Cancer Research and Treatment

Original Articles

General

Emergency Department Utilization of Adult Cancer Patient in Korea: A Nationwide Population-Based Study, 2017-2019: Hye Sook Min, Hye Jung Chang, Ho Kyung Sung; Cancer Res Treat. 2022;54(3):680-689. Published online September 17, 2021; DOI: https://doi.org/10.4143/crt.2021.699

Purpose
The current study aimed to identify the overall characteristics of cancer-related emergency department (ED) visits by adult in Korea, including analyses of factors associated with ED stay time and outcomes nationwide.
Materials and Methods
We collected data on cancer-related ED visits from the National Emergency Department Information System (NEDIS) database between 2017 and 2019.
Results
ED visits by cancer patients comprised 5.5% (667,935 visits) of total ED visits from 2017 to 2019, which was slightly higher than in other counties. Patients with cancer who visited the ED were over 50 years old, the majority being males, and patients with cancer visited EDs in certified tertiary hospitals more frequently than patients without cancer. In multivariate analyses, the adjusted odds ratio for a length of stay more than 8 hours in the ED of certified tertiary hospitals was 126.34 (95% confidence interval, 1.422 to 1.460) when compared to hospitals. Nevertheless, the longer the patients stayed in the ED, the more likely they were to be admitted.
Conclusion
The longer ED stay and higher proportion of cancer patient hospitalizations suggest that cancer patients visit ED to be admitted as well as to receive acute care. The frequency of ED visits and admission may be adjusted to some extent depending on outpatient education, such as self-management of symptoms and situations. Improving cancer care in local communities should be met though provisions such as linking treatment between hospitals or supplying appropriate medical personnel, even for the efficient use of ED resources in hospitals.

Citations

Citations to this article as recorded by

Trends in emergency department visits for emergency care–sensitive conditions before and during the COVID-19 pandemic: a nationwide study in Korea, 2019–2021
Seonji Kim, Ho Kyung Sung, Jeehye Lee, Eunsil Ko, Seong Jung Kim
Clinical and Experimental Emergency Medicine.2024; 11(1): 88. CrossRef
Impact of the early phase of the COVID-19 pandemic on emergency department-to-intensive care unit admissions in Korea: an interrupted time-series analysis
Kyung-Shin Lee, Changwoo Han, Hye Sook Min, Jeehye Lee, Seok Hwa Youn, Younghwan Kim, Jae Young Moon, Young Seok Lee, Su Jin Kim, Ho Kyung Sung
BMC Emergency Medicine.2024;[Epub] CrossRef
Impact of the Early COVID-19 Pandemic on Emergency Department Visits of Adult Cancer Patients With Fever or Respiratory Symptoms: A Korean Nationwide Population-Based Study, 2016–2020
Kyung Shin Lee, Ho Kyung Sung, Youn Young Choi, Changwoo Han, Hye Sook Min
Journal of Korean Medical Science.2024;[Epub] CrossRef
Clinical, Demographic Characteristics and Short-Term Prognosis of Cancer Patients Presenting to the Emergency Department
Şimşek Çelik, Pelin Çelik
Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi.2024; 6(2): 284. CrossRef
Diagnosis of cancer in the Emergency Department: A scoping review
Alix Delamare Fauvel, Jason J. Bischof, Raquel E. Reinbolt, Veronica K. Weihing, Edward W. Boyer, Jeffrey M. Caterino, Henry E. Wang
Cancer Medicine.2023; 12(7): 8710. CrossRef
Factors Influencing Posttraumatic Growth Among Primary Caregivers of Patients with Oncologic Emergencies in Taiwan Intensive Care Units: A Cross-Sectional Study of Patient–Caregiver Dyads
Ya-Hsin Lo, Chih-Hsi Kuo, Ching-Ching Tsai, Shu-Ching Chen
Seminars in Oncology Nursing.2023; 39(5): 151497. CrossRef
Trends in emergency department visits for suicide attempts before and during the COVID-19 pandemic in Korea: A nationwide study, 2016–2021
Seonji Kim, Ho Kyung Sung, Taehui Kim, Sung-keun Ko, SeongJung Kim, Jin-Hee Lee
Journal of Affective Disorders.2023; 331: 184. CrossRef
The severity of clinical symptoms according to cancer diagnosis in fever patients visiting the emergency department: a retrospective analysis
Eun Seam Lee, Purum Kang, You Kyoung Shin, Geun Hee Seol
Journal of Korean Biological Nursing Science.2023; 25(2): 105. CrossRef
Drivers of Emergency Department Use Among Oncology Patients in the Era of Novel Cancer Therapeutics: A Systematic Review
Lauren Fleshner, Andrew Lagree, Audrey Shiner, Marie Angeli Alera, Mateusz Bielecki, Robert Grant, Alex Kiss, Monika K Krzyzanowska, Ivy Cheng, William T Tran, Sonal Gandhi
The Oncologist.2023; 28(12): 1020. CrossRef
Epidemiologic trends of patients who visited nationwide emergency departments: a report from the National Emergency Department Information System (NEDIS) of Korea, 2018–2022
Hyun Ho Yoo, Young Sun Ro, Eunsil Ko, Jin-Hee Lee, So-hyun Han, Taerim Kim, Tae Gun Shin, Seongjung Kim, Hansol Chang
Clinical and Experimental Emergency Medicine.2023; 10(S): S1. CrossRef
Aggressiveness of care in the last days of life in the emergency department of a tertiary hospital in Korea
Jung Sun Kim, Sun Young Lee, Min Sung Lee, Shin Hye Yoo, Jeongmi Shin, Wonho Choi, Yejin Kim, Hyung Sook Han, Jinui Hong, Bhumsuk Keam, Dae Seog Heo
BMC Palliative Care.2022;[Epub] CrossRef
Suicide attempt-related emergency department visits among adolescents: a nationwide population-based study in Korea, 2016–2019
Kyung-Shin Lee, Daesung Lim, Jong-Woo Paik, Youn Young Choi, Jaehyun Jeon, Ho Kyung Sung
BMC Psychiatry.2022;[Epub] CrossRef
The impact of COVID-19 on cancer care in a tertiary hospital in Korea: possible collateral damage to emergency care
Shin Hye Yoo, Jin-Ah Sim, Jeongmi Shin, Bhumsuk Keam, Jun-Bean Park, Aesun Shin
Epidemiology and Health.2022; 44: e2022044. CrossRef
Patient and hospital characteristics predict prolonged emergency department length of stay and in-hospital mortality: a nationwide analysis in Korea
Kyung-Shin Lee, Hye Sook Min, Jae Young Moon, Daesung Lim, Younghwan Kim, Eunsil Ko, You Sun Kim, Joohae Kim, Jeehye Lee, Ho Kyung Sung
BMC Emergency Medicine.2022;[Epub] CrossRef

