluorouracil, which inhibits tumor growth through the inhibition of DNA synthesis,while IFN-β also strongly inhibits tumor growth by inducing the apoptotic process. In reverse transcription polymerase chain reaction analysis, we confirmed that HB1.F3.CD cells expressed the CD gene and HB1.F3.CD.IFN-β cells expressed both CD and IFN-β genes.
Results
In results of a modified trans-well migration assay, HB1.F3.CD and HB1.F3.CD.IFN-β cells selectively migrated toward SW-620, human lymph node–derived metastatic colorectal adenocarcinoma cells. The viability of SW-620 cells was significantly reduced when co-cultured with HB1.F3.CD or HB1.F3.CD.IFN-β cells in the presence of 5-FC. In addition, it was found that the tumor-tropic properties of these engineered human neural stem cells (hNSCs) were attributed to chemoattractant molecules including stromal cell-derived factor 1, c-Kit, urokinase receptor, urokinase-type plasminogen activator, and C-C chemokine receptor type 2 secreted by SW-620 cells. In a xenograft mouse model, treatment with hNSC resulted in significantly inhibited growth of the tumor mass without virulent effects on the animals.
Conclusion
The current results indicate that engineered hNSCs and a prodrug treatment inhibited the growth of SW-620 cells. Therefore, hNSC therapy may be a clinically effective tool for the treatment of lymph node metastatic colorectal cancer. -
Citations
Citations to this article as recorded by- Enhanced anti-tumor efficacy with multi-transgene armed mesenchymal stem cells for treating peritoneal carcinomatosis
Yoon Khei Ho, Jun Yung Woo, Kin Man Loke, Lih-Wen Deng, Heng-Phon Too
Journal of Translational Medicine.2024;[Epub] CrossRef - Genetically engineered neural stem cells expressing cytosine deaminase and interferon-beta enhanced T cell-mediated antitumor immunity against gastric cancer in a humanized mouse model
Youngdong Choi, Hong Kyu Lee, Dohee Ahn, Min-Woo Nam, Ryeo-Eun Go, Kyung-Chul Choi
Life Sciences.2023; 328: 121866. CrossRef - Carboxylesterase-overexpressing hTERT-immortalized human adipose stem cells in prostate tumor growth inhibition by irinotecan
Jae Heon Kim, Eunjeong Oh, Eun Seop Song, Chul Won Yun, Sang Hun Lee, Yun Seob Song
Journal of Cancer Research and Therapeutics.2023; 19(7): 1731. CrossRef - Nerves in gastrointestinal cancer: from mechanism to modulations
Nathalie Vaes, Musa Idris, Werend Boesmans, Maria M. Alves, Veerle Melotte
Nature Reviews Gastroenterology & Hepatology.2022; 19(12): 768. CrossRef - Genetically-modified Stem Cell in Regenerative Medicine and Cancer
Therapy; A New Era
Ali Hassanzadeh, Somayeh Shamlou , Niloufar Yousefi, Marzieh Nikoo, Javad Verdi
Current Gene Therapy.2021; 22(1): 23. CrossRef - Antithyroid cancer effects of human neural stem cells expressing therapeutic genes on anaplastic thyroid cancer cells
Hye‐Ji Shin, Kyung‐A. Hwang, Ryeo‐Eun Go, Seung U. Kim, Kyung‐Chul Choi
Journal of Cellular Biochemistry.2020; 121(2): 1586. CrossRef - Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers
Yuedi Ding, Jun Fan, Lili Deng, Biao Huang, Bin Zhou
Cancer Cell International.2020;[Epub] CrossRef - A highly efficient non-viral process for programming mesenchymal stem cells for gene directed enzyme prodrug cancer therapy
Yoon Khei Ho, Jun Yung Woo, Geraldine Xue En Tu, Lih-Wen Deng, Heng-Phon Too
Scientific Reports.2020;[Epub] CrossRef - A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models
Jae-Rim Heo, Kyung-A Hwang, Seung U. Kim, Kyung-Chul Choi
Cancer Research and Treatment.2019; 51(2): 797. CrossRef - The growth inhibitory effect of human gingiva-derived mesenchymal stromal cells expressing interferon-β on tongue squamous cell carcinoma cells and xenograft model
Lingqian Du, Qianyu Liang, Shaohua Ge, Chengzhe Yang, Pishan Yang
Stem Cell Research & Therapy.2019;[Epub] CrossRef - A promising therapeutic strategy for metastatic gestational trophoblastic disease: Engineered anticancer gene‑expressing stem cells to selectively target choriocarcinoma (Review)
Gyu‑Sik Kim, Kyung‑A Hwang, Kyung‑Chul Choi
Oncology Letters.2019;[Epub] CrossRef - Cancer-Specific Inhibitory Effects of Genetically Engineered Stem Cells Expressing Cytosine Deaminase and Interferon-β Against Choriocarcinoma in Xenografted Metastatic Mouse Models
Gyu-Sik Kim, Jae-Rim Heo, Seung U. Kim, Kyung-Chul Choi
Translational Oncology.2018; 11(1): 74. CrossRef - The growth of K562 human leukemia cells was inhibited by therapeutic neural stem cells in cellular and xenograft mouse models
GEON-TAE PARK, JAE-RIM HEO, SEUNG U. KIM, KYUNG-CHUL CHOI
Cytotherapy.2018; 20(9): 1191. CrossRef - Cytotoxic effect of co-expression of human hepatitis A virus 3C protease and bifunctional suicide protein FCU1 genes in a bicistronic vector
Alexey Komissarov, Ilya Demidyuk, Dina Safina, Marina Roschina, Andrey Shubin, Nataliya Lunina, Maria Karaseva, Sergey Kostrov
Molecular Biology Reports.2017; 44(4): 323. CrossRef - Cell-mediated enzyme prodrug cancer therapies
Rachael Mooney, Asma Abdul Majid, Jennifer Batalla, Alexander J. Annala, Karen S. Aboody
Advanced Drug Delivery Reviews.2017; 118: 35. CrossRef - Combination of Fe/Cu -chelators and docosahexaenoic acid: an exploration for the treatment of colorectal cancer
Nanhui Yu, Hong Zhu, Yuan Yang, Yiming Tao, Fengbo Tan, Qian Pei, Yuan Zhou, Xiangping Song, Qiurong Tan, Haiping Pei
Oncotarget.2017; 8(31): 51478. CrossRef
- Enhanced anti-tumor efficacy with multi-transgene armed mesenchymal stem cells for treating peritoneal carcinomatosis
- 12,155 View
- 163 Download
- 18 Web of Science
- 16 Crossref
- Prediction of Lymph Node Metastasis by Tumor Dimension Versus Tumor Biological Properties in Head and Neck Squamous Cell Carcinomas
- Jeon Yeob Jang, Min Ji Kim, Gwanghui Ryu, Nayeon Choi, Young-Hyeh Ko, Han-Sin Jeong
- Cancer Res Treat. 2016;48(1):54-62. Published online March 6, 2015
- DOI: https://doi.org/10.4143/crt.2014.332
-
Abstract
PDFPubReaderePub
- Purpose
Lymph node metastasis (LNM) is a strong prognostic factor in many solid cancers, including head and neck squamous cell carcinomas (HNSCC), and LNM can be dependent upon primary tumor biology, as well as tumor dimension. Here, we investigate the relative risk of LNM in accordance to tumor dimension and biology in HNSCC subsites.
