Cancer Research and Treatment

Original Articles

The Effect of Hospital Case Volume on Clinical Outcomes in Patients with Nasopharyngeal Carcinoma: A Multi-institutional Retrospective Analysis (KROG-1106): Boram Ha, Kwan Ho Cho, Sung Ho Moon, Chang-Geol Lee, Ki Chang Keum, Yeon-Sil Kim, Hong-Gyun Wu, Jin Ho Kim, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Jong Hoon Lee, Sung Hwan Kim, Won Taek Kim, Young-Taek Oh, Min Kyu Kang, Jin Hee Kim, Ji-Yoon Kim, Moon-June Cho, Chul Seoung Kay, Jin Hwa Choi; Cancer Res Treat. 2019;51(1):12-23. Published online February 5, 2018; DOI: https://doi.org/10.4143/crt.2017.273

Abstract PDF Supplementary Material PubReader ePub

Purpose
The purpose of this study was to investigate the effect of hospital case volume on clinical outcomes in patients with nasopharyngeal carcinoma (NPC).
Materials and Methods
Data on 1,073 patients with cT1-4N0-3M0 NPC were collected from a multi-institutional retrospective database (KROG 11-06). All patients received definitive radiotherapy (RT) either with three-dimensional-conformal RT (3D-CRT) (n=576) or intensity-modulated RT (IMRT) (n=497). The patients were divided into two groups treated at high volume institution (HVI) (n=750) and low volume institution (LVI) (n=323), defined as patient volume ≥ 10 (median, 13; range, 10 to 18) and < 10 patients per year (median, 3; range, 2 to 6), respectively. Endpoints were overall survival (OS) and loco-regional progression-free survival (LRPFS).
Results
At a median follow-up of 56.7 months, the outcomes were significantly better in those treated at HVI than at LVI. For the 614 patients of propensity score-matched cohort, 5-year OS and LRPFS were consistently higher in the HVI group than in the LVI group (OS: 78.4% vs. 62.7%, p < 0.001; LRPFS: 86.2% vs. 65.8%, p < 0.001, respectively). According to RT modality, significant difference in 5-year OS was observed in patients receiving 3D-CRT (78.7% for HVI vs. 58.9% for LVI, p < 0.001) and not in those receiving IMRT (77.3% for HVI vs. 75.5% for LVI, p=0.170).
Conclusion
A significant relationship was observed between HVI and LVI for the clinical outcomes of patients with NPC. However, the difference in outcome becomes insignificant in the IMRT era, probably due to the standardization of practice by education.

Citations

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Accumulated Dose Deviation of Rotational and Residual Setup Errors on Nasopharyngeal Carcinoma Using MIM Treated by Helical Tomotherapy
Wenyan Yao, Jiang Hu, Peixun Xu, Mengxue He, Yongwen Fang, Mingzhi Liu, Zongtai Li, Huilang He, Hui Liu, Wenzhao Sun, Senkui Xu
Technology in Cancer Research & Treatment.2023;[Epub] CrossRef
Systematic Review and Meta-analysis of the Association Between Radiation Therapy Treatment Volume and Patient Outcomes
Jerry Ye Aung Kyaw, Alice Rendall, Erin F. Gillespie, Tom Roques, Laurence Court, Yolande Lievens, Alison C. Tree, Chris Frampton, Ajay Aggarwal
International Journal of Radiation Oncology*Biology*Physics.2023; 117(5): 1063. CrossRef
The Influence of Hospital Volume on the Outcomes of Nasopharyngeal, Sinonasal, and Skull-Base Tumors: A Systematic Review of the Literature
Stephanie Flukes, Rahul K. Sharma, Shivangi Lohia, Marc A. Cohen
Journal of Neurological Surgery Part B: Skull Base.2022; 83(03): 270. CrossRef
A Comprehensive Analysis of Treatment Management and Survival Outcomes in Nasopharyngeal Carcinoma
Khodayar Goshtasbi, Brandon M. Lehrich, Jack L. Birkenbeuel, Arash Abiri, Jeremy P. Harris, Edward C. Kuan
Otolaryngology–Head and Neck Surgery.2021; 165(1): 93. CrossRef
Hospital volume and physician volume in association with survival in patients with nasopharyngeal cancer after radiation therapy
Tzu-Yu Lai, Chiu-Mei Yeh, Yu-Wen Hu, Chia-Jen Liu
Radiotherapy and Oncology.2020; 151: 190. CrossRef

