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- Pediatric cancer
- Gonadal Function in Female Adolescent and Young Adult Survivors of Childhood Cancer
- Hye Young Jin, Jun Ah Lee, Meerim Park, Hyeon Jin Park
- Cancer Res Treat. 2023;55(3):992-1000. Published online January 31, 2023
- DOI: https://doi.org/10.4143/crt.2022.1518
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Abstract
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ePub - Purpose
Childhood cancer survivors (CCSs) are at risk for premature ovarian insufficiency (POI). The aim of this study is to evaluate ovarian function and associated health outcomes in female adolescent and young adult survivors of childhood cancer.
Materials and Methods
Sixty-nine female CCSs were enrolled. Medical records of CCSs were retrospectively reviewed. The subjects were categorized into three groups according to follicular stimulating hormone (FSH) levels (cutoff, 12, 40 IU/L). Anti-müllerian hormone (AMH) level less than 1 ng/mL was considered low AMH level.
Results
Of 69 subjects, 14 (20.3%) had POI and 14 (20.3%) had FSH levels between 12 and 40 IU/L. Forty-one of 69 (59.4%) had normal FSH levels. Pelvic irradiation and stem cell transplantation (SCT) were more frequently performed in subjects with POI (p=0.001 and p < 0.001). AMH levels were remarkably low when FSH levels were over 12 IU/L (p < 0.001). In multivariate analysis, cyclophosphamide equivalent dose and SCT were significant treatment factors for developing low AMH levels (p=0.005 and p=0.002, respectively). Total, low-density lipoprotein cholesterol and triglyceride were significantly different in three groups according to FSH levels (p=0.047, p=0.030, and p=0.045). Z-score of femur neck bone mineral density was significantly reduced when FSH levels were increased (p=0.011).
Conclusion
Gonadal dysfunction is common in CCSs. Gonadal function was associated with a few treatment factors known to increase the risk of POI. Regular monitoring of gonadal function is needed for better health outcomes. -
Citations
Citations to this article as recorded by
- Evaluation of ovarian functions in girls treated for hematological malignancy
Şule Çalışkan Kamış, Begül Yağcı, Ayşe Selcan Koç, Metin Çil
Scientific Reports.2025;[Epub] CrossRef - Impact of haematopoietic stem cell transplantation for benign and malignant haematologic and non-haematologic disorders on fertility: a systematic review and meta-analysis
Angela Vidal, Cristina Bora, Andrea Jarisch, Janna Pape, Susanna Weidlinger, Tanya Karrer, Michael von Wolff
Bone Marrow Transplantation.2025; 60(5): 645. CrossRef - Systematic Review of the Gonadotoxicity and Risk of Infertility of Soft Tissue Sarcoma Chemotherapies in Pre- and Postpubertal Females and Males
Marcel Steinmann, Anita Rietschin, Flavia Pagano, Tanya Karrer, Attila Kollár, Susanna Weidlinger, Michael von Wolff
Journal of Adolescent and Young Adult Oncology.2024; 13(6): 803. CrossRef - Bone Mineral Density in Survivors of Childhood Cancer: A Meta-Analysis
Lilly Velentza, Panagiotis Filis, Mari Wilhelmsson, Per Kogner, Nikolas Herold, Lars Sävendahl
Pediatrics.2024;[Epub] CrossRef
- Evaluation of ovarian functions in girls treated for hematological malignancy
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- Geographical Variations in the Incidence of Childhood Cancer
- Duk Hee Lee, Hai Rim Shin, Kang Weon Park, Yoon Ok Ahn
- J Korean Cancer Assoc. 1998;30(3):425-434.
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Abstract
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- PURPOSE
The incidence of childhood cancer in the Korea was studied to compare incidence rates between countries and between different regions in Korea.
MATERIALS AND METHODS
A tatal of 2,891 cases, registered in the Natinal Cancer Registy from 1993 to 1995, were analysied. Death Certificate Only(DCO) cases were not included. DCO % was estimated about 22%. We calculated the incidence rates according to the International Classification of Childhood Cancer. The age-standardized rates by diagnostic group was compared with those of other countries. The total incidence of childhood cancer were compared among 34 cities in Korea with the rates in the rest of the nation.
RESULTS
The crude incidence of all childhood cancer was 94.1 per million. The cumulative incidence to age 15 was 0.137% and the age-standardized rate, calculated using the world standard population, was 96.1 per million. In the incidence rates by diagnostic group, we observed many similarities with other countries in East Asia. The age-standardized rates of E, F and AL cities were significantly higher(p<0.05). In the 0-4 age group, F, AL and BB cities showed higher rates(p<0.05). In 5~9 years and 10~14 years, F city only had higher rates(p<0.05).
CONCLUSION
Further study will be needed in order to investigate possible environmental factors which may account for the regional variations.
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