Materials and Methods
Medical data of 295 HNSCC patients who had undergone the initial curative surgery (oral tongue 174, oropharynx 75, hypopharynx 46) were analyzed to identify the significant predictive factor for LNM. Tumor volume and thickness were set as tumor dimensional variables, and biological variables included lymphovascular, perineural invasion, and tumor differentiation. Statistical analyses were conducted to assess the predictability of LNM from variables, and subgroup analyses according to the tumor subsites. In addition, we evaluated the impacts of tumor dimension and biological variables on the treatment outcomes and survival in HNSCC subsites.
Results
The overall tumor dimension and biological variables had a similar impact on the prediction of LNM in HNSCC (area under curve, 0.7682 and 0.7717). The prediction sensitivity of LNM in oral tongue cancer was mainly dependent on tumor dimension, while LNM in oro- and hypo-pharynx cancers was more influenced by biological factors. Survival analyses also confirmed that biological factor was more powerful in estimating disease-free survival of hypopharyngeal cancer patients, while tumor dimension was more significant in that of oral cancer patients.
Conclusion
Tumor dimension and biology have a significant, tumor subsite-dependent impact on the occurrence of LNM and disease-free survival in HNSCC. -
Citations
Citations to this article as recorded by- Extra-Capsular Spread of Lymph Node Metastasis in Oral, Oropharyngeal and Hypopharyngeal Cancer: A Comparative Subsite Analysis
Yung Jee Kang, Goeun Park, Sung Yool Park, Taehwan Kim, Eunhye Kim, Yujin Heo, Changhee Lee, Han-Sin Jeong
Cancers.2024; 16(3): 659. CrossRef - The Prognostic Role of Perineural Invasion for Survival in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
Zhuo-Ying Tao, Guang Chu, Yu-Xiong Su
Cancers.2024; 16(14): 2514. CrossRef - A preoperative nomogram model for the prediction of lymph node metastasis in buccal mucosa cancer
Qian Chen, Rui Wei, Shan Li
Cancer Medicine.2023; 12(13): 14120. CrossRef - The Prognostic Prediction Value of Positive Lymph Nodes Numbers for the Hypopharyngeal Squamous Cell Carcinoma
Wendu Pang, Yaxin Luo, Junhong Li, Danni Cheng, Yufang Rao, Minzi Mao, Ke Qiu, Yijun Dong, Jun Liu, Jian Zou, Haiyang Wang, Fei Chen
Frontiers in Medicine.2022;[Epub] CrossRef - Crosstalk between head and neck cancer cells and lymphatic endothelial cells promotes tumor metastasis via CXCL5‐CXCR2 signaling
Bok‐Soon Lee, Jeon Yeob Jang, Chorong Seo, Chul‐Ho Kim
The FASEB Journal.2021;[Epub] CrossRef - A nomogram for predicting occult lymph node metastasis in early hypopharyngeal cancer with cN0
Xiaohui Yuan, Chi-Yao Hsueh, Ming Zhang, Lei Tao, Liang Zhou
European Archives of Oto-Rhino-Laryngology.2021; 278(9): 3515. CrossRef - Individualized elective irradiation of the clinically node‐negative neck in definitive radiotherapy for head and neck squamous cell carcinoma
Jia Kou, Li Lin, Cheng‐Yang Jiao, Meng‐Qiu Tian, Guan‐Qun Zhou, Xue Jiang, Jun Ma, Zhen‐Yu Qi, Yao Lu, Ying Sun
Cancer Communications.2021; 41(4): 303. CrossRef - The prognostic value of tumor depth for cervical lymph node metastasis in hypopharyngeal and supraglottic carcinomas
Lu‐Lu Ye, Jia Rao, Xing‐Wen Fan, Fang‐Fang Kong, Chao‐Su Hu, Hong‐Mei Ying
Head & Neck.2019; 41(7): 2116. CrossRef - Patients with unilateral squamous cell carcinoma of the tongue and ipsilateral lymph node metastasis do not profit from bilateral neck dissection
Christoph Klingelhöffer, Andreas Gründlinger, Gerrit Spanier, Stephan Schreml, Maximilian Gottsauner, Steffen Mueller, Johannes K. Meier, Torsten E. Reichert, Tobias Ettl
Oral and Maxillofacial Surgery.2018; 22(2): 185. CrossRef - Comparison of tumor volume, thickness, and T classification as predictors of outcomes in surgically treated squamous cell carcinoma of the oral tongue
Manish Mair, Deepa Nair, Sudhir Nair, Akshat Malik, Aseem Mishra, Sadhana Kannan, Saurabh Bobdey, Hitesh Singhvi, Pankaj Chaturvedi
Head & Neck.2018; 40(8): 1667. CrossRef - pN status predicts outcomes in surgically treated pT1–pT2 patients of various disease stages with squamous cell carcinoma of the head and neck: a 17-year retrospective single center cohort study
Xu Qian, Branko Sinikovic, Frank Schreiber, Sebastian Ochsenreither, Konrad Klinghammer, Barbara Wollenberg, Andreas M. Kaufmann, Andreas E. Albers
European Archives of Oto-Rhino-Laryngology.2018; 275(11): 2787. CrossRef - Predictive markers for delayed lymph node metastases and survival in early-stage oral squamous cell carcinoma
Ivica Luksic, Petar Suton
Head & Neck.2017; 39(4): 694. CrossRef - Measurement of tumor volume is not superior to diameter for prediction of lymph node metastasis in early gastric cancer with minute submucosal invasion
Jeung Hui Pyo, Sun-Ju Byeon, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Kyoung-Mee Kim, Hyeon Seon Ahn, Kyunga Kim, Yoon-Ho Choi, Jae J. Kim
Oncotarget.2017; 8(69): 113758. CrossRef - Mechanisms of Lymph Node Metastasis in Head and Neck Cancer
Jeon Yeob Jang
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2016; 59(4): 259. CrossRef - Analysis of angiogenic markers in oral squamous cell carcinoma-gene and protein expression
Susanne Jung, Sonja Sielker, Nikolai Purcz, Christoph Sproll, Yahya Acil, Johannes Kleinheinz
Head & Face Medicine.2015;[Epub] CrossRef
- Extra-Capsular Spread of Lymph Node Metastasis in Oral, Oropharyngeal and Hypopharyngeal Cancer: A Comparative Subsite Analysis
- 13,443 View
- 131 Download
- 15 Web of Science
- 15 Crossref
- Impact of Chemoradiation on Prognosis in Stage IVB Cervical Cancer with Distant Lymphatic Metastasis
- Hee Seung Kim, Taehun Kim, Eung Seok Lee, Hak Jae Kim, Hyun Hoon Chung, Jae Weon Kim, Yong Sang Song, Noh Hyun Park
- Cancer Res Treat. 2013;45(3):193-201. Published online September 30, 2013
- DOI: https://doi.org/10.4143/crt.2013.45.3.193
-
Abstract
PDFPubReaderePub
- PURPOSE
The purpose of this study was to determine whether chemoradiation (CCR) is efficient for improving prognosis, compared with systemic chemotherapy (SC), in patients with stage IVB cervical cancer who have distant lymphatic metastasis.