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Annual Report of the Central Cancer Registry in Korea-1999: Based on Registered Data from 128 Hospitals: Jong Myon Bae, Young Joo Won, Kyu Won Jung, Kyung Ae Suh, Don Hee Ahn, Jae Gahb Park; Cancer Res Treat. 2001;33(5):367-372. Published online October 31, 2001; DOI: https://doi.org/10.4143/crt.2001.33.5.367

Abstract PDF

PURPOSE
The Central Cancer Registry Center in Korea (KCCR) conducted a nationwide hospital-based cancer registry to provide basic statistical data on cancer.
MATERIALS AND METHODS
In 1999, 128 hospitals participated in the cancer registry program. All cancer registry data, which was submitted from the participating hospitals by diskettes during the year, were reviewed and analyzed by the committee members who were all Board-qualified clinical oncologists and pathologists. To avoid duplication, every resident registration number was compared by a computer.
Case
s that had been diagnosed by a histological examination were preferentially chosen for inclusion in this data.
RESULTS
Of 94,003 cases that were registered, there was a total of 8,452 (9.0%) duplication cases which were excluded. Of the remaining 85,551 cases, there were 3,231 cases (3.8%) of carcinoma in situ (morphology code/2) which were excluded. A final total of 82,320 cases were analyzed. Of the analyzed cases, 46,908 (57.0%) were males and 35,412 (43.0%) were females. The leading age groups in the order of their relative frequency were those who were 60~64 years of age (15.3%), followed by the 55~59 age group (13.8%). The six leading primary cancer sites in the order of their relative frequency were stomach (20.7%), followed by the bronchus and lung (12.1%), the liver and intrahepatic bile duct (12.0%), the colorectum (9.9%), the breast (6.4%), and then the uterine cervix (5.0%). In males, the five leading primary cancer sites were the stomach (24.2%), the liver and intrahepatic bile duct (16.3%), the bronchus and lung (16.1%), the colorectum (9.7%), and the urinary bladder (3.3%). In females, the stomach (16.2%) was the most common cancer site, followed by the breast (14.7%), the uterine cervix (11.6%), the colorectum (10.2%), and the thyroid (6.8%). Among the 1,077 cases of childhood malignancies, leukemia (35.4%), CNS tumors (16.7%), malignant lymphomas (7.0%), and sympathetic nervous system tumors (6.9%) were the most common cancer types.
CONCLUSION
We analyzed and report the KCCR data from 128 nationwide hospitals during 1999.

