Skip Navigation
Skip to contents

Cancer Res Treat : Cancer Research and Treatment

OPEN ACCESS

Search

Page Path
HOME > Search
2 "Ear canal"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Article
Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma
Jinhyun Choi, Se-Heon Kim, Yoon Woo Koh, Eun Chang Choi, Chang Geol Lee, Ki Chang Keum
Cancer Res Treat. 2017;49(1):178-184.   Published online July 4, 2016
DOI: https://doi.org/10.4143/crt.2016.165
AbstractAbstract PDFPubReaderePub
Purpose
The purpose of this study was to evaluate the clinical outcomes of patients treated with radiotherapy (RT) for a carcinoma of the external auditory canal (EAC) and middle ear.
Materials and Methods
The records of 32 patients who received RT from 1990 to 2013 were reviewed retrospectively. The Pittsburgh classification was used to stage all the cancers (early stage, T1/T2 [n=12]; advanced stage, T3/T4 or N positive [n=20]). Twenty-one patients (65.6%) were treated with postoperative RT and 11 patients (34.4%) were treated with definitive RT. The median radiation doses for postoperative and definitive RT were 60 Gy and 64.8 Gy, respectively. Chemotherapy was administered to seven patients (21.9%).
Results
The 5-year overall survival and disease-free survival rates for all patients were 57% and 52%, respectively. The disease control rates for the patients with early stage versus advanced stage carcinomawere 55.6% (5/9) and 50% (6/12) in the postoperative RT group and 66.7% (2/3) and 37.5% (3/8) in the definitive RT group, respectively. Overall, 15 cases (14 patients, 46.7%) experienced treatment failure; these failures were classified as local in four cases, regional in one case, and distant in 10 cases. The median follow-up period after RT was 51 months (range, 7 to 286 months).
Conclusion
Patients with early stage carcinoma achieved better outcomes when definitive RT was used. Advanced stage carcinoma patients experienced better outcomes with postoperative RT. The high rate of distant failure after RT, with or without surgery, reflected the lack of a consensus regarding the best therapeutic approach for treating carcinoma of the EAC and middle ear.