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Comparison of Native Escherichia coli L-Asparaginase versus Pegylated Asparaginase, in Combination with Ifosfamide, Methotrexate, Etoposide, and Prednisolone, in Extranodal NK/T-Cell Lymphoma, Nasal Type: Hyun Jee Kim, Chan-Young Ock, Tae Min Kim, Sung Hee Lee, Ju-Yeun Lee, Sun hoi Jung, Yoon Sook Cho, Miso Kim, Bhumsuk Keam, Dong-Wan Kim, Il Han Kim, Dae Seog Heo; Cancer Res Treat. 2018;50(3):670-680. Published online July 3, 2017; DOI: https://doi.org/10.4143/crt.2017.051

Abstract PDF Supplementary Material PubReader ePub

Purpose
The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).
Materials and Methods
A total of 41 NTCL patients who received IMEP plus native E. coli L-ASP or PEG-ASP at Seoul National University Hospital were included in this study between January 2013 and March 2016. IMEP/ASP treatment consisted of ifosfamide, methotrexate, etoposide, plus native E. coli L-ASP (6,000 IU/m² on days 1, 3, 5, 7, 9, and 11) or PEG-ASP (2,500 IU/m² on day 1) every 3 weeks. ASP-related toxicities, toxicity patterns, length of hospital stay, and clinical outcomes were compared between the different treatment groups.
Results
The frequency of ASP-related toxicities was similar between the IMEP plus native E. coli L-ASP group and the PEG-ASP group apart from hypofibrinogenemia (native E. coli L-ASP vs. PEG-ASP group, 86.4% vs. 36.8%; p=0.001). Although post-treatment transaminase and albumin levels were significantly high and low, respectively, hepatotoxicity gradients before and after treatment did not differ significantly between the groups. Since PEG-ASP was given at an outpatient clinic in some patients, length of hospital stay was significantly shorter in the IMEP plus PEG-ASP group (median, 4.0 vs. 6.0 days; p=0.002). A favorable tendency of clinical outcomes was observed in NTCL patients treated with IMEP plus PEG-ASP (complete remission rate, 73.7% vs. 45.5%; p=0.067).
Conclusion
IMEP plus PEG-ASP showed similar ASP-related toxicities, shorter length of hospital stay, and a trend towards improved clinical outcomes compared with IMEP plus native E. coli L-ASP in NTCL.