MATERIALS AND METHODS
Among 2,322 patients with cervical cancer between January 2000 and March 2010, 43 patients (1.9%) had stage IVB disease. After exclusion of 19 patients due to insufficient data and hematogenous metastasis, 24 patients (1%) who received CCR (n=10) or SC (n=14) were enrolled. We compared tumor response, progression-free survival (PFS) and overall survival (OS), and disease recurrence between CCR and SC.
RESULTS
Complete response rates were 60% and 0% after CCR and SC (p<0.01). Grade 3 or 4 leukopenia was more common in patients treated with CCR (24.4% vs. 9.1%, p=0.03), whereas grade 3 or 4 neuropenia was more frequent in those treated with SC (28.4% vs. 11.1%, p=0.03). Development of grade 3 proctitis occurred as a late radiotherapy (RT)-related toxicity in only one patient (10%) treated with CCR. In addition, squamous cell carcinoma and CCR were favorable prognostic factors for improvement of PFS (adjusted hazard ratios [HRs], 0.17 and 0.12; 95% confidence intervals [CIs], 0.04 to 0.80 and 0.03 to 0.61), and only CCR was significant for improvement of OS (adjusted HR, 0.15; 95% CI, 0.02 to 0.90). However, no differences in the rate and pattern of disease recurrence were observed between CCR and SC.
CONCLUSION
CCR may be more effective than SC for improving survival, and can be regarded as a feasible method with some caution regarding late RT-related toxicity for treatment of stage IVB cervical cancer with distant lymphatic metastasis. -
Citations
Citations to this article as recorded by- Intensity-Modulated Radiation Therapy for Uterine Cervical Cancer to Reduce Toxicity and Enhance Efficacy – an Option or a Must?: A Narrative Review
Sea-Won Lee, Aeran Kim, Sung Jong Lee, Sung Hwan Kim, Jong Hoon Lee
Cancer Research and Treatment.2024; 56(1): 1. CrossRef - Outcomes associated with treatment to all sites of disease in patients with stage IVB cancer of the cervix
Shira Peleg Hasson, Shira Felder, Limor Helpman, Alexandra Taylor, Mihal Shalamov, Sireen Abuakar, Smadar Bauer, Ronnie Shapira-Frommer, Inbal Greenhouse, Jacob Korach, Tatiana Rabin, Jeffrey Goldstein, Akram Saad
International Journal of Gynecological Cancer.2023; 33(5): 683. CrossRef - Definitive pelvic radiotherapy for patients with newly diagnosed stage IVB cervical cancer: a systematic review
David Viveros-Carreño, Santiago Vieira-Serna, Carlos Fernando Grillo - Ardila, Juliana Rodriguez, Nathalia Mora-Soto, Anuja Jhingran, Pedro T Ramirez, Rene Pareja
International Journal of Gynecological Cancer.2023; 33(7): 1057. CrossRef - Definitive vs palliative pelvic radiation for patients with newly diagnosed stage IVB cervical cancer treated with bevacizumab – An exploratory study
Rachel L. Wiley, Ioana L. Bondre, Randa Jalloul, Ann H. Klopp, Jolyn S. Taylor, Lois M. Ramondetta
Gynecologic Oncology Reports.2022; 40: 100963. CrossRef - Survival, treatment pattern, and treatment outcome in patients with cervical cancer metastatic to distant lymph nodes
Haoliang Lin, Dongyan Wang, Hui Li, Chuling Wu, Fengqian Zhang, Zhongqiu Lin, Tingting Yao
Frontiers in Oncology.2022;[Epub] CrossRef - Dynamic Nomogram Based on the Metastatic Number and Sites and Therapy Strategies Predicting the Prognosis of Patients with Metastatic Cervical Cancer
Yuan Ma, Jing Li, Xinyue Tan, Mengjiao Cai, Xiaozhi Zhang, Jinlu Ma
International Journal of Women's Health.2022; Volume 14: 1807. CrossRef - Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer
Satomi Hattori, Nobuhisa Yoshikawa, Kazumasa Mogi, Kosuke Yoshida, Masato Yoshihara, Satoshi Tamauchi, Yoshiki Ikeda, Akira Yokoi, Kimihiro Nishino, Kaoru Niimi, Shiro Suzuki, Hiroaki Kajiyama
Current Oncology.2021; 28(3): 1663. CrossRef - A Nomogram-Based Risk Classification System Predicting the Overall Survival of Patients With Newly Diagnosed Stage IVB Cervix Uteri Carcinoma
Wenke Yu, Lu Huang, Zixing Zhong, Tao Song, Hong'en Xu, Yongshi Jia, Jinming Hu, Huafeng Shou
Frontiers in Medicine.2021;[Epub] CrossRef - Defining the role of high-dose radiation in oligometastatic & oligorecurrent cervical cancer
Akshay Mangaj, Supriya Chopra, Remi A. Nout
Indian Journal of Medical Research.2021; 154(2): 303. CrossRef - Surgery of primary sites for stage IVB cervical cancer patients receiving chemoradiotherapy: a population-based study
Haoran Li, Yangyang Pang, Xi Cheng
Journal of Gynecologic Oncology.2020;[Epub] CrossRef - Intensity modulated radiation therapy boost in locally-advanced cervical cancer in the absence of brachytherapy
Roberta Lazzari, Giulia Riva, Matteo Augugliaro, Andrea Vavassori, Samantha Dicuonzo, Federica Cattani, Stefania Comi, Nicoletta Colombo, Barbara Alicja Jereczek-Fossa
International Journal of Gynecological Cancer.2020; 30(5): 607. CrossRef - Sarcopenia as a Predictor of Survival Among Patients With Organ Metastatic Cervical Cancer
Nobuhisa Yoshikawa, Akira Shirakawa, Kosuke Yoshida, Satoshi Tamauchi, Shiro Suzuki, Fumitaka Kikkawa, Hiroaki Kajiyama
Nutrition in Clinical Practice.2020; 35(6): 1041. CrossRef - Effect of addition of bevacizumab to chemoradiotherapy in newly diagnosed stage IVB cervical cancer: a single institution experience in Korea
Sang Hee Youn, Yeon-Joo Kim, Sang-Soo Seo, Sokbom Kang, Myong Cheol Lim, Ha Kyun Chang, Sang-Yoon Park, Joo-Young Kim