Citations

Citations to this article as recorded by  
  • Survival Outcomes of Temporal Bone Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis
    Krystelle Sioufi, Aaron David Haynes, Paul W. Gidley, Anastasios Maniakas, Dianna Roberts, Marc‐Elie Nader
    Otolaryngology–Head and Neck Surgery.2024; 171(1): 1.     CrossRef
  • The international expert consensus on management of external auditory canal carcinoma
    Pei Zhou, Rubens de Brito, Yong Cui, Simon Lloyd, Henricus Kunst, J. Walter Kutz, Navin Mani, In Seok Moon, Badr Eldin Mostafa, Cindy Nabuurs, Sampath Chandra Prasad Rao, Bingbin Xie, Yibo Zhang, Chunfu Dai
    European Archives of Oto-Rhino-Laryngology.2024;[Epub]     CrossRef
  • Postoperative Radiotherapy for pT1- and pT2-Classified Squamous Cell Carcinoma of the External Auditory Canal
    Cindy Nabuurs, Wietske Kievit, Charles Leemans, Conrad Smit, Michiel van den Brekel, Robert Pauw, Bernard van der Laan, Jeroen Jansen, Martin Lacko, Weibel Braunius, Chunfu Dai, Xunbei Shi, Giovanni Danesi, Jan Bouček, Daniele Borsetto, Shravan Gowrishank
    Cancers.2024; 16(23): 4026.     CrossRef
  • Clinical outcomes of temporal bone squamous cell carcinoma: A single‐institution experience
    Yongbo Zheng, Ke Qiu, Yangju Fu, Wenjie Yang, Danni Cheng, Yufang Rao, Minzi Mao, Yao Song, Wei Xu, Jianjun Ren, Yu Zhao
    Cancer Medicine.2023; 12(5): 5304.     CrossRef
  • Analysis of Prognostic Factors For External Auditory Canal Carcinoma: A 22‐Year Experience
    Isabelle J. H. Jang, Jiun Fong Thong, Constance E. H. Teo, Kiattisa Sommat
    The Laryngoscope.2023; 133(9): 2203.     CrossRef
  • Neoadjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma: Expecting Its Application in Temporal Bone Squamous Cell Carcinoma
    Meng-wen Shi, Jing Huang, Yu Sun
    Current Medical Science.2023; 43(2): 213.     CrossRef
  • Preoperative simulation using three‐dimensional printer in four temporal bone surgeries
    Ichiro Fukumoto, Yukiyoshi Mita, Rie Shimmi, Yuri Sonobe, Tomohisa Iinuma, Kazuki Yamasaki, Shuji Yonekura, Toshimitsu Nemoto, Toyoyuki Hanazawa
    Clinical Case Reports.2023;[Epub]     CrossRef
  • The Efficacy of Radiotherapy without Surgery for External Auditory Canal Squamous Cell Carcinoma
    Naoto Osu, Atsushi Musha, Hikaru Yumisaki, Kohei Okada, Nobuteru Kubo, Naoko Okano, Yukihiko Takayasu, Masato Shino, Osamu Nikkuni, Shota Ida, Hidemasa Kawamura, Kazuaki Chikamatsu, Tatsuya Ohno
    Journal of Clinical Medicine.2022; 11(19): 5905.     CrossRef
  • Evaluating the prognostic contributions of TNM classifications and building novel staging schemes for middle ear squamous cell carcinoma
    Ke Qiu, Wendu Pang, Jianqing Qiu, Junhong Li, Danni Cheng, Yufang Rao, Yijun Dong, Minzi Mao, Qiurui Liu, Xiaosong Mu, Wei Zhang, Wei Xu, Jianjun Ren, Yu Zhao
    Cancer Medicine.2021; 10(22): 7958.     CrossRef
  • Evaluation of the modified Pittsburgh classification for predicting the disease‐free survival outcome of squamous cell carcinoma of the external auditory canal
    Cindy H. Nabuurs, Wietske Kievit, Nilou Labbé, C. René Leemans, Conrad F. G. M. Smit, Michiel W. M. van den Brekel, Robert J. Pauw, Bernard F. A. M. van der Laan, Jeroen C. Jansen, Martin Lacko, Weibel W. Braunius, Shinya Morita, Małgorzata Wierzbicka, Ta
    Head & Neck.2020; 42(12): 3609.     CrossRef
  • Management of Temporal Bone Malignancy in Ireland
    Robbie S. R. Woods, Anel Naude, John Barry O'Sullivan, Daniel Rawluk, Mohsen Javadpour, Peter Walshe, Peter D. Lacy, James Paul O'Neill, Rory McConn-Walsh
    Journal of Neurological Surgery Part B: Skull Base.2020; 81(06): 680.     CrossRef
  • A retrospective multicenter study of carbon‐ion radiotherapy for external auditory canal and middle ear carcinomas
    Kazuhiko Hayashi, Masashi Koto, Yusuke Demizu, Jun‐ichi Saitoh, Hiroaki Suefuji, Tomoaki Okimoto, Tatsuya Ohno, Yoshiyuki Shioyama, Ryo Takagi, Hiroaki Ikawa, Kenji Nemoto, Takashi Nakano, Tadashi Kamada
    Cancer Medicine.2019; 8(1): 51.     CrossRef
  • Squamous cell carcinoma of the temporal bone: A current review
    Benjamin D. Lovin, Paul W. Gidley
    Laryngoscope Investigative Otolaryngology.2019; 4(6): 684.     CrossRef
  • Carcinoma of middle ear
    Dragoslava Đerić
    Биомедицинска истраживања.2019; 10(2): 179.     CrossRef
  • Surgery With or Without Postoperative Radiation Therapy for Early-stage External Auditory Canal Squamous Cell Carcinoma: A Meta-analysis
    Ryohei Oya, Yukinori Takenaka, Kazuya Takemura, Naoki Ashida, Kotaro Shimizu, Takahiro Kitamura, Yoshifumi Yamamoto, Atsuhiko Uno
    Otology & Neurotology.2017; 38(9): 1333.     CrossRef
  • 10,259 View
  • 240 Download
  • 16 Web of Science
  • 15 Crossref
Close layer
Case Report
Mucoepidermoid Carcinoma in The External Auditory Canal: A Case Report
Jae Ho Chung, Seung Hwan Lee, Chul Won Park, Kyung Tae
Cancer Res Treat. 2012;44(4):275-278.   Published online December 31, 2012
DOI: https://doi.org/10.4143/crt.2012.44.4.275
AbstractAbstract PDFPubReaderePub
Mucoepidermoid carcinoma in the external auditory canal is extremely rare. Strategies used for treatment of mucoepidermoid carcinoma remain controversial. We present a case of mucoepidermoid carcinoma of the external auditory canal. The patient underwent lateral temporal bone resection and the surgical defect was obliterated with temporal muscle. He is currently disease-free, four years after surgery. Proper diagnostic measures and strategy for treatment of mucoepidermoid carcinoma are discussed.

Citations

Citations to this article as recorded by  
  • Primary mucoepidermoid carcinoma of the external auditory canal with a CRTC1::MAML2 fusion: A case report and a review of literature
    Carlo De la Sancha, Matthew Kuhar, Adele Kraft, Ahmed K. Alomari
    Journal of Cutaneous Pathology.2023; 50(11): 947.     CrossRef
  • Neoplasms of the Ear Canal
    Mallory Raymond
    Otolaryngologic Clinics of North America.2023; 56(5): 965.     CrossRef
  • Treatment and survival outcomes of ceruminous carcinomas of the external auditory canal: a SEER database analysis and literature review
    Brian Wanner, Kyle Rismiller, David R. Carr
    Archives of Dermatological Research.2022; 314(6): 583.     CrossRef
  • Treatment, Survival, and Demographics in Temporal Bone Malignancies: A Pooled Data Analysis
    Mitchell R Gore
    Cureus.2022;[Epub]     CrossRef
  • Ceruminous Neoplasms of the Ear
    Priyadharsini Nagarajan
    Head and Neck Pathology.2018; 12(3): 350.     CrossRef
  • Salivary mucoepidermoid carcinoma revisited
    Andrés Coca-Pelaz, Juan P. Rodrigo, Asterios Triantafyllou, Jennifer L. Hunt, Alessandra Rinaldo, Primož Strojan, Missak Haigentz, William M. Mendenhall, Robert P. Takes, Vincent Vander Poorten, Alfio Ferlito
    European Archives of Oto-Rhino-Laryngology.2015; 272(4): 799.     CrossRef
  • State of the art in temporal bone malignancies
    Sampath Chandra Prasad, Flavia D’Orazio, Marimar Medina, Andrea Bacciu, Mario Sanna
    Current Opinion in Otolaryngology & Head and Neck Surgery.2014; 22(2): 154.     CrossRef
  • 11,139 View
  • 58 Download
  • 7 Crossref
Close layer

Cancer Res Treat : Cancer Research and Treatment
Close layer
TOP