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Patient’s Cognitive Function and Attitudes towards Family Involvement in Cancer Treatment Decision Making: A Patient-Family Caregiver Dyadic Analysis
Dong Wook Shin, Juhee Cho, Debra L. Roter, So Young Kim, Jong Hyock Park, Hyung Kook Yang, Hyun Woo Lee, Sun-Seog Kweon, Yune Sik Kang, Keeho Park
Cancer Res Treat. 2018;50(3):681-690.   Published online July 4, 2017
DOI: https://doi.org/10.4143/crt.2017.201
AbstractAbstract PDFPubReaderePub
Purpose
Older patient populations commonly have cognitive impairment, which might impact decisional capacity. We examined patients and family caregivers preferences for family involvement in treatment decision making assuming different level of cognitive impairment, and sought to explore the factors associated with the preferences and the degree to which patients and family members agree on preferences.
Materials and Methods
A total of 358 elderly cancer patient and caregiver dyads were recruited from the 11 cancer centers in Korea andwere asked to express their preferences forfamily involvement in treatment decision making using hypothetical scenarios with three different levels of cognitive status (intact, mild impairment, and severe impairment).
Results
Both patients and family caregivers preferred greater family dominance in treatment decision makingwith the increasing the level of cognitive impairment (39.7%, 60.9%, and 86.6% for patients and 45.0%, 66.2%, and 89.7% for caregivers in each scenarios). Patient and family caregiver concordance in decisional control preference was small for all three scenarios (weighted κ=0.32, κ=0.26, and κ=0.36, respectively). Higher patient education was associated with preference for patient dominance in treatment decision in conditions of both mild and severe cognitive impairment. The association of higher patient education and patient-caregiver preference concordance was positive with intact cognition, while it was negative with severe cognitive impairment.
Conclusion
Decision control preferences were affected by hypothesized cognitive status of the patients. Findings from our study would be helpful to develop effective strategy for optimizing family involvement in cancer treatment decision in the context of deteriorating cognitive function of the patients.

Citations

Citations to this article as recorded by  
  • Comorbid Dementia and Cancer Therapy Decision-Making: A Scoping Review
    Sean N. Halpin, Gabriel Alain, Aaron Seaman, Erin E. Stevens, Hui Zhao, Mackenzie E. Fowler, Qiuyang Zhang, Tamara Cadet, Minzhi Ye, Jessica L. Krok-Schoen
    Journal of Applied Gerontology.2024; 43(8): 1132.     CrossRef
  • Assessing the association between quantity and quality of family caregiver participation in decision-making clinical encounters on patient activation in the metastatic breast cancer setting
    Nicole L. Henderson, Tanvi Padalkar, Garrett Bourne, Emma K. Hendrix, Courtney P. Williams, J. Nicholas Odom, Kristen Triebel, Gabrielle B. Rocque
    Supportive Care in Cancer.2024;[Epub]     CrossRef
  • Fatalism and metaphor in Confucianism: A qualitative study of barriers to genetic testing among first‐degree relatives of hereditary cancer patients from China
    Chaonan Jiang, Li Liu, Ye Wang, Liangzheng Wu, Wenxia Zhang, Xiaodan Wu
    Psycho-Oncology.2023; 32(2): 275.     CrossRef
  • The Role of Nurse on the Treatment Decision Support for Older People with Cancer: A Systematic Review
    Hiroko Komatsu, Yasuhiro Komatsu
    Healthcare.2023; 11(4): 546.     CrossRef
  • A prospective cohort study of decision‐making role preferences of patients with advanced cancer and their family caregivers
    Semra Ozdemir, Sean Ng, Isha Chaudhry, Chetna Malhotra, Eric Andrew Finkelstein
    Cancer.2023; 129(9): 1443.     CrossRef
  • Cancer literacy among Jordanian colorectal cancer survivors and informal carers: Qualitative explorations
    Samar J. Melhem, Shereen Nabhani-Gebara, Reem Kayyali
    Frontiers in Public Health.2023;[Epub]     CrossRef
  • Preferred and actual involvement of caregivers in oncologic treatment decision-making: A systematic review