International Journal of Gynecological Cancer.2020; 30(6): 764. CrossRef - Detection of distant metastatic disease by positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET) at initial staging of cervical carcinoma
Alexander Lin, Sirui Ma, Farrokh Dehdashti, Stephanie Markovina, Julie Schwarz, Barry Siegel, Matthew Powell, Perry Grigsby
International Journal of Gynecological Cancer.2019; 29(3): 487. CrossRef - Score for the Overall Survival Probability of Patients With First-Diagnosed Distantly Metastatic Cervical Cancer: A Novel Nomogram-Based Risk Assessment System
Shilong Zhang, Xin Wang, Zhanming Li, Wenrong Wang, Lishun Wang
Frontiers in Oncology.2019;[Epub] CrossRef - Special Focus on Stage IV Cervical Cancer Patients: A Decade Experience
Sophie Espenel, Max Adrien Garcia, Julien Langrand-Escure, Alexis Vallard, Jane Chloé Trone, Chloé Rancoule, Nicolas Vial, Pablo Moreno-Acosta, Céline Chauleur, Claire Boutet, Michel Peoc'h, Nathalie Prevot-Bitot, Jean Baptiste Guy, Nicolas Magné
Oncology.2019; 97(3): 125. CrossRef - Selection and identification of novel peptides specifically targeting human cervical cancer
Xiaomin Liu, Jingwen Peng, Jie He, Qiaoran Li, Jianbin Zhou, Xiaoqiu Liang, Shengsong Tang
Amino Acids.2018; 50(5): 577. CrossRef - Radiotherapy Improves the Survival of Patients With Metastatic Cervical Cancer: A Propensity-Matched Analysis of SEER Database
Kejie Huang, Mingfang Jia, Ping Li, Jianglong Han, Rui Zhang, Qin Li, Yunfeng Qiao, TangPeng Xu, Peng Ruan, Qibin Song, Yanbo Li, Zhenming Fu
International Journal of Gynecological Cancer.2018; 28(7): 1360. CrossRef - Race and nodal disease status are prognostic factors in patients with stage IVB cervical cancer
Shin Nishio, Koji Matsuo, Koji Yonemoto, Mototsugu Shimokawa, Masayuki Hosaka, Michiko Kodama, Takahito M. Miyake, Kimio Ushijima, Toshiharu Kamura, Shannon N. Westin, Pamela T. Soliman, Robert L. Coleman
Oncotarget.2018; 9(64): 32321. CrossRef - Predictors of Survival in Patients With FIGO Stage IVB Cervical Cancer
Tomoyuki Sasano, Seiji Mabuchi, Hiromasa Kuroda, Ryoko Takahashi, Katsumi Kozasa, Fumiaki Isohashi, Yasuo Yoshioka, M.D. Kazuhiko Ogawa, Tadashi Kimura
International Journal of Gynecological Cancer.2016; 26(3): 528. CrossRef - Advances in diagnosis and treatment of metastatic cervical cancer
Haoran Li, Xiaohua Wu, Xi Cheng
Journal of Gynecologic Oncology.2016;[Epub] CrossRef - Tailored radiotherapeutic strategies for disseminated uterine cervical cancer patients
Jung Ho Im, Hong In Yoon, Sunghoon Kim, Eun Ji Nam, Sang Wun Kim, Ga Won Yim, Ki Chang Keum, Young Tae Kim, Gwi Eon Kim, Yong Bae Kim
Radiation Oncology.2015;[Epub] CrossRef - Cancer of the cervix uteri
Adriana Bermudez, Neerja Bhatla, Eric Leung
International Journal of Gynecology & Obstetrics.2015;[Epub] CrossRef - HER2 as a novel therapeutic target for cervical cancer
Doo-Yi Oh, Seokhwi Kim, Yoon-La Choi, Young Jae Cho, Ensel Oh, Jung-Joo Choi, Kyungsoo Jung, Ji-Young Song, Suzie E. Ahn, Byoung-Gie Kim, Duk-Soo Bae, Woong-Yang Park, Jeong-Won Lee, Sangyong Song
Oncotarget.2015; 6(34): 36219. CrossRef - Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells
Peng Zhang, Hong Li, Bin Yang, Fan Yang, Lin-Lin Zhang, Qing-You Kong, Xiao-Yan Chen, Mo-Li Wu, Jia Liu
Genes & Cancer.2014; 5(5-6): 154. CrossRef
- Intensity-Modulated Radiation Therapy for Uterine Cervical Cancer to Reduce Toxicity and Enhance Efficacy – an Option or a Must?: A Narrative Review
- 13,673 View
- 123 Download
- 25 Crossref
Case Reports
- Benign Metastasizing Leiomyoma with Multiple Lymph Node Metastasis: A Case Report
- Gun Yoon, Tae-Joong Kim, Chang-Ohk Sung, Chel Hun Choi, Jeong-Won Lee, Je-Ho Lee, Duk-Soo Bae, Byoung-Gie Kim
- Cancer Res Treat. 2011;43(2):131-133. Published online June 30, 2011
- DOI: https://doi.org/10.4143/crt.2011.43.2.131
-
Abstract
PDFPubReaderePub
- This is a case report about benign metastasizing leiomyoma with multiple lymph node metastasis. A 34-year-old woman received an abdominal myomectomy for a suspicious leiomyoma. On the pathology report, atypical leiomyoma was suspected. Due to the suspicion of multiple lymph node metastasis on pelvis computed tomography (CT) 1 year after the operation, she was transferred to the Samsung Medical Center on October, 2009 for further work up. According to original slide review, it was determined to be a benign leiomyoma with a mitotic count <5/10 high-power fields, little cytological atypia and no tumor cell necrosis. Additional immunostaining was done. Multiple lymph node metastasis and a small lung nodule were identified on positron emission tomogarphy-CT and chest CT. Extensive debulking surgery and diagnostic video-assisted thoracoscopic surgery (VATS) wedge resection were subsequently done. Metastatic lesions were reported to have a histology similar to that of the original mass. VATS right upper lobectomy with mediastinal lymph node dissection was performed because of the pathology result of VATS (adenocarcinoma). She started taking an aromatase inhibitor (Letrozole(R)) and there was no evidence of recurrence of disease on an imaging study and no post-operative complications until recently.