Citations

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Comparison of Dose Distribution between the Techniques of Non-small Cell Lung Cancer
Seung-chul Lee, Young-jae Kim, Seongjoo Jang
Journal of the Korean Society of Radiology.2016; 10(4): 233. CrossRef
Discussion on the usefulness of dose dynamic multi-leaf collimator-based plan to overcome dose limit of spinal cord in high-dose radiotherapy
E.C. Kim, J.H. Cho, C.S. Park, D.H. Kim, C.W. Choi
Radiation Effects and Defects in Solids.2014; 169(3): 265. CrossRef
Microsatellite Instability Is Associated with the Clinicopathologic Features of Gastric Cancer in Sporadic Gastric Cancer Patients
Shin Hyuk Kim, Byung Kyu Ahn, Young Su Nam, Joo Youn Pyo, Young Ha Oh, Kang Hong Lee
Journal of Gastric Cancer.2010; 10(4): 149. CrossRef
The Effect of Autophagy to Cell Death in Nutrient-Deprived H460 Cells
Hye Yeon Jang, Hyang Jeong Jo, Ki Eun Hwhang, So Young Kim, Kang Kyoo Lee, Sun Rock Moon, Jeong Hyun Shin, Kyung Hwa Cho, Mi Kung Lee, Sam Youn Lee, Soon Ah Park, Jong Kun Park, Hui Jung Kim, Sei Hoon Yang
Tuberculosis and Respiratory Diseases.2010; 69(2): 81. CrossRef
Increased expression of p27 is associated with the cisplatin resistance in gastric cancer cell line YCC-3
Tuong Vy Thi Le, Youngcheol Seo, Chun Jeih Ryu, Hye Ran Lee, Hyun-Ju Park
Archives of Pharmacal Research.2010; 33(7): 1127. CrossRef
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Dong Won Ryu, Chang Wan Jun, Chung Han Lee
Journal of Breast Cancer.2008; 11(2): 89. CrossRef
Relationship between meat and cereal consumption and colorectal cancer in Korea and Japan
Sun‐Il Lee, Hong‐Young Moon, Jung‐Myun Kwak, Jin Kim, Byung‐Wook Min, Jun‐Won Um, Seon‐Han Kim
Journal of Gastroenterology and Hepatology.2008; 23(1): 138. CrossRef
The Global Histone Modification Pattern Correlates with Cancer Recurrence and Overall Survival in Gastric Adenocarcinoma
Young Soo Park, Min Young Jin, Yong Jin Kim, Jeong Hwan Yook, Byung Sik Kim, Se Jin Jang
Annals of Surgical Oncology.2008; 15(7): 1968. CrossRef
Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma
Jaehwi Song, Chang Jae Kim, Yong Gu Cho, Su Young Kim, Suk Woo Nam, Sug Hyung Lee, Nam Jin Yoo, Jung Young Lee, Won Sang Park
Journal of Gastroenterology and Hepatology.2006; 21(8): 1286. CrossRef
A Phase II Trial of Haptaplatin/5-FU and Leucovorin for Advanced Stomach Cancer
Won Sup Lee, Gyeong-Won Lee, Hwal Woong Kim, Ok-Jae Lee, Young-Joon Lee, Gyung Hyuck Ko, Jong-Seok Lee, Joung Soon Jang, Woo Song Ha
Cancer Research and Treatment.2005; 37(4): 208. CrossRef
Altered expression of KCNK9 in colorectal cancers
CHANG JAE KIM, YONG GU CHO, SEONG WHAN JEONG, YOUNG SIL KIM, SU YOUNG KIM, SUK WOO NAM, SUG HYUNG LEE, NAM JIN YOO, JUNG YOUNG LEE, WON SANG PARK
APMIS.2004; 112(9): 588. CrossRef
The E-cadherin −347G→GA promoter polymorphism and its effect on transcriptional regulation
Yong Shin, Il-Jin Kim, Hio Chung Kang, Jae-Hyun Park, Hye-Rin Park, Hye-Won Park, Mi Ae Park, Jong Soo Lee, Kyong-Ah Yoon, Ja-Lok Ku, Jae-Gahb Park
Carcinogenesis.2004; 25(6): 895. CrossRef
Reduced PTEN Expression Is Associated With Poor Outcome and Angiogenesis in Invasive Ductal Carcinoma of the Breast
Ji Shin Lee, Hyung Seok Kim, Young Bog Kim, Min Cheol Lee, Chang Soo Park, Kyung Whan Min
Applied Immunohistochemistry & Molecular Morphology.2004; 12(3): 205. CrossRef
Identification of Genes with Differential Expression in Acquired Drug-Resistant Gastric Cancer Cells Using High-Density Oligonucleotide Microarrays
Hio Chung Kang, Il-Jin Kim, Jae-Hyun Park, Yong Shin, Ja-Lok Ku, Mi Sun Jung, Byong Chul Yoo, Hark Kyun Kim, Jae-Gahb Park
Clinical Cancer Research.2004; 10(1): 272. CrossRef
Radiotherapy for Locally Advanced Lung Cancer
Eun Kyung Choi
Journal of the Korean Medical Association.2003; 46(1): 29. CrossRef

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Annual Report of the Central Cancer Registry in Korea-1998 (Based on Registered Data from 124 Hospitals): Chang In Suh, Kyung Ae Suh, Seong Heum Park, Hee Jin Chang, Jae Wook Ko, Don Hee Ahn; J Korean Cancer Assoc. 2000;32(5):827-834.