    Laura M.L. Tielemans, Kirsten D. van Heugten, Marije E. Hamaker, Inez C. van Walree
    Journal of Geriatric Oncology.2023; 14(6): 101525.     CrossRef
  • Factors Affecting Patient and Caregiver Preferences for Treatment of Myeloma and Indolent Lymphoma
    Chia Jie Tan, Melinda Si Yun Tan, Chandramouli Nagarajan, Wee Joo Chng, Yen-Lin Chee, Melissa Ooi, Lawrence Cheng Kiat Ng, Yunxin Chen, Joanne Su Yin Yoong, Xin Yi Wong, Wei-Ying Jen
    JCO Oncology Practice.2023; 19(12): 1168.     CrossRef
  • The Association Between Mild Cognitive Impairment Diagnosis and Patient Treatment Preferences: a Survey of Older Adults
    Deborah A. Levine, Andrzej T. Galecki, Brenda L. Plassman, Angela Fagerlin, Lauren P. Wallner, Kenneth M. Langa, Rachael T. Whitney, Brahmajee K. Nallamothu, Lewis B. Morgenstern, Bailey K. Reale, Emilie M. Blair, Bruno Giordani, Kathleen Anne Welsh-Bohme
    Journal of General Internal Medicine.2022; 37(8): 1925.     CrossRef
  • Patient activation and treatment decision-making in the context of cancer: examining the contribution of informal caregivers’ involvement
    Chiara Acquati, Judith H. Hibbard, Ellen Miller-Sonet, Anao Zhang, Elena Ionescu
    Journal of Cancer Survivorship.2022; 16(5): 929.     CrossRef
  • Factors influencing family involvement in treatment decision-making for older patients with cancer: A scoping review
    Bea L. Dijkman, Marie Louise Luttik, Hanneke Van der Wal-Huisman, Wolter Paans, Barbara L. van Leeuwen
    Journal of Geriatric Oncology.2022; 13(4): 391.     CrossRef
  • The role of caregivers in the clinical pathway of patients newly diagnosed with breast and prostate cancer: A study protocol
    Clizia Cincidda, Serena Oliveri, Virginia Sanchini, Gabriella Pravettoni
    Frontiers in Psychology.2022;[Epub]     CrossRef
  • Treatment decision-making for older adults with cancer: A qualitative study
    Ni Gong, Qianqian Du, Hongyu Lou, Yiheng Zhang, Hengying Fang, Xueying Zhang, Xiaoyu Wu, Ya Meng, Meifen Zhang
    Nursing Ethics.2021; 28(2): 242.     CrossRef
  • Family Caregiving Situations and Engagement in Advance Care Planning
    Kyeongmo Kim, Michin Hong, Thomas Buckley
    Journal of Palliative Medicine.2020; 23(1): 125.     CrossRef
  • What We Talk about When We Talk about Caregiving: The Distribution of Roles in Cancer Patient Caregiving in a Family-Oriented Culture
    Ansuk Jeong, Dongwook Shin, Jong Hyock Park, Keeho Park
    Cancer Research and Treatment.2019; 51(1): 141.     CrossRef
  • Experience with age discrimination and attitudes toward ageism in older patients with cancer and their caregivers: A nationwide Korean survey
    Dong Wook Shin, Keeho Park, Ansuk Jeong, Hyung Kook Yang, So Young Kim, Mihee Cho, Jong Hyock Park
    Journal of Geriatric Oncology.2019; 10(3): 459.     CrossRef
  • How family caregivers of persons with advanced cancer assist with upstream healthcare decision-making: A qualitative study
    J. Nicholas Dionne-Odom, Deborah Ejem, Rachel Wells, Amber E. Barnato, Richard A. Taylor, Gabrielle B. Rocque, Yasemin E. Turkman, Matthew Kenny, Nataliya V. Ivankova, Marie A. Bakitas, Michelle Y. Martin, Mojtaba Vaismoradi
    PLOS ONE.2019; 14(3): e0212967.     CrossRef
  • 10,806 View
  • 233 Download
  • 17 Web of Science
  • 17 Crossref
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Neurocognitive and Psychological Functioning of Children with an Intracranial Germ Cell Tumor
Younghee Park, Eun-Seung Yu, Boram Ha, Hyeon-Jin Park, Jong-Heun Kim, Joo-Young Kim
Cancer Res Treat. 2017;49(4):960-969.   Published online January 4, 2017
DOI: https://doi.org/10.4143/crt.2016.204
AbstractAbstract PDFPubReaderePub
Purpose
This study was conducted to investigate the neurocognitive functioning of children with intracranial germ cell tumor (IGCT) prior to receiving proton beam therapy (PBT), and to identify differential characteristics of their neurocognitive functioning depending on tumor location. As a secondary object of this study, neurocognitive functions were followed up at 1-2 years after PBT to examine early post-treatment changes.