-
Citations
Citations to this article as recorded by- Pulmonary Benign Metastasizing Leiomyoma in a Postmenopausal Woman: A Case Report and Review of the Literature
Aleksandra Piórek, Adam Płużański, Piotr Wiśniewski, Sylwia Tabor, Kinga Winiarczyk, Magdalena Knetki-Wróblewska, Dariusz M. Kowalski, Maciej Krzakowski
Diseases.2024; 12(8): 181. CrossRef - Benign metastasizing uterine leiomyoma with lymphatic and pulmonary metastases: a case report and literature review
Tong Tong, Qiong Fan, Yudong Wang, Yuhong Li
BMC Women's Health.2023;[Epub] CrossRef - Pulmonary benign metastasizing uterine leiomyoma (PBML): a case report and review of the literature
Mark R. Brincat, Sarah Lam Shang Leen, Asma Faruqi, Michail Sideris, Kelvin Kar Wing Lau, Alexandra Lawrence
Annals of Medicine & Surgery.2023; 85(7): 3686. CrossRef - Benign Metastasizing Leiomyoma of the Lung: Diagnostic Process and Treatment Based on Three Case Reports and a Review of the Literature
Małgorzata Edyta Wojtyś, Olga Kacalska-Janssen, Konrad Ptaszyński, Piotr Lisowski, Michał Kunc, Janusz Wójcik, Tomasz Grodzki
Biomedicines.2022; 10(10): 2465. CrossRef - A case report of atypical uterine leiomyoma
Yun Sook Kim, Hyun Joo Lee
Medicine: Case Reports and Study Protocols.2021; 3(11): e0168. CrossRef - Metastatic leiomyoma or synchronous lesion of the uteri corpus and vulva?
I. V. Barinova, S. N. Buyanova, N. I. Kondrikov, N. A. Shchukina, I. N. Voloshchuk, M. V. Mgeliashvili, S. A. Petrakova, A. A. Aksenova
Arkhiv patologii.2020; 82(1): 62. CrossRef - Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/CT have a role to play?
Feras Abu Saadeh, Ciaran O. Riain, Ciara Mc Cormack, Noreen Gleeson
Irish Journal of Medical Science (1971 -).2019; 188(2): 619. CrossRef - Benign metastasising leiomyoma with lymph node metastases in a patient with endometrial cancer after caesarean section
Serra Akar, Serdar Ugras, Gozde Sahin, Fatih Demir, Çetin Çelik
Journal of Obstetrics and Gynaecology.2019; 39(3): 420. CrossRef - Benign metastasizing leiomyoma presenting with miliary pattern and fatal outcome: Case report with molecular analysis & review of the literature
Kenneth Ofori, Helen Fernandes, Matthew Cummings, Thomas Colby, Anjali Saqi
Respiratory Medicine Case Reports.2019; 27: 100831. CrossRef - Gonadotropin-releasing Hormone Agonist Plus Aromatase Inhibitor in the Treatment of Uterine Leiomyoma in Near Menopause Patient: A Case Series Study
Sanam Moradan
Journal of Menopausal Medicine.2018; 24(1): 62. CrossRef - The Heart as a Site of Metastasis of Benign Metastasizing Leiomyoma: Case Report and Review of the Literature
Mariam Meddeb, Robert D. Chow, Randolph Whipps, Reyaz Haque
Case Reports in Cardiology.2018; 2018: 1. CrossRef - BENIGN UTERUS CANCER WITH LUNG METASTASES: LEIOMYOMATOSIS, LYMPHANGIOLEIMYOMATOSIS, THORACIC ENDOMETRIOSIS (LITERATURE REVIEW, PERSONAL CLINCIAL OBSERVATIONS)
Леншин, Anatoliy Lenshin, Ильин, Andrey Il'in, Демура, Ol'ga Demura, Крайнов, Sergey Kraynov, Побережский, Aleksey Poberezhskiy
Bulletin physiology and pathology of respiration .2017; : 30. CrossRef - Benign metastasizing leiomyoma and 18-FDG-PET/CT: A case report and literature review
Yusuke Sawai, Toshiki Shimizu, Yuta Yamanaka, Maiko Niki, Shosaku Nomura
Oncology Letters.2017; 14(3): 3641. CrossRef - Mesothelial cell deposits in lymph nodes—a diagnostic pitfall
Archana Pandita, Vladimir Osipov
Annals of Diagnostic Pathology.2016; 25: 31. CrossRef - Recommendations and Technical Aspects of 16α-[18F]Fluoro-17β-Estradiol PET to Image the Estrogen Receptor In Vivo
Clasina M. Venema, Giulia Apollonio, Geke A.P. Hospers, Carolina P. Schröder, Rudi A.J.O. Dierckx, Erik F.J. de Vries, Andor W.J.M. Glaudemans
Clinical Nuclear Medicine.2016; 41(11): 844. CrossRef - Single benign metastasising leiomyoma of an inguinal lymph node
Kamil G Laban, Roberto E Tobon-Morales, Janice A L Hodge, Henk W R Schreuder
BMJ Case Reports.2016; : bcr2016216546. CrossRef - Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature
Mohamad S. Mahmoud, Kavita Desai, Farr R. Nezhat
Archives of Gynecology and Obstetrics.2015; 291(1): 223. CrossRef - Benign pulmonary metastasizing leiomyoma of the uterus: A case report
HUI MA, JIE CAO
Oncology Letters.2015; 9(3): 1347. CrossRef - Single-port laparoscopic debulking surgery of variant benign metastatic leiomyomatosis with simultaneous lymphatic spreading and intraperitoneal seeding
Yoo Hyun Chung, Suk Woo Lee, So Young Shin, Chae Chun Rhim, Soyoung Im, Sie Hyeon Yoo, Joo Hee Yoon
Obstetrics & Gynecology Science.2015; 58(4): 314. CrossRef - Benign metastasizing leiomyoma of the lung: A case report and literature review
WEI-TIAN WEI, PENG-CHENG CHEN
Oncology Letters.2015; 10(1): 307. CrossRef - Difficulty in complete transarterial embolization for pulmonary benign metastasizing leiomyoma with massive hemoptysis
Masaya Miyazaki, Akie Nakayama, Daichi Noda, Yasunobu Maehara, Yoshito Tsushima
Japanese Journal of Radiology.2014; 32(1): 53. CrossRef - Pulmonary leiomyomas in a patient with bilateral renal cell cancer mimicking pulmonary metastases
Ying-Yi Chen, Seng-Tang Wu, Hsian-Her Hsu, Ya-Cheng Chen, Shih-Chun Lee, Hung Chang, Tsai-Wang Huang
Clinical Imaging.2014; 38(3): 330. CrossRef - Incidental Benign Metastasizing Leiomyoma in a Patient with Bone Sarcoma: A Case Report
Zanndor Jacob del Real-Romo, Carlos Montero-Cantú, Oscar Villegas-Cabello, José Antonio Díaz-Elizondo, Danae Reyes-Salas, Rene Palomo-Hoil, Guillermo Peralta-Castillo, David Martínez-Sánchez, Eduardo Flores-Villalba