Abstract PDF: PURPOSE
Central Cancer Registry Center in Korea conducted a nation-wide hospital-based cancer registry to provide the basic data on cancer statistics.
MATERIALS AND METHODS
In 1998, 124 hospitals participated in the cancer registry program. All cancer registry data, submitted from the participating hospitals by diskettes during the year, were reviewed and sorted out by the committee members who were all board-qualified clinical oncologists and pathologists. To avoid duplication, every resident registration numbers were compared by the computer. Cases diagnosed by histologic examination were preferentially chosen.
RESULTS
Of 89,226 cases registered, 9,163 (10.3%) duplication cases were excluded. Of the remaining 80,063 cases, 3,195 cases (4.0%) of carcinoma in situ (morphology code /2) were excluded. Finally 76,868 cases were analyzed. Of the analyzed cases, 44,037 (57.3%) were male and 32,831 (42.7%) were female. The leading age groups in the order of relative frequency were 60~64 years of age (15.3%), followed by 55~59 (14.4%). The leading primary cancer sites in the order of relative frequency were stomach (20.9%), followed by liver and intrahepatic bile ducts (12.2%), bronchus and lung (11.9%), colorectum (9.6%), breast (6.1%). In male, the leading primary cancer sites were stomach (24.4%), followed by liver and intrahepatic bile ducts (16.4%), bronchus and lung(16.0%), colorectum(9.2%) and urinary bladder (3.5%). In female, stomach (16.3%) was the most common site, followed by breast (14.1%), uterine cervix (13.0%), colorectum (10.1%) and liver and intrahepatic bile ducts (6.5%). Among the 1,190 cases of childhood malignancies, leukemia (33.4%), CNS tumor (15.7%) and sympathetic nervous system tumor (8.4%) were common.
CONCLUSION
We analyzed and reported the registered cancer data from 124 hospitals during 1998.

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Development of Procedures of Cancer Case Ascertainment in Pusan City Area: Hai Rim Shin, Duk Hee Lee, Tae Soo Park, Yoon Ok Ahn, Hai Rim Shin, Duck Hwan Jeung; J Korean Cancer Assoc. 1996;28(6):943-951.

Abstract PDF: This study was performed to develop the method which could collect completely the cancer cases in Pusan Cancer Registry(PCR). The definite goals were ¨c to see the feasibility and completeness of PCR connected with Central Cancer Registry Program(CCRP), by calculating omitting rates based on utilization rate of hospitals in Pusan and registered hospitals ¨e to evaluate the possibility of generalization to other cities-Taegu, Incheun, Kwangju, Taejeon. Data sources were CCRP and claims from the Korea Medical Insurance Corporation (KMIC). l) In case of using data of the registered and unregistered hospitals in each city, the expected omitting rates were 6.2%(CCRP)-8.5%(KMIC) in Pusan, 4.7% in Taegu, 42.7% in Incheun, 26.3% in Kwangju and 13.5% in Taejeon, respectively. They was suggested to be transferred to the hospitals in other areas from doctor's offices directly. 2) In case of using data of CCR, the expected omitting rates were 9.3% in Pusan, 3.1% in Taegu, 4.2% in Incheun, 5.4% in Kwangju and 0.9% in Taejeon, respectively. 3) In case of using both two data resources -CCR and the unregistered hospitals in each city- the expected omitting rates were 1.2% in Pusan, 1.5% in Taegu, 0.0% in Incheun, 1.2% in Kwangju and 0.0% in Taejeon, respectively. Almost all patients using only the hospital in other areas visited registered hospital which have attended CCR. We could ensure about 100% completeness, combining the CCR and an active surveillance at unregistered hospitals. This model could be one of the most efficient population-based cancer registry in Korea.

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Comparison of Mammalian UV endeonuclase 3 Activities with Respect to Xeroderma Pigmentosum Group D Cells: Joon Kim, Jang Hee Hahm, Seong Hoe Park; J Korean Cancer Assoc. 1996;28(6):951-961.

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