Cancer Research and Treatment

Original Articles

The Prognostic Value of Epidermal Growth Factor Receptor in Primary Breast Cancer: Bong Geun Park, Sung Jae Cha, Sung Joon Park; J Korean Cancer Assoc. 1998;30(4):711-718.

Abstract PDF: PURPOSE
The objective of this study was to ascertain the relationship between epidermal growth factor receptor(EGFR) status and estrogen receptor(ER) and other prognostic factors in primary human breast cancer patients. We tried to evaluate the value of EGFR as a prognostic factor.
MATERIALS AND METHODS
EGFR and ER were measured by immunohistochemical staining. It was performed on section from paraffin blocks of 60 primary breast cancer patients who underwent mastectomy at Chung-Ang University Hospital. And we evaluate the relationship between EGFR and ER and other prognostic factors.
RESULTS
In 20 of 60 patients(33.3%), the staining was positive for the expression of EGFR. Of the 60 patients, 6 were both positive for EGFR and ER, 25 were both negative, 14 were EGFR positive and ER negative, 15 were EGFR negative and ER positive. Between EGFR and estrogen receptor(ER) status, previously known clear inverse relationship was not observed in our study. The EGFR status was not correlated with axillary lymph node involvement, histologic type, and histologic grading. But it was correlated with tumor size(p=0.049), and there was a high tendency of recurrence rate of patients with EGFR-positive tumors as compared with those with EGFR-negative tumors(p=0.078).
CONCLUSION
EGFR status may be valuable as a prognostic factor in determining the prognosis of breast cancer. However, the study of more cases will be needed for the significance of the information about the EGFR as an independent prognostic factor.

2,598 View
14 Download

A Study of Estrogen Receptors in Gastric Cancer: Young Jin Kim, Moon Oh Bae, Shin Kon Kim; J Korean Cancer Assoc. 1994;26(5):722-728.

Abstract PDF: Recently the presence of estrogen receptor(ER) has been demonstrated in some cases of cancer of the digestive tract such as stomach, large intestine, pancreas and the liver which are non-target organs of sex hormones. The authors studied ER in tumors from 95 gastric adenocarcinomas using immunohisto- chemical staining with monoclonal antibody. DNA ploidy using flow cytometry was also as- sessed in 75 cases of gastric carcinomas. ER positivity was 40 of 95(42.1%) gastric carcinomas. The tendency of receptor positivity increased with progression of tumor and lower differentiation. There was no positive relationship between ER positivity and sex, age, gross type, DNA ploidy and the level of carcinoem- bryonic antigen. The results of this study show that hormonal factors are involved in gastric carcinomas and that the cancers have endocrinic characteristics. The sturdies clarifying the rofe of hormones to cancer cells will be valuable in the design of hormonal therapy.

2,798 View
18 Download

First
Prev
Page of 1
Next
Last

Search