Case Reports in Surgery.2014; 2014: 1. CrossRef - Metastasizing Leiomyoma to Heart
Erin N. Consamus, Michael J. Reardon, Alberto G. Ayala, Mary R. Schwartz, Jae Y. Ro
Methodist DeBakey Cardiovascular Journal.2014; 10(4): 251. CrossRef - METASTASISING LEIOMYOMA- A CASE REPORT
Krishna Govindan, Sheela Kuzhiveli Mohammed Ali, Lekshmy Kausthubham Sudheendran
Journal of Evolution of Medical and Dental Sciences.2014; 7(42): 4591. CrossRef - Benign Metastatic Leiomyoma Presenting as a Hemothorax
Anna M. Ponea, Creticus P. Marak, Harmeen Goraya, Achuta K. Guddati
Case Reports in Oncological Medicine.2013; 2013: 1. CrossRef - Novel hormone treatment of benign metastasizing leiomyoma: an analysis of five cases and literature review
Erin I. Lewis, Rebecca J. Chason, Alan H. DeCherney, Alicia Armstrong, John Elkas, Aradhana M. Venkatesan
Fertility and Sterility.2013; 99(7): 2017. CrossRef - Sex-specific lung diseases: effect of oestrogen on cultured cells and in animal models
Bosung Shim, Gustavo Pacheco-Rodriguez, Jiro Kato, Thomas N. Darling, Martha Vaughan, Joel Moss
European Respiratory Review.2013; 22(129): 302. CrossRef - Pulmonary benign metastasizing leiomyoma: a case report and review of the literature
Yili Fu, Hui Li, Bo Tian, Bin Hu
World Journal of Surgical Oncology.2012;[Epub] CrossRef
- Pulmonary Benign Metastasizing Leiomyoma in a Postmenopausal Woman: A Case Report and Review of the Literature
- 12,090 View
- 71 Download
- 29 Crossref
- Recurrent and Metastatic Trichilemmal Carcinoma of the Skin Over the Thigh: A Case Report
- Hyon Seung Yi, Sun Jin Sym, Jinny Park, Eun Kyung Cho, Seung-Yeon Ha, Dong Bok Shin, Jae Hoon Lee
- Cancer Res Treat. 2010;42(3):176-179. Published online September 30, 2010
- DOI: https://doi.org/10.4143/crt.2010.42.3.176
-
Abstract
PDFPubReaderePub
Trichilemmal carcinoma (TC) is an uncommon cutaneous neoplasm that develops from the external root sheath of the hair follicle. It is considered to be a low-grade carcinoma with low metastatic potential. Local recurrence and metastasis are rare after surgical excision. We report here on a case of metastatic TC in the skin over the thigh, and this tumor was treated with cisplatin and cyclophosphamide combination chemotherapy.
-
Citations
Citations to this article as recorded by- Trichilemmal carcinoma metastatic to parotid gland: First report of fine needle aspiration cytology features
Priya Jayakumar, Aanchal Kakkar, Sudheer Arava, Supriya Mallick
Diagnostic Cytopathology.2024;[Epub] CrossRef - Successful treatment of trichilemmal carcinoma with distant metastasis using pembrolizumab: a case report and review
Lei Liu, Tengfei Long, Nannan Wei, Hongyan Zhang, Chaoliang Tang, Jin Gao
Immunotherapy.2024; 16(10): 659. CrossRef - A Rare Case of Trichilemmal Carcinoma of the Scalp
Raymart Macasaet, FNU Arty, Janelle du Toit, Sai Gaddameedi, Shazia M Shah
Cureus.2024;[Epub] CrossRef - Malignant pilar cyst in a young woman: Case report and literature review
Ali Ibrahim Ali Hegy, Amina Ibrahim El-yakub, Yaser Taha Sidahmed
International Journal of Case Reports and Images.2024; 15(1): 89. CrossRef - A Rare Case Of Trichilemmal Carcinoma In A Sun-unexposed Area
Alemwosen Alem, Alazar Aregawi, Teketel Geremew
Journal of Global Surgery (ONE).2024;[Epub] CrossRef - Trichilemmal carcinoma treated by excision combined with photodynamic therapy: a case report and review of literature
Lingyu Qidiao, Yilin Liu, Danni Hu, Xingchi Tao, Chunli Yao
Frontiers in Oncology.2024;[Epub] CrossRef - Systematic analysis and case series of the diagnosis and management of trichilemmal carcinoma
Jiachen Sun, Lihua Zhang, Minglu Xiao, Shiyi Li, Runkai Chen, Ying Li, Yuguang Yang
Frontiers in Oncology.2023;[Epub] CrossRef - When to sweat: A history of chemotherapy in malignant sweat gland tumors. A unique case report and literature review
J. Matthiesen, R. Chiu, T. T. Do, S. Bamdad, J. Lee, S. K. Peng
Clinical Case Reports.2023;[Epub] CrossRef - Recurrent trichilemmal carcinoma of the periorbital region treated with IMRT radiotherapy: A case report and a review of literature
Shan Gao, Qin Xu, Yanli Lan, Lang He
Medicine.2023; 102(24): e34038. CrossRef - Malignant proliferating trichilemmal tumor in abdominal wall: Report of a rare case at an uncommon site with literature review
Mahdokht Azizi, Mazaher Ramezani
Clinical Case Reports.2022;[Epub] CrossRef - Trichilemmal Carcinoma of the Scalp in a Young Female: A Case Report
Qiuyu Jia, Yunyan Yuan, Dandan Mao, Guangdong Wen, Xue Chen
Clinical, Cosmetic and Investigational Dermatology.2022; Volume 15: 139. CrossRef - Current Treatment Options for Cutaneous Adnexal Malignancies
Hiroyuki Goto
Current Treatment Options in Oncology.2022; 23(5): 736. CrossRef - Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation
Iga Płachta, Marcin Kleibert, Anna M. Czarnecka, Mateusz Spałek, Anna Szumera-Ciećkiewicz, Piotr Rutkowski
International Journal of Molecular Sciences.2021; 22(9): 4759. CrossRef - Huge Trichilemmal Carcinoma With Metastasis Presenting With Two Distinct Histological Morphologies: A Case Report
Yao Xie, Lin Wang, Tingting Wang
Frontiers in Oncology.2021;[Epub] CrossRef - Trichilemmal carcinoma in a patient with squamous cell skin cancer
V. A. Smolyannikova, M. A. Nefedova
Arkhiv patologii.2019; 81(1): 31. CrossRef - Locally aggressive trichilemmal carcinoma
Ana María Maya-Rico, Catalina Jaramillo-Pulgarín, Ángela Londoño-García, Bibiana Peña-Zúñiga
Anais Brasileiros de Dermatologia.2018; 93(4): 579. CrossRef - Cells to Surgery Quiz: April 2018
Ali Rajabi-Estarabadi, Sofia Iglesia, Jacob W. Griggs, Pooja Gurnani, Samuel C. Smith, Cassandra IF. Collins, Keyvan Nouri
