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Original Article
Active and Passive Smoking, BRAFV600E Mutation Status, and the Risk of Papillary Thyroid Cancer: A Large-Scale Case-Control and Case-Only Study
Kyoung-Nam Kim, Yunji Hwang, Kyungsik Kim, Kyu Eun Lee, Young Joo Park, June Young Choi, Do Joon Park, BeLong Cho, Daehee Kang, Sue K. Park
Cancer Res Treat. 2019;51(4):1392-1399.   Published online February 20, 2019
DOI: https://doi.org/10.4143/crt.2018.612
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Purpose
The association between tobacco smoking and thyroid cancer remains uncertain. We evaluated the associations of active and passive smokingwith the risk of papillary thyroid cancer (PTC), the most common type of thyroid cancer, and with the BRAFV600E mutation, the most common oncogenic mutation in PTC related to poor prognosis.
Materials and Methods
We conducted this study with newly diagnosed PTC patients (n=2,142) and community controls (n=21,420) individually matched to cases for age and sex. Information on active and passive smoking and potential confounders were obtained from structured questionnaires, anthropometric measurements, and medical records. BRAFV600E mutation status was assessed in PTC patients. We evaluated the associations of active and passive smoking with PTC and BRAFV600E mutation risk using conditional and unconditional logistic regression models, respectively.
Results
We did not find associations between exposure indices of active and passive smoking and PTC risk in both men and women, except for the association between current smoking and lower PTC risk. Cumulative smoking ≥ 20 pack-years was associated with lower BRAFV600E mutation risk in male PTC patients (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.30 to 1.00). The CI for the association was wider in female PTC patients (OR, 0.23; 95% CI, 0.02 to 2.62), possibly owing to a smaller sample size in this stratum.
Conclusion
We did not find consistent associations between active and passive smoking and PTC risk. Cumulative smoking ≥ 20 pack-years was associated with lower BRAFV600E mutation risk in male PTC patients.

Citations

Citations to this article as recorded by  
  • Geographic variation in the association between Hashimoto’s thyroiditis and Papillary thyroid carcinoma, a meta-analysis
    Nabil W. G. Sweis, Ayman A. Zayed, Mira Al Jaberi, Lina AlQirem, Tala Basheer Hyasat, Farah A. Khraisat, Ward Maaita, Ahmad Moayad Naser, Abdullah Nimer, Mamoon Qatamin, Jaleel J. G. Sweis, Nadia Sweis, Abdallah T. Al-Ani, Ahmad M. Alghrabli, Alireza Hagh
    Endocrine.2023; 81(3): 432.     CrossRef
  • Sex-specific Associations between Body Mass Index and Thyroid Cancer Incidence among Korean Adults
    Kyoung-Nam Kim, Kyungsik Kim, Sangjun Lee, Sue K. Park
    Cancer Epidemiology, Biomarkers & Prevention.2023; 32(9): 1227.     CrossRef
  • Effect of Cigarette Smoking on Thyroid Cancer: Meta-Analysis
    Joon-Hyop Lee, Young Jun Chai, Ka Hee Yi
    Endocrinology and Metabolism.2021; 36(3): 590.     CrossRef
  • Tobacco smoking and risk of thyroid cancer according to BRAFV600E mutational subtypes
    Sabbir T. Rahman, Nirmala Pandeya, Rachel E. Neale, Donald S. A. McLeod, Peter D. Baade, Philippa H. Youl, Roger Allison, Susan Leonard, Susan J. Jordan
    Clinical Endocrinology.2021; 95(6): 891.     CrossRef
  • circFAT1(e2) Promotes Papillary Thyroid Cancer Proliferation, Migration, and Invasion via the miRNA-873/ZEB1 Axis
    Jiazhe Liu, Hongchang Li, Chuanchao Wei, Junbin Ding, Jingfeng Lu, Gaofeng Pan, Anwei Mao, Tao Huang
    Computational and Mathematical Methods in Medicine.2020; 2020: 1.     CrossRef
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