Citations

Citations to this article as recorded by

From the midfacial destructive drama to the unfolding EBV story: a short history of EBV-positive NK-cell and T-cell lymphoproliferative diseases
Chi Sing Ng
Pathology.2024; 56(6): 773. CrossRef
Treatment of extranodal NK/T-cell lymphoma: From past to future
Zheng Yan, Shuna Yao, Zhizhong Wang, Wenping Zhou, Zhihua Yao, Yanyan Liu
Frontiers in Immunology.2023;[Epub] CrossRef
Efficacy of a short sandwich protocol, methotrexate, gemcitabine, L‐asparaginase and dexamethasone chemotherapy combined with radiotherapy, in localised newly diagnosed NK/T‐cell lymphoma: A French retrospective study
Sammara Chaubard, Amira Marouf, David Lavergne, François Lemonnier, Julien Rossignol, Aline Clavert, Rémy Gressin, Guillaume Cartron, Agathe Waultier‐Rascalou, Jacques Vargaftig, Gilles Salles, Emmanuel Bachy, Hervé Ghesquières, Olivier Tournilhac, Adrien
British Journal of Haematology.2023; 201(4): 673. CrossRef
Is PEGylation of Drugs Associated with Hypersensitivity Reactions? An Analysis of the Italian National Spontaneous Adverse Drug Reaction Reporting System
Salvatore Crisafulli, Paola Maria Cutroneo, Nicoletta Luxi, Andrea Fontana, Carmen Ferrajolo, Pasquale Marchione, Laura Sottosanti, Giovanna Zanoni, Ugo Moretti, Silvia Franzè, Paola Minghetti, Gianluca Trifirò
Drug Safety.2023; 46(4): 343. CrossRef
Incidence and Related Factors of L-asparaginase-induced Hypersensitivity Reactions Requiring Treatment Changes in Pediatric Patients with Acute Lymphoblastic Leukemia
Eun Eui Noh, Yujin Lee, Sukmin Hong, Sung Hwan Kim, Sung Yun Suh, Yoon Sook Cho, Hyun Jin Park, Bo Kyung Kim, Kyung Taek Hong, Jung Yoon Choi, Hyoung Jin Kang, Ju-Yeun Lee
Journal of Korean Society of Health-System Pharmacists.2023; 40(2): 171. CrossRef
DDGP followed by radiotherapy vs VIPD followed by radiotherapy in newly diagnosed early NK/T-cell lymphoma
Lei Zhang, Chenxing Shangguan, Xin Li, Ling Li, Xinhua Wang, Xiaorui Fu, Zhenchang Sun, Yonggang Shi, Jingjing Wu, Xudong Zhang, Hui Yu, Feifei Nan, Jiaqin Yan, Yu Chang, Zhiyuan Zhou, Xiaolong Wu, Xiaoyan Feng, Xiyang Liu, Hongwei Xue, Liqun Zou, Yi Lu,
Leukemia Research.2022; 118: 106881. CrossRef
DDGP vs. SMILE in Relapsed/Refractory Extranodal Natural Killer/T‐cell Lymphoma, Nasal Type: A Retrospective Study of 54 Patients
Xin Wang, Junxia Hu, Meng Dong, Mengjie Ding, Linan Zhu, Jingjing Wu, Zhenchang Sun, Xin Li, Lei Zhang, Ling Li, Xinhua Wang, Xiaorui Fu, Guannan Wang, Qingjiang Chen, Mingzhi Zhang, Xudong Zhang
Clinical and Translational Science.2021; 14(1): 405. CrossRef
Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge
Yiwei Liu, Colton A. Smith, John C. Panetta, Wenjian Yang, Lauren E. Thompson, Jacob P. Counts, Alejandro R. Molinelli, Deqing Pei, Nancy M. Kornegay, Kristine R. Crews, Hope Swanson, Cheng Cheng, Seth E. Karol, William E. Evans, Hiroto Inaba, Ching-Hon P
Journal of Clinical Oncology.2019; 37(23): 2051. CrossRef
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PEG-L-CHOP treatment is safe and effective in adult extranodal NK/T-cell lymphoma with a low rate of clinical hypersensitivity
Wen Zheng, Yuhuan Gao, Xiaoyan Ke, Weijing Zhang, Liping Su, Hanyun Ren, Ningjing Lin, Yan Xie, Meifeng Tu, Weiping Liu, Lingyan Ping, Zhitao Ying, Chen Zhang, Lijuan Deng, Xiaopei Wang, Yuqin Song, Jun Zhu
BMC Cancer.2018;[Epub] CrossRef

11,984 View
390 Download
8 Web of Science
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