Journal of Investigative Dermatology.2018; 138(4): e37. CrossRef - Adnexal Carcinomas Treated With Mohs Micrographic Surgery: A Comprehensive Review
Stanislav N. Tolkachjov
Dermatologic Surgery.2017; 43(10): 1199. CrossRef - Malignant hair follicle tumors of the periorbital region: A review of literature and suggestion of a management guideline
Paul Ikgan Sia, Edwin Figueira, Alexandra Allende, Dinesh Selva
Orbit.2016; 35(3): 144. CrossRef - Metastatic trichilemmal carcinoma in a patient with breast cancer
Chrysis Sofianos, Nkhensani Y Chauke, Alexandra Grubnik
BMJ Case Reports.2016; : bcr2016217661. CrossRef - A Case of Trichilemmal Carcinoma With Distant Metastases in a Kidney Transplantation Patient
K. Hiramatsu, K. Sasaki, M. Matsuda, M. Hashimoto, T. Eguchi, S. Tomikawa, T. Fujii, G. Watanabe
Transplantation Proceedings.2015; 47(1): 155. CrossRef - Challenges in the diagnosis of cutaneous adnexal tumours
Richard Danialan, Kudakwashe Mutyambizi, Phyu P Aung, Victor G Prieto, Doina Ivan
Journal of Clinical Pathology.2015; 68(12): 992. CrossRef - Survival study and clinicopathological evaluation of trichilemmal carcinoma
SHI-MIN ZHUANG, GE-HUA ZHANG, WEN-KUAN CHEN, SHU-WEI CHEN, LI-PING WANG, HUAN LI, MING SONG
Molecular and Clinical Oncology.2013; 1(3): 499. CrossRef - Unusual Invasion of Trichilemmal Umors: Two Case Reports
Mehtap Karamese, Ahmet Akatekin, Malik Abaci, Zekeriya Tosun, Mustafa Keskin
Modern Plastic Surgery.2012; 02(03): 54. CrossRef
- Trichilemmal carcinoma metastatic to parotid gland: First report of fine needle aspiration cytology features
- 9,910 View
- 71 Download
- 24 Crossref
Original Article
- Clinical Significance of Lymph Node Micrometastasis in Stage I and II Colon Cancer
- Sun Jin Park, Kil Yeon Lee, Si Young Kim
- Cancer Res Treat. 2008;40(2):75-80. Published online June 30, 2008
- DOI: https://doi.org/10.4143/crt.2008.40.2.75
-
Abstract
PDFPubReaderePub
Purpose A 25% rate of recurrence after performing complete resection in node-negative colon cancer patients suggests that their nodal staging is frequently suboptimal. Moreover, the value of occult cancer cells in tumor-free lymph nodes still remains uncertain. The authors evaluated the prognostic significance of the pathologic parameters, including the lymph node occult disease (micrometastases) detected by immunohistochemistry, in patients with node-negative colon cancer.
Materials and Methods The study included 160 patients with curatively resected stage I or II colon cancer and they were without rectal cancer. 2852 lymph nodes were re-examined by re-do hematoxylin and eosin (H-E) staining and immunohistochemical staining. The detection rates were compared with the clinicopathologic characteristics and with the cancer-specific survival.
Results Occult metastases were detected in 8 patients (5%). However, no clinicopathologic parameter was found to be correlated with the presence of micrometastasis. Twenty patients developed recurrence at a median follow-up of 45.7 months: 14 died of colon cancer and 9 died from noncancer-related causes. Univariate analysis showed that lymphatic invasion and the number of retrieved lymph nodes significantly influenced survival, and multivariate analysis revealed that the stage, the number of retrieved lymph nodes and lymphatic invasion were independently related to the prognosis.
Conclusions Inadequate lymph node retrieval and lymphatic invasion were found to be associated with a poorer outcome for node-negative colon cancer patients. The presence of immunostained tumors cells in pN0 lymph nodes was found to have no significant effect on survival, but these tumor were identified by re-do H-E staining. Maximal attention should be paid to the total number of lymph nodes that are retrieved during surgery for colon cancer patients.
-
Citations
Citations to this article as recorded by- In comparison with polypectomy, colorectal resection is associated with improved survival for patients diagnosed with malignant polyps
Andrew P. Zammit, John D. Hooper, Ian Brown, David A. Clark, Andrew D. Riddell
Colorectal Disease.2023; 25(2): 261. CrossRef - Role of one-step nucleic acid amplification in colorectal cancer lymph node metastases detection
Francesco Crafa, Serafino Vanella, Onofrio A Catalano, Kelsey L Pomykala, Mario Baiamonte
World Journal of Gastroenterology.2022; 28(30): 4019. CrossRef - Feasibility of Pooled One-Step Nucleic Acid Amplification for Molecular Staging of Pathologically Node-Negative Colon Cancer: A Prospective Multicenter Study
Kimitaka Tani, Michio Itabashi, Koichi Okuya, Kenji Okita, Ichiro Takemasa, Naohiro Tomita, Shimpei Ogawa, Yoji Nagashima, Masakazu Yamamoto
Annals of Surgical Oncology.2021; 28(13): 8804. CrossRef - Prognostic value of radiologically enlarged lymph nodes in node‐negative colon cancer
W. Song, Z. Chen, Z. Zheng, J. Hu, Y. Chen, W. Deng, X. He, P. Lan
Colorectal Disease.2020; 22(5): 537. CrossRef - Short-term outcomes of a multicentre randomized clinical trial comparing D2 versus D3 lymph node dissection for colonic cancer (COLD trial)
A Karachun, L Panaiotti, I Chernikovskiy, S Achkasov, Y Gevorkyan, N Savanovich, G Sharygin, L Markushin, O Sushkov, D Aleshin, D Shakhmatov, I Nazarov, I Muratov, O Maynovskaya, A Olkina, T Lankov, T Ovchinnikova, D Kharagezov, D Kaymakchi, A Milakin, A
Journal of British Surgery.2020; 107(5): 499. CrossRef - Which Patients with Isolated Para-aortic Lymph Node Metastasis Will Truly Benefit from Extended Lymph Node Dissection for Colon Cancer?