Materials and Methods
Between 2008 and 2014, 34 childrenwith IGCT treatedwho received PBT atNational Cancer Center, Korea were enrolled in this study. Standardized neurocognitive tests of intelligence, memory, and executive functioningwere performedwith baseline psychological assessments using the Child Behavior Checklist (CBCL). Follow-up assessments after PBTwere conducted in 20 patients (T2). The results were analyzed based on the locations of tumors, which included the suprasellar, pineal gland, basal ganglia, and bifocal regions.
Results
The neurocognitive function of IGCT patients was significantly lower than that of the normal population in performance intelligence quotient (p=0.041), processing speed (p=0.007), memory (p < 0.001), and executive functioning (p=0.010). Patients with basal ganglia tumors had significantly lower scores for most domains of neurocognitive functioning and higher scores for CBCL than both the normal population and patients with IGCT in other locations. There was no significant change in neurocognitive function between T1 and T2 for all types of IGCT patients in first 1-2 years after PBT.
Conclusion
Tumor location significantly affects the neuropsychological functioning in patients with IGCT. Neuropsychological functioning should be closely monitored from the time of diagnosis in IGCT patients.

Citations

Citations to this article as recorded by  
  • Neurocognitive Dysfunction After Treatment for Pediatric Brain Tumors: Subtype-Specific Findings and Proposal for Brain Network-Informed Evaluations
    Charlotte Sleurs, Paul Fletcher, Conor Mallucci, Shivaram Avula, Thankamma Ajithkumar
    Neuroscience Bulletin.2023; 39(12): 1873.     CrossRef
  • Proton therapy for pediatric diencephalic tumors
    Adam J. Grippin, Susan L. McGovern
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Neurocognitive and psychological functioning of pediatric brain tumor patients undergoing proton beam therapy for three different tumor types
    Sang Hee Youn, Boram Ha, Eun‐Hee Lee, Boram Park, Song Ei Yang, Eun‐Seung Yu, Joo‐Young Kim
    Pediatric Blood & Cancer.2022;[Epub]     CrossRef
  • The Japan Society for Neuro-Oncology guideline on the diagnosis and treatment of central nervous system germ cell tumors
    Hideo Nakamura, Hirokazu Takami, Takaaki Yanagisawa, Toshihiro Kumabe, Takamitsu Fujimaki, Yoshiki Arakawa, Katsuyuki Karasawa, Keita Terashima, Hideaki Yokoo, Kohei Fukuoka, Yukihiko Sonoda, Kaori Sakurada, Yohei Mineharu, Toshinori Soejima, Motoaki Fuji
    Neuro-Oncology.2022; 24(4): 503.     CrossRef
  • Hyperbaric Oxygen Therapy as a Complementary Treatment in Glioblastoma—A Scoping Review
    Diogo Alpuim Costa, Mafalda Sampaio-Alves, Eduardo Netto, Gonçalo Fernandez, Edson Oliveira, Andreia Teixeira, Pedro Modas Daniel, Guilherme Silva Bernardo, Carla Amaro
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Neurobehavioral Impairment in Pediatric Brain Tumor Survivors: A Meta-Analysis