Sung Uk Bae, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
Cancer Research and Treatment.2018; 50(3): 712. CrossRef - Lymph Node Micrometastasis Cannot be Considered as Positive Lymph Node in Nonmetastatic Colorectal Cancer
Kwang Dae Hong, Jun Won Um, Byung Wook Min, Woong-Bae Ji, Jung-Woo Choi, Young-Sik Kim
The American Surgeon™.2017; 83(2): 127. CrossRef - Lymph node micrometastasis in stage I and II rectal cancer
Hye-Yoon Choi, Kil Yeon Lee, Su Youn Lee, Youn Wha Kim
Korean Journal of Clinical Oncology.2016; 12(2): 110. CrossRef - Risk of recurrence in patients with colon cancer stage II and III: A systematic review and meta-analysis of recent literature
Camilla Böckelman, Bodil E. Engelmann, Tuomas Kaprio, Torben F. Hansen, Bengt Glimelius
Acta Oncologica.2015; 54(1): 5. CrossRef - Targeted lymph node assessment in gastrointestinal neoplasms
Victoria O'Connor, Yuko Kitagawa, Alexander Stojadinovic, Anton J. Bilchik
Current Problems in Surgery.2014; 51(1): 9. CrossRef - The Diagnostic Value of One-Step Nucleic acid Amplification (OSNA) for Sentinel Lymph Nodes in Colon Cancer Patients
F. J. Vogelaar, M. S. Reimers, R. L. A. van der Linden, J. C. van der Linden, V. T. H. B. M. Smit, D. J. Lips, C. J. H. van de Velde, K. Bosscha
Annals of Surgical Oncology.2014; 21(12): 3924. CrossRef - Comparative Analysis between Multilevel Sectioning with Conventional Haematoxylin and Eosin Staining and Immunohistochemistry for Detecting Nodal Micrometastases with Stage I and II Colorectal Cancers
Yin-Ping Wong, Shamsul Azhar Shah, Noorsajida Shaari, Mohd Shafbari Mohamad Esa, Ismail Sagap, Nurismah Md Isa
Asian Pacific Journal of Cancer Prevention.2014; 15(4): 1725. CrossRef - Lymph Node Metastases in Rectal Cancer After Preoperative Radiochemotherapy
Thilo Sprenger, Hilka Rothe, Heinz Becker, Tim Beissbarth, Kia Homayounfar, Korbinian Gauss, Julia Kitz, Hendrik Wolff, Andreas H. Scheel, Michael Ghadimi, Claus Rödel, Lena-Christin Conradi, Torsten Liersch
American Journal of Surgical Pathology.2013; 37(8): 1283. CrossRef - Lymph node micrometastasis in gastrointestinal tract cancer—a clinical aspect
Shoji Natsugoe, Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Akihiro Nakajo, Masataka Matsumoto, Hiroshi Okumura, Yuko Kijima, Masahiko Sakoda, Yuko Mataki, Yasuto Uchikado, Shinichiro Mori, Kosei Maemura, Sumiya Ishigami
International Journal of Clinical Oncology.2013; 18(5): 752. CrossRef - Prognostic significance of histologically detected lymph node micrometastases of sizes between 0.2 and 2 mm in colorectal cancer
Bruno Märkl, C. Herbst, C. Cacchi, T. Schaller, I. Krammer, G. Schenkirsch, A. Probst, H. Spatz
International Journal of Colorectal Disease.2013; 28(7): 977. CrossRef - Prognostic significance of isolated tumor cells in patients with colorectal cancer in recent 10-year studies
YOSHITO AKAGI, TETSUSHI KINUGASA, YOSUKE ADACHI, KAZUO SHIROUZU
Molecular and Clinical Oncology.2013; 1(4): 582. CrossRef - Molecular investigation of lymph nodes in colon cancer patients using one‐step nucleic acid amplification (OSNA)
Ulrich Güller, Andreas Zettl, Mathias Worni, Igor Langer, Daniela Cabalzar‐Wondberg, Carsten T. Viehl, Nicolas Demartines, Markus Zuber
Cancer.2012; 118(24): 6039. CrossRef - Isolated Tumor Cells in Regional Lymph Nodes as Relapse Predictors in Stage I and II Colorectal Cancer
Claudia Mescoli, Laura Albertoni, Salvatore Pucciarelli, Luciano Giacomelli, Valentina M. Russo, Matteo Fassan, Donato Nitti, Massimo Rugge
Journal of Clinical Oncology.2012; 30(9): 965. CrossRef - Molecular Detection of Tumor Cells in Regional Lymph Nodes Is Associated With Disease Recurrence and Poor Survival in Node-Negative Colorectal Cancer: A Systematic Review and Meta-Analysis
Nuh N. Rahbari, Ulrich Bork, Edith Motschall, Kristian Thorlund, Markus W. Büchler, Moritz Koch, Jürgen Weitz
Journal of Clinical Oncology.2012; 30(1): 60. CrossRef - Perspectives on Current Tumor-Node-Metastasis (TNM) Staging of Cancers of the Colon and Rectum
Huankai Hu, Alyssa Krasinskas, Joseph Willis
Seminars in Oncology.2011; 38(4): 500. CrossRef - Clinicopathologic factors associated with lymph node retrieval in resectable colon cancer: A veterans' affairs central cancer registry (VACCR) database analysis
Wilson I Gonsalves, Swapna Kanuri, Tsewang Tashi, Ibrahim Aldoss, Ashwin Sama, Islam Al‐Howaidi, Ashwin Ganta, Mudappa Kalaiah, Ramya Thota, Jairam Krishnamurthy, Xiang Fang, Peter Townley, Apar K. Ganti, Shanmuga Subbiah, Peter T. Silberstein
Journal of Surgical Oncology.2011; 104(6): 667. CrossRef - Impact on Prognosis of Lymph Node Micrometastasis and Isolated Tumor Cells in Stage II Colorectal Cancer
Tai Young Oh, Sun Mi Moon, Ui Sup Shin, Hyang Ran Lee, Sun Hoo Park
Journal of the Korean Society of Coloproctology.2011; 27(2): 71. CrossRef - Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients
Stanley P.L. Leong, Markus Zuber, Robert L. Ferris, Yuko Kitagawa, Ramon Cabanas, Charles Levenback, Mark Faries, Sukamal Saha
Journal of Surgical Oncology.2011; 103(6): 518. CrossRef - Lymph Node Micrometastases and Isolated Tumor Cells Influence Survival in Stage I and II Colon Cancer
Arne E. Faerden, Ole H. Sjo, Ida R. K. Bukholm, Solveig Norheim Andersen, Aud Svindland, Arild Nesbakken, Arne Bakka
Diseases of the Colon & Rectum.2011; 54(2): 200. CrossRef - Detection and prognostic impact of micrometastasis in colorectal cancer
Saad Sirop, Mohammed Kanaan, Alpesh Korant, David Wiese, David Eilender, Sunil Nagpal, Madan Arora, Trevor Singh, Sukamal Saha
Journal of Surgical Oncology.2011; 103(6): 534. CrossRef - A mathematical approach to the optimal examination of lymph nodes
CHI YOUNG AHN, SE HOON KIM, SEON JUNG JANG, SOON WON HONG, HYUNKI KIM, BEOM JIN LIM
APMIS.2011; 119(12): 868. CrossRef - Cytokeratin staining for complete remission in rectal cancer after chemoradiation
Hae Ran Yun, Hee Cheol Kim, Seok Hyung Kim, Seong Hyeon Yun, Woo Yong Lee, Yong Beom Cho, Hee Jeong Shin, Ho-Kyung Chun
International Journal of Colorectal Disease.2010; 25(7): 805. CrossRef
- In comparison with polypectomy, colorectal resection is associated with improved survival for patients diagnosed with malignant polyps
- 11,614 View
- 96 Download
- 27 Crossref
First
Prev