    Yuliang Wang, Anthony Pak Yin Liu, Tatia Mei-Chun Lee, Wilfred Hing Sang Wong, Daniel Yee Tak Fong, Lok Kan Leung, Matthew Ming Kong Shing, Dennis Tak-Loi Ku, Godfrey Chi-Fung Chan, Winnie Wan-Yee Tso
    Cancers.2022; 14(13): 3269.     CrossRef
  • Socio-behavioral dysfunction in disorders of hypothalamic-pituitary involvement: The potential role of disease-induced oxytocin and vasopressin signaling deficits
    Lauren Clarke, Olena Zyga, Psalm L. Pineo-Cavanaugh, Michael Jeng, Nancy J. Fischbein, Sonia Partap, Laurence Katznelson, Karen J. Parker
    Neuroscience & Biobehavioral Reviews.2022; 140: 104770.     CrossRef
  • Neurocognitive impairment following proton therapy for paediatric brain tumour: a systematic review of post-therapy assessments
    Noorazrul Yahya, Hanani Abdul Manan
    Supportive Care in Cancer.2021; 29(6): 3035.     CrossRef
  • Behavior Disorder and Social Function Impairment in Children with Basal Ganglia Germ Cell Tumors
    Wenyi Lv, Jin Feng, Li Chen, Shuai Liu, Xiaoguang Qiu
    Neuropsychiatric Disease and Treatment.2021; Volume 17: 91.     CrossRef
  • Comparison on epidemiology, tumor location, histology, and prognosis of intracranial germ cell tumors between Mayo Clinic and Japanese consortium cohorts
    Hirokazu Takami, Avital Perry, Christopher S. Graffeo, Caterina Giannini, Yoshitaka Narita, Yoichi Nakazato, Nobuhito Saito, Ryo Nishikawa, Masao Matsutani, Koichi Ichimura, David J. Daniels
    Journal of Neurosurgery.2021; 134(2): 446.     CrossRef
  • Functional Outcomes of Germ Cell Tumors
    Masayuki Kanamori, Ryuta Saito, Teiji Tominaga
    Japanese Journal of Neurosurgery.2020; 29(4): 270.     CrossRef
  • Long term toxicity of intracranial germ cell tumor treatment in adolescents and young adults
    Jordan Wong, Karen Goddard, Normand Laperriere, Jennifer Dang, Eric Bouffet, Ute Bartels, David Hodgson, Scott Tyldesley, Juliette Hukin, Sylvia Cheng, Philippe L. Bedard, Andrea C. Lo
    Journal of Neuro-Oncology.2020; 149(3): 523.     CrossRef
  • The impact of neuroimaging advancement on neurocognitive evaluation in pediatric brain tumor survivors: A review
    Juan Fan, Ronald Milosevic, Jiefei Li, Jianjun Bai, Yuqi Zhang
    Brain Science Advances.2019; 5(2): 117.     CrossRef
  • The impact of neuroimaging advancement on neurocognitive evaluation in pediatric brain tumor survivors: A review
    Juan Fan, Ronald Milosevic, Jiefei Li, Jianjun Bai, Yuqi Zhang
    Brain Science Advances.2019; 5(2): 117.     CrossRef
  • Cognitive Profile of Children With Intracranial Germ Cell Tumor According to Tumor Location
    Virginie Coutinho, Georges Dellatolas, Clemence Castaignede-Lalande, Audrey Longaud-Vales, Virginie Kieffer, Lea Guerrini-Rousseau, Jacques Grill, Dominique Valteau-Couanet, Christelle Dufour
    Journal of Pediatric Hematology/Oncology.2018; 40(7): e424.     CrossRef
  • 8,634 View
  • 298 Download
  • 16 Web of Science
  • 15 Crossref
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